Leiden Early Drug Discovery & Development

The scientists behind LED3

Meet the scientists within the LED3 community

Hans Aerts LIC
Leila Akkari LIC

Tumor Microenvironment / Drug Delivery in Cancer / Macrophage
Zach Armstrong LIC

Antivirals / Carbohydrates / Structural Biology
Marta Artola Perez de Azanza LIC

Chemical Biology / Drug Discovery / Glycobiology
Linda Aulin LACDR

PKPD / Antibiotics / Pharmacometrics
Paco Barona Gomez IBL

Chemical Diversity / Evolution / Specialised Metabolites
Matthias Barz LACDR

Polymer-based Nanomedicine / Immune Therapies / Drug Formulations
Joost Batenburg LIACS

Machine Learning / Computational Imaging / Artificial Intelligence
Joost Beltman LACDR

Cell Signaling / Immune System - Tumor Interactions / Computational Modeling
Kim Bonger LIC

Chemical Immunology / Targeted Drug Delivery / Bioorthogonal Chemistry
Sylvestre Bonnet LIC

Photoactivated Chemotherapy / Metallodrugs / Hypoxic Tumors
Ilze Bot LACDR

Cardiovascular Disease / Inflammation / Target Discovery
Steffen Brünle LIC

Structure-based Drug Discovery / Cellular Signaling / G Protein-coupled Receptors
Jeroen Bussmann LACDR

RNA Delivery / Biodistribution / Zebrafish
Victor Carrion Bravo IBL
Young Hae Choi IBL
Jeroen Codee LIC

Organic Synthesis / Carbohydrates / Vaccines
Erik Danen LACDR

Cancer / Fibrosis / Drug Target Discovery
Jeroen Demmers LACDR

Proteomics / Mass Spectrometry / Protein Interactions
Pingtao Ding IBL

Plant-microbe Interactions / Gene Regulatory Networks / Systems Biology
Micha Drukker LACDR
Miranda van Eck LACDR

Cardiovascular Therapeutics / Molecular Pharmacology / Target Discovery
Marco van Eijk LIC

Macrophage / Lysosome / (Glyco)sphingolipid Metabolism
Somayah Elsayed IBL

Microbial Natural Products / Bioactive Metabolites / Antimicrobial Resistance
Daan van der Es LACDR

Medicinal Chemistry / Chemical Biology / Molecular Pharmacology
Dmitri Filippov LIC

Bioorganic Chemistry / ADP-ribosylation / Nucleic Acid Chemistry
Amanda Foks LACDR

Cardiovascular Disease / Aging / Immunology
Sebastian Geibel LIC

Mycobacteria / Type VII Secretion Systems / Cryo-EM
Tingjie Guo LACDR

Translational PKPD / CNS Pharmacology / Novel Treatment Modalities
Joachim van Guyse LACDR

Polymer Chemistry / Drug Delivery Systems / Biotherapeutics
Stephan Hacker LIC

Antibiotics / Chemical Proteomics / Covalent Inhibitors
Thomas Hankemeier LACDR
Coen van Hasselt LACDR

PKPD / Antibiotics / Systems Pharmacology
Laura Heitman LACDR

G Protein-coupled Receptors / Novel Chemical Modalities / Receptor Pharmacology
Menno Hoekstra LACDR

Lipid Metabolism / Endocrinology / Animal Models
Sandra Irmisch IBL

Bioactive Plant Metabolites / Biosynthetic Pathway Discovery / Engineering Production Systems
Hubertus Irth IBL
Anthe Janssen LIC

Computational Drug Discovery / Chemical Biology / AI
Lars Jeuken LIC

Bioenergetics and Respiration / Metalloproteins / Membrane Biophysics
Sander van Kasteren LIC

Bioorthogonal Chemistry / Vaccine Development / Immunometabolism
Madeline Kavanagh LIC

Chemoproteomics & Target ID / Autoimmune & Inflammation / MedChem & Tuberculosis
Roxanne Kieltyka LIC

