Sylvia Le Dévédec
Universitair docent
- Naam
- Dr. S.E. Le Dévédec
- Telefoon
- +31 71 527 4285
- s.e.ledevedec@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-0615-9616
Voor meer informatie zie de Engelse profielpagina
Universitair docent
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Toxicology
- Sijben H.J., Dall’ Acqua L., Liu R., Jarret A., Christodoulaki E., Onstein S., Wolf G., Verburgt S.J., Le Dévédec S.E., Wiedmer T., Superti-Furga G., IJzerman A.P. & Heitman L.H. (2022), Impedance-based phenotypic readout of transporter function: a case for glutamate transporters, Frontiers in Pharmacology 13: 872335.
- Stel W. van der, Yang H., Le Dévédec S.E., Water B. van de, Beltman J.B. & Danen E.H.J. (2022), High-content high-throughput imaging reveals distinct connections between mitochondrial morphology and functionality for oxphos complex I, III, and V inhibitors, Cell Biology and Toxicology.
- Burger G.A., Water B. van de, Le Dévédec S.E. & Beltman J.B. (2022), Density-dependent migration characteristics of cancer cells driven by pseudopod interaction, Frontiers in Cell and Developmental Biology 10: 854721.
- Tong. C., Wondergem A.J., Brink M. van den, Kwakernaak M.C., Chen Y., Hendrix M.M.R.M., Voets I.K., Danen E.H.J., Le Dévédec S., Heinrich D.M. & Kieltyka R.E. (2022), Spatial and temporal modulation of cell instructive cues in a filamentous supramolecular biomaterial, ACS Applied Materials and Interfaces 14(15): 17042-17054.
- Lerink L.J.S., Kok M.J.C., Mulvey J.F., Le Dévédec S.E., Markovski A.A., Wüst R.C.I., Alwayn I.P.J., Ploeg R.J., Schaapherder A.F.M., Bakker J.A. & Lindeman J.H.N. (2022), Preclinical models versus clinical renal ischemia reperfusion injury: a systematic review based on metabolic signatures, American Journal of Transplantation 22(2): 344-370.
- Stel W. van der, Yang H., Vrijenhoek N.G., Schimming J.P., Callegaro G., Carta G., Darici S., Delp J., Forsby A., White A., Le Dévédec S.E., Leist M., Jennings P., Beltman J.B., Water B. van de & Danen E.H.J. (2022), Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation, Archives of Toxicology 96: 259-285.
- Snijders K.E., Fehér A., Táncos Z., Bock I., Téglási A., Berk L. van den, Niemeijer M., Bouwman P., Le Dévédec S.E., Moné M.J., Rossom R. van, Kumar M., Wilmes A., Jennings P., Verfaillie C.M., Kobolák J., Braak B. ter, Dinnyés A. & Water B. van de (2021), Fluorescent tagging of endogenous heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages, Archives of Toxicology 95(10): 3285-3302.
- Braak S.J. ter, Niemeijer M.C., Wolters L., Le Dévédec S.E., Bouwman R.J.P. & Water B. van de (2022), Towards an advanced testing strategy for genotoxicity using image-based 2D and 3D HepG2 DNA damage response fluorescent protein reporters, Mutagenesis 37(2): 130-142.
- Wijaya L.S., Trairatphisan P., Gabor A., Niemeijer M.C., Keet J., Alcalà Morera A., Snijders K.E., Wink S., Yang H., Schildknecht S., Stevens J.L., Bouwman R.J.P., Kamp H., Hengstler J., Beltman J.B., Leist M., Le Dévédec S.E., Saez-Rodriguez J. & Water B. van de (2021), Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury, Biochemical Pharmacology 190.
- Koedoot E., Wolters L., Smid M., Stoilov P., Burger G.A., Herpers B.H.A., Yan K., Price L.S., Martens J.W.M., Le Dévédec S.E. & Water B. van de (2021), Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy, Scientific Reports 11: 7529.
- Duijndam B., Goudriaan A., Hoorn T. van den, Stel W. van der, Le Dévédec S.E., Bouwman R.J.P., Laan J.W. van der & Water B. van de (2021), Physiologically relevant estrogen receptor alpha pathway reporters for single-cell imaging-based carcinogenic hazard assessment of estrogenic compounds, Toxicological Sciences 181(2): 187-198.
- Koedoot E., Steijn E. van, Vermeer M., González-Prieto R., Vertegaal A.C.O., Martens J.W.M., Le Dévédec S.E. & Water B. van de (2021), Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention, Journal of Experimental & Clinical Cancer Research 40.
