Ariane Briegel
Hoogleraar Ultrastructuurbiologie
- Naam
- Prof.dr. A. Briegel
- Telefoon
- +31 71 527 8850
- a.briegel@biology.leidenuniv.nl
Voor meer informatie, zie de Engelse versie.
Promovendi
Postdocs
Vakken
Nieuws
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Subsidies voor hoogwaardige onderzoeksfaciliteiten -
Subsidie van 17 miljoen voor ontwikkeling elektronenmicroscopie in Nederland -
Kleinste Universiteit Leiden-logo gemaakt -
Nobelprijs Scheikunde voor 3D-beelden van moleculen
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Data science en electron nanoscopy komen samen tijdens 18e LCDS meeting -
Duizenden beelden van bevroren bacteriën -
Helder beeld van bacteriën
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New IBL-professor in Ultrastructural Biology: Ariane Briegel
Hoogleraar Ultrastructuurbiologie
- Wiskunde en Natuurwetenschappen
- Instituut Biologie Leiden
- IBL Biotechnology & Health
- Ultee E., Schenkel F., Yang W., Brenzinger S., Depelteau J.S. & Briegel A. (2018), An Open-Source Storage Solution for Cryo-Electron Microscopy Samples, Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 24(1): 60-63.
- Briegel A. & Jensen G. (2017), Progress and Potential of Electron Cryotomography as Illustrated by Its Application to Bacterial Chemoreceptor Arrays, Annual Review of Biophysics 46: 1-21.
- Zielinska A., Billini M., Moll A., Kremer K., Briegel A., Martinez A.I., Jensen G.J. & Thanbichler M. (2017), LytM factors affect the recruitment of autolysins to the cell division site in Caulobacter crescentus, Molecular Microbiology 106(3): 419-438.
- Alvarado A., Kjaer A., Yang W., Mann P., Briegel A., Waldor M.K. & Ringgaard S. (2017), Coupling chemosensory array formation and localization, ELIFE 6: e31058.
- Briegel A., Oikonomou C.M., Chang Y.-W., Kjær A., Huang A.N., Kim K.W., Ghosal D., Nguyen H.H., Kenny D., l R Ogorzalek Loo R.R., Gunsalus R.P. & Jensen G.J. (2017), Morphology of the archaellar motor and associated cytoplasmic cone in Thermococcus kodakaraensis, EMBO Reports 18(9): 1660-1670.
- Bardy S.L., Briegel A., Rainville S. & Krell T. (2017), Recent Advances and Future Prospects in Bacterial and Archaeal Locomotion and Signal Transduction, Journal of Bacteriology 199(18): e00203.
- Dobro M.J., Oikonomou C.M., Piper A., Cohen J., Guo k., Jensen T., Donermeyer J., Park Y., Solis B.A., Kjaer A., Jewett A.I., McDowall A.W., Chen S., Chang Y.-W., Shi J., Subramanian P., Iancu C.V., Li Z., Briegel A., Tocheva E.I., Pilhofer M. & Jensen G.J. (2017), Uncharacterized Bacterial Structures Revealed by Electron Cryotomography, Journal of Bacteriology 199(17): e00100-17.
- Yao Q., Jewett A.I., Chang Y.-W., Oikonomou C.M., Beeby M., Iancu C.V., Briegel A., Ghosal D. & Jensen G.J. (2017), Short FtsZ filaments can drive asymmetric cell envelope constriction at the onset of bacterial cytokinesis, EMBO JOURNAL 36(11): 1577-1589.
- Haglin E.R., Briegel A. & Thompson L.K. (2017), Hijacking His-Tags to Make Functional Multi-Protein Complexes, Biophysical Journal 112(3): 360A-360A.
- Haglin E.R., Briegel A. & Thompson L.K. (2017), Hijacking His-Tags to Make Functional Multi-Protein Complexes, Biophysical Journal 112(3): 360A-360A.
- Briegel A. (13 januari 2017), Big pictures of small microbes (Oratie, Science, Leiden). Leiden: Universiteit Leiden.
- Ramijan K., Willemse J.J., Ultee E., Wondergem A.J., Meij A. van der, Briegel A., Heinrich D, Wezel G.P. van & Claessen D. (2016), Reversible metamorphosis in a bacterium, .
- Briegel A., Ortega D.R., Mann P., Kjaer A., Ringgaard S. & Jensen G.J. (2016), Chemotaxis cluster 1 proteins form cytoplasmic arrays in Vibrio cholerae and are stabilized by a double signaling domain receptor DosM, Proceedings of the National Academy of Sciences of the United States of America 113(37): 10412-10417.
