Sander van Kasteren
Hoogleraar Moleculaire Immunologie
- Naam
- Prof.dr. S.I. van Kasteren
- Telefoon
- +31 71 527 4725
- s.i.van.kasteren@chem.leidenuniv.nl
- ORCID iD
- 0000-0003-3733-818X
Meer informatie is beschikbaar op de Engelse profielpagina.
Promovendi
Nieuws
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Nobelprijs voor scheikunde gaat naar ‘klikchemie’ -
Sander van Kasteren: van moleculenbouwer tot hoogleraar Chemische Immunologie -
Samenwerking van instituten tegen TBC in het Leidsch Dagblad -
Leidse onderzoekers slaan handen ineen tegen tuberculose -
Op zoek naar verbeterde therapeutische vaccins -
ERC Consolidator Grants voor vier Leidse wetenschappers -
Leidse chemici ontrafelen één van de mysteries van Multiple Sclerose -
Wetenschappers hebben ook een moraal -
KNCV Silver Master Award voor Thomas Bakkum -
Alles moet kapot! -
Sander van Kasteren bij Kennislink over een chemische schakelaar in de afweer
-
Chemische verbinding beïnvloedt afweersysteem -
ERC Starting Grant voor chemicus Sander van Kasteren -
Leidse wetenschappers pakken kanker aan de basis aan
Oud-promovendi
Hoogleraar Moleculaire Immunologie
- Wiskunde en Natuurwetenschappen
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Bio-organic Synthesis
- Torres-Garcia D., Plassche M.A.T. van de, Boven E. van, Leeuwen T. van, Groenewold M.G.J., Sarris A.J.C., Klein L., Overkleeft H.S. & Kasteren S.I. van (2022), Methyltetrazine as a small live-cell compatible bioorthogonal handle for imaging enzyme activities in situ, RSC Chemical Biology 3(11): 1325-1330.
- Doelman W. & Kasteren S.I. van (2022), Synthesis of glycopeptides and glycopeptide conjugates, Organic and Biomolecular Chemistry 20(33): 6487-6507.
- Bertheussen K., Plassche M.A.T. van de, Bakkum T., Gagestein B., Ttofi I., Sarris A.J.C., Overkleeft H.S., Stelt M. van der & Kasteren S.I. van (2022), Live-cell imaging of sterculic acid - a naturally occurring 1,2-cyclopropene fatty acid - by bioorthogonal reaction with turn-on tetrazine-fluorophore conjugates, Angewandte Chemie (International Edition) 61(38): e202207640.
- Riera R., Hogervorst T.P., Doelman W., Ni Y., Pujals S., Bolli E., Codee J.D.C., Kasteren S.I. van & Albertazzi L. (2021), Single-molecule imaging of glycan-lectin interactions on cells with Glyco-PAINT, Nature Chemical Biology 17: 1281-1288.
- Leun A.M. van der, Hoekstra M.E., Reinalda L., Scheele C.L.G.J., Toebes M., Graaff M.J. van de, Chen L.Y.Y., Li H., Bercovich A., Lubling Y., David E., Thommen D.S., Tanay A., Rheenen J. van, Amit I., Kasteren S.I. van & Schumacher T.N. (2021), Single-cell analysis of regions of interest (SCARI) using a photosensitive tag, Nature Chemical Biology 17: 1139-1147.
- Ignacio B.J., Bakkum T., Bonger K.M., Martin N.I. & Kasteren S.I. van (2021), Metabolic labeling probes for interrogation of the host-pathogen interaction, Organic and Biomolecular Chemistry 19(13): 2856-2870.
- Leeuwen T. van, Araman C., Pournara L.P., Kampstra A.S.B., Bakkum T., Marqvorsen M.H.S., Nascimento C.R., Groenewold G.J.M., Wulp W. van der, Camps M.G.M., Janssen G.M.C., Veelen P.A. van, Westen G.J.P. van Janssen A.P.A., Florea B.I., Overkleeft H.S., Ossendorp F.A., Toes R.E.M. & Kasteren S.I. van (2021), Bioorthogonal protein labelling enables the study of antigen processing of citrullinated and carbamylated auto-antigens, RSC Chemical Biology 2(3): 855-862.