Supramolecular Materials / Hydrogels / 3D Cell Culture
Akos Kovács IBL

Chemical Ecology / Specialized Metabolites / Plant Microbiome
Alexander Kros LIC

Drug Delivery / RNA Therapeutics / Lipid Nanoparticles and Liposomes
Elizabeth (Liesbeth) de Lange LACDR

Central Nervous System / Pharmacokinetics / Physiology-based
Sylvia Le Dévédec LACDR

Phenotypic Profiling / Advanced Microscopy / FAIR Data Lifecycle
Martijn Manson LACDR
Nathaniel Martin IBL

Antibiotics / Natural Products / Inhibitors
Alireza Mashaghi Tabari LACDR

Biomolecular Condensate / Organ-on-a-chip and Bioprinting / Quantum Sensing
Marnix Medema IBL

Natural Products / Genome Mining / Antibiotics
Annemarie Meijer IBL

Infectious Disease / Autophagy / Host-directed Therapeutics
Anne-Grete Märtson LACDR

Antiviral Pharmacology / (Pre-clinical and Clinical) PK/PD / Translational Infection Models
Hermen Overkleeft LIC

Activity-based Protein Profiling / Glycobiology / Enzymology
Sebastian Pomplun LACDR

Encoded Libraries / Macrocycles / Nucleic Acid Binding Proteins
Mike Preuss LIACS

Retrosynthesis / AI Algorithms / Drug Candidate Generation
Arthur Ram IBL

Cell Wall Antifungals / Fungal Cell Factory / Bioactive Compounds
Robert Rissmann LACDR

Clinical / Translational / Dermatology
Daniel Rozen IBL

Antibiotic Evolution / Streptomyces / Antibiotic Resistance
Lennart Schada von Borzyskowski IBL

Sustainable Drug Production / Genome Mining / Antibiotics
Bram Slütter LACDR

Vaccination / Cardiovascular Disease / Immune Tolerance
Herman Spaink IBL

Infectious Disease / Mycobacteria / Zebrafish Models
Mario van der Stelt LIC

Medicinal Chemistry / Chemical Proteomics / Neuroscience - Oncology
Lu Su LACDR

Synthetic Therapeutics / Supramolecular Biomaterials / Drug Delivery Systems
Marcellus Ubbink LIC

Enzyme / NMR Spectroscopy / Protein Evolution
Fons Verbeek LIACS

Image Analysis / Artificial Intelligence / Data Visualiazation
Bob van de Water LACDR

hiPSC-derived 2D and 3D Models / Drug Safety Assessment / Drug Target Discovery
Tom van der Wel LIC

Chemical Genetics / Lipid Signaling / CRISPR/Cas Gene Editing
Anne Wentink LIC

Molecular Chaperones / Protein Aggregation / Neurodegeneration
Gerard van Westen LACDR

Artificial Intelligence / Cofolding / Machine Learning
Gilles van Wezel IBL

Antibiotic Discovery / Natural Product Biosynthesis / Synthetic Biology
Rob van Wijk LACDR

Translational Immuno-pharmacology / Pharmacokinetics/Pharmacodynamics / Infectious Disease Zebrafish Model
Han de Winde IBL

Systems and Synthetic Biology / Biotechnology for Health / Natural Compounds Discovery

Tumor Microenvironment / Drug Delivery in Cancer / Macrophage

Antivirals / Carbohydrates / Structural Biology

Chemical Biology / Drug Discovery / Glycobiology

PKPD / Antibiotics / Pharmacometrics

Chemical Diversity / Evolution / Specialised Metabolites

Polymer-based Nanomedicine / Immune Therapies / Drug Formulations

Machine Learning / Computational Imaging / Artificial Intelligence

Cell Signaling / Immune System - Tumor Interactions / Computational Modeling

Chemical Immunology / Targeted Drug Delivery / Bioorthogonal Chemistry

Photoactivated Chemotherapy / Metallodrugs / Hypoxic Tumors

Cardiovascular Disease / Inflammation / Target Discovery

Structure-based Drug Discovery / Cellular Signaling / G Protein-coupled Receptors

