Peter ten Dijke
Hoogleraar Moleculaire Celbiologie, in het bijzonder de signaaltransductie
- Naam
- Prof.dr. P. ten Dijke
- Telefoon
- +31 71 526 9270
- p.ten_dijke@lumc.nl
- ORCID iD
- 0000-0002-7234-342X
• Sectie Hoofd “Cancer Signaling Networks and Molecular Therapeutics”, Afdeling Cel en Chemische Biologie, LUMC • Onderzoeker Oncode Institute • Eredoctororaat van Uppsala Universiteit (2005) • Gast professor aan Uppsala Universiteit Sweden, Tsukuba Universiteit, Japan en Zhejiang Universiteit, China.
Meer informatie over Peter ten Dijke
Zie ook
Cel signalering
Mijn onderzoek richt zich op hoe menselijke cellen signalen opvangen en afgeven om daarmee elkaars gedrag te beïnvloeden. Inzicht daarin is van groot belang om allerlei levensprocessen te begrijpen. Bijvoorbeeld hoe uit een bevruchte eicel een embryo ontstaat. Of hoe een kankercelongecontroleerd gaat groeien en zich verspreidt naar andere organen. Bovendien kunnen we deze kennis toepassen bij de ontwikkeling van nieuwe geneesmiddelen om het ontregelde proces weer terug in balans te brengen. Ten Dijke onderzoekt hoe de corruptie van deze normale processen leidt tot verschillende ziektes, waaronder kanker, hart- en vaatziekten en fibrose. Bovendien kan de modulatie van deze signaaltransductie routes krachtige regeneratieve effecten induceren.
De “one size fits all”-aanpak van de geneeskunde is aan het veranderen. In de afgelopen jaren is er een fundamentele stap gezet naar behandelingen die zijn toegesneden op de specifieke behoeften van patiënten. Ten Dijke ontwerpt hulpmiddelen om deze paradigmaverschuiving in de patiëntenzorg mogelijk te maken.
Wetenschappelijke carrière
Peter ten Dijke begon in 1979 met de studie Moleculaire wetenschappen aan de Landbouwuniversiteit Wageningen en behaalde zijn doctoraal in januari 1987. Zijn interesse voor toegepast kankeronderzoek bracht hem bij het Amerikaanse bedrijf Oncogene Science in New York, waar hij het derde lid van de TGF-β familie identificeerde. Op basis van de resultaten van zijn onderzoek uitgevoerd in New York promoveerde hij in 1991 aan de Landbouwuniversiteit Wageningen. Zijn post-doctoraal onderzoek deed Ten Dijke aan het Ludwiginstituut voor kankeronderzoek in Uppsala in Zweden. Tijdens deze twee jaar identificeerde hij een groot aantal receptoren voor verschillende TGF-β familieleden. In 1999 kwam Ten Dijke weer naar Nederland. Hij werkte vijf jaar bij het Nederlands Kanker Instituut in Amsterdam, waar zijn onderzoek een belangrijke bijdrage heeft geleverd aan de kennis over de rol van TGF-β in kanker. Sinds 2005 is hij werkzaam bij de afdeling cel en chemische biologie van het LUMC.
Ten Dijke is per 1 juni 2005 benoemd tot hoogleraar in de Faculteit der Geneeskunde op het gebied van de moleculaire celbiologie, in het bijzonder de signaaltransductie. Titel van zijn oratie: “Met signaaltransductie terug in balans”.
Prijzen en eervolle benoemingen
- Lange-termijn EMBO Fellowship (1992-1993),
- Kleine Fernström prijs voor beloftevolle wetenschapper in Zweden (1998),
- VICI persoonlijke subsidie van NWO-MW (2006)
- LUMC onderwijs prijs voor beste cursus biomedische wetenschappen (2010),
- Chang Jiang Scholar prijs van Chinese ministerie van onderwijs. FEBS nationale lecture prijs (2015),
- Noreen Cunningham lecture prijs (2015)
- EMBO member (2016).