- Dalen F.J. van, Bakkum T., Leeuwen T. van, Groenewold G.J.M., Deu E., Koster A.J., Kasteren S.I. van & Verdoes M. (2021), Application of a highly selective cathepsin S two-step activity-based probe in multicolor bio-orthogonal correlative light-electron microscopy, Frontiers in Chemistry 8: 628433.
- Doelman W., Marqvorsen M.H.S., Chiodo F., Bruijns S.C.M., Marel G.A. van der, Kooyk Y. van, Kasteren S.I. van & Araman C. (2021), Synthesis of asparagine derivatives harboring a Lewis X type DC-SIGN ligand and evaluation of their impact on immunomodulation in multiple sclerosis, Chemistry-a European Journal 27(8): 2742-2752.
- Bakkum T., Heemskerk M.T., Bos E., Groenewold G.J.M., Oikonomeas-Koppasis N., Walburg K.V., Veen S. van, Lienden M.J.C. van der, Leeuwen T. van, Haks M.C., Ottenhoff T.H.M., Koster A.J. & Kasteren S.I. van (2020), Bioorthogonal correlative light-electron microscopy of mycobacterium tuberculosis in macrophages reveals the effect of antituberculosis drugs on subcellular bacterial distribution, ACS Central Science 6(11): 1997-2007.
- Andrian T., Bakkum T., Elsland D.M. van, Bos E., Koster A.J., Albertazzi L., Kasteren S.I. van & Pujals S. (2021), Super-resolution correlative light-electron microscopy using a click-chemistry approach for studying intracellular trafficking. In: Müller-Reichert T. & Verkade P. (red.) Correlative Light and Electron Microscopy IV. Methods in Cell Biology nr. 162: Elsevier. 303-331.
- Geus M.A.R. de, Groenewold G.J.M., Maurits E., Araman C. & Kasteren S.I. van (2020), Synthetic methodology towards allylic trans-cyclooctene-ethers enables modification of carbohydrates: bioorthogonal manipulation of the lac repressor, Chemical Science 11(37): 10175-10179.
- Oosenbrug T., Graaff M.J. van de, Haks M.C., Kasteren S.I. van & Ressing M.E. (2020), An alternative model for type I interferon induction downstream of human TLR2, Journal of Biological Chemistry 295: 14325-14342.
- Graaff M.J. van de Oosenbrug T. Marqvorsen M.H.S. Nascimento C.R. Geus M.A.R. de Manoury B. Ressing M.E. Kasteren S.I. van (2020), Conditionally controlling human TLR2 activity via Trans-Cyclooctene Caged Ligands, Bioconjugate Chemistry 31(6): 1685-1692.
- Voorneveld J., Florea B.I., Bakkum T., Mendowicz R.J., Veer M.S. van der, Gagestein B., Kasteren S.I. van, Stelt M. van der, Overkleeft H.S. & Filippov D.V. (2020), Olaparib-Based Photoaffinity Probes for PARP-1 Detection in Living Cells, CHEMBIOCHEM 21: 1-5.
- Busemann A. Araman M.C. Flaspohler I. Pratesi A. Zhou X.Q. Rixel V.H.S. van Siegler M.A. Messori L. Kasteren S.I. van Bonnet S.A. (2020), Alkyne Functionalization of a Photoactivated Ruthenium Polypyridyl Complex for Click-Enabled Serum Albumin Interaction Studies, Journal of Inorganic Chemistry 59(11): 7710-7720.
- Maurits E., Graaff M.J. van de, Maiorana S., Wander D.P.A., Dekker P.M., Zanden S.Y. van der, Florea B.I., Neefjes J.J.C., Overkleeft H.S. & Kasteren S.I. van (2020), Immunoproteasome inhibitor-doxorubicin conjugates target multiple myeloma cells and release doxorubicin upon low-dose photon irradiation, Journal of the American Chemical Society 142(16): 7250-7253.
