Universiteit Leiden

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Cell Systems and Drug Safety

The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational models and combine these with quantitative imaging-based phenotypic screening for drug target and drug lead discovery. As an example, we study cancer metastasis and therapy resistance, for which we use genetic (RNAi, CRISPR/Cas9) and pharmacological screening coupled to quantitative microscopy and quantitative systems biology modelling.

Our research groups are:

In the end our research is geared towards optimizing the desired therapeutic effect and minimizing adverse reactions of the drugs of tomorrow.

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