- Member of the Royal Netherlands Academy of Science
- Member of European Academy (2021)
Hoogleraar Moleculaire Celbiologie, in het bijzonder de signaaltransductie
- Faculteit Geneeskunde
- Divisie 4
- Cel en Chemische biologie
- Gu, Y.Z.; Zhang, Z.K. & Dijke, P. ten (2023), Harnessing epithelial-mesenchymal plasticity to boost cancer immunotherapy, Cellular & Molecular Immunology 20(4): 318-340.
- Gu, Y.Z.; Zhang, Z.K.; Camps, M.G.M.; Ossendorp, F.; Wijdeven, R.H. & Dijke, P. ten (2023), Genome-wide CRISPR screens define determinants of epithelial-mesenchymal transition mediated immune evasion by pancreatic cancer cells, Science Advances 9(28).
- Rotteveel, L.; Poot, A.J.; Kooijman, E.J.M.; Schuit, R.C.; Schalij, I.; Sun, X.Q.; Kurakula, K.; Happé, C.; Beaino, W.; Dijke, P. ten; Lammertsma, A.A.; Bogaard, H.J. & Windhorst, A.D. (2023), Genome-wide CRISPR screens define determinants of epithelial-mesenchymal transition mediated immune evasion by pancreatic cancer cells, EJNMMI Research 9(28).
- Groeneveldt, C.; Ginkel, J.Q.; Kinderman, P.; Sluijter, M.; Griffioen, L.; Labrie, C.; Wollenberg, D.J.M. van den; Hoeben, R.C.; Burg, S.H. van der; Dijke, P. ten; Hawinkels, L.J.A.C.; Hall, T. van & Montfoort, N. van (2023), Intertumoral differences dictate the outcome of TGF-β blockade on the efficacy of viro-immunotherapy, Cancer Research Communications 3(2): 325-337.
- Hao, Y.; Ji, Z.H.; Zhou, H.Z.; Wu, D.R.; Gu, Z.L.; Wang, D.X. & Dijke, P. ten (2023), Lipid-based nanoparticles as drug delivery systems for cancer immunotherapy, MEDCOMM 4(4).
- Fan, C.N.; Wang, Q.; Kuipers, T.B.; Cats, D.; Iyengar, P.V.; Hagenaars, S.C.; Mesker, W.E.; Devilee, P.; Tollenaar, R.A.E.M.; Mei, H.L. & Dijke, P. ten (2023), LncRNA LITATS1 suppresses TGF-β-induced EMT and cancer cell plasticity by potentiating TβRI degradation, The EMBO Journal 42.
- Carter, E.P.; Yoneten, K.K.; Gavara, N.; Tyler, E.J.; Gauthier, V.; Murray, E.R.; Dijke, P. ten; Cameron, A.J.; Pearce, O. & Grose, R.P. (2023), Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function, The Journal of Pathology 262.
- Marvin, D.L.; Dijkstra, J.; Zulfiqar, R.M.; Vermeulen, M.; Dijke, P. ten & Ritsma, L. (2023), TGF-β type I receptor signaling in melanoma liver metastases increases metastatic outgrowth, International Journal of Molecular Sciences 24(10).
- Fan, C.N.; González-Prieto, R.; Kuipers, T.B.; Vertegaal, A.C.O.; Veelen, P.A. van; Mei, H.L. & Dijke, P. ten (2023), The lncRNA LETS1 promotes TGF-β-induced EMT and cancer cell migration by transcriptionally activating a TβR1-stabilizing mechanism, Science Signaling 16(790).
- Rahman, Z.; Bordoloi, A.D.; Rouhana, H.; Tavasso, M.; Zon, G. van der; Garbin, V.; Dijke, P. ten & Boukany, P.E. (2023), Interstitial flow potentiates TGF-β/Smad-signaling activity in lung cancer spheroids in a 3D-microfluidic chip, Lab on a Chip 24(3).
- Hao, Y.; Ma, S.; Gu, Z.L.; Haghparast, A.; Schomann, T.; Yu, Z.F.; He, Y.Y.; Dong, X.X.; Cruz, L.J. & Dijke, P. ten (2023), Combination of photodynamic therapy and stimulator of interferon genes (STING) agonist inhibits colorectal tumor growth and recurrence, Cancer Communications 43(4).
