Gilles van Wezel
Scientific director / professor of Molecular biotechnology
- Name
- Prof.dr. G.P. van Wezel
- Telephone
- +31 71 527 4310
- g.wezel@biology.leidenuniv.nl
- ORCID iD
- 0000-0003-0341-1561
Gilles van Wezel is a molecular biologist by training, with strong affinity for global regulatory processes that control the major processes in the bacterial cell. This led him via the control of protein synthesis (PhD thesis), via carbon catabolite repression (postdoc), to the two current main subjects: control of growth and cell division and control of antibiotic production in Streptomyces.
More information about Gilles van Wezel
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‘But how many bacteria live on my hands, then?’ Micro-day in photos -
Bacteria without cell wall gobble up DNA from environment -
Gilles van Wezel reappointed for four years -
ERC Advanced Grants for four Leiden researchers -
Awaken sleeping antibiotics with ERC Advanced grant
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Leiden researchers join forces against tuberculosis -
These eleven Leiden Science researchers are among the most highly cited -
Discovery Leiden nominated for KIJK: Best Tech-idea of 2021 -
New tenure track: understanding and engineering microbial metabolism for health and sustainability -
Frederic Lens: building bridges in biodiversity research -
Artificial intelligence helps in the search for new antibiotics -
IBL coordinates project to search for new medicines in marine biodiversity
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Omid Karami receives the Krijn Rietveld Memorial Innovation Award during festive ceremony -
Omid Karami wins Krijn Rietveld Memorial Innovation Award -
Careful restart Cell Observatory and labs -
Science Groot funding for Leiden scientists -
Leiden biology appreciated with large NWO grants -
Snake venom glands grown in lab -
Altruism in bacteria: colonies divide the work -
How mammoth poop contributes to antibiotics research -
Bacteria inside plant roots battle fungal disease -
Gravitation Grant: more than twenty million for sustainable crops -
European collaboration shines a light on enzyme discovery for industry -
New antibiotic named after Leiden -
30 years and Professor: the story of Changsheng Wu -
Interview with PhD student: Doris van Bergeijk -
Unilever Research Prize for master student Lukas Kiefer -
New Scientific Director for the Institute of Biology Leiden
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Science and business working together on affordable alternatives for antibiotics -
Launching event National Antibiotic Development Platform -
Better and faster ways of searching for antibiotics -
Six million boost to search for new antibiotics -
Scientists discover how to improve the production of antibiotics and enzymes in soil bacteria -
New insights into the production of antibiotics by bacteria -
New STW-grant to redirect the plant micro biome: “Back to the Roots” -
The bite that heals: New antibiotics with help from venomous animals -
Soil bacteria can produce a wealth of new antibiotics
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The quest for more antibiotics
Former PhD Candidates
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Doris van Bergeijk -
Alexander Kloosterman
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Chao Du
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Zheren Zhang
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Sanne Westhoff
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Xiansha Xiao
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Anne van der Meij
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Wen Yang
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Ana Karenina Carmiol Ramijan
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Mariana Avalos Garcia
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Lizah van der Aart
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Raffaella Tassoni
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Boris Zacchetti
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Mia Urem
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Maria Petrus
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Dino van Dissel
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Changsheng Wu
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Le Zhang
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Hua Zhu
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Giulia Mangiameli
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Katherine Celler
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Magdalena Swiatek
I am a molecular biologist by training, with strong affinity for global regulatory processes that control the major processes in the bacterial cell. This led me via the control of protein synthesis (PhD thesis), via carbon catabolite repression (postdoc), to the two current main subjects: control of growth and cell division and control of antibiotic production in Streptomyces. The latter is then applied for novel approaches for drug discovery. To me the strict separation often seen between so-called ‘applied’ and ‘fundamental’ research is an illusion, and the two main research lines reflect that. A leading thread in the research is the resonance between these seemingly separated research fields. Rather than black box approaches, I seek to understand the biological principles, which is then applied in a rational design and evolution approach to obtain novel technologies and leads for industrial applications.
I obtained a VICI grant from the Dutch Technology foundation STW (2009-2014) and was appointed full Professor in Molecular Biotechnology in Leiden in 2010. In 2012 my group moved from Chemistry to Biology, to unite the Microbiology and Applied Microbiology groups in a new Centre for Microbial Biotechnology. However, our research is multidisciplinary, with strong links to all institutes of the Faculty of Sciences, as well as to the Leiden University Medical Centre (LUMC) and the Netherlands Centre for Electron Nanoscopy (NECEN).
Research
Focus of my research is to provide novel insight into the complex regulatory pathways that control growth, development and antibiotic production of filamentous actinomycetes, and apply this knowledge for improved commercialization of these important industrial microorganisms. A major driving force behind my research is the strong resonance between fundamental and applied research, which in my view should be mutually supportive and cross-feeding.
The main Research Lines of my group are:
- Discovery of novel antimicrobials
- Nutrient sensing and global control of antibiotic production
- Control of cell division and morphogenesis in streptomycetes
- Sugar metabolism and carbon catabolite control
Scientific director / professor of Molecular biotechnology
- Science
- Instituut Biologie Leiden
- IBL Microbial Sciences
- Tracanna V., Ossowicki A., Petrus M.L.C., Overduin S., Terlouw B.R., Lund G., Robinson S.L., Warris S., Schijlen E.G.W.M., Wezel G.P. van, Raaijmakers J.M., Garbeva P. & Medema M.H. (2021), Dissecting disease-suppressive rhizosphere microbiomes by functional amplicon sequencing and 10× metagenomics, mSystems 6(3).
- Bakker A.T., Kotsogianni A.I., Mirenda L., Straub V.M., Avalos Garcia M., Berg R.J.B.H.N. van den, Florea B.I., Wezel G.P. van, Janssen A.P.A., Martin N.I. & Stelt M. van der (2022), Chemical proteomics reveals antibiotic targets of oxadiazolones in MRSA, Journal of the American Chemical Society 145(2): 1136-1143.
- Kapteijn R., Shitut S.S., Aschmann D., Zhang L., Beer M. de, Daviran D., Roverts R., Akiva A., Wezel G.P. van, Kros A. & Claessen D. (2022), Endocytosis-like DNA uptake by cell wall-deficient bacteria, Nature Communications 13(1): 5524.
- Du C., Willemse J.J., Erkelens A.M., Carrion Bravo V.J., Dame R.T. & Wezel G.P. van (2022), System-wide analysis of the GATC-binding nucleoid-associated protein Gbn and its impact on Streptomyces development, mSystems 7(3): e00061-22.
- Zhong X., Zhang L., Wezel G.P. van, Vijgenboom E. & Claessen D. (2022), Role for a lytic polysaccharide monooxygenase in cell wall remodeling in streptomyces coelicolor, mBio 13(2): e00456-22.
- Machushynets N.V., Elsayed S.S.M.A., Du C., Siegler M.A., Cruz M. de la, Genillou O., Hankemeier T. & Wezel G.P. van (2022), Discovery of actinomycin L, a new member of the actinomycin family of antibiotics, Scientific Reports 12: 2813.
- Bergeijk D.A. van, Elsayed S.S.M.A., Du C., Nuñez Santiago I., Roseboom A.M., Zhang L., Carrion Bravo V.J., Spaink H.P. & Wezel G.P. van (2022), The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces, Communications Chemistry 5: 14.
- Blin K., Shaw S., Kloosterman A.M., Charlop-Powers Z., Wezel G.P. van, Medema M.H. & Tilmann W. (2021), antiSMASH 6.0: improving cluster detection and comparison capabilities, Nucleic Acids Research 49(W1): W29-W35.
