Interview with PhD student: Doris van Bergeijk
Leiden University is partner of the Netherlands Centre for One Health (NCOH). This initiative brings together leading academic research institutes in the Netherlands in an open innovation network that responds to the theme: One Health. NCOH interviewed Doris van Bergeijk: PhD student of the project ‘The effect of host-microbe interactions on the secondary metabolism of actinomycetes’ at Leiden University (Institute of Biology Leiden).
‘My interest in antibiotic research started during a microbiology course in the second year of my bachelor. We had to test bacteria from the sewage against different antibiotics and I was shocked by their multi-drug resistance. To me it was clear that we were in need of new antibiotics (or alternatives) and I am very excited that I am now working on a project that will hopefully contribute to the discovery of new antibiotics.’
‘Actinomycetes are filamentous bacteria that are well known for their antibiotic production. Sequencing has shown that the genomes of actinomycetes contain a wealth of undiscovered biosynthetic gene clusters and this discovery has spiked research into this direction. Signals from the host/environment of these bacteria might influence the expression of these clusters. I aim to find host-specific signals, for example stress hormones, that can influence the antibiotic production with the ultimate goal to use actinomycetes to control microbial infections.’
‘So far, I have discovered that certain signaling molecules indeed influence the antibiotic production of actinomycetes. I now aim to identify the biosynthetic gene clusters that respond to these hormones and the corresponding metabolites. Additionally, I have had the unique opportunity to isolate and sequence actinomycetes from mammoth stool. This data, together with the metagenomics data of the gut microbiome of the mammoth, allows us to study bacteria from the past and analyse the biosynthetic gene clusters that are present. Hopefully this can give us insight in the way these genes have developed over time and what role actinomycetes can play in the protection of higher organisms.’
Leiden University is a partner of the Netherlands Centre for One Health (NCOH). This initiative brings together leading academic research institutes in the Netherlands in an open innovation network that responds to the theme: One Health. NCOH has an integrated approach to the global risks of infectious diseases and sustainable solutions for major societal challenges in the field of animal and public health, healthy wildlife and ecosystems.
Prof. Dr. Gilles van Wezel is co-director of the research theme Tackling Antimicrobial Resistance (AMR) within NCOH and a member of the Executive Board. NCOH-AMR forms the basis for a high quality consortium with top expertise in the field of antibiotic resistance. NCOH-AMR combines the expertise of Dutch knowledge institutions to jointly create solutions for the urgent problem of antibiotic resistance. Prof. Geert de Snoo is a member of the board of directors.