Joachim van Guyse
Assistant Professor
- Name
- Dr. J.F.R. van Guyse
- Telephone
- 071 5274314
- j.f.r.van.guyse@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0001-5725-6531
Joachim Van Guyse is an assistant professor at the Division of BioTherapeutics at the Leiden Academic Center for Drug Research
More information about Joachim van Guyse
PhD candidates
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Joachim F. R. Van Guyse studied Chemistry at Ghent University in Belgium. After graduating in 2014, he pursued a Ph.D. degree in Chemistry under the supervision of Prof. Richard Hoogenboom at Ghent University, where his work focused primarily on the development of synthetic methodologies to obtain new functional poly(2-oxazoline) and poly(acrylamide)-based materials with biomedical potential, in addition to the development of supramolecular materials.
After obtaining his Ph.D. in 2019, he joined the group of Prof. Kazunori Kataoka at the Innovation Center of NanoMedicine (ICONM) in Kawasaki, Japan, where he developed poly(2-oxazoline)s block-copolypeptides for biomedical applications, more specifically for promoting therapeutic efficacy and/or gene delivery. In 2020, he was awarded a post-doctoral fellowship from the Japan Society for the Promotion of Science (JSPS) for the development of polymer-micelle carriers for mRNA delivery.
In 2022, he was appointed as assistant professor at Leiden university, where his research focusses on the development of polymers for the delivery of biotherapeutics. So far, Joachim Van Guyse has contributed over 30 research papers, book chapters and patents covering a broad range of topics, including polymer chemistry, supramolecular chemistry, surface functionalization and nanomedicine.
Assistant Professor
- Faculty of Science
- LACDR
- Divisie Biotherapeutics
- Nagorna Z., Barz M. & Guyse J.F.R. van (2025), Toward quantitative end-group fidelity in the synthesis of high molecular weight polysarcosine, ACS Macro Letters 14(5): 532-537.
- Buijs E., Nagorna Z., Guyse J.F.R. van & Barz M. (2025), Synthesis of heterotelechelic poly(N-ethylglycine) polymers: from polypeptoid lipid conjugates to protein-polymer conjugates, Macromolecular Rapid Communications 46(20): e00422.
- Babu A., Sivakumar G., Kim M., Chauhan D., Badri R., Nagorna Z., Kar P., Sasmal P.K., Guyse J.F.R. van, Banerjee S., Lee Y. & Maji S. (2025), Development of charged polyampholyte interfaces: synthesis, properties, and antifouling application, ACS Biomaterials Science and Engineering 11(11): 6593-6604.
- Podevyn A., Guyse J.F.R. van, Bouten P.J.M. & Hest J.C.M. van: Hoogenboom R. (2025), Unraveling structure–reactivity and structure–property relationships for the amidation of methyl ester-functionalized poly(2-Oxazoline)s, Macromolecules 58(4): 2026-2037.
- Li J., Toh K., Wen P., Liu X., Dirisala A., Guo H., Guyse J.F.R. van, Abbasi S., Anraku Y., Mochida Y., Kinoh H., Cabral H., Tanaka M. & Kataoka K. (2025), Steric stabilization-independent stealth cloak enables nanoreactors-mediated starvation therapy against refractory cancer, Nature Biomedical Engineering : .
- Loccufier E., Abebe M.G., Geltmeyer J., Meirman T., Altan O.I.K., Guyse J.F.R. van, Khousakoun E., Gidik H., Mohsenzadeh E., Lahem D., Hoogenboom R., Maes B. & Clerck K. de (2025), Dimensionally stable nanofibrous nonwoven as a flexible dynamic emissivity switching temperature-regulating material, Advanced Materials : e17161.
- Zhao B., Luo S., Wei J., Guyse J.F.R. van, Zhang H. & Barz M. (2025), Orthogonal one-pot synthesis of multifunctional polypept(o)ide-based core-shell cylindrical polymer brushes, European Polymer Journal 241: 114385.
- Das A., Babu A., Chakraborty S., Guyse J.F.R. van, Hoogenboom R. & Maji S. (2024), Poly(N-isopropylacrylamide) and its copolymers: a review on recent advances in the areas of sensing and biosensing, Advanced Functional Materials 34(37): 2402432.
- Guyse J.F.R. van., Abbasi S., Toh K., Nagorna Z., Li J., Dirisala A., Quader S., Uchida S. & Kataoka K. (2024), Facile generation of heterotelechelic poly(2-oxazoline)s towards accelerated exploration of poly(2-oxazoline)-based nanomedicine, Angewandte Chemie (International Edition) 63(27): e202404972.