- Boer C. de, McGregor N.G.S., Peterse E., Schröder S.P., Florea B.I., Jiang J., Reijngoud J., Ram A.F.J., Wezel G.P. van, Marel G.A. van der, Codee J.D.C., Overkleeft H.S. & Davies G.J. (2021), Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases, RSC Chemical Biology 2(6): 1701.
- Avalos Garcia M., Garbeva P., Vader L., Wezel G.P. van, Dickschat J. & Ulanova D. (2022), Biosynthesis, evolution and ecology of microbial terpenoids, Natural Product Reports 39(2): 249-272.
- Martinet L., Naomé A., Deflandre B., Maciejewska M., Tellatin D., Tenconi E., Smargiasso N., Pauw E. de, Wezel G.P. van & Rigali S. (2019), A single biosynthetic gene cluster is responsible for the production of Bagremycin antibiotics and Ferroverdin iron chelators, mBio 10(4).
- Zhang L., Ramijan K., Carrion Bravo V.J., Aart L.T. van der, Willemse J.J., Wezel G.P. van & Claessen D. (2021), An alternative and conserved cell wall enzyme that can substitute for the lipid II synthase MurG, mBio 12(2): e03381.
- Xiao X., Willemse J.J., Voskamp P., Li X., Prota A.E., Lamers M., Pannu N.S., Abrahams J.P. & Wezel G.P. van (2021), Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB in Streptomyces, Open Biology 11(2).
- Kloosterman A.M., Medema M.H. & Wezel G.P. van (2021), Omics-based strategies to discover novel classes of RiPP natural products, Current Opinion in Biotechnology 69: 60-67.
- Zhang L., Willemse J., Yagüe P., Waal E.C. de, Claessen D. & Wezel G.P. van (2020), Branching of sporogenic aerial hyphae in sflA and sflB mutants of Streptomyces coelicolor correlates to ectopic localization of DivIVA and FtsZ in time and space bioRxiv. [Working paper].
- Kloosterman A.M., Cimermancic P., Elsayed S.S.M.A., Du C., Hadjithomas M., Donia M.S., Fischbach M.A., Wezel G.P. van & Medema M.H. (2020), Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides, PLoS Biology 18(12): e3001026.
- Tenconi E., Traxler M., Tellatin D., Wezel G.P. van & Rigali S. (2020), Prodiginines postpone the onset of sporulation in Streptomyces coelicolor, Antibiotics 9(12): 847.
- Petrus M.L.C., Kiefer L.A., Puri P., Heemskerk E., Seaman M.S., Barouch D.H., Arias S., Wezel P.G. van & Havenga M. (2019), A microbial expression system for high-level production of scFv HIV-neutralizing antibody fragments in Escherichia coli, Applied Microbiology and Biotechnology 103(21-22): 8875-8888.
- Kloosterman A.M., Shelton K.E., Wezel G.P. van, Medema M.H. & Mitchell D.A. (2020), RRE-finder: a genome-mining tool for class-independent RiPP discovery, mSystems 5(5): e00267-20.
- Sulheim S., Kumelj T., Dissel D. van, Salehzadeh-Yazdi A., Du C., Wezel G.P. van, Nieselt K., Almaas E., Wentzel A. & Kerkhoven E.J. (2020), Enzyme-constrained models and omics analysis of Streptomyces coelicolor reveal metabolic changes that enhance heterologous production, iScience 23(9): 101525.
- Xiao X., Elsayed S.S.M.A., Wu C., Heul H.U. van der, Metsä-Ketelä M., Du C., Prota A.E., Chen C.C., Liu W., Guo R.T., Abrahams J.P. & Wezel G.P. van (2020), Functional and structural insights into a novel promiscuous ketoreductase of the lugdunomycin biosynthetic pathway, ACS Chemical Biology 15(9): 2529-2538.
- Elsayed S.S., Genta-Jouve G., Carrion V.J., Nibbering P.H., Siegler M.A., Boer W., Hankemeier T. & Wezel G.P. van (2020), Atypical spirotetronate polyketides identified in the underexplored genus streptacidiphilus, Journal of Organic Chemistry 85(16): 10648-10657.
- Uiterweerd M.T., Nuñez Santiago I., Heul H.U. van der, Wezel G.P. van & Minnaard A.J. (2020), Iso‐maleimycin, a constitutional isomer of maleimycin, from streptomyces sp. QL37, European Journal of Organic Chemistry (32): 5145-5152.
- Ultee E., Aart L.T. van der, Zhang L., Dissel M.D. van, Diebolder C.A., Wezel G.P. van, Claessen D. & Briegel A. (2020), Teichoic acids anchor distinct cell wall lamellae in an apically growing bacterium, Communications Biology 3: 314.
- Bergeijk D.A. van, Terlouw B.R., Medema M.H. & Wezel G.P. van (2020), Ecology and genomics of actinobacteria: new concepts for natural product discovery, Nature Reviews Microbiology 18(10): 546-558.
- Lu X., Liu X., Chen Z., Li J., Wezel G.P. van, Chen W. & Wen Y. (2020), The ROK‐family Regulator Rok7B7 directly controls carbon catabolite repression, antibiotic biosynthesis, and morphological development in streptomyces avermitilis, Environmental Microbiology 22(12): 5090-5108.
- Ossowicki A., Tracanna V., Petrus L.M.C., Wezel G.P. van, Raaijmakers J.M., Medema M.H. & Garbeva P. (2020), Microbial and volatile profiling of soils suppressive to Fusarium culmorum of wheat, Proceedings of the Royal Society B: Biological Sciences 287(1921): 20192527.
- Ramijan Carmiol A.K., Zhang Z., Wezel G.P. van & Claessen D. (2020), Genome rearrangements and megaplasmid loss in the filamentous bacterium Kitasatospora viridifaciens are associated with protoplast formation and regeneration, Antonie van Leeuwenhoek 113(6): 825-837.
- McGregor N.G.S., Artola M., Nin-Hill A., Linzel D., Haon M., Reijngoud J., Ram A., Rosso M.N., Marel G.A. van der, Codée J.D.C., Wezel G.P. van, Berrin J.G., Rovira C., Overkleeft H.S. & Davies G.J. (2020), Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining α-l-Arabinofuranosidases, Journal of the American Chemical Society 142(10): 4648-4662.
- Westhoff S., Kloosterman A., Hoesel S.F.A. van, Wezel G.P. van & Rozen D.E. (2021), Competition sensing alters antibiotic production in streptomyces, mBio 12.
- Zhang Z., Du C., De Barsy F., Liem M., Liakopoulos A., Wezel G.P. van, Choi Y.H., Claessen D. & Rozen D.E. (2020), Antibiotic production in Streptomyces is organized by a division of labor through terminal genomic differentiation, Science Advances 6(3): eaay5781.
- Westhoff S., Otto S.B., Swinkels A., Bode B., Wezel G.P. van & Rozen D.E. (2020), Spatial structure increases the benefits of antibiotic production in Streptomyces, Evolution 74(1): 179-187.
- Avalos M., Garbeva P., Raaijmakers J.M. & Wezel G.P. van (2020), Production of ammonia as a low-cost and long-distance antibiotic strategy by Streptomyces species, The ISME journal 14(2): 569-583.
- Carrión V.J., Perez-Jaramillo J., Cordovez V., Tracanna V., Hollander M. de, Ruiz-Buck D., Mendes L.W., Ijcken W.F.J. van, Gomez-Exposito R., Elsayed S.S., Mohanraju P., Arifah A., Oost J. van der, Paulson J.N., Mendes R., Wezel G.P. van, Medema M.H. & Raaijmakers J.M. (2019), Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome, Science 366(6465): 606-612.
