Universiteit Leiden

nl en

Piet Hein van der Graaf

Hoogleraar Systeemfarmacologie

Naam
Prof.dr. P.H. van der Graaf
Telefoon
+31 71 527 4341
E-mail
p.vandergraaf@lacdr.leidenuniv.nl

Meer informatie is beschikbaar op de Engelse profielpagina.

Hoogleraar Systeemfarmacologie

  • Wiskunde en Natuurwetenschappen
  • Leiden Academic Centre for Drug Research
  • LACDR/Pharmacology

Werkadres

Gorlaeus Laboratoria
Einsteinweg 55
2333 CC Leiden
Kamernummer HB624

Contact

  • Witte W.E.A. de, Danhof M., Graaf P.H. van der & Lange E.C.M. de (2016), In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant., Trends in pharmacological sciences 37(10): 831-842.artikel in tijdschrift (refereed)
  • Brink W.J. van den, Wong Y.C., Gülave B., Graaf P.H. van der & Lange E.C.M. de (2016), Revealing the Neuroendocrine Response After Remoxipride Treatment Using Multi-Biomarker Discovery and Quantifying It by PK/PD Modeling, AAPS JOURNAL .artikel in tijdschrift (refereed)
  • Kantae V., Krekels E.H., Ordas A., González O., Wijk R.C. van, Harms A.C., Racz P..I, Graaf P.H. van der, Spaink H.P. & Hankemeier T. (2016), Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude, Zebrafish 2016.artikel in tijdschrift (refereed)
  • Bakshi S.D., Lange E.C.M. de, Graaf P.H. van der, Danhof M. & Peletier L.A. (2016), Understanding the Behavior of Systems Pharmacology Models Using Mathematical Analysis of Differential Equations: Prolactin Modeling as a Case Study, CPT: Pharmacometrics & Systems Pharmacology 5(7): 339-351.artikel in tijdschrift (refereed)
  • Hasselt J.G. van, Rizk M.L., Lala M., Chavez-Eng C, Visser S.A., Kerbusch T., Danhof M., Rao G. & Graaf P.H. van der (2016), Pooled population pharmacokinetic model of imipenem in plasma and the lung epithelial lining fluid, British Journal of Clinical Pharmacology 81: 1113–1123.artikel in tijdschrift (refereed)
  • Witte W.E., Wong Y.C., Nederpelt I., Heitman L.H., Danhof M., Graaf P.H. van der, Gilissen R.A. & de Lange E.C. (2016), Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients., Expert opinion on drug discovery 11(1): 45-63.artikel in tijdschrift (refereed)
  • Graaf P.H. van der (27 mei 2013), Toekomstmedicijn (Oratie. LACDR, Science, Leiden). Leiden: Universiteit Leiden.inaugurele rede
  • Stevens J, van den Berg D.J., de Ridder S., Niederländer H.A., van der Graaf P.H., Danhof M. & de Lange E.C.M. (2010), Online solid phase extraction with liquid chromatography-tandem mass spectrometry to analyze remoxipride in small plasma-, brain homogenate-, and brain microdialysate samples., J Chromatogr B Analyt Technol Biomed Life Sci 878(13-14): 969-75.artikel in tijdschrift (refereed)
  • Peletier L.A., Benson N. & Graaf P.H. van der (2010), Impact of protein binding on receptor occupancy: A two-compartment model, Journal of Theoretical Biology 265: 657-671.artikel in tijdschrift (refereed)
  • Peletier L.A., Benson N. & Graaf P.H. van der (2009), Impact of plasma-protein binding on receptor occupancy: An analytical description., Journal of Theoretical Biology 256: 253-262.artikel in tijdschrift
  • Zuideveld K.P., Graaf P.H. van der, Peletier L.A. & Danhof M. (2007), Allometric scaling of pharmacodynamic responses: application to 5-Ht1A receptor mediated responses from rat to man, Pharmaceutical Research 24(11): 2031-2039.artikel in tijdschrift (refereed)
  • Jonker D.M., Visser S.A.G., Graaf P.H. van der, Voskuyl R.A. & Danhof M. (2005), Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo, Pharmacology and Therapeutics 106(1): 1-18.artikel in tijdschrift
  • Jonker D.M., Visser S.A.G., Graaf P.H. van der, Voskuyl R.A. & Danhof M. (2005), Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo, Pharmacology and Therapeutics 106(1): 1-18.artikel in tijdschrift (refereed)
