Joachim van Guyse
Assistant Professor
- Name
- Dr. J.F.R. van Guyse
- Telephone
- 071 5274314
- j.f.r.van.guyse@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0001-5725-6531
Joachim Van Guyse is an assistant professor at the Division of BioTherapeutics at the Leiden Academic Center for Drug Research
More information about Joachim van Guyse
PhD candidates
News
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Symposium Taiwan: Island of Diversity -
Crystal Ennis on New Arab: Trump’s threat to Oman signals more than the end of US diplomacy -
Clodagh Murphy on The Conversation: ‘Elizabeth I’s emotion in her letters was carefully constructed by secretaries’ -
Louis Sicking in Dag og tid on the legacy of Archbishop Olav Engelbrektsson -
Anne-Isabelle Richard on thehig.eu: ‘European countries have supported European cooperation out of direct self-interest’ -
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LDE-Nairobi Interdisciplinary Master's Thesis Lab
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New exhibition sheds light on Jerusalem’s rich history -
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Leiden Law School at the ELU-S Annual Conference in Lisbon -
Daniel Peat Re-Elected to the Board of the European Society of International Law -
King to receive findings of research into his family’s role in colonial history -
Leiden Revisited: sharing knowledge and reuniting alumni -
From four professors to 250 researchers: celebrating 30 years of LIACS -
Archaeology student Sofía Espinoza Gutiérrez nominated for ECHO Award -
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Archaeologist Rachel Schats wins LUS Teaching Prize 2026 -
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How do science and policy strengthen each other? Institute of Public Administration leads €4.75 million research project -
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Ae Ree Nam wins the 2026 Faculty Teaching Award -
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New: DEAI Library in Van Steenis -
Marie Soressi appointed Head of the Department of World Archaeology -
You remember exactly where you were on 9/11, but is that memory accurate? -
Turning scientific insights into impact: the winners of the Krijn Rietveld Awards 2026 -
Sigrid van Wingerden appointed Professor of Criminology -
International Studies graduation ceremony: ‘You see the bigger picture’ -
Dean Jasper Knoester kicks off the academic year: ‘Stay curious and make connections’ -
‘The countryside is more than just farmers and tractors’: Judith Pollmann to use Spinoza Prize to promote rural history -
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Sustainable fish on the menu: Leiden Leadership Programme students collaborate with the Marine Stewardship Council -
U.S. Ambassador to NATO Ivo H. Daalder Appointed to the Kooijmans Chair -
Larissa Schulte Nordholt: ‘In colonial territories, local and European agricultural knowledge intermingled’ -
Daniëlla Dam-de Jong appointed Chair of the CAVV and Member of the Netherlands National Group of the Permanent Court of Arbitration -
New: The Academic Pride Podcast -
KNAW Grant Enables International Research into Mental Health Conditions in Young People -
Tom Brand: ‘It’s the combination of analysis and language that makes linguistics so enjoyable’ -
Political leaders chose moral messaging after downing of MH17 and attacks in Belgium -
Rutger Hoekstra appointed Professor of Sustainable and Inclusive Wellbeing -
First-trimester scan detects anomalies earlier, but may also have a downside -
‘What do you think I should do?’ The first question from new Scientific Director Dennis Claessen -
Renewed FGGA Ethics Committee -
First-ever Opening of the Academic Year in The Hague: ‘One academic community together’ -
UN Report on Palestinian children’s rights: ‘We shall call out these crimes for what they are’ -
Festival: What is the future of humanity? -
‘Meta realises it failed to adequately protect children’ -
Day of Languages and Cultures -
Roman reenactors surprise children in the Wilhelmina children's hospital -
Call for Applications: Feminist Africa Online Writing Workshop
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Amy Senne appointed as assessor in the Faculty Board -
Computer model could help improve our understanding of how skin cancer spreads -
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US start deportations to Liberia, EU has similar plans -
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Lost at Lowlands: Leiden psychologists study atopia -
Leiden professors warn that EU tax package comes with a price tag -
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Light over Dejima - Symposium, Book Launch and Exhibition Opening -
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Psychologists will investigate why you can get lost even in your own neighbourhood -
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Leiden researchers receive over €1 million for research into BRCA1 cancer treatment -
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Jilles Tjoelker new Student Assessor for Archaeology per September 1 -
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Environmental hotspots: one-third of agricultural land accounts for two-thirds of global impact
Joachim F. R. Van Guyse studied Chemistry at Ghent University in Belgium. After graduating in 2014, he pursued a Ph.D. degree in Chemistry under the supervision of Prof. Richard Hoogenboom at Ghent University, where his work focused primarily on the development of synthetic methodologies to obtain new functional poly(2-oxazoline) and poly(acrylamide)-based materials with biomedical potential, in addition to the development of supramolecular materials.