- Schröder S.P., Boer C. de, McGregor N.G.S., Rowland R.J., Moroz O., Blagova E., Reijngoud J., Arentshorst M., Osborn D., Morant M.D., Abbate E., Stringer M.A., Krogh K.B.R.M., Raich L., Rovira C., Wezel G.P. van, Berrin J.G., Florea B.I., Ram A.F.J., Codée J.D.C., Marel G.A. van der, Wu L., Wilson K.S., Overkleeft H.S. & Davies G.J. (2019), Dynamic and functional profiling of Xylan-degrading enzymes in aspergillus secretomes using activity-based probes, ACS Central Science 5(6): 1067-1078.
- Martín-Sánchez L., Singh K.S., Avalos M., Wezel G.P. van, Dickschat J.S. & Garbeva P. (2019), Phylogenomic analyses and distribution of terpene synthases among Streptomyces, Beilstein Journal of Organic Chemistry 15: 1181-1193.
- Brenzinger S., Aart L.T. van der, Wezel G.P. van, Lacroix J-M., Glatter T. & Briegel A. (2019), Structural and proteomic changes in viable but non-culturable vibrio cholerae, Frontiers in Microbiology 10: 793.
- Machushynets N.V., Wu C., Elsayed S.S., Hankemeier T. & Wezel G.P. van (2019), Discovery of novel glycerolated quinazolinones from Streptomyces sp. MBT27, Journal of Industrial Microbiology and Biotechnology 46(3-4): 483-492.
- Aart L.T. van der, Nouioui I., Kloosterman A., Mariano Igual J., Willemse J., Goodfellow M. & Wezel G.P. van (2019), Polyphasic classification of the gifted natural product producer Streptomyces roseifaciens sp. nov, International Journal of Systematic and Evolutionary Microbiology 69(4): 899-908.
- Wu C., Heul H.U. van der, Melnik A.V., Pannu N., Dorrestein P.C., Minnaard A.J., Choi Y.H. & Wezel G.P. van (2019), Lugdunomycin, an angucycline-derived molecule with unprecedented chemical architecture, Angewandte Chemie International Edition 58(9): 2809-2814.
- Ramijan Carmiol A.K., Ultee E., Willemse J.J., Zhang Z., Wondergem A.J., Meij A. van der, Heinrich D.M., Briegel A., Wezel G.P. van & Claessen D. (2018), Stress-induced formation of cell wall-deficient cells in filamentous actinomysetes, Nature Communications 9: 5164.
- Aart L.T. van der, Spijksma G.K., Harms A.C., Vollmer W., Hankemeier T. & Wezel G.P. van (2018), High-Resolution analysis of the Peptidoglycan composition in Streptomyces coelicolor, Journal of Bacteriology 200(20): e00290.
- Avalos Garcia M., Wezel G.P. van, Raaijmakers J.M. & Garbeva P. (2018), Healthy scents: microbial volatiles as new frontier in antibiotic research?, Current Opinion in Microbiology 45: 84-91.
- Avalos M., Boetzer M., Pirovano W., Arenas N.E., Douthwaite S. & Wezel G.P. van (2018), Complete genome sequence of escherichia coli AS19, an antibiotic-sensitive variant of E. coli strain B REL606, Genome Announcements 6(18).
- Meij A. van der, Willemse J.J., Schneijderberg M.A., Geurts R., Raaijmakers J.M. & Wezel G.P. van (2018), Inter- and intracellular colonization of Arabidopsis roots by endophytic actinobacteria and the impact of plant hormones on their antimicrobial activity, Antonie van Leeuwenhoek 111(5): 679-690.
- Zacchetti B., Andrianos A., Dissel D. van, Ruiter E.M. de, Wezel G.P. van & Claessen D. (2018), Microencapsulation extends mycelial viability of Streptomyces lividans 66 and increases enzyme production, BMC Biotechnology 18.
- Chao D. & Wezel G.P. van (2018), Mining for Microbial Gems: Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline, Proteomics 18(18).
- Dissel M.D. van & Wezel G.P. van (2018), Morphology-driven downscaling of Streptomyces lividans to micro-cultivation, Antonie van Leeuwenhoek 111(3): 457-469.
- Dissel M.D. van, Willemse J.J., Zacchetti B., Claessen D., Pier G.B. & Wezel G.P. van (2018), Production of poly-β-1, 6-N-acetylglucosamine by MatAB is required for hyphal aggregation and hydrophilic surface adhesion by Streptomyces, Microbial Cell 5(6): 269-279.
- Heul H.U. van der, Byly B.L., McDowall K.J. & Seipke R.F. Wezel G.P. van (2018), Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era: new perspectives from the post-genomic era, Natural Product Reports 35: 575-604.
- Willemse J.J., Büke F., Dissel M.D. van, Grevink S., Claessen D. & Wezel G.P. van (2018), SParticle, an algorithm for the analysis of filamentous microorganisms in submerged cultures, Antonie van Leeuwenhoek 111: 171-182.
- Zhang L., Willemse J.J., Hoskisson P.A. & Wezel G.P. van (2018), Sporulation-specific cell division defects in ylmE mutants of Streptomyces coelicolor are rescued by additional deletion of ylmD, Scientific Reports 8(1).
- Gubbens J., Wu C., Zhu H., Filippov D.V., Florea B.I., Rigali S., Overkleeft H.S. & Wezel G.P. van (2017), Intertwined Precursor Supply during Biosynthesis of the Catecholate-Hydroxamate Siderophores Qinichelins in Streptomyces sp MBT76, ACS Chemical Biology 12(11): 2756-2766.
- Meij A. van der, Worsley S.F., Hutchings M.I. & Wezel G.P. van (2017), Chemical ecology of antibiotic production by actinomycetes, FEMS Microbiology Reviews 41(3): 392-416.
- Ramijan Carmiol A.K., Wezel G.P. van & Claessen D. (2017), Genome Sequence of the Filamentous Actinomycete Kitasatospora viridifaciens, Genome Announcements 5(6): e01560.
- Westhoff S., Leeuwe T.M. van, Qachach O., Zhang Z., Wezel G.P. van & Rozen D.E. (2017), The evolution of no-cost resistance at sub-MIC concentrations of streptomycin in Streptomyces coelicolor, The ISME journal 11(5): 1168-1178.
- Nouioui I., Rückert C., Willemse J., Wezel G.P. van, Klenk H.-P., Busche T., Kalinowski J., Bredhold H. & Zotchev S.B. (2017), Actinoalloteichus fjordicus sp. nov. isolated from marine sponges: phenotypic, chemotaxonomic and genomic characterisation, Antonie van Leeuwenhoek 110(12): 1705–1717.
- Wu C., Ichinose K., Choi Y.H. & Wezel G.P. van (2017), Aromatic polyketide GTRI-02 is a previously unidentified product of the act gene cluster in Streptomyces coelicolor A3(2), Chembiochem 18(14): 1428-1434.
- Wu C., Duo C., Ichinose K., Choi Y.H. & Wezel G.P. van (2017), Discovery of C-glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a combined NMR-based metabolomics and bioinformatics workflow, Journal of Natural Products 80(2): 269-277.
- Westhoff S., Wezel G.P. van & Rozen D.E. (2017), Distance-dependent danger responses in bacteria, Current Opinion in Microbiology 36: 95-101.
- Barka E.A., Vatsa P., Sanchez L., Gaveau-Vaillant N., Jacquard C., Meier-Kolthoff J.P., Klenk H.P., Clement C., Ouhdouch Y. & Wezel G.P. van (2016), Correction for Barka et al., Taxonomy, Physiology, and Natural Products of Actinobacteria (vol 80, pg 1, 2016), MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS 80(4): 1.
- Tassoni R., Aart L.T. van der, Ubbink M., Wezel G.P. van & Pannu N.S. (2017), Structural and functional characterization of the alanine racemase from Streptomyces coelicolor A3(2), Biochemical and Biophysical Research Communications 483(1): 122-128.
