Systems Pharmacology and Pharmacy
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.
We work in a reach of therapeutic areas using a combination of experimental and computational approaches (see Infrastructure).
To learn more about the research groups within SPP, please visit the individual group pages:
- Antiviral Pharmacology (Anne-Grete Märtson)
- Quantitative Clinical Pharmacology (Catherijne Knibbe)
- Predictive Pharmacology (Liesbeth de Lange)
- Quantitative Pharmacology (Coen van Hasselt)
- Medical Systems Biophysics and Bioengineering (Alireza Mashaghi)
- Pharmacy (Miranda van Eck)
- Translational Immuno-Pharmacology (Rob van Wijk)
News
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Personalised medicine? Then you’ll need to look beyond genetics -
Major study offers practical guidance on antibiotic dosing in patients with obesity -
Leiden scientists create first-ever dengue-on-a-chip to study this deadly virus -
Let the robot lend a hand in the pharmacy (it’s more sustainable too) -
Finally solved: how the body's own marijuana spreads through the brain -
Four Leiden professors elected members of the KHMW -
From liquid to solid: revolutionary technique uncovers disease-related changes in tiny droplets within our cells -
Obesity and medication: when does bodyweight matter? -
Lianne Stevens wins The The European Journal of Pharmaceutical Sciences 2024 Best Paper Award -
‘A few nerves before lectures show that my work matters’ -
One million euros grant for smart antibiotic combinations – tackling resistant infections and antimicrobial resistance -
Anne van Rongen wins the Wayne A. Colburn Memorial Award -
During the next pandemic, this mathematical model will speed up the search for treatment -
Stiffness and viscosity of cells differ in cancer and other diseases -
With 30 million dollars, this consortium aims to tackle tuberculosis -
Best poster award of the 5th QSPainRelief General Assembly meeting -
Towards translation of CNS pharmacokinetics from mice to men -
Review paper on the potential impact drug-metabolizing enzymes on brain exposure -
International Symposium on Circuit Topology Organized by Leiden University -
Rethinking antibiotic therapy of urinary tract infections -
Improving nature’s antibiotic -
Reliable research with virtual patients -
Dutch Research Council Open Science Fund grants for five Leiden projects -
How to determine medication dosages for premature babies -
NWO-XS grants for two innovative research projects -
ENW grant from the Dutch Research Council (NWO): Reversing antimicrobial resistance using bacteriophage -
Master's student Nicole ter Laak wins KNMP Studentenprijs 2023 -
Organ failure caused by viruses, how does it work? Now there are methods to find out -
Biological Origami at molecular level: folding a single protein -
New treatments for life-threatening disease sepsis -
Grant Elise Mathilde Fund & LUF: Using virus to kill bacteria: design of innovative phage-antibiotic combination treatments to combat antimicrobial resistance -
Improving painkiller dosing in the clinic -
Children become bacteria to learn about antibiotics -
Developing new therapies to fight muscle disease -
Researchers tackle antibiotic-resistant bacteria -
Combating antibiotic resistance together -
Leiden researchers join forces against tuberculosis
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Drugging the undruggable: NWO Open Competition grant for Alireza Mashaghi -
Bioprinting human tissues for drug testing -
Combatting antibiotic resistance in a clever way
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Improving the treatment of newborn babies with life-threatening sepsis -
How do children's kidneys eliminate drugs? -
Master projects continue thanks to lab automation -
Virtual children help prevent withdrawal syndrome in real children -
How do you determine the right medicine dosage for a child? -
Bio-inspired engineering to fight emerging viral diseases -
‘Looking back, this past year will be a very important period in my life’ -
Two times KNMP Student Award for Leiden students -
Four bold Faculty of Science researchers receive NWO XS grants -
Three LUF grants for talented Leiden Science researchers -
Leiden scientists develop topological barcodes for folded molecules -
International media report on Leiden dosage app for corona patients -
App helps doctors find the right dose of corona medication -
The QSPainRelief consortium will improve the treatment of chronic pain -
Honorary Doctor Elizabeth de Lange honoured in Uppsala -
Ebola-on-a-chip: Leiden scientists against a fatal virus -
Mathematical model predicts drug concentration in the brain -
Pharmacologist Elizabeth de Lange receives Honorary Doctorate in Pharmacy from Uppsala University -
Prestigious award for pharmacologist Meindert Danhof -
Pharmacologist Rob van Wijk is highlighted author of the month -
26 million for research into the impact of non-genetic factors on health -
Bas Goulooze wins prestigious prize for research withdrawal symptoms in children -
€8.5m for research into healthy ageing and vitality -
The Mastermind approach to brain research -
‘Test medicines after five days’ -
Detecting diseases with molecules in the body -
‘Take medicine target saturation into account’ -
German n-tv visits In Ovo and Thomas Hankemeier -
Rob van Wijk has won the oral presentations of the National PhD Competition during the FIGON Dutch Medicine Days -
Successful LACDR Spring symposium 2018 -
Rob van Wijk discusses the role of zebrafish in drug discovery -
MICA-mediated immunity: a new opportunity for improving corneal graft survival -
Diagnosing patients with the help of statistical physics -
Innovative approach to antibiotic resistance -
Capillary Electrophoresis-Mass Spectrometry for Metabolomics -
Sensing drug responses of single cells using optical tweezers -
Seventeen million for Dutch X-omics Initiative -
Leiden PhD team in finals international pharmacological competition -
De Lange appointed Professor of Predictive pharmacology -
Discoverer of the Year bridges science and medicine -
NWO awards funding for LACDR research project to develop novel engineering approaches to study cancer immunity
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Alireza Mashaghi appointed Adjunct Professor at Fudan University -
Successful symposium Present-day Practicals. -
Topology of polymer chains under nanoscale confinement: insights into genome folding
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Interdisciplinary research and new friends during LACDR Summer School -
Predicting drug behaviour in the brain -
ZonMW awards funding for LACDR research project to develop novel biomarkers for bacterial infections -
Winning the 2016 Pharmaceutical Research Meritorious Manuscript Award -
Six million boost to search for new antibiotics -
Metabolomics Facility Leiden Featured in NWO Large-Scale Scientific Infrastructure website -
Seven new Medical Delta professors -
Wilbert de Witte received the Poster Award at the Dutch Pharmacological Society Spring Meeting -
Prof.dr. Catherijne Knibbe wins VIDI grant
Recent dissertations
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Advancing the LeiCNS-PK3.0 model for prediction of CNS Pharmacokinetics Nonlinear BBB Transport, Inter-species Scaling, and Machine Learning -
Robotic reconstitution of cytostatic drugs and monoclonal antibodies: transforming aseptic drug compounding in hospital pharmacies -
Metabolomics in community-acquired pneumonia: exploring metabolomics-based biomarkers for diagnosis and treatment response monitoring of community-acquired pneumonia -
Quantitative pharmacology approaches to inform treatment strategies against tuberculosis -
The LeiCNS-PK3.0 model development and applications: healthy-to-diseased CNS pharmacokinetic translation