After obtaining his Ph.D. in 2019, he joined the group of Prof. Kazunori Kataoka at the Innovation Center of NanoMedicine (ICONM) in Kawasaki, Japan, where he developed poly(2-oxazoline)s block-copolypeptides for biomedical applications, more specifically for promoting therapeutic efficacy and/or gene delivery. In 2020, he was awarded a post-doctoral fellowship from the Japan Society for the Promotion of Science (JSPS) for the development of polymer-micelle carriers for mRNA delivery.
In 2022, he was appointed as assistant professor at Leiden university, where his research focusses on the development of polymers for the delivery of biotherapeutics. So far, Joachim Van Guyse has contributed over 30 research papers, book chapters and patents covering a broad range of topics, including polymer chemistry, supramolecular chemistry, surface functionalization and nanomedicine.
Assistant Professor
- LACDR
- Divisie Biotherapeutics
- Li J., Toh K., Wen P., Liu X., Dirisala A., Guo H., Guyse J.F.R. van, Abbasi S., Anraku Y., Mochida Y., Kinoh H., Cabral H., Tanaka M. & Kataoka K. (2026), Steric stabilization-independent stealth cloak enables nanoreactors-mediated starvation therapy against refractory cancer, Nature Biomedical Engineering 10: 1445-1465.
- Loccufier E., Abebe M.G., Geltmeyer J., Meirman T., Altan O.I.K., Guyse J.F.R. van, Khousakoun E., Gidik H., Mohsenzadeh E., Lahem D., Hoogenboom R., Maes B. & Clerck K. de (2026), Dimensionally stable nanofibrous nonwoven as a flexible dynamic emissivity switching temperature-regulating material, Advanced Materials 38(22): e17161.
- Nagorna Z., Barz M. & Guyse J.F.R. van (2025), Toward quantitative end-group fidelity in the synthesis of high molecular weight polysarcosine, ACS Macro Letters 14(5): 532-537.
- Buijs E., Nagorna Z., Guyse J.F.R. van & Barz M. (2025), Synthesis of heterotelechelic poly(N-ethylglycine) polymers: from polypeptoid lipid conjugates to protein-polymer conjugates, Macromolecular Rapid Communications 46(20): e00422.
- Babu A., Sivakumar G., Kim M., Chauhan D., Badri R., Nagorna Z., Kar P., Sasmal P.K., Guyse J.F.R. van, Banerjee S., Lee Y. & Maji S. (2025), Development of charged polyampholyte interfaces: synthesis, properties, and antifouling application, ACS Biomaterials Science and Engineering 11(11): 6593-6604.
- Podevyn A., Guyse J.F.R. van, Bouten P.J.M. & Hest J.C.M. van: Hoogenboom R. (2025), Unraveling structure–reactivity and structure–property relationships for the amidation of methyl ester-functionalized poly(2-Oxazoline)s, Macromolecules 58(4): 2026-2037.
- Zhao B., Luo S., Wei J., Guyse J.F.R. van, Zhang H. & Barz M. (2025), Orthogonal one-pot synthesis of multifunctional polypept(o)ide-based core-shell cylindrical polymer brushes, European Polymer Journal 241: 114385.
- Das A., Babu A., Chakraborty S., Guyse J.F.R. van, Hoogenboom R. & Maji S. (2024), Poly(N-isopropylacrylamide) and its copolymers: a review on recent advances in the areas of sensing and biosensing, Advanced Functional Materials 34(37): 2402432.
- Guyse J.F.R. van., Abbasi S., Toh K., Nagorna Z., Li J., Dirisala A., Quader S., Uchida S. & Kataoka K. (2024), Facile generation of heterotelechelic poly(2-oxazoline)s towards accelerated exploration of poly(2-oxazoline)-based nanomedicine, Angewandte Chemie (International Edition) 63(27): e202404972.
