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Winning the 2016 Pharmaceutical Research Meritorious Manuscript Award

The publication by the group of Catherijne Knibbe was awarded the 2016 AAPS Pharmaceutical Research Meritorious Manuscript Award.

This winning manuscript, titled 'A neonatal amikacin covariate model can be used to predict ontogeny of other drugs eliminated through glomerular filtration in neonates' was judged by the selection committee of the American Association of Pharmaceutical Scientists (AAPS) as the most outstanding of the journal Pharmaceutical Research.

The publication focusses on the challenge of predicting safe and effective doses for young children and neonates. The study aims to evaluate whether the internally and externally validated covariate model for amikacin in (pre)term neonates contains system-specific information, which can be used for extrapolation to other drugs.

In this study, the amikacin neonatal covariate model proved successful for extrapolation to netilmicin, tobramycin, vancomycin and gentamicin, which are all almost entirely eliminated through renal elimination and which share physicochemical properties.

This concept of extrapolation of information from one drug to another may facilitate rational dosing in young children and neonates where research is typically limited by ethical and practical constraints.

Roosmarijn F.W. De Cock, Pharm.D., Ph.D. 
Karel M. Allegaert, M.D., Ph.D. 
Catherine M.T. Sherwin, B.Sci., Ph.D. 
Elisabet I. Nielesen, Ph.D. 
Matthijs de Hoog, M.D. Ph.D. 
Johannes van den Anker, M.D., Ph.D. 
Meindert Danhof, Pharm.D., Ph.D.
Catherijne A.J. Knibbe, Pharm D Ph.D. 

The publication can be downloaded here [pdf] >

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