- Tocquin P., Naômé A., Jourdan S., Anderssen S., Hiard S., Wezel G.P. van, Hanikenne M., Baurain D. & Rigali S. (2016), PREDetector 2.0: Online and Enhanced Version of the Prokaryotic Regulatory Elements Detector Tool bioRxiv. [Working paper].
- Urem M., Swiatek-Polatynska M.A., Rigali S. & Wezel G.P. van (2016), Intertwining nutrient-sensory networks and the control of antibiotic production in Streptomyces, Molecular Microbiology 102(2): 183-195.
- Aart L.T. van der, Lemmens N., Wamel W.J. van & Wezel G.P. van (2016), Substrate Inhibition of VanA by D-Alanine Reduces Vancomycin Resistance in a VanX-Dependent Manner, Antimicrobial Agents and Chemotherapy 60(8): 4930-4939.
- Celler K., Koning R.I., Willemse J., Koster A.J. & Wezel G.P. van (2016), Cross-membranes orchestrate compartmentalization and morphogenesis in Streptomyces, NATURE COMMUNICATIONS 7: 11836.
- Busarakam K., Bull A.T., Trujillo M.E., Riesco R., Sangal V., Wezel G.P. van & Goodfellow M. (2016), Modestobacter caceresii sp. nov., novel actinobacteria with an insight into their adaptive mechanisms for survival in extreme hyper-arid Atacama Desert soils, Systematic and Applied Microbiology 39(4): 243-251.
- Zacchetti B., Willemse J.J., Recter B., Dissel M.D. van, Wezel G.P. van, Wösten H.A.B. & Claessen D. (2016), Aggregation of germlings is a major contributing factor towards mycelial heterogeneity of Streptomyces, Scientific Reports 6.
- Wu C., Zhu H., Wezel G.P. van & Choi Y.H. (2016), Metabolomics-guided analysis of isocoumarin production by Streptomyces species MBT76 and biotransformation of flavonoids and phenylpropanoids, Metabolomics 12(5): 90.
- Zhang L., Willemse J., Claessen D. & Wezel G.P. van (2016), SepG coordinates sporulation-specific cell division and nucleoid organization in Streptomyces coelicolor, Open Biology 6(4).
- Baltz R.H., Ikeda H., Katz L., Kim E.S., Wezel G.P. van & Wright G. (2016), Introduction to the special issue: "Natural product discovery and development in the genomic era", Journal of Industrial Microbiology and Biotechnology 43(2-3): 109.
- Barka E.A., Vatsa P., Sanchez L., Gaveau-Vaillant N., Jacquard C., Klenk H.P., Clement C., Ouhdouch Y. & Wezel G.P. van (2016), Taxonomy, Physiology, and Natural Products of Actinobacteria, Microbiology and Molecular Biology Reviews 80(1): 1-43.
- Kolter R. & Wezel G.P. van (2016), Goodbye to brute force in antibiotic discovery?, Nature Microbiology 1.
- Sevillano L., Vijgenboom E., Wezel G.P. van, Diaz M. & Santamaria R.I. (2016), New approaches to achieve high level enzyme production in Streptomyces lividans, Microbial Cell Factories 15.
- Petrus M.L.C., Vijgenboom E., Chaplin A.K., Worrall J.A.R., Wezel G.P. van & Claessen D. (2016), The DyP-type peroxidase DtpA is a Tat-substrate required for GlxA maturation and morphogenesis in Streptomyces, Open Biology 6(1): 150149.
- Urem M., Rossum T. van, Bucca G., Moolenaar G.F., Laing E., Swiatek-Połatynska M.A., Willemse J., Tenconi E., Rigali S., Goosen N., Smith C.P. & Wezel G.P. van (2016), OsdR of Streptomyces coelicolor and the dormancy regulator DevR of Mycobacterium tuberculosis control overlapping regulons, MSphere 1(3).
- Yagüe Menéndez P., Willemse J.J., Koning R.I., Rioseras B., López-García M.T., Gonzalez-Quinonez N., Lopez-Iglesias C., Shliaha P.V., Rogowska-Wrzesinska A., Koster A.J., Jensen O.N., Wezel G.P. van & Manteca A. (2016), Subcompartmentalization by cross-membranes during early growth of Streptomyces hyphae, Nature Communications 7.
- Wu C., Medema M.H., Läkamp R.M., Zhang L., Dorrestein P.C., Choi Y.H. & Wezel G.P. van (2016), Leucanicidin and endophenasides result from methyl-rhamnosylation by the same tailoring enzymes in Kitasatospora sp. MBT66, ACS Chemical Biology 11(2): 478-490.
- Cordovez V., Carrion V.J.J., Etalo D.W., Mumm R., Zhu H., Wezel G.P. van & Raaijmakers J.M. (2015), Diversity and functions of volatile organic compounds produced by Streptomyces from a disease-suppressive soil, Frontiers in Microbiology 6.
- Wu C., Du C., Gubbens J., Choi Y.H. & Wezel G.P. van (2015), Metabolomics-driven discovery of a prenylated isatin antibiotic produced by Streptomyces species MBT28, Journal of Natural Products 78(10): 2355–2363.
- Wu C., Choi Y.H. & Wezel G.P. van (2016), Metabolic profiling as a tool for prioritizing antimicrobial compounds, Journal of Industrial Microbiology and Biotechnology 43(2-3): 299-312.
- Abrudan M.I., Smakman F., Gimbergen A., Westhoff S., Miller E.L., Wezel G.P. van & Rozen D.E. (2015), Socially mediated induction and suppression of antibiosis during bacterial coexistence, Proceedings of the National Academy of Sciences of the United States of America 112(35): 11054–11059.
- Tenconi E., Urem M., Świątek-Połatyńska M.A., Titgemeyer F., Müller Y.A., Wezel G.P. van & Rigali S. (2015), Multiple allosteric effectors control the affinity of dasR for its target sites, Biochemical and Biophysical Research Communications 464(1): 324-329.
- Wu C., Zacchetti B., Ram A.F.J., Wezel G.P. van, Claessen D. & Choi Y.H. (2015), Expanding the chemical space for natural products by Aspergillus-Streptomyces co-cultivation and biotransformation, Scientific Reports 2015(5): 10868.
- Wu C., Kim H.K., Wezel G.P. van & Choi Y.H. (2015), Metabolomics in the natural products field: a gateway to novel antibiotics, Drug Discovery Today: Technologies 13: 11-17.
- Kim S.H., Traag B.A., Hasan A.H., McDowall K.J., Kim B.G. & Wezel G.P. van (2015), Transcriptional analysis of the cell division-related ssg genes in Streptomyces coelicolor reveals direct control of ssgR by AtrA, Antonie van Leeuwenhoek 108(1): 201-213.
- Świątek-Połatyńska M.A., Bucca G., Laing E., Gubbens J., Titgemeyer F., Smith C.P., Rigali S. & Wezel G.P. van (2015), Genome-wide analysis of in vivo binding of the master regulator DasR in Streptomyces coelicolor identifies novel non-canonical targets, PLoS ONE 10(4): e0122479.
- Dissel M.D. van, Claessen D., Roth M. & Wezel G.P. van (2015), A novel locus for mycelial aggregation forms a gateway to improved Streptomyces cell factories, Microbial Cell Factories 14: 44.
- Wu C., Wezel G.P. van & Choi Y.H. (2015), Identification of novel endophenaside antibiotics produced by Kitasatospora sp. MBT66, Journal of Antibiotics 68(7): 445-452.