- Liu, S.J.; Dinther, M. van; Hagenaars, S.C.; Gu, Y.Z.; Kuipers, T.B.; Mei, H.L.; Gomez-Puerto, M.C.; Mesker, W.E. & Dijke, P. ten (2023), Differential optineurin expression controls TGF beta signaling and is a key determinant for metastasis of triple negative breast cancer, International Journal of Cancer 152(12).
- Zhang, J.; Dinther, M. van; Thorikay, M.; Gourabi, B.M.; Kruithof, B.P.T. & Dijke, P. ten (2023), Opposing USP19 splice variants in TGF-beta signaling and TGF-beta-induced epithelial-mesenchymal transition of breast cancer cells, Cellular and Molecular Life Sciences 80(2).
- Gao, Z.C.; Houthuijzen, J.M.; Dijke, P. ten & Brazil, D.P. (2023), GREM1 signaling in cancer, Journal of Cell Communication and Signaling 17.
- Dinther, M. van; Cunningham, K.T.; Singh, S.P.; White, M.P.J.; Campion, T.; Ciancia, C.; Veelen, P.A. van; Ru, A.H. de; González-Prieto, R.; Mukundan, A.; Byeon, C.H.; Staggers, S.R.; Hinck, C.S.; Hinck, A.P.; Dijke, P. ten & Maizels, R.M. (2023), CD44 acts as a coreceptor for cell- specific enhancement of signaling and regulatory T cell induction by TGM1, a parasite TGF-β mimic, Proceedings of the National Academy of Sciences 120(34).
- Gu, Z.L.; Hao, Y.; Schomann, T.; Ossendorp, F.; Dijke, P. ten & Cruz, L.J. (2023), Enhancing anti-tumor immunity through liposomal oxaliplatin and localized immunotherapy via STING activation, Journal of Controlled Release 357: 531-544.
- Xie, F.; Zhou, X.X.; Li, H.Y.; Su, P.; Liu, S.J.; Li, R.; Zou, J.; Wei, X.; Pan, C.; Zhang, Z.K.; Zheng, M.; Liu, Z.; Meng, X.L.; Ovaa, H.; Dijke, P. ten; Zhou, F.F. & Zhang, L. (2022), USP8 promotes cancer progression and extracellular vesicle-mediated CD8+T cell exhaustion by deubiquitinating the TGF-beta receptor T beta RII, The EMBO Journal 41(16).
- Hao, Y.; Chung, C.K.; Yu, Z.F.; Veld, R.H.I.V. 't; Ossendorp, F.A.; Dijke, P. ten & Cruz, L.J. (2022), Combinatorial therapeutic approaches with nanomaterial-based photodynamic cancer therapy, Pharmaceutics 14(1).
- Iyengar, P.V.; Marvin, D.L.; Lama, D.; Tan, T.Z.; Suriyamurthy, S.; Xie, F.; Dinther, M. van; Mei, H.L.; Verma, C.S.; Zhang, L.; Ritsma, L. & Dijke, P. ten (2022), TRAF4 inhibits bladder cancer progression by promoting BMP/SMAD signaling, Molecular Cancer Research 20(10): 1516-1531.
- Huang, Y.S.; Liu, S.J.; Shan, M.J.; Hagenaars, S.C.; Mesker, W.E.; Cohen, D.; Wang, L.; Zheng, Z.; Devilee, P.; Tollenaar, R.A.E.M.; Li, Z.F.; Song, Y.M.; Zhang, L.; Li, D. & Dijke, P. ten (2022), RNF12 is regulated by AKT phosphorylation and promotes TGF-beta driven breast cancer metastasis, Cell Death and Disease 13(1).
- Marvin, D.L.; You, L.; Bornes, L.; Dinther, M. van; Peters, N.; Dang, H.; Hakuno, S.K.; Hornsveld, M.; Kranenburg, O.; Rheenen, J. van; Rohling, J.H.T.; Chien, M.P.; Dijke, P. ten & Ritsma, L. (2022), Dynamic visualization of TGF-beta/SMAD3 transcriptional responses in single living cells, Cancers 14(10).