- Kok M.J.C. de, Schaapherder A.F., Wüst R.C.I., Zuiderwijk M., Bakker J.A., Lindeman J.H.N. & Le Dévédec S.E. (2021), Circumventing the crabtree effect in cell culture: a systematic review, Mitochondrion 59: 83-95.
- Lindeman J.H., Wijermars L.G., Kostidis S., Mayboroda O.A., Harms A.C., Hankemeier T., Bierau J., Sai Sankar Gupta K.B., Giera M., Reinders M.E., Zuiderwijk M.C., Le Dévédec S.E., Schaapherder A.F. & Bakker J.A. (2020), Results of an explorative clinical evaluation suggest immediate and persistent post-reperfusion metabolic paralysis drives kidney ischemia reperfusion injury, Kidney International 98(6): 1476-1488.
- Gonzalez-Beltran A.N., Masuzzo P., Ampe C., Bakker G.J., Besson S., Eibl R.H., Friedl P., Gunzer M., Kittisopikul M., Devedec S.E. le, Leo S., Moore J., Paran Y., Prilusky J., Rocca-Serra P., Roudot P., Schuster M., Sergeant G., Stromblad S., Swedlow J.R., Erp M. van, Troys M. van, Zaritsky A., Sansone S.A. & Martens L. (2020), Community standards for open cell migration data, GigaScience 9(5): giaa041.
- Leone M.L., Romeijn S.G., Du G., Dévédec S.E. Le, Vrieling H., O'Mahony C., Bouwstra J.A. & Kersten G.F.A. (2020), Diphtheria toxoid dissolving microneedle vaccination: Adjuvant screening and effect of repeated-fractional dose administration, International Journal of Pharmaceutics 580: 119182.
- Koenders S.T.A., Wijaya L.S., Erkelens M.N., Bakker A.T., Noord V.E. van der, Rooden E.J. van, Burggraaff L., Putter P.C., Botter E., Wals K., Elst H. van den, Dulk H. den, Florea B.I., Water B. van de, Westen G.J.P. van, Mebius R.E., Overkleeft H.S., Le Dévédec S.E. & Stelt M. van der (2019), Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells, ACS Central Science 5(12): 1965-1974.
- Liu S., González Prieto R., Zhang M., Geurink P.P., Kooij R., Iyengar P.V., Dinther M. van, Bos E., Zhang X., Le Dévédec S.E., Water B. van de, Koning R.I., Zhu H.J., Mesker W.E., Vertegaal A., Ovaa H., Zhang L., Martens J.W.M. & Dijke P. ten (2020), Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis, Clinical Cancer Research 26(6): 1460-1473.
- He J., Wink S., Bont H. de, Le Dévédec S., Zhang Y. & Water B. van de (2019), FRET biosensor-based kinase inhibitor screen for ERK and AKT activity reveals differential kinase dependencies for proliferation in TNBC cells, Biochemical Pharmacology 169: 113640.
- Rixel V.H.S. van, Ramu V., Auyeung A.B., Beztsinna N., Leger D.Y., Lameijer L.N., Hilt S.T., Le Devedec S.E., Yildiz T., Betancourt T., Gildner M.B., Hudnall T.W., Sol V., Liagre B., Kornienko A. & Bonnet S. (2019), Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model, Journal of the American Chemical Society 141(46): 18444-18454.
- Koedoot E., Wolters L., Water B. van de & Dévédec S.E.L. (2019), Splicing regulatory factors in breast cancer hallmarks and disease progression, Oncotarget 10(57): 6021-6037.
- Nair N.U., Das A., Rogkoti V.M., Fokkelman M., Marcotte R., Jong C.G. de, Koedoot E., Lee J.S., Meilijson I., Hannenhalli S., Neel B.G., Water B. van de, Le Dévédec S.E. & Ruppin E. (2019), Migration rather than proliferation transcriptomic signatures are strongly associated with breast cancer patient survival, Scientific Reports 9: 10989.
- Koedoot E., Fokkelman M., Rogkoti V.M., Smid M., Sandt I. van de, Bont H.J.G.M. de, Pont C.M., Klip J.E., Wink S., Timmermans M.A., Wiemer E.A.C., Stoilov P., Foekens J.A., Le Dévédec S.E., Martens J.W.M. & Water B. van de (2019), Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes, Nature Communications 10(1): 2983.