- Medema M.H., Kottmann R., Yilmaz P., Cummings M., Biggins J.B., Blin K., De Bruijn I., Chooi Y.H., Claesen J., Coates R.C., Cruz-Morales P., Duddela S., Düsterhus S., Edwards D.J., Fewer D.P., Garg N., Geiger C., Gomez-Escribano J.P., Greule A., Hadjithomas M., Haines A.S., Helfrich E.J.N., Hillwig M.L., Ishida K., Jones A.C., Jones C.S., Jungmann K., Kegler C., Kim H.U., Kötter P., Krug D., Masschelein J., Melnik A.V., Mantovani S.M., Monroe E.A., Moore M., Moss N., Nützmann H-W., Pan G., Pati A., Petras D., Reen F.J., Rosconi F., Rui Z., Tian Z., Tobias N.J., Tsunematsu Y., Wiemann P., Wyckoff E., Yan X., Yim G., Yu F., Xie Y., Aigle B., Apel A.K., Balibar C.J., Balskus E.P., Barona-Gómez F., Bechthold A., Bode H.B., Borriss R., Brady S.F., Brakhage A.A., Caffrey P., Cheng Y-Q., Clardy J., Cox R.J., De Mot R., Donadio S., Donia M.S., Van der Donk W.A., Dorrestein P.C., Doyle S., Driessen A.J.M., Ehling-Schulz M., Entian K-D., Fischbach M.A., Gerwick L., Gerwick W.H., Gross H., Gust B., Hertweck C., Höfte M., Jensen S.E., Ju J., Katz L., Kaysser L., Klassen J.L., Keller N.P., Kormanec J., Kuipers O.P., Kuzuyama T., Kyrpides N.C., Kwon H-J., Lautru S., Lavigne R., Lee C.Y., Linquan B., Liu X., Liu W., Luzhetskyy A., Mahmud T., Mast Y., Méndez C., Metsä-Ketelä M., Micklefield J., Mitchell D.A., Moore B.S., Moreira L.M., Müller R., Neilan B.A., Nett M., Nielsen J., O'Gara F., Oikawa H., Osbourn A., Osburne M.S., Ostash B., Payne S.M., Pernodet J-L., Petricek M., Piel J., Ploux O., Raaijmakers J.M., Salas J.A., Schmitt J.K., Scott B., Seipke R.F., Shen B., Sherman D.H., Sivonen K., Smanski M.J., Sosio M., Stegmann E., Süssmuth R.D., Tahlan K., Thomas C.M., Tang Y., Truman A.W., Viaud M., Walton J.D., Walsh C.T., Weber T., Van Wezel G.P., Wilkinson B., Willey J.M., Wohlleben W., Wright G.D., Ziemert N. & Zhang C. (2015), Minimum information about a biosynthetic gene cluster, Nature Chemical Biology 11(9): 625-631.
- Lambert S., Traxler M., Craig M., Maciejewska M., Ongena M., Wezel G.P. van, Kolter R. & Rigali S. (2014), Altered desferrioxamine-mediated iron utilization is a common trait of bald mutants of streptomyces coelicolor, Metallomics 6(8): 1390-1399.
- Romero D.A., Hasan A.H., Lin Y., Kime L., Ruiz‐Larrabeiti O., Urem M., Bucca G., Mamanova L., Laing E.E., Wezel G.P. van, Smith C.P., Kaberdin V.R. & McDowall K.J. (2014), A comparison of key aspects of gene regulation in Streptomyces coelicolor and Escherichia coli using nucleotide‐resolution transcription maps produced in parallel by global and differential RNA‐sequencing, Molecular Microbiology 94(5): 963-987.
- Girard G.A.O., Willemse J.J., Zhu H., Claessen D., Bukarasam K., Goodfellow M. & Wezel G.P. van (2014), Analysis of novel kitasatosporae reveals significant evolutionary changes in conserved developmental genes between Kitasatospora and Streptomyces, Antonie van Leeuwenhoek 106(2): 365-380.
- Claessen D. & Wezel G.P. van (2014), Bacterial Proliferation: Off the wall, eLife 3.
- Claessen D., Rozen D.E., Kuipers O.P., Søgaard-Andersen L. & Wezel G.P. van (2014), Bacterial solutions to multicellularity: a tale of biofilms, filaments and fruiting bodies, Nature Reviews Microbiology 12(2): 115-124.
- Koning R.I., Celler K., Willemse J.J., Bos E., Wezel G.P. van & Koster A.J. (2014), Correlative cryo-fluorescence light microscopy and cryo-electron tomography of Streptomyces, Methods in Cell Biology 124: 217-239.
- Zhu H., Swierstra J., Wu C., Girard G.A.O., Choi Y.H., Wamel W. van, Sandiford S.K. & Wezel G.P. van (2014), Eliciting antibiotics active against the ESKAPE pathogens in a collection of actinomycetes isolated from mountain soils, Microbiology 160(8): 1714-1725.
- H.K. Kim, Y.H. Choi, R. Verpoorte & G.P. van Wezel (2014), Means and methods for increasing antibiotic activity. [patent]
- Dissel M.D. van, Claessen D. & Wezel G.P. van (2014), Morphogenesis of streptomyces in submerged cultures, Advances in Applied Microbiology 89: 1-45.
- Gubbens J., Zhu H., Girard G.A.O., Song L., Florea B.I., Aston P., Ichinose K., Filippov D.V., Young-Hae C., Overkleeft H.S, Challis G.L. & Wezel G.P. van (2014), Natural product proteomining, a quantitative proteomics platform, allows rapid discovery of biosynthetic gene clusters for different classes of natural products, Chemistry & Biology 21(6): 707-718.
- Chenouard N., Smal I., De Chaumont F., Maska M., Sbalzarini I.F., Gong Y., Cardinale J., Carthel C., Coraluppi S., Winter M., Cohen A.R., Godinez W.J., Rohr K., Kalaidzidis Y., Liang L., Duncan J., Shen H., Xu Y., Magnusson K.E.G., Jaldén J., Blau H.M., Paul-Gilloteaux P., Roudot P., Kervrann C., Waharte F., Tinevez J.Y., Shorte S.L., Willemse J.J., Celler K.A., Wezel G.P. van, Dan H.W., Tsai Y.S., Ortiz de Solórzano C., Olivo-Marin J.C. & Meijering E. (2014), Objective comparison of particle tracking methods, Nature Methods 11(3): 281-289.
- Busarakam K., Bull A.T., Girard G.A.O., Labeda D.P., Wezel G.P. van & Goodfellow M. (2014), Streptomyces leeuwenhoekii sp. nov., the producer of chaxalactins and chaxamycins, forms a distinct branch in Streptomyces gene trees, Antonie van Leeuwenhoek 105(5): 849-861.
- Wezel G.P. van, Zhu H. & Sandiford S.K. (2014), Triggers and cues that activate antibiotic production by actinomycetes, Journal of Industrial Microbiology and Biotechnology 41(2): 371-386.
- Girard G.A.O., Traag B.A., Sangal V., Mascini N., Hoskisson P.A., Goodfellow M. & Wezel G.P. van (2013), A novel taxonomic marker that discriminates between morphologically complex actinomycetes, Open Biology 3(10).
- Clark L.C., Seipke R.F., Prieto P., Willemse J.J., Wezel G.P. van, Hutchings M.I. & Hoskisson P.A. (2013), Mammalian cell entry genes in Streptomyces may provide clues to the evolution of bacterial virulence, Scientific Reports 3: 1109.
- Celler K.A., Koning R.I., Koster A.J. & Wezel G.P. van (2013), Multi dimensional view of the bacterial cytoskeleton, Journal of Bacteriology 195(8): 1627-1636.