- Brevé T.G., Filius M., Araman C., Helm M.P. van der, Hagedoorn P.L., Joo C., Kasteren S.I. van & Eelkema R. (2020), Conditional Copper-Catalyzed Azide-Alkyne Cycloaddition by Catalyst Encapsulation, Angewandte Chemie International Edition 59(24): 9340-9344.
- Geus M.A.R. de, Maurits E., Sarris A.J.C., Hansen T., Kloet M.S., Kamphorst K., Hoeve W. ten, Robillard M.S., Pannwitz A., Bonnet S.A., Codée J.D.C., Filippov D.V., Overkleeft H.S. & Kasteren S.I. van (2020), Fluorogenic Bifunctional Trans-cyclooctenes as Efficient Tools for Investigating Click-to-Release Kinetics, Chemistry-a European Journal 26(44): 9900-9904.
- Dou Y., Jansen D.T.S.L., Bosch A. van den, Man R.A. de, Montfoort N. van, Araman C., Kasteren S.I. van, Zom G.G., Krebber W.J., Melief C.J.M., Woltman A.M. & Buschow S.I. (2020), Design of TLR2-ligand-synthetic long peptide conjugates for therapeutic vaccination of chronic HBV patients, Antiviral Research 178: 104746.
- Marqvorsen M.H.S., Araman C. & Kasteren S.I. van (2019), Going Native: Synthesis of Glycoproteins and Glycopeptides via Native Linkages To Study Glycan-Specific Roles in the Immune System, Bioconjugate Chemistry 30(11): 2715-2726.
- Marqvorsen M.H.S., Paramasivam S., Doelman W., Fairbanks A.J. & Kasteren S.I. van (2019), Efficient synthesis and enzymatic extension of an N-GlcNAz asparagine building block, Chemical Communications 55(36): 5287-5290.
- Meel E. van, Bos E., Lienden M.J.C. van der, Overkleeft H.S., Kasteren S.I. van, Koster A.J. & Aerts J.M.F.G. (2019), Localization of Active Endogenous and Exogenous GBA by Correlative Light-Electron Microscopy in Human Fibroblasts, Traffic 20(5): 346-356.
- Martínez-Fábregas J., Prescott A., Kasteren S.I. van, Pedrioli D.L., McLean I., Moles A., Reinheckel T., Poli V. & Watts C. (2018), Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis, Nature Communications 9(1): 5343.
- Araman C., Gent M. van, Meeuwenoord N.J., Heijmans N., Marqvorsen M.H.S., Faber B.W., Hart B.A. 't & Kasteren S.I. van (2019), Amyloid-like behavior of site-specifically citrullinated myelin oligodendrocyte protein (MOG) peptide fragments inside EBV infected B-cells influences their cytotoxicity and autoimmunogenicity, Biochemistry 58(6): 763-775.
- Sarris A.J.C., Hansen T., Geus M.A.R. de, Maurits E., Doelman W., Overkleeft H.S., Codée J.D.C., Filippov D.V. & Kasteren S.I. van (2018), Fast and pH-Independent Elimination of trans-Cyclooctene by Using Aminoethyl-Functionalized Tetrazines, Chemistry-a European Journal 24(68): 18075-18081.
- Stathopoulou C., Gangaplara A., Mallett G., Flomerfelt F.A., Liniany L.P., Knight D., Samsel L.A., Berlinguer-Palmini R., Yim J.J., Felizardo T.C., Eckhaus M.A., Edgington-Mitchell L., Martinez-Fabregas J., Zhu J., Fowler D.H., Laurence A., Kasteren S.I. van, Watts C., Bogyo M., Amarnath S. & Shevach E.M. (2018), PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells, Immunity 49(2): 247-263.e7.
- Kasteren S.I. van, Neefjes J.J.C. & Ovaa H. (2018), Creating molecules that modulate immune responses, Nature Reviews Chemistry 2: 184-193.