- Frateur O., Becelaere J., Merckx R., Guyse J.F.R. van, Purino M., Hoogenboom R. & Clerck K. de (2024), Development of reversibly photo-crosslinkable water-stable poly(2-ethyl-2-oxazoline) nanofibers via functionalization with cinnamoyl moieties, European Polymer Journal 212: 113076.
- Bauer T.A., Simić L., Guyse J.F.R. van, Duro-Castaño A., Nebot V.J. & Barz M. (2024), Polypept(o)ides: origins, synthesis, applications and future directions, Progress in Polymer Science 158: 101889.
- Guyse J.F.R. van, Bernhard Y., Podevyn A. & Hoogenboom R. (2023), Non-activated esters as reactive handles in direct post-polymerization modification, Angewandte Chemie (International Edition) 62(40): e202303841.
- Göppert N.E., Quader S., Guyse J.F.R. Van, Weber C., Kataoka K. & Schubert U.S. (2023), Amphiphilic poly(2-oxazoline)s with glycine-containing hydrophobic blocks tailored for panobinostat- and imatinib-loaded micelles, Biomacromolecules 24(12): 5915-5925.
- Bernhard Y., Guyse J.F.R. van, Purino M. & Hoogenboom R. (2023), Direct synthesis of poly(N-alkyl acrylamide) (co)polymers with pendant reactive amino groups by organocatalyzed amidation of polymethylacrylate, European Polymer Journal 192: 112077.
- Verjans J., Sedlačík T., Jerca V.V., Bernhard Y., Guyse. J.F.R. Van & Hoogenboom R. (2023), Poly(N-allyl acrylamide) as a reactive platform toward functional hydrogels, ACS Macro Letters 12(1): 79-85.
- Guyse J.F.R. van, Leiske M.N., Verjans J., Bernhard Y. & Hoogenboom R. (2022), Accelerated post-polymerization amidation of polymers with side-chain ester groups by intramolecular activation, Angewandte Chemie (International Edition) 61(29): e202201781.
- Dirisala A., Uchida S., Li J Guyse J.F.R. Van, Hayashi K., Vummaleti S.V.C., Kaur S., Mochida Y., Fukushima S. & Kataoka K. (2022), Effective mRNA Protection by Poly(l-ornithine) synergizes with endosomal escape functionality of a charge-conversion polymer toward maximizing mRNA introduction efficiency, Macromolecular Rapid Communications 43(12): e2100754.
- Quader S. & Guyse J.F.R. van (2022), Bioresponsive polymers for nanomedicine: expectations and reality!, Polymers 14(17): 3659.
- Becelaere J., Broeck E. van den, Schoolaert E., Vanhoorne V., Guyse J.F.R. van, Vergaelen M., Borgmans S., Creemers K., Speybroeck V. van, Vervaet C., Hoogenboom R. & Clerck K. de (2022), Stable amorphous solid dispersion of flubendazole with high loading via electrospinning, Journal of Controlled Release 351: 123-136.
- Van Guyse J.F.R. & Hoogenboom R. (2022), Poly(2-Oxazoline)s. In: Matyjaszewski K., Gnanou Y., Hadjichristidis N. & Muthukumar M. (Eds.), Macromolecular engineering: from precise synthesis to macroscopic materials and Applications: Wiley-VCH.
- Guyse J.F.R. van, Bera D. & Hoogenboom R. (2021), Adamantane functionalized poly(2-oxazoline)s with broadly tunable LCST-behavior by molecular recognition, Polymers 13(3): 374.
- Li J., Ge Z., Toh K., Liu X., Dirisala A., Ke W., Wen P., Zhou H., Wang Z., Xiao S., Guyse J.F.R. van, Tockary T.A, Xie J., Gonzalez-Carter D., Kinoh H., Uchida S., Anraku Y. & Kataoka K. (2021), Enzymatically transformable polymersome-based nanotherapeutics to eliminate minimal relapsable cancer, Advanced Materials 33(49): 2105254.
- Park J.R., Bolle E.C.L., Santos Cavalcanti A.D., Podevyn A., Guyse J.F.R., Forget A., Hoogenboom R. & Dargaville T.R. (2021), Injectable biocompatible poly(2-oxazoline) hydrogels by strain promoted alkyne-azide cycloaddition, Biointerphases 16(1): 011001.