- Briegel A., Ortega D.R., Mann P., Kjaer A., Ringgaard S. & Jensen G.J. (2016), Chemotaxis cluster 1 proteins form cytoplasmatic arrays in Vibrio cholera and are stabilized by a double signaling domain receptor DosM, Proceedings of the National Academy of Sciences of the United States of America 113(37): 10412-10417.
- Oikonomou C.M., Swulius M.T., Briegel A., Beeby M., Yao Q., Chang Y.-W. & Jensen G.J. (2016), Electron cryotomography, Methods in Microbiology 43: 115-139.
- Skennerton C., Haroon M., Briegel A., Shi J., Jensen G.J., Tyson G. & Orphan V. (2016), Phylogenomic Analysis of Candidatus 'Izimaplasma' species: Free-living representatives from a Tenericutes Clade found in Methane Seeps., ISME Journal 10: 2679-2692.
- Willett J.W., Herrou J., Briegel A., Rotskoff G. & Crosson S. (2015), Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen, Proceedings of the National Academy of Sciences of the United States of America 112(28): E3709-E3718.
- Briegel A., Ortega D.R., Huang A.N., Oikonomou C.M., Gunsalus R.P. & Jensen G.J. (2015), Structural conservation of chemotaxis machinery across Archaea and Bacteria, Environmental Microbiology Reports 7(3): 414-419.
- Briegel A., Ladinsky M.S., Oikonomou C., Jones C.W., Harris M.J., Fowler D.J., Chang Y.-W., Thompson L.K. & Armitage J.P. Jensen G.J. (2014), Structure of bacterial cytoplasmic chemoreceptor arrays and implications for chemotactic signaling., ELIFE 3: e02151.
- Briegel A., Wong M.L., Hodges H.L., Oikonomou C.M., Piasta K.N., Harris M.J., Fowler D.J., Thompson L.K., Falke J.J., Kiessling L.L. & Jensen G.J. (2014), Correction to New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography (vol 53, pg 1575, 2014), Biochemistry 53(41): 6624-6624.
- Briegel A., Wong M.L., Hodges H.L., Oikonomou C.M., Piasta K.N., Harris M.J., Fowler D.J., Thompson L.K., Falke J.J., Kiessling L.L. & Jensen G.J. (2014), New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography, Biochemistry 53(10): 1575-1585.
- Briegel A., Pilhofer M., Mastronarde D.N. & Jensen G.J. (2013), The challenge of determining handedness in electron tomography and the use of DNA origami gold nanoparticle helices as molecular standards, Journal of Structural Biology 183(1): 95-98.
- Briegel A., Ames P., Gumbart J.C., Oikonomou C.M., Parkinson J.S. & Jensen G.J. (2013), The mobility of two kinase domains in the Escherichia coli chemoreceptor array varies with signalling state, Molecular Microbiology 89(5): 831-841.
- Yamaichi Y., Bruckner R., Ringgaard S., Moll A., Cameron D.E., Briegel A., Jensen G.J., Davis B.M. & Waldor M.K. (2012), A multidomain hub anchors the chromosome segregation and chemotactic machinery to the bacterial pole, Genes & development 26(20): 2348-2360.
- Briegel A., Li X.X., Bilwes A.M., Huges K.T., Jensen G.J. & Crane B.R. (2012), Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteins, Proceedings of the National Academy of Sciences of the United States of America 109(10): 3766-3771.
- Schlimpert S., Klein E.A., Briegel A., Hughes V., Kahnt J., Bolte K., Maier U.G., Brun Y.V., Jensen G.J., Gitai Z. & Thanbichler M. (2012), General protein diffusion barriers create compartments within bacterial cells, Cell 151(6): 1270-1282.
- Briegel A., Beeby M., Thanbichler M. & Jensen G.J. (2011), Activated chemoreceptor arrays remain intact and hexagonally packed, Molecular Microbiology 82(3): 748-757.
- Swulius M.T., Chen S., Ding H.J., Li Z., Briegel A., Pilhofer M., Tocheva E.I., Lybarger S.R., Johnson T.L., Sandkvist M. & Jensen G.J. (2011), Long helical filaments are not seen encircling cells in electron cryotomograms of rod-shaped bacteria, Biochemical and biophysical research communications 407(4): 650-655.
- Chen S., Beeby M., Murphy G.E., Leadbetter J.R., Hendrixson D.R., Briegel A., Li Z., Shi J., Tocheva E.I., Muller A., Dobro M.J. & Jensen G.J. (2011), Structural diversity of bacterial flagellar motors, The EMBO journal 30: 2972-2981.
