Marcel Schaaf
Universitair hoofddocent
- Naam
- Dr. M.J.M. Schaaf
- Telefoon
- +31 71 527 4975
- m.j.m.schaaf@biology.leidenuniv.nl
Voor meer informatie, zie de Engelse versie.
Promovendi
Vakken
Universitair hoofddocent
- Wiskunde en Natuurwetenschappen
- Instituut Biologie Leiden
- IBL Animal Sciences & Health
- Schaaf M.J.M. (2017), Nuclear receptor research in zebrafish, Journal of Molecular Endocrinology 59(1): R65-R76.
- Chatzopoulou A., Schoonheim P.J., Torraca V., Meijer A.H., Spaink H.P. & Schaaf M.J.M. (2017), Functional analysis reveals no transcriptional role for glucocorticoid receptor beta-isoform in zebrafish, MOLECULAR AND CELLULAR ENDOCRINOLOGY 447: 61-70.
- Schaaf M.J.M. (2017), The First Fifteen Years of Steroid Receptor Research in Zebrafish; Characterization and Functional Analysis of the Receptors, Nuclear Receptor Research 4: 101286.
- Amin B., Slabbekoorn H., Schaaf M.J.M. & Tudorache C. (2016), "Early birds" take it easy: diurnal timing is correlated with overall level in activity of zebrafish larvae, BEHAVIOUR 153(13-14): 1745-1762.
- Hosseini R., Lamers G.E.M., Soltani H.M., Meijer A.H., Spaink H.P. & Schaaf M.J.M. (2016), Efferocytosis and extrusion of leukocytes determine the progression of early mycobacterial pathogenesis, JOURNAL OF CELL SCIENCE 129(18): 3385-3395.
- Chatzopoulou Chatzi A., Heijmans J.P., Burgerhout E., Oskam N., Spaink H.P., Meijer A.H. & Schaaf M.J.M. (2016), Glucocorticoid-Induced Attenuation of the Inflammatory Response in Zebrafish., Endocrinology 157(7): 2772-2784.
- Carattino A.J., Keizer V.I.P., Schaaf M.J.M. & Orrit M.A.G.J. (2016), Background suppression in imaging gold nanorods through detection of anti-Stokes emission, Biophysical Journal 111(11): 2492-2499.
- Harkes R., Keizer V.I.P., Schaaf M.J.M. & Schmidt T. (2015), Depth-of-Focus Correction in Single-Molecule Data Allows Analysis of 3D Diffusion of the Glucocorticoid Receptor in the Nucleus, PLoS ONE 10(11): e0141080.
- Chatzopoulou A., Upasana R., Meijer A.H., Alia A., Spaink H.P. & Schaaf M.J.M. (2015), Transcriptional and Metabolic Effects of Glucocorticoid Receptor alpha and beta Signaling in Zebrafish, Endocrinology 156(5): 1757-1769.
- Chatzopoulou Chatzi A., Roy U., Meijer A.H., Alia A., Spaink H.P. & Schaaf M.J.M. (2015), Transcriptional and metabolic effects of glucocorticoid receptor α and β signaling in zebrafish., Endocrinology 156(5): 1757-1759.
- Neo Y.Y., Parie L., Bakker F., Snelderwaard P.C, Tudorache C., Schaaf M.J.M. & Slabbekoorn H.W. (2015), Behavioral changes in response to sound exposure and no spatial avoidance of noisy conditions in captive zebrafish, Frontiers in Behavioral Neuroscience 9: 28.
- Tudorache C., Braake A. ter, Tromp M., Slabbekoorn H.W. & Schaaf M.J.M. (2015), Behavioral and physiological indicators of stress coping styles in larval zebrafish, Stress 18(1): 121-128.
- Geurtsen A., Maarten H. Lamers & Schaaf M.J.M. (2015), Interactive Digital Gameplay Can Lower Stress Hormone Levels in Home Alone Dogs — A Case for Animal Welfare Informatics. In: Chorianopoulos K., Divitini M., Baalsrud Hauge J., Jaccheri L., Malaka R. (red.) Entertainment Computing - ICEC 2015 (Lecture Notes in Computer Science Vol. 9353). Trondhei,: Springer International Publishing. 238-251.
- Van Royen ME, van Cappellen WA, Geverts B, Schmidt T, Houtsmuller AB & Schaaf MJ. (2014), Androgen receptor complexes probe DNA for recognition sequences by short random interactions., JOURNAL OF CELL SCIENCE .