- Li N., Kuo C.L., Paniagua G., Elst H. van der, Verdoes M., Willems L.I., Linden W.A. van der, Ruben M., Genderen E. van, Gubbens J., Wezel G.P. van, Overkleeft H.S. & Florea B.I. (2013), Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS, Nature Protocols 8(6): 1155-1168.
- Celler K.A., Wezel G.P. van & Willemse J.J/ (2013), Single particle tracking of dynamically localizing TatA complexes in Streptomyces coelicolor, Biochemical and Biophysical Research Communications 438(1): 38-42.
- Cruz-Morales P., Vijgenboom E., Iruegas-Bocardo F., Girard G., Yañez-Guerra L.A., Ramos-Aboites H.E., Pernodet J.L., Anné J., Wezel G.P. van & Barona-Gómez F. (2013), The genome sequence of Streptomyces lividans 66 reveals a novel tRNA-dependent peptide biosynthetic system within a metal-related genomic island, Genome Biology and Evolution 5(6): 1165-1175.
- Swiatek M.A., Gubbens J., Bucca G., Song E., Yang Y.H., Laing E., Kim B.G., Smith C.P. & Wezel G.P. van (2013), The ROK-family regulator Rok7B7 pleiotropically affects xylose utilization, carbon catabolite repression and antibiotic production in Streptomyces coelicolor, Journal of Bacteriology 195(6): 1236-1248.
- Hoskisson P.A., Jones A.L., Wezel G.P. van & Barona-Gómez F. (2012), The evolution of actinomycetes: papers from the 16th International Symposium on the Biology of Actinomycetes, Antonie van Leeuwenhoek 102(3): 407-408.
- Craig M., Lambert S., Jourdan S., Tenconi E., Colson S., Maciejewska M., Martin J.F., Ongena M., Wezel G.P. van & Rigali S. (2012), Unsuspected control of siderophore production by N-acetylglucosamine in Streptomycetes, Environmental Microbiology Reports 4(5): 512-521.
- Swiatek M.A., Tenconi E., Rigali S. & Wezel G.P. van (2012), Functional analysis of the N-acetylglucosamine metabolic genes of Streptomyces coelicolor and role in the control of development and antibiotic production, Journal of Bacteriology 194(5): 1136-1144.
- Veluw G.J. van, Petrus M.L.C., Gubbens J., Graaf R. de, Jong I.P. de, Wezel G.P. van, Wosten H.A. & Claessen D. (2012), Analysis of two distinct mycelial populations in liquid-grown Streptomyces cultures using a flow cytometry-based proteomics approach, Applied Microbiology and Biotechnology 96(5): 1301-1312.
- Yang Y.H., Song E., Willemse J., Park S.H., Kim W.S., Kim E.J., Lee B.R., Kim J.N., Wezel G.P. van & Kim B.G. (2012), A novel function of Streptomyces integration host factor (sIHF) in the control of antibiotic production and sporulation in Streptomyces coelicolor, Antonie van Leeuwenhoek 101(3): 479-492.
- Jakimowicz D. & Wezel G.P. van (2012), Cell division and DNA segregation in Streptomyces: how to build a septum in the middle of nowhere?, Molecular Microbiology 85(3): 393-404.
- Willemse J., Ruban-Osmialowska B., Widdick D., Celler K., Hutchings M.I., Wezel G.P. van & Palmer T. (2012), Dynamic Localization of Tat Protein Transport Machinery Components in Streptomyces coelicolor, Journal of Bacteriology 194(22): 6272-6281.
- Swiatek M.A., Urem M., Tenconi E., Rigali S. & Wezel G.P. van (2012), Engineering of N-acetylglucosamine metabolism for improved antibiotic production in Streptomyces coelicolor A3(2) and an unsuspected role of NagA in glucosamine metabolism, Bioengineered 3(5): 280-285.
- Li J., Girard G., Florea B.I., Geurink P.P., Li N., Marel G.A. van der, Overhand M., Overkleeft H.S. & Wezel G.P. van (2012), Identification and isolation of lantibiotics from culture: a bioorthogonal chemistry approach, Organic and Biomolecular Chemistry 10(43): 8677-8683.
- Gubbens J., Janus M., Florea B.I., Overkleeft H.S. & Wezel G.P. van (2012), Identification of glucose kinase dependent and independent pathways for carbon control of primary metabolism, development and antibiotic production in Streptomyces coelicolor by quantitative proteomics, Molecular Microbiology 86(6): 1490-1507.
- Gubbens J., Zhu H. & Wezel G.P. van (2012), Proteomining. ( octrooi nr. 12169178.6). [patent]
- Celler K., Picioreanu C., Loosdrecht M.C.M. van & Wezel G.P. van (2012), Structured morphological modeling as a framework for rational strain design of Streptomyces species, Antonie van Leeuwenhoek 102: 409-423.
- Xu Q., Wezel G.P. van, Chiu H.J., Jaroszewski L., Klock H.E., Knuth M.W., Miller M.D., Lesley S.A., Godzik A., Elsliger M.A., Deacon A.M. & Wilson I.A. (2012), Structure of an MmyB-Like Regulator from C. aurantiacus, Member of a New Transcription Factor Family Linked to Antibiotic Metabolism in Actinomycetes, PLoS ONE 7(7): e41359.
- Willemse J.J., Mommaas A.M. & Wezel G.P. van (2012), Constitutive expression of ftsZ overrides the whi developmental genes to initiate sporulation of Streptomyces coelicolor, Antonie van Leeuwenhoek 101(3): 619-632.
- Wezel G.P. van (15 April 2011), Wetenschapper in wonderland : onderzoek in geuren en kleuren (Inaugural address). Leiden: Universiteit Leiden.
- Willemse J.J., Borst J.W., Waal E.C. de, Bisseling T. & Wezel G.P. van (2011), Positive control of cell division: FtsZ is recruited by SsgB during sporulation of Streptomyces, Genes & development 25(1): 89-99.
- Barends S., Zehl M., Bialek S., Waal E. de, Traag B.A., Willemse J., Nørregaard Jensen O., Vijgenboom E. & Wezel G.P. van (2010), Transfer–messenger RNA controls the translation of cell-cycle and stress proteins in Streptomyces, EMBO Reports 11(2): 119-125.
- Nothaft H., Rigali S., Boomsma B., Swiatek M., McDowall K.J., Wezel G.P. van & Titgemeyer F. (2010), The permease gene nagE2 is the key to N -acetylglucosamine sensing and utilization in Streptomyces coelicolor and is subject to multi-level control, Molecular Microbiology 75(5): 1133-1144.
- Barends S., Barend K. & Wezel G.P. van (2010), The tmRNA-tagging mechanism and the control of gene expression: a review, WIREs RNA 2(2): 233-246.
- Birkó Z., Swiatek M., Szájli E., Medzihradszky K.F., Vijgenboom E., Penyige A., Keserű J., Wezel G.P. van & Biró S. (2009), Lack of a-factor production induces the expression of nutrient scavenging and stress-related proteins in streptomyces griseus, Molecular and Cellular Proteomics 8(10): 2396-2403.
- Wezel G. van, McKenzie N. & Nodwell J. (2009), Applying the genetics of secondary metabolism in model actinomycetes to the discovery of new antibiotics. In: Hopwood D.A. (Ed.) Complex Enzymes in Microbial Natural Product Biosynthesis, Part A: Overview Articles and Peptides. Methods in Enzymology no. 458: Academic Press. 117-141.
- Tian T., Mutikainen I., Van Wezel G.P., Aliaga-Alcalde N. & Reedijk J. (2009), Chemical, structural and biological studies of cis-[Pt(3-Acpy)2Cl2], Journal of Inorganic Biochemistry 103(9): 1221-1227.