- Chen S., McDowall A., Dobro M.J., Briegel A., Ladinsky M., Shi J., Tocheva E.I., Beeby M., Pilhofer M., Ding H.J., Li Z., Morris D.M. & Jensen G.J. (2010), Electron cryotomography of bacterial cells.. [overig]
- Kuhn J., Briegel A., Morschel E., Kahnt J., Leser K., Wick S., Jensen G.J. & Thanbichler M. (2010), Bactofilins, a ubiquitous class of cytoskeletal proteins mediating polar localization of a cell wall synthase in Caulobacter crescentus, The EMBO journal 29: 327-339.
- Briegel A., Chen S., Koster A.J., Plitzko J.M & Schwartz C.L. Jensen G.J. (2010), Correlated light and electron cryo-microscopy, Methods in enzymology 481: 317-341.
- Moll A., Schlimpert S., Briegel A., Jensen G.J. & Thanbichler M. (2010), DipM, a new factor required for peptidoglycan remodeling during cell division in Caulobacter crescentus, Molecular Microbiology 77(1): 90-107.
- Cabeen M.T., Murolo M.A., Briegel A., Khai Bui N., Vollmer W., Ausmees N., Jensen G.J. & Jacobs-Wagner C. (2010), Mutations in the Lipopolysaccharide biosynthesis pathway interfere with crescentin-mediated cell curvature in Caulobacter crescentus, Journal of Bacteriology 192(13): 3368-3378.
- Ingerson-Mahar M., Briegel A., Werner J.N., Jensen G.J. & Gitai Z. (2010), The metabolic enzyme CTP synthase forms cytoskeletal filaments, Nature Cell Biology 12: 739-746.
- Briegel A., Ortega D.R., Tocheva E.I., Wuichet K., Li Z., Chen S., Müller A., Iancu C.V., Murphy G.E., Dobro M.J., Zhulin I.B. & Jensen G.J. (2009), Universal architecture of bacterial chemoreceptor arrays, Proceedings of the National Academy of Sciences 106(40): 17181-17186.
- Tivol W.F., Briegel A. & Jensen G.J. (2008), An improved cryogen for plunge freezing., Microscopy and Microanalysis 14(5): 375-379.
- Ebersbach G., Briegel A., Jensen G.J. & Jacobs-Wagner C. (2008), A self-associating protein critical for chromosome attachment, division, and polar organization in caulobacter, Cell 134(6): 956-968.
- Junglas B., Briegel A., Burghardt T., Walther P., Wirth R., Huber H. & Rachel R. (2008), Ignicoccus hospitalis and Nanoarchaeum equitans: ultrastructure, cell-cell interaction, and 3D reconstruction from serial sections of freeze-substituted cells and by electron cryotomography, Archives of Microbiology 190: 395-408.
- Briegel A., Ding H.J., Li Z., Werner J., Gitai Z., Prabha Dias D., Jensen R.B. & Jensen G.J. (2008), Location and architecture of the Caulobacter crescentus chemoreceptor array, Molecular Microbiology 69(1): 30-41.
- Vestergaard G., Shah S.A., Bize A., Reitberger W., Reuter M., Phan H., Briegel A., Rachel R., Garrett R.A. & Prangishvili D. (2008), Stygiolobus rod-shaped virus and the interplay of crenarchaeal rudiviruses with the CRISPR antiviral system, Journal of Bacteriology 190(20): 6837-6845.
- Iancu C.V., Tivol W.F., Schooler J.B., Prabha Dias D., Henderson G.P., Murphy G.E., Wright E.R., Li Z., Yu Z., Briegel A., Gan L., He Y. & Jensen G.J. (2007), Electron cryotomography sample preparation using the Vitrobot, Nature Protocols 1: 2813-2819.
- Jensen G.J. & Briegel A. (2007), How electron cryotomography is opening a new window onto prokaryotic ultrastructure, Current Opinion in Structural Biology 17(2): 260-267.
- Osman S., Moissl C., Hosoya N., Briegel A., Mayilraj S., Satomi M. & Venkateswaran K. (2007), Tetrasphaera remsis sp nov., isolated from the Regenerative Enclosed Life Support Module Simulator (REMS) air system, International Journal of Systematic and Evolutionary Microbiology 57: 2749-2753.
- Briegel A., Dias D.P., Li Z., Jensen R.B., Frangakis A.S. & Jensen G.J. (2006), Multiple large filament bundles observed in Caulobacter crescentus by electron cryotomography., Molecular Microbiology 62(1): 5-14.
- Moissl C., Rachel R., Briegel A., Engelhardt H. & Huber R. (2005), The unique structure of archaeal 'hami', highly complex cell appendages with nano-grappling hooks, Molecular Microbiology 56(2): 361-370.
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