Ariane Briegel
Hoogleraar Ultrastructuurbiologie / Co-director NeCEN
- Naam
- Prof.dr. A. Briegel
- Telefoon
- +31 71 527 8850
- a.briegel@biology.leidenuniv.nl
- ORCID iD
- 0000-0003-3733-3725
Voor meer informatie, zie de Engelse versie.
Promovendi
Postdocs
Nieuws
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Een unieke verdediging: Bacterie verliest celwand bij aanwezigheid virus -
Gevaarlijke microben in lager veiligheidslevel lab? Met een nieuwe techniek zou het kunnen -
Wetenschappers ontdekken meeliftende bacteriën -
Blog: De neus van deze wormvormige bacterie heeft een verrassende symmetrie -
AI-onderzoek in Zuid-Holland: drie voorbeelden -
Briegel ontvangt beurs Moore Foundation in wereldwijde competitie -
Evolutie van bacteriële beweging ontrafeld
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Een headset en voldoende koffie: thuiswerken in tijden van corona -
ENW-Groot-subsidies voor Leidse bètawetenschappers -
Leidse biologie gewaardeerd met grote NWO-beurzen -
Kinderkanker opsporen met bacteriën -
Niko Tinbergenlezing 2019: Stamcellen, mini-organen en het eeuwige leven -
De beloften én de donkere kant van stamcellen -
Ariane Briegel ontvangt NWO-beurs voor onderzoek gedreven door nieuwsgierigheid -
Nieuw management voor nanoscopiecentrum NeCEN -
Zwaartekrachtsubsidie: ruim twintig miljoen voor duurzame gewassen -
Hoe de cholerabacterie mensen zo ziek maakt -
Genomineerden VIVA400-award bekend -
Bacteriën bevriezen en fotograferen -
Subsidie van 17 miljoen voor ontwikkeling elektronenmicroscopie in Nederland
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Subsidies voor hoogwaardige onderzoeksfaciliteiten -
Nobelprijs Scheikunde voor 3D-beelden van moleculen
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Ariane Briegel in NRC Handelsblad over supermicroscoop -
Leiden versterkt band met Latijns-Amerika en Cariben -
Duizenden beelden van bevroren bacteriën -
Helder beeld van bacteriën
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Science faculteiten van Universitas Indonesie en Universiteit Leiden versterken samenwerking
Oud-promovendi
Hoogleraar Ultrastructuurbiologie / Co-director NeCEN
- Wiskunde en Natuurwetenschappen
- Instituut Biologie Leiden
- IBL Microbial Sciences
- Depelteau J.S., Renault L.L.R., Althof N., Cassidy C.K., Mendonca L.M., Jensen G.J., Resch G.P. & Briegel A. (2022), UVC inactivation of pathogenic samples suitable for cryo-EM analysis, Communications Biology 5: 29.
- Liedtke J., Depelteau J.S. & Briegel A. (2022), How advances in cryo-electron tomography have contributed to our current view of bacterial cell biology, Journal of Structural Biology: X 6: 100065.
- Ongenae V., Briegel A & Claessen D (2021), Cell wall deficiency as an escape mechanism from phage infection, Open Biology 11(9).
- Kaplan M., Chreifi G., Metskas L.A., Liedtke J., Wood C.R., Oikonomou C.M., Nicolas W.J., Subramanian P., Zacharoff L.A., Wang Y., Chang Y.W., Beeby M., Dobro M., Zhu Y., McBride M., Briegel A., Shaffer C. & Jensen G.J. (2021), In situ imaging of bacterial outer membrane projections and associated protein complexes using electron cryo-tomography, eLife 10: e73099.
- Kaplan M., Tocheva E.I., Briegel A., Dobro M.J., Chang Y.W., Subramanian P., McDowall A.W., Beeby M. & Jensen G.J. (2021), Loss of the bacterial flagellar motor switch complex upon cell lysis, mBio 12(3): e00298-21.
- Muok A.R., Claessen D. & Briegel A. (2021), Microbial hitchhiking: how Streptomyces spores are transported by motile soil bacteria, ISME Journal 15(9): 2591-2600.