- Sinha A.; Mehta P.; Fan C.; Zhang J.; Marvin D.L.; Dinther M. van; Ritsma L.; Boukany P.E. & Dijke P. ten (2022), Visualizing Dynamic Changes During TGF-β-Induced Epithelial to Mesenchymal Transition , Methods in molecular biology (Clifton, N.J.) 2488.
- Schmid, C.D.; Olsavszky, V.; Reinhart, M.; Weyer, V.; Trogisch, F.A.; Sticht, C.; Winkler, M.; Kurschner, S.W.; Hoffmann, J.; Ola, R.; Staniczek, T.; Heineke, J.; Straub, B.K.; Mittler, J.; Schledzewski, K.; Dijke, P. ten; Richter, K.; Dooley, S.; Geraud, C.; Goerdt, S. & Koch, P.S. (2022), ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver, Hepatology 77(4).
- Mehta, P.; Rahman, Z.; Dijke, P. ten & Boukany, P.E. (2022), Microfluidics meets 3D cancer cell migration, TRENDS IN CANCER 8(8): 683-697.
- Liu, Q.; Muralidharan, A.; Saateh, A.; Ding, Z.Y.; Dijke, P. ten & Boukany, P.E. (2022), A programmable multifunctional 3D cancer cell Invasion micro platform, Small 18(20).
- Marvin, D.L.; Spaans, V.M.; Kroon, C.D. de; Slieker, R.C.; Khelil, M.; Dijke, P. ten; Ritsma, L. & Jordanova, E.S. (2022), Low transforming growth factor-beta pathway activity in cervical adenocarcinomas, Frontiers in Oncology 12.
- Yan, X.H.; Zhang, L.; Miyazawa, K. & Dijke, P. ten (2022), Editorial: TGF-beta and BMP signaling in cancer, Frontiers in Cell and Developmental Biology 10.
- Guilliams, M.; Bonnardel, J.; Haest, B.; Vanderborght, B.; Wagner, C.; Remmerie, A.; Bujko, A.; Martens, L.; Thone, T.; Browaeys, R.; Ponti, F.F. de; Vanneste, B.; Zwicker, C.; Svedberg, F.R.; Vanhalewyn, T.; Goncalves, A.; Lippens, S.; Devriendt, B.; Cox, E.; Ferrero, G.; Wittamer, V.; Willaert, A.; Kaptein, S.J.F.; Neyts, J.; Dallmeier, K.; Geldhof, P.; Casaert, S.; Deplancke, B.; Dijke, P. ten; Hoorens, A.; Vanlander, A.; Berrevoet, F.; Nieuwenhove, Y. van; Saeys, Y.; Saelens, W.; Vlierberghe, H. van; Devisscher, L. & Scott, C.L. (2022), Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches, Cell 185(2): 379-+.
- Rotteveel, L.; Kurakula, K.; Kooijman, E.J.M.; Schuit, R.C.; Verlaan, M.; Schreurs, M.; Beaino, W.; Dinther, M.A.H. van; Dijke, P. ten; Lammertsma, A.A.; Poot, A.J.; Bogaard, H.J. & Windhorst, A.D. (2022), Synthesis and preclinical evaluation of [C-11]LR111 and [F-18]EW-7197 as PET tracers of the activin-receptor like kinase-5, Nuclear Medicine and Biology 112: 9-19.
- Orlova, V.V.; Nahon, D.M.; Cochrane, A.; Cao, X.; Freund, C.; Hil, F. van den; Westermann, C.J.J.; Snijder, R.J.; Amstel, J.K.P. van; Dijke, P. ten; Lebrin, F.; Mager, H.J. & Mummery, C.L. (2022), Vascular defects associated with hereditary hemorrhagic telangiectasia revealed in patient-derived isogenic iPSCs in 3D vessels on chip, Stem Cell Reports 17(7): 1536-1545.
