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Division of Systems Biomedicine and Pharmacology

The aim of the division of Systems Biomedicine and Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

Welcome to the division of Systems Biomedicine and Pharmacology. The division consists of the following 7 research groups: Analytical Bioscience and Metabolomics (Prof. Thomas Hankemeier), Biomedical Microscale Analytics (Dr. Rawi Ramautar), Medical Systems Biophysics and Bioengineering (Dr. Alireza Mashaghi), Predictive Pharmacology (Prof. Liesbeth de Lange), Quantitative Clinical Pharmacology (Prof. Catherijne Knibbe), Quantitative Pharmacology (Dr. Coen van Hasselt) and Systems Pharmacology (Prof. Piet van der Graaf).

Previously, medical treatments and drugs were designed for an "average patient". This may provide success for some patients, but not for others. Today, the importance to step away from a "one-size-fits-all" approach however, has become clear. And we aim for a much more effective approach that takes into account the differences between individuals, their genes, environments, lifestyles, all of which also influences their individual responses to treatment.

This calls for a thorough understanding of diseases, at the system-level, and is aimed at predicting the modulation of disease networks by drugs in cells, organs, and the body as a whole. To achieve this, we gather metabolomics data from patients and preclinical in-vitro models that are derived from patients (organ-on-a-chip models using human iPSC derived cells) or in-vivo data which we integrate into systems pharmacology modelling.

Our new strategies on pharmacology and personalised medicine development, require further clinical collaborations to help us optimizing and validating. In the end, to result in concepts of system therapeutics.

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