- Ultee E., Zhong X.B., Shitut S., Briegel A. & Claessen D. (2021), Formation of wall‐less cells in Kitasatospora viridifaciens requires cytoskeletal protein FilP in oxygen‐limiting conditions, Molecular Microbiology 115(6): 1181-1190.
- Muok A.R., Ortega D.R, Kurniyati K., Yang W., Maschmann Z.A., Sidi Mabrouk A., Li C., Crane B.R. & Briegel A. (2020), Atypical chemoreceptor arrays accommodate high membrane curvature, Nature Communications 11: 5763.
- Muok A.R. & Briegel A. (2021), Intermicrobial hitchhiking: how nonmotile microbes leverage communal motility, Trends in Microbiology 29(6): 542-550.
- Muok A.R., Chua T.K., Srivastava M., Yang W., Maschmann Z., Borbat P.P., Chong J., Zhang S., Freed J.H., Briegel A. & Crane B.R. (2020), Engineered chemotaxis core signaling units indicate a constrained kinase-off state, Science Signaling 13(657): eabc1328.
- Thormann K.M., Kreienbaum M., Dörrich A.K., Brandt D., Leonhard T., Hager F., Brenzinger S., Hahn J., Glatter T., Ruwe M., Briegel A. & Kalinowski J. (2020), Isolation and characterization of shewanella phage thanatos infecting and lysing shewanella oneidensis and promoting nascent biofilm formation, Frontiers in Microbiology 11: 573260.
- Justen A.M., Hodges H.L., Kim L.M., Sadecki P.W., Porfirio S., Ultee E., Black I., Chung G.S., Briegel A., Azadi P. & Kiessling L.L. (2020), Polysaccharide length affects mycobacterial cell shape and antibiotic susceptibility, Science Advances 6(38): eaba4015.
- Willemse J.J., Vaart M. van der, Yang W. & Briegel A. (2020), Mathematical mirroring for identification of local symmetry centers in microscopic images local symmetry detection in FIJI, Microscopy and Microanalysis 26(5): 978-988.
- Ultee E., Aart L.T. van der, Zhang L., Dissel M.D. van, Diebolder C.A., Wezel G.P. van, Claessen D. & Briegel A. (2020), Teichoic acids anchor distinct cell wall lamellae in an apically growing bacterium, Communications Biology 3: 314.
- Ortega D.R., Kjaer A. & Briegel A. (2020), The chemosensory systems of Vibrio cholerae, Molecular Microbiology 114(3): 367-376.
- Ortega D.R., Yang W., Subramanian P., Mann P., Kjær A., Chen S., Watts K.J., Pirbadian S., Collins D.A., Kooger R., Kalyuzhnaya M.G., Ringgaard S., Briegel A. & Jensen G.J. (2020), Repurposing a chemosensory macromolecular machine, Nature Communications 11: 2041.
- Depelteau J.S. Koning G. Yang W. Briegel A. (2020), An economical, portable manual cryogenic plunge freezer for the preparation of vitrified biological samples for cryogenic electron microscopy, Microscopy and Microanalysis 26(3): 413-418.
- O’Neal L., Gullett J.M., Aksenova A., Hubler A., Briegel A., Ortega D., Kjær A., Jensen G. & Alexandre G. (2019), Distinct chemotaxis protein paralogs assemble into chemoreceptor signaling arrays to coordinate signaling output, mBio 10: e01757.
- Yang W., Cassidy C.K., Ames P., Diebolder C.A., Schulten K., Luthey-Schulten Z., Parkinson J.S. & Briegel A. (2019), In situ conformational changes of the escherichia coli serine chemoreceptor in different signaling states, mBio 10(4): e00973.
- Herrou J., Willett J.W., Fiebig A., Czyż D.M., Cheng J.X., Ultee E., Briegel A., Bigelow L., Babnigg G., Kim Y. & Crosson S. (2019), Brucella periplasmic protein EipB is a molecular determinant of cell envelope integrity and virulence, Journal of Bacteriology 201: e00134.