- Lin, T.; Wang, S.S.; Munker, S.; Jung, K.; Macias-Rodriguez, R.U.; Ruiz-Margain, A.; Schierwagen, R.; Liu, H.; Shao, C.; Fan, C.L.; Feng, R.L.; Yuan, X.D.; Wang, S.; Wandrer, F.; Meyer, C.; Wimmer, R.; Liebe, R.; Kroll, J.; Zhang, L.; Schiergens, T.; Dijke, P. ten; Teufel, A.; Marx, A.; Mertens, P.R.; Wang, H.; Ebert, M.P.A.; Bantel, H.; Toni, E. de; Trebicka, J.; Dooley, S.; Shin, D.; Ding, H.G. & Weng, H.L. (2022), Follistatin-controlled activin-HNF4 alpha-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure, Hepatology 75(2): 322-337.
- Fan, C.N.; Wang, Q.; Zon, G. van der; Ren, J.; Agaser, C.; Slieker, R.C.; Iyengar, P.V.; Mei, H.L. & Dijke, P. ten (2022), OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-beta type I receptor, Signal Transduction and Targeted Therapy 7(1).
- Guo, J.X.; Liu, B.; Thorikay, M.; Yu, M.M.; Li, X.Y.; Tong, Z.; Salmon, R.M.; Read, R.J.; Dijke, P. ten; Morrell, N.W. & Li, W. (2022), Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10, Nature Communications 13(1).
- Zhang, J.; Zon, G. van der; Ma, J.; Mei, H.L.; Cabukusta, B.; Agaser, C.C.; Madunic, K.; Wuhrer, M.; Zhang, T. & Dijke, P. ten (2022), ST3GAL5-catalyzed gangliosides inhibit TGF-beta-induced epithelial-mesenchymal transition via T beta RI degradation, The EMBO Journal 42.
- Duurland, C.L.; Santegoets, S.J.; Abdulrahman, Z.; Loof, N.M.; Sturm, G.; Wesselink, T.H.; Arens, R.; Boekestijn, S.; Ehsan, I.; Poelgeest, M.I.E. van; Finotello, F.; Hackl, H.; Trajanoski, Z.; Dijke, P. ten; Braud, V.M.; Welters, M.J.P. & Burg, S.H. van der (2022), CD161 expression and regulation defines rapidly responding effector CD4+T cells associated with improved survival in HPV16-associated tumors, Journal for ImmunoTherapy of Cancer 10(1).
- Li C.; Ma J.; Groenewoud A;. Ren J.; Liu S.; Snaar-Jagalska, B.E. & Dijke, P. ten (2022), Establishment of Embryonic Zebrafish Xenograft Assays to Investigate TGF-β Family Signaling in Human Breast Cancer Progression , Methods in molecular biology (Clifton, N.J.) 2488.
- Liu, S.; Wang, Y.; Thaler, M.; Schadewijk, A. van; Huizen, M. van; Cohen, D.; Kikkert, M.; Hemert, M.J. van; Dijke, P. ten; Hiemstra, P.S. & Does, A.M. van der (2022), Developing advanced cell culture models to study COVID-19-associated pulmonary fibrosis, European Respiratory Journal 60.
- Xie, F.; Zhou, X.X.; Su, P.; Li, H.Y.; Tu, Y.F.; , J.J. du; Pan, C.; Wei, X.; Zheng, M.; Jin, K.; Miao, L.Y.; Wang, C.; Meng, X.L.; Dam, H. van; Dijke, P. ten; Zhang, L. & Zhou, F.F. (2022), Breast cancer cell-derived extracellular vesicles promote CD8(+) T cell exhaustion via TGF-beta type II receptor signaling, Nature Communications 13(1).
- Hao, Y.; Gu, Z.L.; Yu, Z.F.; Schomann, T.; Sayedipour, S.; Aguilar, J.C.; Dijke, P. ten & Cruz, L.J. (2022), Photodynamic therapy in combination with the Hepatitis B Core Virus-like Particles (HBc VLPs) to prime anticancer immunity for colorectal cancer treatment, Cancers 14(11).
- Hao, Y.; Chung, C.K.; Gu, Z.L.; Schomann, T.; Dong, X.X.; Veld, R.V.H. in 't; Camps, M.G.M.; Dijke, P. ten; Ossendorp, F.A. & Cruz, L.J. (2022), Combinatorial therapeutic approaches of photodynamic therapy and immune checkpoint blockade for colon cancer treatment, Molecular Biomedicine 3.
