Joachim van Guyse
Assistant Professor
- Name
- Dr. J.F.R. van Guyse
- Telephone
- 071 5274314
- j.f.r.van.guyse@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0001-5725-6531
Joachim Van Guyse is an assistant professor at the Division of BioTherapeutics at the Leiden Academic Center for Drug Research
More information about Joachim van Guyse
PhD candidates
News
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Willemijn Waal in National Geographic Portugal: ‘Hittites were very pragmatic’ -
Andrew Gawthorpe on the Conversation: ‘US and allies not prepared for protracted conflict’ -
Andrew Gawthorpe in Libération: ‘Shortage of long-range interceptors should not be a major problem for Iran’ -
Dr Sarah Schrader appointed Head of Department Archaeological Sciences -
Contributions in New World Archaeology Vol. 18 dedicated to our late colleague Dr Andrzej Antczak -
Protecting the tiniest lives: how biological signals can improve care for premature babies -
Sexual abuse between siblings: what can be done about it? -
Adam Lichtenheld receives ISA Distinguished Book Award 2026 -
‘Interaction between politics, science and colonial impact often overlooked’ -
Agency workers in primary care 'unacceptable' -
Why online care does not work for everyone (and how we can change that) -
Noise at sea: research on how wind farms affect fish -
Interior design Aleida Nijland: light, recognisable and future-proof -
eLaw Summer School on the EU Digital Omnibus -
Smart combinations of antibiotics can slow down resistance -
Leiden University wins Frits Kalshoven International Humanitarian Law Competition 2026 -
Five Humanities master's programmes highly rated in Keuzegids 2026 -
Working together for ‘broad prosperity’ in the Leiden region -
Call for Papers: Universities and Society at the End of Empire and Beyond (UniSoc) -
How cells work together: the mathematics behind biological shapes
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Students compete in Monaco with ‘flying’ liquid-hydrogen boat -
Keuzegids Master’s guide: which programmes score above average? -
Why the Netherlands should repatriate foreign terrorist fighters and their families -
Replication study on sentence comprehension: what role does the frontal lobe play? -
Sharp rise in women in top business positions -
Serge Lemay appointed professor of Iontronics at Leiden Institute of Physics -
Leiden experts: attack on Iran violates international law -
Iran's future if the regime falls -
Japanese Literature Reading List -
France’s nuclear cooperation plan within Treaty limits -
Exhibition Archaeo‑Sexism on display throughout March in Van Steenis -
Jan Pronk reappointed as Executive Director of the Faculty of Archaeology -
Sarah Wolff on Global Europe: ‘Lack of reflection in developing EU labor migration policy one of the main weaknesses’ -
Andrew Gawthorpe on France24 about Trump’s ambassadors: ‘Controversial’
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Andrew Gawthorpe on the Conversation: ‘Attack on Iran one of USA’s riskiest military decisions’
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In Memoriam professor Rudolf de Bruyn Ouboter -
War in the Middle East: What are the implications? -
Japanese Ambassador visits Leiden University -
Joëlle Kraaijeveld wins Jan Brouwer Thesis Prize -
Leiden research that matters: how science is shaping European pesticide policy -
International Women’s Day: four women on pride, leadership and impact -
Sharp increase in staff rescreening -
LUMC receives tens of millions for research into new stem cell-based treatments -
Summer School: ‘The European Union, the United Nations and Global Governance’ -
Vasiliki Kosta appointed member of the Committee of the KNAW -
Frederic Lens appointed Professor of Biodiversity and Anatomy of Plants -
Professor Marlou Schrover bids farewell -
Unequal academic freedom: women’s expertise more likely to be questioned -
Dutch inmate posts vlogs about prison life -
70,000 year old secrets revealed: Umhlatuzana Rock shelter, | A talk by Gerrit Dusseldorp -
Podcast: Ageism in the Age of AI -
Ben Arps receives Indonesian Culture Award -
Iran deserves our attention: ‘We must share our knowledge about this conflict’ -
Puck Rouffaer wins the Volkskrant-IISG thesis prize -