- Roy S., Maheswari P.U., Lutz M., Spek A., Den Dulk H., Barends S., Van Wezel G.P., Hartl F. & Reedijk J. (2009), DNA cleavage and antitumour activity of platinum(II) and copper(II) compounds derived from 4-methyl-2-N-(2-pyridylmethyl)aminophenol: spectroscopic, electrochemical and biological investigation, Dalton Transactions 2009(48): 10846-10860.
- Willemse J.J. & Wezel G.P. van (2009), Imaging of Streptomyces coelicolor A3 (2) with reduced autofluorescence reveals a novel stage of FtsZ localization, PLoS ONE 4(1): e242.
- Roy S., Westmaas J.A., Hagen K., Wezel G.P. van & Reedijk J. (2009), Platinum(II) compounds with chelating ligands based on pyridine and pyrimidine: DNA and protein binding studies, Journal of Inorganic Biochemistry 103(9): 1288-1297.
- Xu Q., Traag B.A., Willemse J.J., McMullan D., Miller M.D., Elslier M.-A., Abdubek P., Astakhova T., Axelrod H.L., Bakolitsa C., Carlton D., Chen C., Chiu H.-J., Chruszcz M., Clayton T., Das D., Deller M.C., Duan L., Ellrott K., Ernst D., Farr C.L., Feuerhelm J., Grant J.C., Grzechnik A., Grzechnik S.K., Won Han G., Jaroszewski L., Jin K.K., Klock H.E., Knuth M.W., Kozbial P., Sri Krishna S., Kumar A., Marciano D., Minor W., Mommaas A.M., Morse A.T., Nigoghossian E., Nopakun A., Okach L., Oommachen S., Paulsen J., Puckett C., Reyes R., Rife C.L., Sefcovic N., Tien H.J., Trame C.B., Bedeam H. van den, Wang S., Weekes D., Hodgson K.O., Wooley J., Deacon A.M., Godzik A., Lesley S.A., Wilson I.A. & Wezel G.P. van (2009), Structural and Functional Characterizations of SsgB, a Conserved Activator of Developmental Cell Division in Morphologically Complex Actinomycetes, Journal of Biological Chemistry 284: 25268-25279.
- Roy S., Hagen K.D., Maheswari P.A., Lutz M., Spek A.L., Reedijk J. & Wezel G.P. van (2008), Phenanthroline derivatives with improved selectivity as DNA-targeting anticancer or antimicrobial drugs, ChemMedChem 3(9): 1427-1434.
- Maheswari P.U., Ster M. van der, Smulders S., Barends S., Wezel G.P. van, Massera C., Roy S., Dulk H. den, Gamez P. & Reedijk J. (2008), Structure, cytotoxicity, and DNA-cleavage properties of the complex [CuII(pbt)Br2], Inorganic Chemistry 47(9): 3719-3727.
- Colson S., Wezel G.P. van, Craig M., Noens E.E.E., Nothaft H., Mommaas M., Titgemeyer F., Joris B. & Rigali S. (2008), The chitoblose-binding protein, DasA, acts as a link between chitin utilization and morphogenesis in Streptomyces coelicolor, Microbiology 154(2): 373-382.
- Traag B.A. & Wezel G.P. van (2008), The SsgA-like proteins in actinomycetes: small proteins up to a big task, Antonie van Leeuwenhoek 94(1): 85-97.
- Traag B.A., Seghezzi N., Vijgenboom E. & Wezel G.P. van (2007), Characterization of the sporulation control protein SsgA by use of an efficient method to create and screen random mutant libraries in streptomycetes, Applied and Environmental Microbiology 73(7): 2085-2092.
- Wezel G.P. van, König M., Mahr K., Nothaft H., Thomae A.W., Bibb M.J. & Titgemeyer F. (2007), A New Piece of an Old Jigsaw: Glucose Kinase is Activated Post-translationally in a Glucose Transport-Dependent Manner in Streptomyces coelicolor A3(2), J. Mol. Microbiol. Biotechnol. 12: 67-74.
- Colson S., Stephan J., Hertrich T., Saito A., Wezel G.P. van, Titgemeyer F. & Rigali S. (2007), Conserved cis-acting elements upstream of genes composing the chitinolytic system of streptomycetes are dasR-responsive elements, Journal of Molecular Microbiology and Biotechnology 12(1-2): 60-66.
- Olsthoorn-Tieleman L.N., Palstra R.J., Wezel G.P. van, Bibb M.J. & Pleij C.W.A. (2007), Elongation factor Tu3 from the kirromycin-producer Streptomyces ramocissimus is resistant to three classes of EF-Tu-specific inhibitors, Journal of Bacteriology 189: 3581-3590.
- Noens E.E., Mersinias V., Willemse J.J., Traag B.A., Laing E., Chater K.F., Smith C.P., Koerten H.K. & Wezel G.P. van (2007), Loss of the controlled localization of growth stage‐specific cell‐wall synthesis pleiotropically affects developmental gene expression in an ssgA mutant of Streptomyces coelicolor, Molecular Microbiology 64(5): 1244-1259.
- Hiard S., Maree R., Colson S., Hoskisson P.A., Titgemeyer F., Wezel G.P. van, Joris B., Wehenkel L. & Rigali S. (2007), PREDetector: a new tool to identify regulatory elements in bacterial genomes, Biochemical and Biophysical Research Communications 357(4): 861-864.
- Maheswari P.U., Lappalainen K., Sfregola M., Barends S., Gamez P., Turpeinen U., Mutikainen I., Wezel G.P. van & Reedijk J. (2007), Structure and DNA cleavage properties of two copper(II) complexes of the pyridine-pyrazole-containing ligands mbpzbpy and Hmpzbpya, Dalton Transactions 2007(33): 3676-3683.
- Birko Z., Bialek S.M., Buzas K., Szajli E., Traag B.A., Medzihradszky K.F., Rigali S., Vijgenboom E., Penyige A., Kele Z., Wezel G.P. van & Biro S. (2007), The secreted signaling protein factor C triggers the A-factor response regulon in Streptomyces griseus: overlapping signaling routes, Molecular and Cellular Proteomics 6(7): 1248-1256.
- Maheswari P.U., Barends S., Ozalp-Yaman S., Hoog P. de., Casellas H., Teat S.J., Massera C., Lutz M., Spek A.L., Wezel G.P. van, Gamez P. & Reedijk J. (2007), Unique ligand-based oxidative DNA cleavage by zinc(II) complexes of hpyramol and hpyrimol, Chemistry 13(18): 5213-5222.
- Mazza P., Noens E.E.E., Schirner K., Grantcharova N., Mommaas A.M., Koerten H.K., Muth G., Flardh K., Wezel G.P. van & Wohlleben W. (2006), MreB of Streptomyces coelicolor is not essential for vegetative growth but is required for the integrity of aerial hyphae and spores, Molecular Microbiology 60(4): 838-852.
- Maheswari P.U., Roy S., Dulk H. den, Barends S., Wezel G.P. van, Kozlevcar B., Gamez P. & Reedijk J. (2006), The square-planar cytotoxic [cUii(PYRIMOL)cL] complex acts as an efficient DNA cleaver without reductant, Journal of the American Chemical Society 128(3): 710-711.
- Rigali S., Nothaft H., Noens E.E.E., Schlicht M., Colson S., Müller M., Joris B., Koerten H.K., Hopwood D.A., Titgemeyer F. & Wezel G.P. van (2006), The sugar phosphotransferase system of Streptomyces coelicolor is regulated by the GntR-family regulator DasR and links N-acetylglucosamine metabolism to the control of development, Molecular Microbiology 61(5): 1237-1251.
- Wezel G.P. van, Krabben P., Traag B.A., Keijser B.J.F., Kerste R., Vijgenboom E., Heijnen J.J. & Kraal B. (2006), Unlocking Streptomyces spp. for Use as Sustainable Industrial Production Platforms by Morphological Engineering, Applied and Environmental Microbiology 72(8): 5283-5288.
