Universiteit Leiden

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Quantitative Clinical Pharmacology

The Quantitative Clinical Pharmacology group is led by Prof. Catherijne Knibbe. Her research group aims to define how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals, the elderly or critically ill patients. Through combining the statistical power of the population approach with physiologically-based approaches and large datasets from (routine) clinical practice, computer models are developed that can predict the efficacy and safety of drugs in each individual pediatric or adult patient.

Knowledge on how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals, the elderly or critically-ill patients, is not only crucial for novel compounds but also for existing drugs which are often used in an off-label manner.

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