A world first at the microscopic scale: metamaterials that can shrink and expand on their own -
Researcher in the classroom: the importance of inclusive education -
ALMA reveals hidden chemical processes at the heart of the Milky Way -
Four years of war in Ukraine: what Europe can learn from the battlefield -
EU pushes ahead, forming ‘lead groups’ to bypass obstructive members -
The EU-Mercosur agreement: Latest developments, significance, and next steps
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Dutch cabinet’s plans hit low- and middle-income households -
CFP: Jaʿfar al-Ṣādiq -
Michiel van Elk in The Conversation on the importance of mystical experiences for therapy -
Rogier Creemers on CNN about Sundance 2.0: ‘The more capable these apps become, the more potentially harmful they become’ -
Bad luck in 2026: Extra leave required for long Christmas break -
Hub for Impactful and Engaged Research launched -
Evanthia's minor now allows her to combine her favourite subjects -
Decolonisation at university: ‘There was a feeling that something new and positive was happening’ -
New Dutch government: these members studied or taught at Leiden University -
Interdisciplinary archaeological investigation uncovers gender- and age-selective violence 2,800 years ago -
COIn grant enables Leiden researchers to improve their research infrastructure. -
In memoriam: Vincent van Heuven (1949-2026) -
90 years of labour law in Leiden: Evolving with the times -
New report: Understanding tenure security in rural Mozambique -
Old agreements under pressure in new space race -
Unemployed and work-disabled hit harder by new cabinet plans -
Council adviser during municipal elections: ‘New councillors can’t wait to get started’ -
Largest radio survey ever maps the Universe in unprecedented detail -
AI not to blame for recent wave of layoffs -
The State of Open Science at FGGA -
Asylum process must speed up, but concerns voiced about due care -
The scent of plums and paper swans: LUC students see how elderly people care for one another -
In memoriam: Takamitsu Muraoka (1938-2026) -
Professor Madalina Busuioc on AI as a ‘go-to’ solution: The institutional costs of uncritical adoption -
Addressing femicide is a clear human rights obligation -
Sandra Palmen is State Secretary and alumna: ‘My main goal is to get the childcare benefit redress operation back on track’ -
A platform for a complex conflict: ‘Friction is good’ -
Knowing the ocean means living with uncertainty -
New Visiting Professor for Central European Studies Saskia Jaszoltowski delivers talk about her work -
Summer School Science Communication: ‘You make an impact together with your audience’ -
Tougher strategy needed to tackle doxing -
Quantum research in two ways: from proving someone's location to simulating financial markets -
Listen to students -
Eric Storm in Spanish media -
Eric Storm in Romanian media
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Andrew Shield in Norwegian newspaper Aftenposten: ‘Blurring of the distinction between dating, sex and the social aspect’
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Are Dutch judges still impartial? -
'Beb & Bob| Collateral Damage' shows the human story behind the forgotten bombing of Rotterdam -
Better understanding of cancer drugs – Leiden spin-off Omivera receives seed investment -
Martijn Treur wins incentive prize for bachelor's thesis
Joachim F. R. Van Guyse studied Chemistry at Ghent University in Belgium. After graduating in 2014, he pursued a Ph.D. degree in Chemistry under the supervision of Prof. Richard Hoogenboom at Ghent University, where his work focused primarily on the development of synthetic methodologies to obtain new functional poly(2-oxazoline) and poly(acrylamide)-based materials with biomedical potential, in addition to the development of supramolecular materials.
After obtaining his Ph.D. in 2019, he joined the group of Prof. Kazunori Kataoka at the Innovation Center of NanoMedicine (ICONM) in Kawasaki, Japan, where he developed poly(2-oxazoline)s block-copolypeptides for biomedical applications, more specifically for promoting therapeutic efficacy and/or gene delivery. In 2020, he was awarded a post-doctoral fellowship from the Japan Society for the Promotion of Science (JSPS) for the development of polymer-micelle carriers for mRNA delivery.