- Tudorache C, Ter Braake A, Tromp M, Slabbekoorn H & Schaaf MJ. (2014), Behavioural and physiological indicators of stress coping styles in larval zebrafish., Stress 19(Nov): 1-23.
- Groeneweg F.L., Royen M.E. van, Fenz F.S., Keizer V.I.P., Geverts B., Prins J., Kloet E.R. de, Houtsmuller A.B., Schmidt T. & Schaaf M.J.M. (2014), Quantitation of Glucocorticoid Receptor DNA-Binding Dynamics by Single-Molecule Microscopy and FRAP, PLoS ONE 9(3): 90532.
- Tudorache Christian, Schaaf Marcel J. M. & Slabbekoorn Hans (2013), Covariation between behaviour and physiology indicators of coping style in zebrafish (Danio rerio), Journal of Endocrinology 219(3): 251-258.
- Kanwal Zakia, Zakrzewska Anna, den Hertog Jeroen, Spaink Herman P., Schaaf Marcel J. M. & Meijer Annemarie H. (2013), Deficiency in Hematopoietic Phosphatase Ptpn6/Shp1 Hyperactivates the Innate Immune System and Impairs Control of Bacterial Infections in Zebrafish Embryos, JOURNAL OF IMMUNOLOGY 190(4): 1631-1645.
- Kanwal Z., Zakrzewska A., den Hertog J., Spaink H.P., Schaaf M.J. & Meijer A.H. (2013), Deficiency in hematopoietic phosphatase Ptpn6/Shp1 hyperactivates the innate immune system and impairs control of bacterial infections in zebrafish embryos, JOURNAL OF IMMUNOLOGY 190(1631-1645).
- Palstra A.P., Schaaf M.J.M. & Planas J.V. (2013), Exercise physiology of zebrafish: Swimming effects on skeletal and cardiac muscle growth, on the immune system, and the involvement of the stress axis.. In: Palstra, A. Planas, J. (red.) Swimming physiology of fish: Towards using exercise to farm a fit fish in sustainable aquaculture..: Springer-Verlag Berlin Heidelberg. 323-342.
- Porta F., Lamers G.E.M., Morhayim J., Chatzopoulou A., Schaaf M., Dulk H. den, Backendorf C.M.P., Zink J.I. & Kros A. (2013), Folic acid modified mesoporous silica nanoparticles for cellular and nuclear targeted drug delivery, Advanced Healthcare Materials 2: 281-286.
- Ziv L., Muto A., Schoonheim P.J., Meijsing S.H., Strasser D., Ingraham H.A., Schaaf M.J.M., Yamamoto K.R. & Baier H. (2012), An affective disorder in zebrafish with mutation of the glucocorticoid receptor., Molecular Psychiatry .
- Porta F., Lamers G.E., Morrhayim G., Chatzopoulou A., Schaaf M.J.M., Dulk H. den, Backendorf C., Zink J.I. & Kros A. (2012), Folic Acid-Modified Mesoporous Silica Nanoparticles for Cellular and Nuclear Targeted Drug Delivery., Advanced Healthcare Materials .
- Raterink R.J., Kloet F.M. van der, Li J., Wattel N.A., Schaaf M.J.M., Spaink H.P., Berger R., Vreeken R.J. & Hankemeier T. (2012), Rapid metabolic screening of early zebrafish embryogenesis based on direct infusion-nanoESI-FTMS., METABOLOMICS .
- Meckel T., Semrau S., Schaaf M.J.M. & Schmidt T. (2012), Robust assessment of protein complex formation in vivo via single-molecule intensity distributions of autofluorescent proteins, Journal of Biomedical Optics 16: 76016.
- Schaaf M.J.M. & Schmidt Th. (2011), In Vivo Single-Molecule Microscopy Using the Zebrafish Model System. In: Sako Y, Ueda M (red.) Cell Signaling Reactions: Single-Molecular Kinetic Analyses..
- Meckel T.M., Semrau S., Schaaf M.J.M. & Schmidt Th. (2011), Robust assesment of protein complex formation in vivo via single molecule intensity distibutions of autofluorescent proteins, Journal for Biomedical Optics 16(076016).
- Schoonheim P.J., Chatzopoulou A. & Schaaf M.J.M. (2010), The zebrafish as an in vivo model system for glucocorticoid resistance, Steroids 75(12): 918-925.
- Vaart M. van der & Schaaf M.J.M. (2009), Naturally occurring C-terminal splice variants of nuclear receptors., Nucl. Recept. Signal. 7: e007.