- Gracht A.M.F. van der, Geus M.A.R. de, Camps M.G.M., Ruckwardt T.J., Sarris A.J.C., Bremmers J.S., Maurits E., Pawlak J.B., Posthoorn M.M., Bonger K.M., Filippov D.V., Overkleeft H.S., Robillard M.S., Ossendorp F.A. & Kasteren S.I. van (2018), Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans-Cyclooctene-Modified Epitopes, ACS Chemical Biology 13(6): 1569-1576.
- Elsland D.M. van, Pujals S., Bakkum T., Bos E., Oikonomeas-Koppasis N., Berlin I., Neefjes J., Meijer A.H., Koster A.J., Albertazzi L. & Kasteren S.I. van (2018), Ultrastructural Imaging of Salmonella-Host Interactions Using Super-resolution Correlative Light-Electron Microscopy of Bioorthogonal Pathogens, ChemBioChem 19(16): 1766-1770.
- Bakkum T., Leeuwen T. van, Sarris A.J.C., Elsland D.M. van, Poulcharidis D., Overkleeft H.S. & Kasteren S.I. van (2018), Quantification of Bioorthogonal Stability in Immune Phagocytes Using Flow Cytometry Reveals Rapid Degradation of Strained Alkynes, ACS Chemical Biology 13(5): 1173-1179.
- Hos B.J., Tondini E., Kasteren S.I. van & Ossendorp F.A. (2018), Approaches to Improve Chemically Defined Synthetic Peptide Vaccines, Frontiers in Immunology 9: 884.
- Soethoudt M., Stolze S.C., Westphal M.V., Stralen L. van, Martella A., Rooden E.J. van, Guba W., Varga Z.V., Deng H., Kasteren S.I. van, Grether U., IJzerman A.P., Pacher P., Carreira E.M., Overkleeft H.S., Heitman L.H., Ioan-Facsinay A. & Stelt M. van der (2018), A selective photoaffinity probe that enables assessment of cannabinoid CB2 receptor expression and ligand engagement in human cells, Journal of the American Chemical Society 140(19): 6067-6075.
- Kasteren S.I. van, Florea B.I. & Overkleeft H.S. (2017), Activity-Based Protein Profiling: From Chemical Novelty to Biomedical Stalwart. In: Florea B.I. Overkleeft H.S. (red.) Activity-based Proteomics: Methods and Protocols. Methods in molecular biology (Clifton, N.J.) New York: Humana Press. 1-8.
- Pawlak J.B. & Kasteren S.I. van (2017), Antigen Processing and Cross-Presentation, eLS : 1-11.
- Elsland D.M. van, Bos E., Pawlak J.B., Overkleeft H.S., Koster A.J. & Kasteren S.I. van (2017), Correlative light and electron microscopy reveals discrepancy between gold and fluorescence labelling, Journal of Microscopy 267(3): 309-317.
- Oosenbrug T., Graaff M.J. van de, Ressing M.E. & Kasteren S.I. van (2017), Chemical Tools for Studying TLR Signaling Dynamics, Cell Chemical Biology 24(7): 801-812.
- Perez-Balderas F., Kasteren S.I. van, Aljabali A.A., Wals K., Serres S., Jefferson A., Sarmiento Soto M., Khrapitchev A.A., Larkin J.R., Bristow C., Lee S.S., Bort G., De Simone F., Campbell S.J., Choudhury R.P., Sibson N.R., Anthony D.C. & Davis B.G. (2017), Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI, NATURE COMMUNICATIONS 8: 1-10.
- Poulcharidis D., Belfor K., Kros A. & Kasteren S.I. van (2017), A flow cytometry assay to quantify intercellular exchange of membrane components, Chemical Science - hard copy 8(8): 5585-5590.
- Poolman J.M., Maity C., Boekhoven J., Mee L. van der, Sage V.A.A. le, Groenewold G.J.M., Kasteren S.I. van, Versluis F., Esch J.H. van & Eelkema R. (2016), A toolbox for controlling the properties and functionalisation of hydrazone-based supramolecular hydrogels, Journal of Materials Chemistry. B 4(5): 852-858.