RNA Delivery / Biodistribution / Zebrafish

Organic Synthesis / Carbohydrates / Vaccines

Cancer / Fibrosis / Drug Target Discovery

Proteomics / Mass Spectrometry / Protein Interactions

Plant-microbe Interactions / Gene Regulatory Networks / Systems Biology

Cardiovascular Therapeutics / Molecular Pharmacology / Target Discovery

Macrophage / Lysosome / (Glyco)sphingolipid Metabolism

Microbial Natural Products / Bioactive Metabolites / Antimicrobial Resistance

Medicinal Chemistry / Chemical Biology / Molecular Pharmacology

Bioorganic Chemistry / ADP-ribosylation / Nucleic Acid Chemistry

Cardiovascular Disease / Aging / Immunology

Mycobacteria / Type VII Secretion Systems / Cryo-EM

Translational PKPD / CNS Pharmacology / Novel Treatment Modalities

Polymer Chemistry / Drug Delivery Systems / Biotherapeutics

Antibiotics / Chemical Proteomics / Covalent Inhibitors

PKPD / Antibiotics / Systems Pharmacology

G Protein-coupled Receptors / Novel Chemical Modalities / Receptor Pharmacology

Lipid Metabolism / Endocrinology / Animal Models

Bioactive Plant Metabolites / Biosynthetic Pathway Discovery / Engineering Production Systems

Computational Drug Discovery / Chemical Biology / AI

Bioenergetics and Respiration / Metalloproteins / Membrane Biophysics

Bioorthogonal Chemistry / Vaccine Development / Immunometabolism

Chemoproteomics & Target ID / Autoimmune & Inflammation / MedChem & Tuberculosis

Supramolecular Materials / Hydrogels / 3D Cell Culture

Chemical Ecology / Specialized Metabolites / Plant Microbiome

Drug Delivery / RNA Therapeutics / Lipid Nanoparticles and Liposomes

Central Nervous System / Pharmacokinetics / Physiology-based

Phenotypic Profiling / Advanced Microscopy / FAIR Data Lifecycle

Antibiotics / Natural Products / Inhibitors

Biomolecular Condensate / Organ-on-a-chip and Bioprinting / Quantum Sensing

Natural Products / Genome Mining / Antibiotics

Infectious Disease / Autophagy / Host-directed Therapeutics

Antiviral Pharmacology / (Pre-clinical and Clinical) PK/PD / Translational Infection Models

Activity-based Protein Profiling / Glycobiology / Enzymology

Encoded Libraries / Macrocycles / Nucleic Acid Binding Proteins

Retrosynthesis / AI Algorithms / Drug Candidate Generation

Cell Wall Antifungals / Fungal Cell Factory / Bioactive Compounds

Clinical / Translational / Dermatology

Antibiotic Evolution / Streptomyces / Antibiotic Resistance

Sustainable Drug Production / Genome Mining / Antibiotics

Vaccination / Cardiovascular Disease / Immune Tolerance

Infectious Disease / Mycobacteria / Zebrafish Models

Medicinal Chemistry / Chemical Proteomics / Neuroscience - Oncology

Synthetic Therapeutics / Supramolecular Biomaterials / Drug Delivery Systems

Enzyme / NMR Spectroscopy / Protein Evolution

Image Analysis / Artificial Intelligence / Data Visualiazation

hiPSC-derived 2D and 3D Models / Drug Safety Assessment / Drug Target Discovery

Chemical Genetics / Lipid Signaling / CRISPR/Cas Gene Editing

Molecular Chaperones / Protein Aggregation / Neurodegeneration

Artificial Intelligence / Cofolding / Machine Learning

Antibiotic Discovery / Natural Product Biosynthesis / Synthetic Biology

Translational Immuno-pharmacology / Pharmacokinetics/Pharmacodynamics / Infectious Disease Zebrafish Model

Systems and Synthetic Biology / Biotechnology for Health / Natural Compounds Discovery