- Ferreira J.L., Gao F.Z., Rossmann F.M., Nans A., Brenzinger S., Hosseini R., Wilson A., Briegel A., Thormann K.M., Rosenthal P.B. & Beeby M. (2019), γ-proteobacteria eject their polar flagella under nutrient depletion, retaining flagellar motor relic structures, PLoS Biology 17(3): e3000165.
- Ultee E., Ramijan K., Dame R.T., Briegel A. & Claessen D. (2019), Stress-induced adaptive morphogenesis in bacteria. In: Poole R.K (red.) Advances in Microbial Physiology. nr. 74: Academic Press. 97-141.
- Kaplan M., Ghosal D., Subramanian P., Oikonomou C.M., Kjaer A., Pirbadian S., Ortega D.R., Briegel A., El-Naggar M.Y. & Jensen G.J. (2019), The presence and absence of periplasmic rings in bacterial flagellar motors correlates with stator type, eLife 8: e43487.
- Depelteau J.S., Brenzinger S. & Briegel A. (2019), Bacterial and Archaeal Cell Structure. In: Schmidt T.M. (red.) Encyclopedia of Microbiology.: ScienceDirect. 348-360.
- Yang W. & Briegel A. (2019), Diversity of bacterial chemosensory arrays, Trends in Microbiology 28(1): 68-80.
- Muok A.R., Briegel A. & Crane B.R. (2019), Regulation of the chemotaxis histidine kinase CheA: a structural perspective, Biochimica et Biophysica Acta 1862(1): 183030.
- Yang W., Alvarado A., Glatter T., Ringgaard S. & Briegel A. (2018), Baseplate variability of Vibrio cholerae chemoreceptor arrays, Proceedings of the National Academy of Sciences of the United States of America 115(52): 13365–13370.
- Herrou J., Willett J.W., Fiebig A., Varesio L.M., Czyż D.M., Cheng J.X., Ultee E., Briegel A., Bigelow L., Babnigg G., Kim Y. & Crosson S. (2019), Periplasmic protein EipA determines envelope stress resistance and virulence in Brucella abortus, Molecular Microbiology 111(3): 637-661.
- Ramijan Carmiol A.K., Ultee E., Willemse J.J., Zhang Z., Wondergem A.J., Meij A. van der, Heinrich D.M., Briegel A., Wezel G.P. van & Claessen D. (2018), Stress-induced formation of cell wall-deficient cells in filamentous actinomysetes, Nature Communications 9: 5164.
- Ultee E., Schenkel F., Yang W., Brenzinger S., Depelteau J.S. & Briegel A. (2018), An Open-Source Storage Solution for Cryo-Electron Microscopy Samples, Microscopy and Microanalysis 24(1): 60-63.
- Ringgaard S., Yang W., Alvarado A., Schirner K. & Briegel A. (2018), Chemotaxis arrays in Vibrio species and their intracellular positioning by the ParC/ParP system, Journal of Bacteriology 200(15): e00793-17.
- Briegel A. & Uphoff S. (2018), Editorial overview: The new microscopy, Current Opinion in Microbiology 43: 208–211.
- Yang W. & Briegel A. (2018), Use of Cryo-EM to study the structure of chemoreceptor arrays in vivo. In: Manson M. (red.) Bacterial Chemosensing. Methods in Molecular Biology nr. MMB 1729 New York, NY, U.S.A.: Humana Press. 173-185.
- Briegel A. & Jensen G. (2017), Progress and Potential of Electron Cryotomography as Illustrated by Its Application to Bacterial Chemoreceptor Arrays, Annual Review of Biophysics 46: 1-21.
- Alvarado A., Kjaer A., Yang W., Mann P., Briegel A., Waldor M.K. & Ringgaard S. (2017), Coupling chemosensory array formation and localization, ELIFE 6: e31058.
- Briegel A., Oikonomou C.M., Chang Y.-W., Kjær A., Huang A.N., Kim K.W., Ghosal D., Nguyen H.H., Kenny D., Ogorzalek l.R., Loo R.R., Gunsalus R.P. & Jensen G.J. (2017), Morphology of the archaellar motor and associated cytoplasmic cone in Thermococcus kodakaraensis, EMBO Reports 18(9): 1660-1670.