- Dargaville T.R., Harkin D.G., Park J.R., Cavalcanti A., Bolle E.C.L., Savi F.M., Farrugia B.L., Monnery B.D., Bernhard Y., Guyse J.F.R. van, Podevyn A. & Hoogenboom R. (2021), Poly(2-allylamidopropyl-2-oxazoline)-based hydrogels: from accelerated gelation kinetics to in vivo compatibility in a murine subdermal implant model, Biomacromolecules 22(4): 1590-1599.
- Xu X., Guyse J.F.R. van, Jerca V.V. & Hoogenboom R. (2020), Metal ion selective self-assembly of a ligand functionalized polymer into [1+1] macrocyclic and supramolecular polymer structures via metal-ligand coordination, Macromolecular Rapid Communications 41(1): e1900305.
- Bernhard Y., Sedlacek O., Guyse J.F.R. van, Bender J., Zhong Z., Geest B.G. de & Hoogenboom R. (2020), Poly(2-ethyl-2-oxazoline) conjugates with salicylic acid via degradable modular ester linkages, Biomacromolecules 21(8): 3207-3215.
- Guyse J.F.R. van, Bernhard Y. & Hoogenboom R. (2020), Stoichiometric control over partial transesterification of polyacrylate homopolymers as platform for functional copolyacrylates, Macromolecular Rapid Communications 41(19): 2000365.
- Egghe T., Cools P., Guyse J.F.R. van, Asadian M., Khalenkow D., Nikiforov A., Declercq H., Skirtach A.G., Morent R., Hoogenboom R. & Geyter N. de (2020), Water-stable plasma-polymerized N,N-dimethylacrylamide coatings to control cellular adhesion, ACS Applied Materials and Interfaces 12(2): 2116-2128.
- Merckx R., Swift T., Rees R., Guyse J.F.R. van, Schoolaert E., Clerck K. de, Ottevaere H., Thienpont H., Jerca V.V. & Hoogenboom R. (2020), Förster resonance energy transfer in fluorophore labeled poly(2-ethyl-2-oxazoline)s, Journal of Materials Chemistry 8(40): 14125-14137.
- Guyse J.F.R. van, Cools P., Egghe T., Asadian M., Vergaelen M., Rigole P., Yan W., Benetti E.M., Jerca V.V., Declercq H., Coenye T., Morent R., Hoogenboom R. & Geyter N. de (2019), Influence of the aliphatic side chain on the near atmospheric pressure plasma polymerization of 2-alkyl-2-oxazolines for biomedical applications, ACS Applied Nano Material 11(34): 31356-31366.
- Guyse J.F.R. van, Rosa V.R. de la, Lund R., Bruyne M. de, Rycke R. de, Filippov S.K. & Hoogenboom R. (2019), Striking effect of polymer end-group on C60 nanoparticle formation by high shear vibrational milling with alkyne-functionalized Poly(2-oxazoline)s, ACS Macro Letters 8(2): 172-176.
- Guyse J.F.R. van, Rosa V.R. de la & Hoogenboom R. (2018), Mechanochemical preparation of stable Sub-100 nm γ-Cyclodextrin:Buckminsterfullerene (C60) nanoparticles by electrostatic or steric stabilization, Chemistry: a European Journal 24(11): 2758-2766.
- Asadian M., Onyshchenko I., Thukkaram M., Esbah Tabaei P.S., Guyse J. van, Cools P., Declercq H., Hoogenboom R., Morent R. & Geyter N. De (2018), Effects of a dielectric barrier discharge (DBD) treatment on chitosan/polyethylene oxide nanofibers and their cellular interactions, Carbohydrate Polymers 201: 402-415.
- Grande S., Cools P., Asadian M., Guyse J. Van, Onyshchenko I., Declercq H., Morent R., Hoogenboom R. & Geyter N. De (2018), Fabrication of PEOT/PBT nanofibers by atmospheric pressure plasma jet treatment of electrospinning solutions for tissue engineering, Macromolecular Bioscience 18(12): e1800309.
- Verbraeken B., Hullaert J., Guyse J.F.R. van, Hecke K. van, Winne J. & Hoogenboom R. (2018), The elusive seven-membered cyclic imino ether Tetrahydrooxazepine, Journal of the American Chemical Society 140(50): 17404-17408.
- Grande S., Guyse J. Van, Nikiforov A.Y., Onyshchenko I., Asadian M., Morent R., Hoogenboom R. & Geyter N. De (2017), Atmospheric pressure plasma jet treatment of poly-ε-caprolactone polymer solutions to improve electrospinning, ACS Applied Materials and Interfaces 9(38): 33080-33090.