- Schaaf M.J.M., Koopmans W.J., Meckel T., Noort J. van, Snaar-Jagalska B.E., Schmidt T.S. & Spaink H.P. (2009), Single-molecule microscopy reveals membrane microdomain organization of cells in a living vertebrate., Biophysical Journal 97: 1206-1214.
- Sarabdjitsingh R.A., Meijer O.C., Schaaf M.J.M. & Kloet E.R. de (2009), Subregion-specific differences in translocation patterns of mineralocorticoid and glucocorticoid receptors in rat hippocampus., Brain Res. 1249: 43-53.
- Schaaf M.J.M., Chatzopoulou A. & Spaink H.P. (2009), The zebrafish as a model system for glucocorticoid receptor research., Comp. Biochem. Physiol. A Mol. Integr. Physiol. 153: 75-82.
- Brittijn S.A., Duivesteijn S.J., Belmamoune M., Bertens L.M.F., Bitter W., Bruijn J.D. de, Champagne D.L., Cuppen E., Flik G., Vandenbroucke-Grauls C.M., Janssen R.A., Jong I.M. de, Kloet E.R. de, Kros A., Meijer A.H., Metz J.R., Sar A.M. van der, Schaaf M.J.M., Schulte-Merker S., Spaink H.P., Tak P.P., Verbeek F.J., Vervoordeldonk M.J., Vonk F.J., Witte F., Yuan H. & Richardson M.K. (2009), Zebrafish development and regeneration: new tools for biomedical research., European Journal of Pharmaceutics and Biopharmaceutics 53: 835-850.
- Zhu Y., Hanna R.N., Schaaf M.J.M., Spaink H.P. & Thomas P. (2008), Candidates for membrane progestin receptors-Past approaches and future challenges, Comp Biochem.Physiol C.Toxicol.Pharmacol 148(4): 381-389.
- Schaaf M.J.M., Champagne D., Laanen I.H. van, Wijk D.C. van, Meijer A.H., Meijer O.C., Spaink H.P. & Richardson M.K. (2008), Discovery of a functional glucocorticoid receptor {beta}-isoform in zebrafish, Endocrinology 149(4): 1591-1599.
- Fitzsimons C.P., Ahmed S., Wittevrongel C., Schouten T.G., Dijkmans T.F., Scheenen W.J., Schaaf M.J.M., Kloet E.R. de & Vreugdenhil E. (2008), The microtubule associated protein Doublecortin-like regulates the transport of the glucocorticoid receptor in neuronal progenitor cells, Molecular Endocrinology 22: 248-262.
- Brittijn S.A., Duivesteijn S.J., Bitter W., Bruin J.D. de, Champagne D., Cuppen E., Flik G., Janssen R., Jong I.M. de, Kloet E.R. de, Kros A., Meijer A.H., Sar A.M. van der, Schaaf M.J.M., Schulte-Merker S., Spaink H.P., Tak P.P., Vandenbroucke-Grauls C.M.J.E., Vervoordeldonk M.J., Vonk F.J., Witte F. & Richardson M.K. (2008), Zebrafish Developmental Patterning: New Tools for Medical Research, International Journal of Developmental Biology .
- Meckel T., Schaaf M., Snaar-Jagalska E., Spaink H.P. & Schmidt T. (2007), Transient cluster formation of toll-like receptor 2 revealed by single molecule microscopy, Biophysical Journal : 18A-18A.
- Vreugdenhil E., Fitzsimons C.P., Kolk S.M., Schaaf M.J.M. & Lucassen P.J. (2007), Doublecortin-Like, a Microtubule Associated Protein Expressed in Radial Glia is Crucial for Neuronal Precursor Division and Radial Process Stability, European Journal of Neuroscience 25: 635-648.
- Schaaf M.J.J., Willetts L., Hayes B.P., Maschera B., Stylianou E. & Farrow S.N. (2006), The relationship between intranuclear mobility of the NF-kappa B subunit p65 and its DNA binding affinity, Journal of Biological Chemistry 281(31): 22409-22420.
- Schaaf M.J., Lewis-Tuffin L.J. & Cidlowski J.A. (2005), Ligand-selective targeting of the glucocorticoid receptor to neclear subdomains is associated with decreased receptor mobility, Molecular Endocrinology (19): 1501-15.
- Schaaf M.J. & Cidlowski J.A. (2003), Molecular determinants of glucocorticoïd receptor mobility in living cells: the importance of ligand affinity., Journal of Steroid Biochemistry and Molecular Biology (23): 1922-34.
