Catherijne Knibbe
Professor of Individualized drug treatment
- Name
- Prof.dr. C.A.J. Knibbe
- Telephone
- +31 71 527 6329
- c.knibbe@antoniusziekenhuis.nl
- ORCID iD
- 0000-0001-9893-4415

Catherijne Knibbe (Prof. Dr.) is Professor of Individualized Drug Treatment.
More information about Catherijne Knibbe
Group members
News
Former PhD candidates
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Tjerk Geersing
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Koen van Rhee
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Lianne Stevens
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Aline Engbers
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Lu Chen
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Sjoerd de Hoogd
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Sinziana Cristea
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Cornelis Smit
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Sebastiaan Goulooze
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Roeland Wassman
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Yvette Lentferink
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Jantine Brussee
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Elisa Calvier
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Rick Admiraal
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Marloes van der Aa
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Anne van Rongen
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Margreke Brill
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Soulmaz Fazeli Farsani
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Roosmarijn de Cock
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Laura van Gulik
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Ibrahim Ince
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Jeroen Diepstraten
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Chenguang Wang
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Elke Krekels
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Simone van Kralingen
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Imke Bartelink
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Sabine Ahlers
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Mariska Peeters
Profile
Catherijne Knibbe is clinical pharmacologist-hospital pharmacist in the St. Antonius Hospital in Nieuwegein/Utrecht and professor of Individualized Drug Treatment at the LACDR, Faculty of Science at Leiden University. At the Erasmus MC/Sophia Children’s Hospital, she holds a guest appointment for different collaborative pediatric clinical pharmacology projects.
Research and Clinical Activities
Knibbe leads the Quantitative Clinical Pharmacology group which focuses on the development and application of advanced computational techniques combining the statistical power of the Population approach with Physiologically-Based approaches, to predict the efficacy and safety of drugs and optimize dosing in special patient populations like such as (prematurely born) neonates or children, individuals with obesity or critically ill patients.
Her research is supported by different grants, among which the prestigious Vidi grant in 2013 for her research project ‘From Descriptive to Predictive Pharmacology in Children using Semi-Physiological population modelling’, a Veni grant in 2006 entitled ‘Rational Dosing in Children using Population Pharmacokinetic and Pharmacodynamic Modelling’, and different other ZonMw grants for dosing individualization in neonates, children and individuals with obesity.
She has 25+ years of experience with (design of) pediatric clinical trials and adult clinical pharmacology studies both from investigator-initiated and drug development point of view, through her own clinical studies in the hospital, as co-investor of many pediatric clinical studies in the Sophia Children’s Hospital Rotterdam, and as vice-chair/member of the national IRB (CCMO) from 2011-2023.
In the St. Antonius hospital, Dr. Knibbe is consultant for the department of Intensive Care and Anesthesiology, is supervisor of the Clinical Pharmacology training program, is co-supervisor of the Hospital Pharmacy training program, and is member of the Daily Board of the Department of Clinical Pharmacy of the St. Antonius hospital.
She has supervised 28 PhD students, is currently co-supervising 8 PhD students and Post Docs, and is co-author of over 300 international peer-reviewed publications and contributions to books. She is a frequently invited speaker on national and international conferences.
Other activities
Dr. Knibbe is an active member (FCP) of the American College of Clinical Pharmacology (ACCP) where she serves in the Board of Regents, as Associate Editor of the Journal of Clinical Pharmacology, as co-chair of the Annual Meeting program committee 2024, and in many other capacities. She is chair of the GGG Board at ZonMw, member of the national expert group on dosing guidelines for obese and bariatric surgery patients of the KNMP, member of the Neodose working group of the Dutch Paediatric Formulary, External Expert of EMA (ad hoc), and has been member of the Central Committee of Research Involving Human Subjects (the 'CCMO') in The Hague from 2011-2023, member of the Board and certification committee of the Dutch Society of Clinical Pharmacology & Biopharmacy from 2004-2023, chair of the Concilium Hospital Pharmacy of the Dutch Society of Hospital Pharmacy and member of the national Committee of State ‘Doek’ involving medical-ethical aspects of (non-therapeutic) research in children (2007-2009).
Awards
Dr. Knibbe became a Fellow (FCP) of the American College of Clinical Pharmacology (ACCP) in 2019. In 2009, she was awarded the ‘Huizenga penning’ by the Dutch Society of Hospital Pharmacy, which is an award presented to young Dutch hospital-pharmacists for scientific work of outstanding quality. In 2002, she received the Best PhD Thesis Award 2002 by the Dutch Society of Clinical Pharmacology and Biopharmacy. Many of her (former) PhD students have received awards for their work.
Professor of Individualized drug treatment
- Faculty of Science
- Leiden Academic Centre for Drug Research
- LACDR/Pharmacology
- Ziekenhuisapotheker-Klinisch Farmacoloog (Staflid)
- guestappointment
- Lid programma commissie(s)
- Geven van lezingen op nascholingsactiviteiten