- Bardy S.L., Briegel A., Rainville S. & Krell T. (2017), Recent Advances and Future Prospects in Bacterial and Archaeal Locomotion and Signal Transduction, Journal of Bacteriology 199(18): e00203.
- Dobro M.J., Oikonomou C.M., Piper A., Cohen J., Guo k., Jensen T., Donermeyer J., Park Y., Solis B.A., Kjaer A., Jewett A.I., McDowall A.W., Chen S., Chang Y.-W., Shi J., Subramanian P., Iancu C.V., Li Z., Briegel A., Tocheva E.I., Pilhofer M. & Jensen G.J. (2017), Uncharacterized Bacterial Structures Revealed by Electron Cryotomography, Journal of Bacteriology 199(17): e00100-17.
- Haglin E.R., Yang W., Briegel A. & Thompson L.K. (2017), His-tag-mediated dimerization of chemoreceptors leads to assembly of functional nanoarrays, Biochemistry 56(44): 5874-5885.
- Zielinska A., Billini M., Moll A., Kremer K., Briegel A., Martinez A.I., Jensen G.J. & Thanbichler M. (2017), LytM factors affect the recruitment of autolysins to the cell division site in Caulobacter crescentus, Molecular Microbiology 106(3): 419-438.
- Yao Q., Jewett A.I., Chang Y.-W., Oikonomou C.M., Beeby M., Iancu C.V., Briegel A., Ghosal D. & Jensen G.J. (2017), Short FtsZ filaments can drive asymmetric cell envelope constriction at the onset of bacterial cytokinesis, EMBO Journal 36(11): 1577-1589.
- Haglin E.R., Briegel A. & Thompson L.K. (2017), Hijacking His-Tags to Make Functional Multi-Protein Complexes, Biophysical Journal 112(3): 360A-360A.
- Haglin E.R., Briegel A. & Thompson L.K. (2017), Hijacking His-Tags to Make Functional Multi-Protein Complexes, Biophysical Journal 112(3): 360A-360A.
- Briegel A. (13 januari 2017), Big pictures of small microbes (Oratie, Science, Leiden). Leiden: Universiteit Leiden.
- Briegel A., Ortega D.R., Mann P., Kjaer A., Ringgaard S. & Jensen G.J. (2016), Chemotaxis cluster 1 proteins form cytoplasmatic arrays in Vibrio cholera and are stabilized by a double signaling domain receptor DosM, Proceedings of the National Academy of Sciences of the United States of America 113(37): 10412-10417.
- Briegel A., Ortega D.R., Mann P., Kjaer A., Ringgaard S. & Jensen G.J. (2016), Chemotaxis cluster 1 proteins form cytoplasmic arrays in Vibrio cholerae and are stabilized by a double signaling domain receptor DosM, Proceedings of the National Academy of Sciences of the United States of America 113(37): 10412-10417.
- Oikonomou C.M., Swulius M.T., Briegel A., Beeby M., Yao Q., Chang Y.-W. & Jensen G.J. (2016), Electron cryotomography, Methods in Microbiology 43: 115-139.
- Skennerton C., Haroon M., Briegel A., Shi J., Jensen G.J., Tyson G. & Orphan V. (2016), Phylogenomic Analysis of Candidatus 'Izimaplasma' species: Free-living representatives from a Tenericutes Clade found in Methane Seeps, ISME Journal 10: 2679-2692.
- Willett J.W., Herrou J., Briegel A., Rotskoff G. & Crosson S. (2015), Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen, Proceedings of the National Academy of Sciences of the United States of America 112(28): E3709-E3718.
- Briegel A., Ortega D.R., Huang A.N., Oikonomou C.M., Gunsalus R.P. & Jensen G.J. (2015), Structural conservation of chemotaxis machinery across Archaea and Bacteria, Environmental Microbiology Reports 7(3): 414-419.