- Piette A., Derouaux A., Gerkens P., Noens E.E.E., Mazzucchelli G., Vion S., Koerten H.K., Titgemeyer F., Pauw E.S. de, Leprince P., Wezel G.P. van, Galleni M. & Rigali S. (2005), From dormant to germinating spores of streptomyces coelicolor A3(2) new perspectives from the crp null mutant, Journal of Proteome Research 4(5): 1699-1708.
- Wezel G.P. van, Mahr K., König M., Traag B.A., Pimentel-Schmitt E.F., Willimek A. & Titgemeyer F. (2005), Glcp constitutes the major glucose uptake system of Streptomyces coelicor A A3(2), Molecular Microbiology 55(2): 624-636.
- Noens E.E.E., Mersinias V., Traag B.A., Smith C.P., Koerten H.K. & Wezel G.P. van (2005), SsgA-like proteins determine the fate of peptidoglycan during sporulation of Streptomyces coelicolor, Molecular Microbiology 58(4): 929-944.
- Titgemeyer F., Bertram R., Schlicht M., Wezel G.P. van & Rigali S. (2005), Sugar transport and C-regulation in antibiotic-producing streptomycetes = Zuckertransport und C-regulation in antibiotika-produzierenden streptomyceten, BIOspektrum 11(3): 300-302.
- Wezel G.P. van & Vijgenboom E. (2004), Novel aspects of signaling in Streptomyces development, Advances in Applied Microbiology 56: 65-88.
- Traag B.A., Kelemen G.H. & Wezel G.P. van (2004), Transcription of the sporulation gene ssgA is activated by the IclR-type regulator SsgR in a whi-independent manner in Streptomyces coelicolor A3(2), Molecular Microbiology 53(3): 985-1000.
- Flärdh K. & Wezel G.P. van (2003), Cell division during growth and development. In: Pandalai E.G. (Ed.) Recent Res. Devel. Bacteriol... 71-90.
- Keijser B.J.F., Noens E.E.E., Kraal B., Koerten H.K. & Wezel G.P. van (2003), The streptomyces coelicolor sggB gene is required for early stages of sporulation, FEMS Microbiology Letters 225(1): 59-67.
- Keijser B.J.F., Wezel G.P. van, Canters G.W. & Vijgenboom E. (2002), Developmental regulation of the Streptomyces lividans ram genes: involvement of RamR in regulation of the ramCSAB operon, Journal of Bacteriology 184(16): 4420-4429.
- Wezel G.P. van, White J., Hoogvliet G. & Bibb M.J. (2000), Application of redD, the transcriptional activator gene of the undecylprodigiosin biosynthetic pathway, as a reporter for transcriptional activity in Streptomyces coelicolor A3(2) and Streptomyces lividans, Journal of Molecular Microbiology and Biotechnology 2(4): 551-556.
- Wezel G.P. van, Meulen J. van der, Taal E., Koerten H. & Kraal B. (2000), Efffects of increased and deregulated expression of cell division genes on the morphology and on antibiotic production of streptomycetes, ANTONIE VAN LEEUWENHOEK JOURNAL OF MICROBIOLOGY 78: 269-276.
- Mahr K., Wezel G.P. van, Svensson C., Krengel U., Bibb M.J. & Titgemeyer F. (2000), Glucose kinase of Streptomyces coelicolor A3(2): large-scale purification and biochemical analysis, Antonie van Leeuwenhoek 78: 253-261.
- Wezel G.P. van, Meulen J.R. van der, Kawamoto S., Luiten R.G.M., Koerten H.K. & Kraal B. (2000), ssgA Is essential for sporulation of streptomyces coelicolor A3(2) and affects Hyphal Development by stimulating septum formation, Journal of Bacteriology 182(20): 5663-5662.
- Keijser B.J.F., Wezel G.P. van, Canters G.W., Kieser T. & Vijgenboom E. (2000), The ram dependence of Streptomyces lividans differentiation is by-passed by copper, Journal of Molecular Microbiology and Biotechnology 2(4): 565-574.
- Liu M., Kirpekar F., Wezel G.P. van & Douthwaite S. (2000), The tylosin resistance gene tlrB of Streptomyces fradiae encodes a methyltransferase that targets G748 in 23S rRNA, Molecular Microbiology 37(4): 811-820.
- Biro S., Birko Z. & Wezel G.P. van (2000), Transcriptional and functional analysis of the gene for factor C, an extracellular signal protein involved in cytodifferentiation of Streptomyces griseus, Antonie van Leeuwenhoek 78(3-4): 277-285.
- Birko Z., Sumegi A., Vinnai A., Wezel G.P. van, Szestak F., Vitalis S., Szabo P.T., Kele Z., Janaki T. & Biro S. (1999), Characterization of the gene for Factor C, an extracellular signal protein involved in morphological differentiation of Streptomyces griseus, Microbiology 145: 2245-2253.
- Hoogvliet G., Wezel G.P. van & Kraal B. (1999), Evidence that a single EF-Ts suffices for the recycling of multiple and divergent EF-Tu species in Streptomyces coelicolor A3(2) and Streptomyces ramocissimus, Microbiology 145: 2293-2301.
- Tieleman L., Wezel G.P. van, Bibb M. & Kraal B. (1997), Growth phase-dependent transcription of the Streptomyces ramocissimus tuf1 gene occurs from two promoters, Journal of Bacteriology 179(11): 3619-3624.
- Wezel G.P. van White J., Young P., Postma P.W. & Bibb M.J. (1997), Substrate induction and glucose repression of maltose utilization by Streptomyces coelicolor A3(2) is controlled by malR, a member of the lacI-galR family of regulatory genes, Molecular Microbiology 23(3): 537-549.
- Wezel G.P. van, White J., Bibb M.J. & Postma P.W. (1997), The malEFG gene cluster of Streptomyces coelicolor A3(2): characterization, disruption and transcriptional analysis, Molecular and General Genetics 254(5): 604-608.
- Wezel G.P. van, Takano E., Vijgenboom E., Bosch L. & Bibb M.J. (1995), The tuf3 gene of Streptomyces-coelicolor A3(2) encodes an inessential elongation-factor tu that is apparently subjest to positive stringent control , Microbiology 141(10): 2519-2528.
- Wezel G.P. van, Buttner M.J., Vijgenboom E., Bosch L., Hopwood D.A. & Kieser H.M. (1995), Mapping of genes involved in macromolecular-synthesis on the chromosome of Streptomyces-coelicolor A3(2), Journal of Bacteriology 177(2): 473-476.
- Wezel G.P. van, Krab I.M., Stephen D., Bibb M.J., Vijgenboom E. & Bosch L. (1994), Transcription analysis of the stretomyces-coelicolor A3(2) ribosomal-RNA operon, Microbiology 140(12): 3357-3365.
- Wezel G.P. van, Woudt L.P., Vervenne R., Verdurmen M.L.A., Vijgenboom E. & Bosch L. (1994), Cloning and sequencing of the tuf genes of Streptomyces coelicolor A3(2), BBA - Gene Structure and Expression 1219(2): 543-547.
- Vijgenboom E., Woudt L.P., Heinstra P.W.H., Rietveld K., Haarlem J. van, Wezel G.P. van, Shochat S. & Bosch L. (1994), Three tuf-like genes in the kirromycin producer Streptomyces ramocissimus, Microbiology 140(4): 983-998.
- Wezel G.P. van, Vijgenboom E. & Bosch L. (1991), A comparative study of the ribosomal RNA operons of streptomyces coelicolor A3(2) and sequence analysis of rrnA, Nucleic Acids Research 19(16): 4399-4403.
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