In 2022, he was appointed as assistant professor at Leiden university, where his research focusses on the development of polymers for the delivery of biotherapeutics. So far, Joachim Van Guyse has contributed over 30 research papers, book chapters and patents covering a broad range of topics, including polymer chemistry, supramolecular chemistry, surface functionalization and nanomedicine.
Assistant Professor
- Faculty of Science
- LACDR
- Divisie Biotherapeutics
- Li J., Toh K., Wen P., Liu X., Dirisala A., Guo H., Guyse J.F.R. van, Abbasi S., Anraku Y., Mochida Y., Kinoh H., Cabral H., Tanaka M. & Kataoka K. (2026), Steric stabilization-independent stealth cloak enables nanoreactors-mediated starvation therapy against refractory cancer, Nature Biomedical Engineering : .
- Loccufier E., Abebe M.G., Geltmeyer J., Meirman T., Altan O.I.K., Guyse J.F.R. van, Khousakoun E., Gidik H., Mohsenzadeh E., Lahem D., Hoogenboom R., Maes B. & Clerck K. de (2026), Dimensionally stable nanofibrous nonwoven as a flexible dynamic emissivity switching temperature-regulating material, Advanced Materials : e17161.
- Nagorna Z., Barz M. & Guyse J.F.R. van (2025), Toward quantitative end-group fidelity in the synthesis of high molecular weight polysarcosine, ACS Macro Letters 14(5): 532-537.
- Buijs E., Nagorna Z., Guyse J.F.R. van & Barz M. (2025), Synthesis of heterotelechelic poly(N-ethylglycine) polymers: from polypeptoid lipid conjugates to protein-polymer conjugates, Macromolecular Rapid Communications 46(20): e00422.
- Babu A., Sivakumar G., Kim M., Chauhan D., Badri R., Nagorna Z., Kar P., Sasmal P.K., Guyse J.F.R. van, Banerjee S., Lee Y. & Maji S. (2025), Development of charged polyampholyte interfaces: synthesis, properties, and antifouling application, ACS Biomaterials Science and Engineering 11(11): 6593-6604.
- Podevyn A., Guyse J.F.R. van, Bouten P.J.M. & Hest J.C.M. van: Hoogenboom R. (2025), Unraveling structure–reactivity and structure–property relationships for the amidation of methyl ester-functionalized poly(2-Oxazoline)s, Macromolecules 58(4): 2026-2037.
- Zhao B., Luo S., Wei J., Guyse J.F.R. van, Zhang H. & Barz M. (2025), Orthogonal one-pot synthesis of multifunctional polypept(o)ide-based core-shell cylindrical polymer brushes, European Polymer Journal 241: 114385.
- Das A., Babu A., Chakraborty S., Guyse J.F.R. van, Hoogenboom R. & Maji S. (2024), Poly(N-isopropylacrylamide) and its copolymers: a review on recent advances in the areas of sensing and biosensing, Advanced Functional Materials 34(37): 2402432.
- Guyse J.F.R. van., Abbasi S., Toh K., Nagorna Z., Li J., Dirisala A., Quader S., Uchida S. & Kataoka K. (2024), Facile generation of heterotelechelic poly(2-oxazoline)s towards accelerated exploration of poly(2-oxazoline)-based nanomedicine, Angewandte Chemie (International Edition) 63(27): e202404972.
- Frateur O., Becelaere J., Merckx R., Guyse J.F.R. van, Purino M., Hoogenboom R. & Clerck K. de (2024), Development of reversibly photo-crosslinkable water-stable poly(2-ethyl-2-oxazoline) nanofibers via functionalization with cinnamoyl moieties, European Polymer Journal 212: 113076.
- Bauer T.A., Simić L., Guyse J.F.R. van, Duro-Castaño A., Nebot V.J. & Barz M. (2024), Polypept(o)ides: origins, synthesis, applications and future directions, Progress in Polymer Science 158: 101889.
- Guyse J.F.R. van, Bernhard Y., Podevyn A. & Hoogenboom R. (2023), Non-activated esters as reactive handles in direct post-polymerization modification, Angewandte Chemie (International Edition) 62(40): e202303841.