  • Zuideveld K.P., Graaf P.H. van der, Newgreen D., Thurlow R., Petty N., Jordan P., Peletier L.A. & Danhof M. (2004), Mechanism-based pharmacokinetic/pharmacodynamic modeling of 5-HT1A receptor agonists: estimation of in vivo affinity and intrinsic efficacy on body termperature in rats, Journal of Pharmacology and Experimental Therapeutics 308: 1012-1020.artikel in tijdschrift (refereed)
  • Danhof M., Graaf P.H. van der, Visser S.A.G. & Zuideveld K.P. (2004), Mechanism-based pharmacodynamic modelling for prediction of exposure response. In: D'Argenio D.Z. (Red.) Advanced Methods of Pharmacokinetic & Pharmacodynamic Systems Analysis. Boston: Kluwer Academic Publishers. 49-65.boekdeel
  • Visser S.A.G., Gubbens-Stibbe J.M., Graaf P.H. van der, Danhof M. & Peletier L.A. (2003), Mechanism-based Pharmacokinetic/Pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in viro-in vivi modulators, Journal of Pharmacology and Experimental Therapeutics 304: 88-101.artikel in tijdschrift (refereed)
  • Visser S.A.G., Graaf P.H. van der, Danhof M. & Peletier L.A. (2003), Mechanism-Based Modeling of the Pharmacodynamic Interaction of Alphaxalone and Midazolam in Rats, Journal of Pharmacology and Experimental Therapeutics 307: 765-775.artikel in tijdschrift (refereed)
  • Visser S.A.G., Wolters F.L.C., Graaf P.H. van der, Peletier L.A. & Danhof M. (2003), Dose-Dependent EEG Effects of Zolpidem Provide Evidence for GABAA Receptor Subtype Selectivity in Vivo, Journal of Pharmacology and Experimental Therapeutics 304: 1251-1257.artikel in tijdschrift (refereed)
  • Visser S.A.G., Wolters F.L.C., Gubbens-Stibbe J.M., Tukker E., Graaf P.H. van der, Peletier L.A. & Danhof M. (2003), Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations, Journal of Pharmacology and Experimental Therapeutics 304(1): 88-101.artikel in tijdschrift (refereed)
  • Lorenzen A., Beukers M.W., Graaf P.H. van der, Lang H., Muijlwijk-Koezen J.E. van, Groote M. de, Menge W., Schwabe U. & IJzerman A.P. (2002), Modulation of agonist responses at the A1 adenosine receptor by an irreversible antagonist, receptor-G protein uncoupling and by the G protein activation state, Biochemical Pharmacology 64: 1251-1265.artikel in tijdschrift (refereed)
  • Visser S.A.G., Smulders J.G.M., Reijers B.P.R., Graaf P.H. van der, Peletier L.A. & Danhof M. (2002), Mechanism-based pharmacokinetic-pharmacodynamic modelling of concentration-dependent hysteresis and biphasic electroencephalogram effects of alphaxalone in rats, Journal of Pharmacology and Experimental Therapeutics 302: 1158-1167.artikel in tijdschrift (refereed)
  • Visser S.A.G., Gladdines W.W.F.T., Graaf P.H. van der, Peletier L.A. & Danhof M. (2002), Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABAA receptor in vivo, Journal of Pharmacology and Experimental Therapeutics 303: 616-626.artikel in tijdschrift (refereed)
  • Visser S.A.G., Wolters F.L.C., Gubbens-Stibbe J.M., Tukker H.E., Graaf P.H. van der & Peletier L.A. (2002), Mechanism-based Pharmacokinetic-Pharmacodynamic Modelling the electroencephalogram effects of GABAA receptor modulators: in vitro – in vivo correlations, Journal of Pharmacology and Experimental Therapeutics 304: 88-101.artikel in tijdschrift (refereed)
  • Zuideveld K.P., Treijtel N., Maas H.J., Gubbens-Stibbe J.M., Peletier L.A., Graaf P.H. van der & Danhof M. (2002), A competitive interaction model predicts the effect of WAY-100,635 on the Time Course of R-(+)-8-Hydroxy-2-(di-n-propylamino)tetralin-Induced Hypothermia, Journal of Pharmacology and Experimental Therapeutics 300: 330-338.artikel in tijdschrift (refereed)