- Rijk R.H. de, Schaaf M.J.M., Stam F.J., Jong I.E.M., Swaab D.F., Ravid R., Vreugdenhil E., Cidlowski J.A., Kloet E.R. de & Lucassen P.J. (2003), Very low levels of the glucocorticoid receptor beta isoform in the human hippocampus as shown by Taqman RT-PCR and immunocytochemistry., Molecular Brain Research 116: 17-26.
- Rijk R.H. de, Schaaf M.J.M., Stam F.J., Jong I.E.M., Swaab D.F., Ravid R., Vreugdenhil E., Cidlowski J.A., Kloet E.R. de & Lucassen P.J. (2003), Very low levels of the glucocorticoid receptor beta-isoform in the human hippocampus as shown by Taqman RT-PCR and immunocytochemistry., Molecular Brain Research 116: 17-26.
- Rijk R.H. de, Schaaf M.J.M., Stam F.J., Jong I.E.M., Swaab D.F., Ravid R., Vreugdenhil E., Kloet E.R. de & Lucassen P.J. (2003), Very low levels of the glucocorticoid receptor B isoform in the human hippocampus as shown by Tagman RT-PCR and immunocytochemistry, Molecular Brain Research 116: 17-26.
- Schaaf M.J. & Cidlowski J.A. (2002), AUUUA motifs in the 3'UTR of human glucocorticoïd receptor alpha and beta mRNA destabilize mRNA and decrease receptor protein expression, (67): 627-36.
- Rijk R.H. de, Schaaf M.J.M. & Kloet E.R. de (2002), Glucocorticoid receptor variants: clinical implications., Journal of Steroid Biochemistry & Molecular Biology 81: 103-122.
- Schaaf M.J. & Cidlowski J.A. (2002), Molecular mechanisms of glucocorticoïd action and resistance, (83): 37-48.
- Schaaf M.J. & Cidlowski J.A. (2002), The glucocorticoïd receptor beta-isoform: a perspective on its relevance in human health and diseasse., (Ernst Schering Res Found). [overig]
- Rijk R.H. de, Schaaf M.J.M., Turner G, Datson N.A., Vreugdenhil E., Cidlowski J., Kloet E.R. de, Emery P., Sternberg E.M. & Detera-Wadleigh S.D. (2001), A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor betaisoform mRNA is associated with rheumatoid arthritis, Journal of Rheumatology 28: 2383-2388.
- Schaaf M.J.M., Workel J.O., Lesscher H., Vreugdenhil E., Oitzl M.S. & Kloet E.R. de (2001), Correlation between hippocampal BDNF mRNA expression and memory performance in senescent rats., Brain Research 915: 227-233.
- Vreugdenhil E., Kloet E.R. de, Schaaf M.J.M. & Datson N.A. (2001), Genetic dissection of corticosterone receptor function in the rat hippocampus., European Neuropsychopharmacology 11: 423-430.
- Schaaf M.J.M., Duurland R., Kloet E.R. de & Vreugdenhil E. (2000), Circadian variation in BDNF mRNA expression in the rat hipocampus, Molecular Brain Research 75: 342-344.
- Schaaf M.J.M., Kloet E.R. de & Vreugdenhil E. (2000), Corticosterone effects on BDNF expression in the hippocampus (Review), Stress 3: 201-208.
- Schaaf M.J., Sibug R.M., Duurland R., Fluttert M.F., Oitzl M.S., Kloet E.R. de & Vreugdenhil E. (1999), Corticosterone effects on BDNF mRNA expression in the rat hippocampus during morris water maze training., 3(2): 173-83.
- Vreugdenhil E., Datson N., Engels B., Jong J. de, Koningsbruggen S. van, Schaaf M. & Kloet E.R. de (1999), Kainate-elicited seizures induce mRNA encoding a CaMK-related peptide: a putative modulator of kinase activity in rat hippocampus., Journal of neurobiology 39(1): 41-50.
- Schaaf M.J.M., Jong J. de, Kloet E.R. de & Vreugdenhil E. (1998), Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone, Brain Research Bulletin 813: 112-120.
- Schaaf M.J.M., Hoetelmans R.W.M., Kloet E.R. de & Vreugdenhil E. (1997), Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus., Journal of Neuroscience Research 48: 334-341.
- Vreugdenhil E., Jong J. de, Schaaf M.J., Meijer O.C., Busscher J., Vuijst C. & Kloet E.R. de (1996), Molecular dissection of corticosteroid action in the rat hippocampus. Application of the differential display techniques. Journal of Molecular Neuroscience : 135-46.
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