- Elsland D.M. van, Bos E., Boer W. de, Overkleeft H.S., Koster A.J. & Kasteren S.I. van (2016), Detection of bioorthogonal groups by correlative light and electron microscopy allows imaging of degraded bacteria in phagocytes, CHEMICAL SCIENCE 7(1): 752-758.
- Pawlak J.B., Hos B.J., Graaff M.J. van de, Megantari O.A., Meeuwenoord N., Overkleeft H.S., Filippov D.V., Ossendorp F. & Kasteren S.I. van. (2016), The Optimization of Bioorthogonal Epitope Ligation within MHC-I Complexes, ACS Chemical Biology .
- Versluis F., Elsland D.M. van, Mytnyk S., Perrier D.L., Trausel F., Poolman J.M., Maity C., Sage V.A. le, Kasteren S.I. van, Esch J.H. & Eelkema R. (2016), Negatively Charged Lipid Membranes Catalyze Supramolecular Hydrogel Formation, Journal of the American Chemical Society 138(28): 8670-8673.
- Jagessar S.A., Holtman I.R., Hofman S., Morandi E., Heijmans N., Laman J.D., Gran B., Faber B.W., Kasteren S.I. van, Eggen B.J. & t Hart B.A. (2016), Lymphocryptovirus Infection of Nonhuman Primate B Cells Converts Destructive into Productive Processing of the Pathogenic CD8 T Cell Epitope in Myelin Oligodendrocyte Glycoprotein, Journal of immunology (Baltimore, Md. : 1950) 197(4): 1074-1088.
- Elsland D.M. van & Kasteren S.I. van (2016), Imaging Bioorthogonal Groups in Their Ultrastructural Context with Electron Microscopy, Angewandte Chemie (International ed. in English) 55(33): 9472-9473.
- Pawlak J.B., Gential G.P.P., Ruckwardt T.J., Bremmers J.S., Meeuwenoord N.J., Ossendorp F.A., Overkleeft H.S., Filippov D.V. & Kasteren S.I. (2015), Bioorthogonal Deprotection on the Dendritic Cell Surface for Chemical Control of Antigen Cross-Presentation, Angewandte Chemie International Edition 54(19): 5628-5631.
- Watts C. & Kasteren S.I. van (2015), Inhibitors against endosomal/lysosomal enzymes ( octrooi nr. 9,050,374), (USPTO). [octrooi]
- Elsland D.M. van, Bos E., Overkleeft H.S., Koster A.J. & Kasteren S.I. van (2015), The potential of bioorthogonal chemistry for correlative light and electron microscopy: a call to arms, Journal of Chemical Biology 8(4): 1-5.
- Burkhard C., Verheije M.H., Wicht O., Kasteren S.I. van, Kuppeveld F.J. van, Haagmans B.L., Pelkmans L., Rottier P.J.M., Bosch B.J. & Haan C.A.M. de (2014), Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner, PLOS PATHOGENS 10(11).
- Willems Lianne I., Overkleeft Herman S. & Van Kasteren Sander I. (2014), Current Developments in Activity-Based Protein Profiling, BIOCONJUGATE CHEMISTRY 25(7): 1181-1191.
- Engelsma Sander B., Willems Lianne I., Van Paaschen Claudia E., Van Kasteren Sander I., Van der Marel Gijsbert A., Overkleeft Herman S. & Filippov Dmitri V. (2014), Acylazetine as a Dienophile in Bioorthogonal Inverse Electron-Demand Diels-Alder Ligation, 16(10): 2744-2747.
- Kasteren S.I. van, Overkleeft H.S., Ovaa H. & Neefjes J.J.C. (2014), Chemical biology of antigen presentation by MHC molecules, Current Opinion in Immunology 26: 21-31.
- Kasteren S.I. van & Overkleeft H.S. (2014), Endo-lysosomal proteases in antigen presentation , Current opinion in chemical biology 23(0): 8 - 15.
- Ekkebus R., Kasteren S.I. van, Kulathu Y., Scholten A., Berlin I., Geurink P.P., Jong A. de, Goerdayal S., Neefjes J.J.C., Heck A.J.R., Komander D. & Ovaa H. (2013), On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases, Journal of the American Chemical Society 135(8): 2867-2870.