- Göppert N.E., Quader S., Guyse J.F.R. Van, Weber C., Kataoka K. & Schubert U.S. (2023), Amphiphilic poly(2-oxazoline)s with glycine-containing hydrophobic blocks tailored for panobinostat- and imatinib-loaded micelles, Biomacromolecules 24(12): 5915-5925.
- Bernhard Y., Guyse J.F.R. van, Purino M. & Hoogenboom R. (2023), Direct synthesis of poly(N-alkyl acrylamide) (co)polymers with pendant reactive amino groups by organocatalyzed amidation of polymethylacrylate, European Polymer Journal 192: 112077.
- Verjans J., Sedlačík T., Jerca V.V., Bernhard Y., Guyse. J.F.R. Van & Hoogenboom R. (2023), Poly(N-allyl acrylamide) as a reactive platform toward functional hydrogels, ACS Macro Letters 12(1): 79-85.
- Guyse J.F.R. van, Leiske M.N., Verjans J., Bernhard Y. & Hoogenboom R. (2022), Accelerated post-polymerization amidation of polymers with side-chain ester groups by intramolecular activation, Angewandte Chemie (International Edition) 61(29): e202201781.
- Dirisala A., Uchida S., Li J Guyse J.F.R. Van, Hayashi K., Vummaleti S.V.C., Kaur S., Mochida Y., Fukushima S. & Kataoka K. (2022), Effective mRNA Protection by Poly(l-ornithine) synergizes with endosomal escape functionality of a charge-conversion polymer toward maximizing mRNA introduction efficiency, Macromolecular Rapid Communications 43(12): e2100754.
- Quader S. & Guyse J.F.R. van (2022), Bioresponsive polymers for nanomedicine: expectations and reality!, Polymers 14(17): 3659.
- Becelaere J., Broeck E. van den, Schoolaert E., Vanhoorne V., Guyse J.F.R. van, Vergaelen M., Borgmans S., Creemers K., Speybroeck V. van, Vervaet C., Hoogenboom R. & Clerck K. de (2022), Stable amorphous solid dispersion of flubendazole with high loading via electrospinning, Journal of Controlled Release 351: 123-136.
- Van Guyse J.F.R. & Hoogenboom R. (2022), Poly(2-Oxazoline)s. In: Matyjaszewski K., Gnanou Y., Hadjichristidis N. & Muthukumar M. (Eds.), Macromolecular engineering: from precise synthesis to macroscopic materials and Applications: Wiley-VCH.
- Guyse J.F.R. van, Bera D. & Hoogenboom R. (2021), Adamantane functionalized poly(2-oxazoline)s with broadly tunable LCST-behavior by molecular recognition, Polymers 13(3): 374.
- Li J., Ge Z., Toh K., Liu X., Dirisala A., Ke W., Wen P., Zhou H., Wang Z., Xiao S., Guyse J.F.R. van, Tockary T.A, Xie J., Gonzalez-Carter D., Kinoh H., Uchida S., Anraku Y. & Kataoka K. (2021), Enzymatically transformable polymersome-based nanotherapeutics to eliminate minimal relapsable cancer, Advanced Materials 33(49): 2105254.
- Park J.R., Bolle E.C.L., Santos Cavalcanti A.D., Podevyn A., Guyse J.F.R., Forget A., Hoogenboom R. & Dargaville T.R. (2021), Injectable biocompatible poly(2-oxazoline) hydrogels by strain promoted alkyne-azide cycloaddition, Biointerphases 16(1): 011001.
- Dargaville T.R., Harkin D.G., Park J.R., Cavalcanti A., Bolle E.C.L., Savi F.M., Farrugia B.L., Monnery B.D., Bernhard Y., Guyse J.F.R. van, Podevyn A. & Hoogenboom R. (2021), Poly(2-allylamidopropyl-2-oxazoline)-based hydrogels: from accelerated gelation kinetics to in vivo compatibility in a murine subdermal implant model, Biomacromolecules 22(4): 1590-1599.