  • Zuideveld K.P., Gestel A. van, Peletier L.A., Graaf P.H. van der & Danhof M. (2002), Pharmacokinetic-pharmacodynamic modelling of the hypothermic and corticosterone effects of the 5-HT1A-receptor agonist flesinoxan, European Journal of Pharmacology 445: 43-54.artikel in tijdschrift (refereed)
  • Zuideveld K.P., Rusic-Pavletic J., Maas J., Peletier L.A., Graaf P.H. van der & Danhof M. (2002), Pharmacokinetic-Pharmacodynamic modeling of buspirone and its metabolite 1-(2-Pyrimidinyl)-Piperazine in rats, Journal of Pharmacology and Experimental Therapeutics 303: 1130-1137.artikel in tijdschrift (refereed)
  • Graaf P.H. van der, Nilsson J., Schaick E.A. van & Danhof M. (1999), Multivariate quantitative structure-pharmacokinetic relationships (QSPKR) analysis of adenosine A1 receptor agonists in rat, Journal of Pharmaceutical Sciences 88: 306-312.artikel in tijdschrift (refereed)
  • Cleton A., Graaf P.H. van der, Ghijsen W., Voskuyl R.A. & Danhof M. (1999), Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy, Pharmaceutical Research 16: 1702-1709.artikel in tijdschrift (refereed)
  • Cox E.H., Kerbusch Th., Graaf P.H. van der & Danhof M. (1998), Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: correlation with the interaction at the m-opioid receptor, Journal of Pharmacology and Experimental Therapeutics 284(3): 1095-1103.artikel in tijdschrift (refereed)
  • Stam W.B., Graaf P.H. van der & Saxena P.R. (1998), Characterization of receptors mediating contraction of the rat isolated small mesenteric artery and aorta to arginine vasopressin and oxytocin, British Journal of Pharmacology 125: 865-873.artikel in tijdschrift (refereed)
  • Stam W.B., Graaf P.H. van der & Saxena P.R. (1998), Functional characterization of the pharmacological profile of the putative a1B-adrenoceptor antagonist, (+)-cyclazosin, European Journal of Pharmacology 361: 79-83.artikel in tijdschrift (refereed)
  • Graaf P.H. van der, Schaick E.A. van, Visser S.A.G., Greef H.J.M.M. de, IJzerman A.P. & Danhof M. (1998), Mechanism-based pharmacokinetic-pharmacodynamic modeling of anti-lipolytic effects of adenosine A1 receptor agonists in rats: prediction of tissue-dependent efficay in vivo, Journal of Pharmacology and Experimental Therapeutics.artikel in tijdschrift (refereed)
  • Graaf P.H. van der (1998), Analysis of drug-receptor interactions in vivo: mechanism-based PK/PD modelling of adenosine A1 receptor ligands and synthetic opiates (Lezing). Noordwijkerhout, NL.overig
  • Graaf P.H. van der (1998), Receptor modulation and expression of efficacy by in vitro and in vivo strategies (Lezing). Leiden, NL.overig
  • Cleton A., Graaf P.H. van der, Voskuyl R.A. & Danhof M. (1998), Mechanism-based modelling of the adaptive changes in the pharmacodynamics of midazolan in rats with experimentally induced epilepsy. In: Danhof M., Steimer J.L. (Red.) Measurements and kinetics of in vivo drug effects. Advances in simultaneous pharmacokinetic pharmacodynamic modelling. Leiden: LACDR.boekdeel
  • LEO Foundation Member Nomination Committee
  • Certara Vice President
  • Minerva Scholarship Fund Leiden Raad van Toewijzing
  • KNMP Programmacommissie Wetenschappelijke Bijeenkomsten
  • Stichting Galenusprijs Jury Galenusprijzen
  • Treeway Member Scientific Advisory Board
  • Lorenz Center Member Life Sciences Board
  • LUMC Jury Prof. S.E. De Jongh Prijs
  • American Society for Clinical Pharmacology and Therapeutics Strategic Planning Taskforce
  • Centre for Human Drug Research (CHDR), Leiden Voorzitter Scientific Advisory Board
  • Virtual Liver Network, Germany Scientific Advisory Board
  • American Society for Clinical Pharmacology & Therapeutics Editor-in-Chief
  • Saltwood Consultants & Xenologiq Consultancy