- Ovaa H., Ekkebus R., Kasteren S.I. van, Jong de A. & Geurink P.P. (2013), Cysteine protease capturing agents ( octrooi nr. 14/412,990), (USPTO). [octrooi]
- Kasteren S. van (2012), Synthesis of post-translationally modified proteins, Biochemical Society Transactions 40: 929-944.
- Kujala P., Raymond C.R., Romeijn M., Godsave S.F., Kasteren S.I. van, Wille H., Prusiner S.B., Mabbott N.A. & Peters P.J. (2011), Prion Uptake in the Gut: Identification of the First Uptake and Replication Sites, PLOS PATHOGENS 7(12): e1002449.
- Kasteren S.I. van, Berlin I., Colbert J.D., Keane D., Ovaa H. & Watts C. (2011), A Multifunctional Protease Inhibitor To Regulate Endolysosomal Function, ACS CHEMICAL BIOLOGY 6(11): 1198-1204.
- Sibson N.R., Anthony D.C., Kasteren S. van, Dickens A., Perez-Balderas F., McAteer M.A., Choudhury R.P. & Davis B.G. (2011), Molecular MRI Approaches to the Detection of CNS Inflammation. In: Magnetic Resonance Neuroimaging. nr. 711: Humana Press. 379-396.
- Garnier P., Wang X.T., Robinson M.A., Kasteren S. van, Perkins A.C., Frier M., Fairbanks A.J. & Davis B.G. (2010), Lectin-directed enzyme activated prodrug therapy (LEAPT): Synthesis and evaluation of rhamnose-capped prodrugs, JOURNAL OF DRUG TARGETING 18(10): 794-802.
- Serres S., Anthony D.C., Jiang Y., Broom K.A., Campbell S.J., Tyler D.J., Kasteren S.I. van, Davis B.G. & Sibson N.R. (2009), Systemic Inflammatory Response Reactivates Immune-Mediated Lesions in Rat Brain, Journal of Neuroscience 29(15): 4820-4828.
- Kasteren S.I. van, Campbell S.J., Serres S., Anthony D.C., Sibson N.R. & Davis B.G. (2009), Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease, Proceedings of the National Academy of Sciences of the United States of America 106(1): 18-23.
- Kasteren S.I. van, Garnier P. & Davis B.G. (2009), Chemical Methods for Mimicking Post-Translational Modifications. In: Protein Engineering. nr. 22: Springer Berlin Heidelberg. 97-125.
- Gamblin D.P., Kasteren S. van, Bernardes G.J.L., Chalker J.M., Oldham N.J., Fairbanks A.J. & Davis B.G. (2008), Chemical site-selective prenylation of proteins, Molecular Biosystems 4(6): 558-561.
- Gamblin D.P., Kasteren S.I. van, Chalker J.M. & Davis B.G. (2008), Chemical approaches to mapping the function of post-translational modifications, FEBS Journal 275(9): 1949-1959.
- Kasteren S.I. van, Kramer H.B., Gamblin D.P. & Davis B.G. (2007), Site-selective glycosylation of proteins: creating synthetic glycoproteins, NATURE PROTOCOLS 2(12): 3185-3194.
- Kasteren S.I. van, Kramer H.B., Jensen H.H., Campbell S.J., Kirkpatrick J., Oldham N.J., Anthony D.C. & Davis B.G. (2007), Expanding the diversity of chemical protein modification allows post-translational mimicry, 446(7139): 1105-1109.
- Davis B., Kasteren S. van, Anthony D. & Sibson N. (2007), Imaging agent comprising iron containing colloidal particle conjugated to oligosaccharides ( octrooi nr. 2,007,020,450), (WO). [octrooi]
- Gamblin D.P., Garnier P., Kasteren S. van, Oldham N.J., Fairbanks A.J. & Davis B.G. (2004), Glyco-SeS: Selenenylsulfide-mediated protein glycoconjugation - A new strategy in post-translational modification, Angewandte Chemie International Edition 43(7): 828-833.
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