- Xu X., Guyse J.F.R. van, Jerca V.V. & Hoogenboom R. (2020), Metal ion selective self-assembly of a ligand functionalized polymer into [1+1] macrocyclic and supramolecular polymer structures via metal-ligand coordination, Macromolecular Rapid Communications 41(1): e1900305.
- Bernhard Y., Sedlacek O., Guyse J.F.R. van, Bender J., Zhong Z., Geest B.G. de & Hoogenboom R. (2020), Poly(2-ethyl-2-oxazoline) conjugates with salicylic acid via degradable modular ester linkages, Biomacromolecules 21(8): 3207-3215.
- Guyse J.F.R. van, Bernhard Y. & Hoogenboom R. (2020), Stoichiometric control over partial transesterification of polyacrylate homopolymers as platform for functional copolyacrylates, Macromolecular Rapid Communications 41(19): 2000365.
- Egghe T., Cools P., Guyse J.F.R. van, Asadian M., Khalenkow D., Nikiforov A., Declercq H., Skirtach A.G., Morent R., Hoogenboom R. & Geyter N. de (2020), Water-stable plasma-polymerized N,N-dimethylacrylamide coatings to control cellular adhesion, ACS Applied Materials and Interfaces 12(2): 2116-2128.
- Merckx R., Swift T., Rees R., Guyse J.F.R. van, Schoolaert E., Clerck K. de, Ottevaere H., Thienpont H., Jerca V.V. & Hoogenboom R. (2020), Förster resonance energy transfer in fluorophore labeled poly(2-ethyl-2-oxazoline)s, Journal of Materials Chemistry 8(40): 14125-14137.
- Guyse J.F.R. van, Cools P., Egghe T., Asadian M., Vergaelen M., Rigole P., Yan W., Benetti E.M., Jerca V.V., Declercq H., Coenye T., Morent R., Hoogenboom R. & Geyter N. de (2019), Influence of the aliphatic side chain on the near atmospheric pressure plasma polymerization of 2-alkyl-2-oxazolines for biomedical applications, ACS Applied Nano Material 11(34): 31356-31366.
- Guyse J.F.R. van, Rosa V.R. de la, Lund R., Bruyne M. de, Rycke R. de, Filippov S.K. & Hoogenboom R. (2019), Striking effect of polymer end-group on C60 nanoparticle formation by high shear vibrational milling with alkyne-functionalized Poly(2-oxazoline)s, ACS Macro Letters 8(2): 172-176.
- Guyse J.F.R. van, Rosa V.R. de la & Hoogenboom R. (2018), Mechanochemical preparation of stable Sub-100 nm γ-Cyclodextrin:Buckminsterfullerene (C60) nanoparticles by electrostatic or steric stabilization, Chemistry: a European Journal 24(11): 2758-2766.
- Asadian M., Onyshchenko I., Thukkaram M., Esbah Tabaei P.S., Guyse J. van, Cools P., Declercq H., Hoogenboom R., Morent R. & Geyter N. De (2018), Effects of a dielectric barrier discharge (DBD) treatment on chitosan/polyethylene oxide nanofibers and their cellular interactions, Carbohydrate Polymers 201: 402-415.
- Grande S., Cools P., Asadian M., Guyse J. Van, Onyshchenko I., Declercq H., Morent R., Hoogenboom R. & Geyter N. De (2018), Fabrication of PEOT/PBT nanofibers by atmospheric pressure plasma jet treatment of electrospinning solutions for tissue engineering, Macromolecular Bioscience 18(12): e1800309.
- Verbraeken B., Hullaert J., Guyse J.F.R. van, Hecke K. van, Winne J. & Hoogenboom R. (2018), The elusive seven-membered cyclic imino ether Tetrahydrooxazepine, Journal of the American Chemical Society 140(50): 17404-17408.
- Grande S., Guyse J. Van, Nikiforov A.Y., Onyshchenko I., Asadian M., Morent R., Hoogenboom R. & Geyter N. De (2017), Atmospheric pressure plasma jet treatment of poly-ε-caprolactone polymer solutions to improve electrospinning, ACS Applied Materials and Interfaces 9(38): 33080-33090.