- Briegel A., Ladinsky M.S., Oikonomou C., Jones C.W., Harris M.J., Fowler D.J., Chang Y.-W., Thompson L.K., Armitage J.P. & Jensen G.J. (2014), Structure of bacterial cytoplasmic chemoreceptor arrays and implications for chemotactic signaling, ELIFE 3: e02151.
- Briegel A., Wong M.L., Hodges H.L., Oikonomou C.M., Piasta K.N., Harris M.J., Fowler D.J., Thompson L.K., Falke J.J., Kiessling L.L. & Jensen G.J. (2014), Correction to New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography (vol 53, pg 1575, 2014), Biochemistry 53(41): 6624-6624.
- Briegel A., Wong M.L., Hodges H.L., Oikonomou C.M., Piasta K.N., Harris M.J., Fowler D.J., Thompson L.K., Falke J.J., Kiessling L.L. & Jensen G.J. (2014), New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography, Biochemistry 53(10): 1575-1585.
- Briegel A., Pilhofer M., Mastronarde D.N. & Jensen G.J. (2013), The challenge of determining handedness in electron tomography and the use of DNA origami gold nanoparticle helices as molecular standards, Journal of Structural Biology 183(1): 95-98.
- Briegel A., Ames P., Gumbart J.C., Oikonomou C.M., Parkinson J.S. & Jensen G.J. (2013), The mobility of two kinase domains in the Escherichia coli chemoreceptor array varies with signalling state, Molecular Microbiology 89(5): 831-841.
- Yamaichi Y., Bruckner R., Ringgaard S., Moll A., Cameron D.E., Briegel A., Jensen G.J., Davis B.M. & Waldor M.K. (2012), A multidomain hub anchors the chromosome segregation and chemotactic machinery to the bacterial pole, Genes & development 26(20): 2348-2360.
- Briegel A., Li X.X., Bilwes A.M., Huges K.T., Jensen G.J. & Crane B.R. (2012), Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteins, Proceedings of the National Academy of Sciences of the United States of America 109(10): 3766-3771.
- Schlimpert S., Klein E.A., Briegel A., Hughes V., Kahnt J., Bolte K., Maier U.G., Brun Y.V., Jensen G.J., Gitai Z. & Thanbichler M. (2012), General protein diffusion barriers create compartments within bacterial cells, Cell 151(6): 1270-1282.
- Briegel A., Beeby M., Thanbichler M. & Jensen G.J. (2011), Activated chemoreceptor arrays remain intact and hexagonally packed, Molecular Microbiology 82(3): 748-757.
- Swulius M.T., Chen S., Ding H.J., Li Z., Briegel A., Pilhofer M., Tocheva E.I., Lybarger S.R., Johnson T.L., Sandkvist M. & Jensen G.J. (2011), Long helical filaments are not seen encircling cells in electron cryotomograms of rod-shaped bacteria, Biochemical and biophysical research communications 407(4): 650-655.
- Chen S., Beeby M., Murphy G.E., Leadbetter J.R., Hendrixson D.R., Briegel A., Li Z., Shi J., Tocheva E.I., Muller A., Dobro M.J. & Jensen G.J. (2011), Structural diversity of bacterial flagellar motors, The EMBO journal 30: 2972-2981.
- Moll A., Schlimpert S., Briegel A., Jensen G.J. & Thanbichler M. (2010), DipM, a new factor required for peptidoglycan remodelling during cell division in Caulobacter crescentus, Molecular Microbiology 77(1): 90-107.
- Chen S., McDowall A., Dobro M.J., Briegel A., Ladinsky M., Shi J., Tocheva E.I., Beeby M., Pilhofer M., Ding H.J., Li Z., Morris D.M. & Jensen G.J. (2010), Electron cryotomography of bacterial cells.. [overig].
- Kuhn J., Briegel A., Morschel E., Kahnt J., Leser K., Wick S., Jensen G.J. & Thanbichler M. (2010), Bactofilins, a ubiquitous class of cytoskeletal proteins mediating polar localization of a cell wall synthase in Caulobacter crescentus, The EMBO journal 29: 327-339.