- Verkoeijen S., Ma Y.F., Roosmalen W. van, Lalai R., Miltenburg M.H.A.M. van, Graauw M. de, Water B. van de & Le Dévédec S.E. (2019), Paxillin serine 178 phosphorylation in control of cell migration and metastasis formation through regulation of EGFR expression in breast cancer, Journal of Cancer Metastasis and Treatment 5: 51.
- Buijs J.T., Laghmani E., Akker R.F.P. van den, Tieken C., Vletter E.M., Molen K.M. van der, Crooijmans J.J., Kroone C., Le Devedec S.E., Pluijm G. van der & Versteeg H.H. (2019), The direct oral anticoagulants rivaroxaban and dabigatran do not inhibit orthotopic growth and metastasis of human breast cancer in mice, Journal of Thrombosis and Haemostasis 17(6): 951-963.
- Koedoot E., Smid M., Foekens J.A., Martens J.W.M., Le Dévédec S.E. & Water B. van de (2019), Co-regulated gene expression of splicing factors as drivers of cancer progression, Scientific Reports 9(1): 5484.
- Buijs J.T., Laghman E.H., Akker R.F.P. van den, Tieken C., Vletter E., Molen K. van der, Crooijmans J., Kroone C., Pluijm G. van der, Le Devedec S.E. & Versteeg H.H. (2018), Direct oral anticoagulants do not inhibit growth and metastasis of human triple negative breast cancer in immunodeficient mice, Thrombosis Research 164(1): S221-S222.
- Lameijer L.N., Ernst D., Hopkins S.L., Meijer M.S., Askes S.H.C., Le Dévédec S.E. & Bonnet S.A. (2017), A Red-Light-Activated Ruthenium-Caged NAMPT Inhibitor Remains Phototoxic in Hypoxic Cancer Cells, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56(38): 11549-11553.
- Roosmalen W. van, Le Devedec S.E., Golani O., Smid M., Pulyakhina I., Timmermans A.M., Look M.P., Zi D., Pont C., Graauw M. de, Naffar-Abu-Amara S., Kirsanova C., Rustici G., Hoen P.A.C. 't, Martens J.W.M., Foekens J.A., Geiger B. & Water B.J. van de (2015), Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant, Journal of Clinical Investigation 125(4): 1648-1664.
- Yizhak K., Gaude E., Le Devedec S., Waldman Y.Y., Stein G.Y., Water B. van de, Frezza C. & Ruppin E. (2014), Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer, ELIFE 3: e03641.
- Yizhak K., Le Dévédec S.E., Rogkoti V.M., Baenke F., Boer V.C. de, Frezza C., Schulze A., Water B. van de & Ruppin E. (2014), A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration, Molecular Systems Biology 10(8): 744.
- Di Z., Klop M.J.D., Rogkoti V.M., Le Dèvèdec S.E., Water B. van de, Verbeek F.J., Price L.S. & Meerman J.H.N. (2014), Ultra High Content Image Analysis and Phenotype Profiling of 3D Cultured Micro-Tissues, PLoS ONE 9(10): e109688.
- Graauw M. de, Cao L., Winkel L., Miltenburg M.H.A.M. van, Devedec S.E. le, Klop M., Yan K., Pont C.M., Rogkoti V.M., Tijsma A., Chaudhuri A., Lalai R.A., Price L., Verbeek F. & Water B. van de (2014), Annexin A2 depletion delays EGFR endocytic trafficking via cofilin activation and enhances EGFR signaling and metastasis formation, ONCOGENE 33(20): 2610-2619.
- Truong H.H., Xiong J., Ghotra V.P.S., Nirmala E., Haazen L., Le Dévédec S.E., Balcioglu H.E., He S., Snaar-Jagalska B.E., Vreugdenhil E., Meerman J.H.N., Water B. van de & Danen E.H.J. (2014), beta(1) Integrin Inhibition Elicits a Prometastatic Switch Through the TGF beta-miR-200-ZEB Network in E-Cadherin-Positive Triple-Negative Breast Cancer, Science Signaling 7(312): ra15.
- Truong H.H., Xiong J., Ghotra V.P, Nirmala .E, Haazen L.C.J.M., Dévédec S.E. le, Balcioğlu H.E., He S., Snaar-Jagalska B.E., Vreugdenhil E., Meerman J.H.N., Water B. van de & Danen E.H. (2014), β1 integrin inhibition elicits a prometastatic switch through the TGFβ-miR-200-ZEB network in E-cadherin-positive triple-negative breast cancer, Science Signaling 7(312): ra15.