- Frateur O., Becelaere J., Merckx R., Guyse J.F.R. van, Purino M., Hoogenboom R. & Clerck K. de (2024), Development of reversibly photo-crosslinkable water-stable poly(2-ethyl-2-oxazoline) nanofibers via functionalization with cinnamoyl moieties, European Polymer Journal 212: 113076.
- Bauer T.A., Simić L., Guyse J.F.R. van, Duro-Castaño A., Nebot V.J. & Barz M. (2024), Polypept(o)ides: origins, synthesis, applications and future directions, Progress in Polymer Science 158: 101889.
- Guyse J.F.R. van, Bernhard Y., Podevyn A. & Hoogenboom R. (2023), Non-activated esters as reactive handles in direct post-polymerization modification, Angewandte Chemie (International Edition) 62(40): e202303841.
- Göppert N.E., Quader S., Guyse J.F.R. Van, Weber C., Kataoka K. & Schubert U.S. (2023), Amphiphilic poly(2-oxazoline)s with glycine-containing hydrophobic blocks tailored for panobinostat- and imatinib-loaded micelles, Biomacromolecules 24(12): 5915-5925.
- Bernhard Y., Guyse J.F.R. van, Purino M. & Hoogenboom R. (2023), Direct synthesis of poly(N-alkyl acrylamide) (co)polymers with pendant reactive amino groups by organocatalyzed amidation of polymethylacrylate, European Polymer Journal 192: 112077.
- Verjans J., Sedlačík T., Jerca V.V., Bernhard Y., Guyse. J.F.R. Van & Hoogenboom R. (2023), Poly(N-allyl acrylamide) as a reactive platform toward functional hydrogels, ACS Macro Letters 12(1): 79-85.
- Guyse J.F.R. van, Leiske M.N., Verjans J., Bernhard Y. & Hoogenboom R. (2022), Accelerated post-polymerization amidation of polymers with side-chain ester groups by intramolecular activation, Angewandte Chemie (International Edition) 61(29): e202201781.
- Dirisala A., Uchida S., Li J Guyse J.F.R. Van, Hayashi K., Vummaleti S.V.C., Kaur S., Mochida Y., Fukushima S. & Kataoka K. (2022), Effective mRNA Protection by Poly(l-ornithine) synergizes with endosomal escape functionality of a charge-conversion polymer toward maximizing mRNA introduction efficiency, Macromolecular Rapid Communications 43(12): e2100754.
- Quader S. & Guyse J.F.R. van (2022), Bioresponsive polymers for nanomedicine: expectations and reality!, Polymers 14(17): 3659.
- Becelaere J., Broeck E. van den, Schoolaert E., Vanhoorne V., Guyse J.F.R. van, Vergaelen M., Borgmans S., Creemers K., Speybroeck V. van, Vervaet C., Hoogenboom R. & Clerck K. de (2022), Stable amorphous solid dispersion of flubendazole with high loading via electrospinning, Journal of Controlled Release 351: 123-136.
- Van Guyse J.F.R. & Hoogenboom R. (2022), Poly(2-Oxazoline)s. In: Matyjaszewski K., Gnanou Y., Hadjichristidis N. & Muthukumar M. (Eds.), Macromolecular engineering: from precise synthesis to macroscopic materials and Applications: Wiley-VCH.
- Guyse J.F.R. van, Bera D. & Hoogenboom R. (2021), Adamantane functionalized poly(2-oxazoline)s with broadly tunable LCST-behavior by molecular recognition, Polymers 13(3): 374.
- Li J., Ge Z., Toh K., Liu X., Dirisala A., Ke W., Wen P., Zhou H., Wang Z., Xiao S., Guyse J.F.R. van, Tockary T.A, Xie J., Gonzalez-Carter D., Kinoh H., Uchida S., Anraku Y. & Kataoka K. (2021), Enzymatically transformable polymersome-based nanotherapeutics to eliminate minimal relapsable cancer, Advanced Materials 33(49): 2105254.
- Park J.R., Bolle E.C.L., Santos Cavalcanti A.D., Podevyn A., Guyse J.F.R., Forget A., Hoogenboom R. & Dargaville T.R. (2021), Injectable biocompatible poly(2-oxazoline) hydrogels by strain promoted alkyne-azide cycloaddition, Biointerphases 16(1): 011001.
- Dargaville T.R., Harkin D.G., Park J.R., Cavalcanti A., Bolle E.C.L., Savi F.M., Farrugia B.L., Monnery B.D., Bernhard Y., Guyse J.F.R. van, Podevyn A. & Hoogenboom R. (2021), Poly(2-allylamidopropyl-2-oxazoline)-based hydrogels: from accelerated gelation kinetics to in vivo compatibility in a murine subdermal implant model, Biomacromolecules 22(4): 1590-1599.