- Briegel A., Chen S., Koster A.J., Plitzko J.M., Schwartz C.L. & Jensen G.J. (2010), Correlated light and electron cryo-microscopy, Methods in enzymology 481: 317-341.
- Moll A., Schlimpert S., Briegel A., Jensen G.J. & Thanbichler M. (2010), DipM, a new factor required for peptidoglycan remodeling during cell division in Caulobacter crescentus, Molecular Microbiology 77(1): 90-107.
- Cabeen M.T., Murolo M.A., Briegel A., Khai Bui N., Vollmer W., Ausmees N., Jensen G.J. & Jacobs-Wagner C. (2010), Mutations in the Lipopolysaccharide biosynthesis pathway interfere with crescentin-mediated cell curvature in Caulobacter crescentus, Journal of Bacteriology 192(13): 3368-3378.
- Ingerson-Mahar M., Briegel A., Werner J.N., Jensen G.J. & Gitai Z. (2010), The metabolic enzyme CTP synthase forms cytoskeletal filaments, Nature Cell Biology 12: 739-746.
- Briegel A., Ortega D.R., Tocheva E.I., Wuichet K., Li Z., Chen S., Müller A., Iancu C.V., Murphy G.E., Dobro M.J., Zhulin I.B. & Jensen G.J. (2009), Universal architecture of bacterial chemoreceptor arrays, Proceedings of the National Academy of Sciences 106(40): 17181-17186.
- Tivol W.F., Briegel A. & Jensen G.J. (2008), An improved cryogen for plunge freezing, Microscopy and Microanalysis 14(5): 375-379.
- Ebersbach G., Briegel A., Jensen G.J. & Jacobs-Wagner C. (2008), A self-associating protein critical for chromosome attachment, division, and polar organization in caulobacter, Cell 134(6): 956-968.
- Junglas B., Briegel A., Burghardt T., Walther P., Wirth R., Huber H. & Rachel R. (2008), Ignicoccus hospitalis and Nanoarchaeum equitans: ultrastructure, cell-cell interaction, and 3D reconstruction from serial sections of freeze-substituted cells and by electron cryotomography, Archives of Microbiology 190: 395-408.
- Briegel A., Ding H.J., Li Z., Werner J., Gitai Z., Prabha Dias D., Jensen R.B. & Jensen G.J. (2008), Location and architecture of the Caulobacter crescentus chemoreceptor array, Molecular Microbiology 69(1): 30-41.
- Vestergaard G., Shah S.A., Bize A., Reitberger W., Reuter M., Phan H., Briegel A., Rachel R., Garrett R.A. & Prangishvili D. (2008), Stygiolobus rod-shaped virus and the interplay of crenarchaeal rudiviruses with the CRISPR antiviral system, Journal of Bacteriology 190(20): 6837-6845.
- Iancu C.V., Tivol W.F., Schooler J.B., Prabha Dias D., Henderson G.P., Murphy G.E., Wright E.R., Li Z., Yu Z., Briegel A., Gan L., He Y. & Jensen G.J. (2007), Electron cryotomography sample preparation using the Vitrobot, Nature Protocols 1: 2813-2819.
- Jensen G.J. & Briegel A. (2007), How electron cryotomography is opening a new window onto prokaryotic ultrastructure, Current Opinion in Structural Biology 17(2): 260-267.
- Osman S., Moissl C., Hosoya N., Briegel A., Mayilraj S., Satomi M. & Venkateswaran K. (2007), Tetrasphaera remsis sp nov., isolated from the Regenerative Enclosed Life Support Module Simulator (REMS) air system, International Journal of Systematic and Evolutionary Microbiology 57: 2749-2753.
- Briegel A., Dias D.P., Li Z., Jensen R.B., Frangakis A.S. & Jensen G.J. (2006), Multiple large filament bundles observed in Caulobacter crescentus by electron cryotomography, Molecular Microbiology 62(1): 5-14.
- Moissl C., Rachel R., Briegel A., Engelhardt H. & Huber R. (2005), The unique structure of archaeal 'hami', highly complex cell appendages with nano-grappling hooks, Molecular Microbiology 56(2): 361-370.
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