- Le Dévédec S.E., Geverts B., Bont H.J.G.M. de, Yan K., Verbeek F.J., Houtsmuller A.B. & Water B. van de (2012), The residence time of focal adhesion kinase (FAK) and paxillin at focal adhesions in renal epithelial cells is determined by adhesion size, strength and life cycle status, Journal of Cell Science 125(19): 4498-4506.
- Damiano L., Devedec S.E. le, Stefano P. di, Repetto D., Lalai R., Truong H., Xiong J.L., Danen E.H., Yan K., Verbeek F.J., Luca E. de, Attanasio F., Buccione R., Turco E., Water B. van de & Defilippi P. (2012), p140Cap suppresses the invasive properties of highly metastatic MTLn3-EGFR cells via impaired cortactin phosphorylation, ONCOGENE 31(5): 624-633.
- Roosmalen W.P.E. van, Le Dévédec S.E., Zovko S., Bont H.J.G.M. & Water B. van de (2011), Functional screening with a live cell imaging-based random cell migration assay. In: Wells C., Parsons M. (red.) Cell Migration. Methods in molecular biology (Clifton, N.J.) nr. 769: Humana Press. 435-448.
- Le Dévédec S.E., Roosmalen W. van, Pont C.M., Lalai R., Bont H.J.G.M. de & Water B. van de (2011), Two-photon intravital multicolour imaging to study metastatic behaviour of cancer cells in vivo.. In: Wells C.M., Parsons M. (red.) Cell Migration. Methods in molecular biology (Clifton, N.J.) nr. 769: Springer. 331-349.
- Le Devedec S.E., Lalai R., Pont C.M., Bont H.J.G.M. & Water B. van de (2011), Two-Photon Intravital Multicolor Imaging Combined with Inducible Gene Expression to Distinguish Metastatic Behavior of Breast Cancer Cells In Vivo, Molecular Imaging and Biology 13(1): 67-77.
- Le Devedec S.E., Yan K., Bont H.J.G.M. de, Ghotra V., Truong H., Danen E.H.J., Verbeek F. & Water B. van de (2010), Systems microscopy approaches to understand cancer cell migration and metastasis, Cellular and Molecular Life Sciences 67(19): 3219-3240.
- Graauw M. de, Miltenburg M.H. van, Schmidt M.K., Pont C.M., Lalai R.A., Kartopawiro J., Pardali E., Le Dévédec S.E., Smit V.T., Wal A. van der, Veer L.J. van 't, Cleton-Jansen A.-M., Dijke P. ten & Water B. van de (2010), Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells, Proceedings of the National Academy of Sciences of the United States of America 107(14): 6340-6345.
- Yan K., Verbeek F.J., Le Dévédec S.E. & Water B. van de (2009), Cell Tracking and Data Analysis of in Vitro Tumour Cells From Time-Lapse Image Sequences. In: Proceedings of the Fourth International Conference on Computer Vision Theory and Applications, VISAPP. VISAPP 2009: PROCEEDINGS OF THE FOURTH INTERNATIONAL CONFERENCE ON COMPUTER VISION THEORY AND APPLICATIONS, VOL 1 no. Volume 1: Scitepress. 281-286.
- Le Dévédec S.E., Roosmalen W.P.E. van, Maria N., Grimbergen M., Pont C.M., Lalai R.A. & Water B. van de (2009), An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2(-/-) gamma c(-/-) mouse, Clinical & Experimental Metastasis 26(7): 673-684.
- Ma Y., Water B. van de & Le Dévédec S.E. (2009), Focal Adhesion Kinase (FAK) Inhibition as a potential strategy for anticancer therapies, DRUGS OF THE FUTURE 34(6): 477-483.
- Graauw M. de, Le Devedec S.E., Tijdens R.B., Smeets M.B., Deelder A.M. & Water B. van de (2007), Proteomic analysis of alternative protein tyrosine phosphorylation in 1,2-dichlorovinyl-cysteine-induced cytotoxicity in primary cultured rat renal proximal tubular cells, Journal of Pharmacology and Experimental Therapeutics 322(1): 89-100.
- Water B. van de, Graauw M. de, Le Devedec S.E. & Alderliesten M. (2006), Cellular stress responses and molecular mechanisms of nephrotoxicity, Toxicology Letters 162(1): 83-93.
Geen relevante nevenwerkzaamheden