- Xu X., Guyse J.F.R. van, Jerca V.V. & Hoogenboom R. (2020), Metal ion selective self-assembly of a ligand functionalized polymer into [1+1] macrocyclic and supramolecular polymer structures via metal-ligand coordination, Macromolecular Rapid Communications 41(1): e1900305.
- Bernhard Y., Sedlacek O., Guyse J.F.R. van, Bender J., Zhong Z., Geest B.G. de & Hoogenboom R. (2020), Poly(2-ethyl-2-oxazoline) conjugates with salicylic acid via degradable modular ester linkages, Biomacromolecules 21(8): 3207-3215.
- Guyse J.F.R. van, Bernhard Y. & Hoogenboom R. (2020), Stoichiometric control over partial transesterification of polyacrylate homopolymers as platform for functional copolyacrylates, Macromolecular Rapid Communications 41(19): 2000365.
- Egghe T., Cools P., Guyse J.F.R. van, Asadian M., Khalenkow D., Nikiforov A., Declercq H., Skirtach A.G., Morent R., Hoogenboom R. & Geyter N. de (2020), Water-stable plasma-polymerized N,N-dimethylacrylamide coatings to control cellular adhesion, ACS Applied Materials and Interfaces 12(2): 2116-2128.
- Merckx R., Swift T., Rees R., Guyse J.F.R. van, Schoolaert E., Clerck K. de, Ottevaere H., Thienpont H., Jerca V.V. & Hoogenboom R. (2020), Förster resonance energy transfer in fluorophore labeled poly(2-ethyl-2-oxazoline)s, Journal of Materials Chemistry 8(40): 14125-14137.
- Guyse J.F.R. van, Cools P., Egghe T., Asadian M., Vergaelen M., Rigole P., Yan W., Benetti E.M., Jerca V.V., Declercq H., Coenye T., Morent R., Hoogenboom R. & Geyter N. de (2019), Influence of the aliphatic side chain on the near atmospheric pressure plasma polymerization of 2-alkyl-2-oxazolines for biomedical applications, ACS Applied Nano Material 11(34): 31356-31366.
- Guyse J.F.R. van, Rosa V.R. de la, Lund R., Bruyne M. de, Rycke R. de, Filippov S.K. & Hoogenboom R. (2019), Striking effect of polymer end-group on C60 nanoparticle formation by high shear vibrational milling with alkyne-functionalized Poly(2-oxazoline)s, ACS Macro Letters 8(2): 172-176.
- Guyse J.F.R. van, Rosa V.R. de la & Hoogenboom R. (2018), Mechanochemical preparation of stable Sub-100 nm γ-Cyclodextrin:Buckminsterfullerene (C60) nanoparticles by electrostatic or steric stabilization, Chemistry: a European Journal 24(11): 2758-2766.
- Asadian M., Onyshchenko I., Thukkaram M., Esbah Tabaei P.S., Guyse J. van, Cools P., Declercq H., Hoogenboom R., Morent R. & Geyter N. De (2018), Effects of a dielectric barrier discharge (DBD) treatment on chitosan/polyethylene oxide nanofibers and their cellular interactions, Carbohydrate Polymers 201: 402-415.
- Grande S., Cools P., Asadian M., Guyse J. Van, Onyshchenko I., Declercq H., Morent R., Hoogenboom R. & Geyter N. De (2018), Fabrication of PEOT/PBT nanofibers by atmospheric pressure plasma jet treatment of electrospinning solutions for tissue engineering, Macromolecular Bioscience 18(12): e1800309.
- Verbraeken B., Hullaert J., Guyse J.F.R. van, Hecke K. van, Winne J. & Hoogenboom R. (2018), The elusive seven-membered cyclic imino ether Tetrahydrooxazepine, Journal of the American Chemical Society 140(50): 17404-17408.
- Grande S., Guyse J. Van, Nikiforov A.Y., Onyshchenko I., Asadian M., Morent R., Hoogenboom R. & Geyter N. De (2017), Atmospheric pressure plasma jet treatment of poly-ε-caprolactone polymer solutions to improve electrospinning, ACS Applied Materials and Interfaces 9(38): 33080-33090.