Sylvia Le Dévédec
Universitair docent
- Naam
- Dr. S.E. Le Dévédec
- Telefoon
- +31 71 527 4285
- s.e.ledevedec@lacdr.leidenuniv.nl
Promovendi
Universitair docent
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Toxicology
- Roosmalen W. van, Le Devedec S.E., Golani O., Smid M., Pulyakhina I., Timmermans A.M., Look M.P., Zi D., Pont C., Graauw M. de, Naffar-Abu-Amara S., Kirsanova C., Rustici G., Hoen P.A.C. 't, Martens J.W.M., Foekens J.A., Geiger B. & Water B.J. van de (2015), Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant, JOURNAL OF CLINICAL INVESTIGATION 125(4): 1648-1664.
- Yizhak K., Gaude E., Le Devedec S., Waldman Y.Y., Stein G.Y., Water B. van de, Frezza C. & Ruppin E. (2014), Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer, ELIFE 3: e03641.
- Di Z., Klop M.J.D., Rogkoti V.M., Le Dèvèdec S.E., Water B. van de, Verbeek F.J., Price L.S. & Meerman J.H.N. (2014), Ultra High Content Image Analysis and Phenotype Profiling of 3D Cultured Micro-Tissues, PLoS ONE 9(10): e109688.
- Yizhak K., Le Devedec S.E., Rogkoti V.M., Baenke F., Boer V.C. de, Frezza C., Schulze A., Water B. van de & Ruppin E. (2014), A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration, Molecular Systems Biology 10(8): 744.
- Graauw M. de, Cao L., Winkel L., Miltenburg M.H.A.M. van, Devedec S.E. Le, Klop M., Yan K., Pont C.M., Rogkoti V.M., Tijsma A., Chaudhuri A., Lalai R.A., Price L., Verbeek F. & Water B. van de (2014), Annexin A2 depletion delays EGFR endocytic trafficking via cofilin activation and enhances EGFR signaling and metastasis formation, ONCOGENE 33(20): 2610-2619.
- Truong H.H., Xiong J., Ghotra V..P, Nirmala .E, Haazen L.C.J.M., Dévédec S.E. Le, Balcioğlu H.E., He S., Snaar B.E., Vreugdenhil E., Meerman J.H.N., Water B. van de & Danen E.H. (2014), β1 integrin inhibition elicits a prometastatic switch through the TGFβ-miR-200-ZEB network in E-cadherin-positive triple-negative breast cancer., SCIENCE SIGNALING 7(312): ra15.
- Truong H.H., Xiong J., Ghotra V.P.S., Nirmala E., Haazen L., Le Dévédec S.E., Balcioglu H.E., He S., Snaar-Jagalska B.E., Vreugdenhil E., Meerman J.H.N., Water B. van de & Danen E.H.J. (2014), beta(1) Integrin Inhibition Elicits a Prometastatic Switch Through the TGF beta-miR-200-ZEB Network in E-Cadherin-Positive Triple-Negative Breast Cancer, SCIENCE SIGNALING 7(312).
- Le Dévédec S.E., Geverts B., Bont H.J.G.M. de, Yan K., Verbeek F.J., Houtsmuller A.B. & Water B. van de (2012), The residence time of focal adhesion kinase (FAK) and paxillin at focal adhesions in renal epithelial cells is determined by adhesion size, strength and life cycle status, JOURNAL OF CELL SCIENCE 125(19): 4498-4506.
- Damiano L., Devedec S.E. Le, Stefano P. Di, Repetto D., Lalai R., Truong H., Xiong J.L., Danen E.H., Yan K., Verbeek F.J., Luca E. De, Attanasio F., Buccione R., Turco E., Water B. van de & Defilippi P. (2012), p140Cap suppresses the invasive properties of highly metastatic MTLn3-EGFR cells via impaired cortactin phosphorylation, ONCOGENE 31(5): 624-633.
- Le Dévédec S.E., Roosmalen W. van, Pont C.M., Lalai R., Bont H.J.G.M. de & Water B. van de (2011), Two-photon intravital multicolour imaging to study metastatic behaviour of cancer cells in vivo.. In: Wells C.M., Parsons M. (red.) Cell Migration. Methods in molecular biology (Clifton, N.J.) nr. 769: Springer. 331-349.
- Roosmalen W.P.E. van, Le Dévédec S.E., Zovko S., Bont H.J.G.M. & Water B. van de (2011), Functional screening with a live cell imaging-based random cell migration assay. In: Wells C., Parsons M. (red.) Cell Migration. Methods in molecular biology (Clifton, N.J.) nr. 769: Humana Press. 435-448.
- Le Devedec S.E., Lalai R., Pont C.M., Bont H.J.G.M. & Water B. van de (2011), Two-Photon Intravital Multicolor Imaging Combined with Inducible Gene Expression to Distinguish Metastatic Behavior of Breast Cancer Cells In Vivo, Molecular Imaging and Biology 13(1): 67-77.
- Le Devedec S.E., Yan K., de Bont H., Ghotra V., Truong H., Danen E.H., Verbeek F. & van de Water B. (2010), Systems microscopy approaches to understand cancer cell migration and metastasis, Cellular and Molecular Life Sciences 67(19): 3219-3240.
- de Graauw M., van Miltenburg M.H., Schmidt M. K., Pont C., Lalai R., Kartopawiro J., Pardali E., Le Devedec S.E., Smit V.T., van der Wal A., Van't Veer L.J., Cleton-Jansen A.-M., ten Dijke P. & van de Water B. (2010), Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells, Proceedings of the National Academy of Sciences of the United States of America 107(14): 6340-6345.
- Le Dévédec SE, van Roosmalen W, Maria N, Grimbergen M, Pont C, Lalai R & van de Water B (2009), An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2(-/-) gammac (-/-) mouse., Clinical and Experimental Metastasis 26(7): 673-84.
- Yan K., Verbeek F.J., Le Devedec S. & van de Water B. (2009), Cell Tracking and Data Analysis of in Vitro Tumour Cells From Time-Lapse Image Sequences, VISAPP 2009: PROCEEDINGS OF THE FOURTH INTERNATIONAL CONFERENCE ON COMPUTER VISION THEORY AND APPLICATIONS, VOL 1 : 281-286.
- Le Devedec S.E., van Roosmalen W., Maria N., Grimbergen M., Pont C., Lalai R. & van de Water B. (2009), An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2(-/-) gamma c(-/-) mouse, CLINICAL & EXPERIMENTAL METASTASIS 26(7): 673-684.
- Ma Y., Water B. van de & Le Devedec S. (2009), Focal Adhesion Kinase (FAK) Inhibition as a potential strategy for anticancer therapies, DRUGS OF THE FUTURE 34(6): 477-483.
- de Graauw M., Le Devedec S., Tijdens I., Smeets M.B., Deelder A.M. & van de Water B. (2007), Proteomic analysis of alternative protein tyrosine phosphorylation in 1,2-dichlorovinyl-cysteine-induced cytotoxicity in primary cultured rat renal proximal tubular cells, Journal of Pharmacology and Experimental Therapeutics 322(1): 89-100.
- van de Water B., de Graauw M., Le Devedec S. & Alderliesten M. (2006), Cellular stress responses and molecular mechanisms of nephrotoxicity, Toxicology Letters 162(1): 83-93.
- Le Devedec S.E., Nagelkerke F. & van de Water B. (2004), Live cell imaging of FAK-mediated focal adhesion reorganization during the cellular stress response, Molecular Biology of the Cell 15: 54A-55A.
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