Extreme obesity demands tailor-made medication
Doctors and pharmacists should take greater account of obesity when dosing medicines. The distribution in the body and the breakdown of a medicine can vary considerably in obese patients. This is stated by clinical pharmacologist Catherijne Knibbe in the Annual Review of Pharmacology and Toxicology.
People with extreme obesity have often undergone physical changes that can affect the absorption, distribution and degradation of medication. These abnormalities require individualized doses, advises Catherijne Knibbe, Professor of Individualized drug treatment.
Knibbe, C.A. et.al. Drug Disposition in Obesity: Toward Evidence-Based Dosing. Drug Disposition in Obesity: Toward Evidence-Based Dosing, Annual Review of Pharmacology and Toxicology, Volume 55