- Tsubakihara, Y.; Ohata, Y.; Okita, Y.; Younis, S.; Eriksson, J.; Sellin, M.E.; Ren, J.; Dijke, P. ten; Miyazono, K.; Hikita, A.; Imamura, T.; Kato, M.; Heldin, C.H. & Moustakas, A. (2022), TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition, Molecular Oncology 16(12): 2330-2354.
- Ma, J.; Sanchez-Duffhues, G.; Caradec, J.; Benderitter, P.; Hoflack, J. & Dijke, P. ten (2022), Development of small macrocyclic kinase inhibitors, FUTURE MEDICINAL CHEMISTRY 14(6): 389-391.
- Zhang, J.; Zhang, Z.J.; Holst, S.; Bloechl, C.; Madunic, K.; Wuhrer, M.; Dijke, P. ten & Zhang, T. (2022), Transforming growth factor-beta challenge alters the N-, O-, and glycosphingolipid glycomes in PaTu-S pancreatic adenocarcinoma cells, Journal of Biological Chemistry 298(3).
- Bulk, J. van den; Miranda, N.F.C.C. de & Dijke, P. ten (2021), Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression, CLINICAL SCIENCE 135(1).
- Sinha, A.; Iyengar, P.V. & Dijke, P. ten (2021), E3 ubiquitin ligases: key regulators of TGF beta signaling in cancer progression, International Journal of Molecular Sciences 22(2).
- Li, C.; Teixeira, A.F.; Zhu, H.J. & Dijke, P. ten (2021), Cancer associated-fibroblast-derived exosomes in cancer progression, Molecular Cancer 20(1).
- Liu, S.J.; Ren, J. & Dijke, P. ten (2021), Targeting TGF beta signal transduction for cancer therapy, Signal Transduction and Targeted Therapy 6(1).
- Ma, J.; Zon, G. van der; Goncalves, M.A.F.V.; Dinther, M. van; Thorikay, M.; Sanchez-Duffhues, G. & Dijke, P. ten (2021), TGF-beta-induced endothelial to mesenchymal transition is determined by a balance between SNAIL and ID factors, Frontiers in Cell and Developmental Biology 9.
- Ruiter, R.D. de; Smilde, B.J.; Pals, G.; Bravenboer, N.; Knaus, P.; Schoenmaker, T.; Botman, E.; Sanchez-Duffhues, G.; Pacifici, M.; Pignolo, R.J.; Shore, E.M.; Egmond, M. van; Oosterwyck, H. van; Kaplan, F.S.; Hsiao, E.C.; Yu, P.B.; Bocciardi, R.; Cunto, C.L. de; Delai, P.L.R.; Vries, T.J. de; Hilderbrandt, S.; Jaspers, R.T.; Keen, R.; Koolwijk, P.; Morhart, R.; Netelenbos, J.C.; Rustemeyer, T.; Scott, C.; Stockklausner, C.; Dijke, P. ten; Triffit, J.; Ventura, F.; Ravazzolo, R.; Micha, D. & Eekhoff, E.M.W. (2021), Fibrodysplasia ossificans progressiva: what have we achieved and where are we now?, Frontiers in Endocrinology 12.
- Hua, W.; Kostidis, S.; Mayboroda, O.; Giera, M.; Hornsveld, M. & Dijke, P. ten (2021), Metabolic reprogramming of mammary epithelial cells during TGF-beta-induced epithelial-to-mesenchymal transition, Metabolites 11(9).
- Kurakula, K.; Hagdorn, Q.A.J.; Feen, D.E. van der; Noordegraaf, A.V.; Dijke, P. ten; Boer, R.A. de; Bogaard, H.J.; Goumans, M.J. & Berger, R.M.F. (2021), Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-beta signalling, Angiogenesis 25.
- Ma, J.; Zon, G. van der; Sanchez-Duffhues, G. & Dijke, P. ten (2021), TGF-beta-mediated endothelial to mesenchymal transition (EndMT) and the functional assessment of EndMT effectors using CRISPR/Cas9 gene editing, Journal of Visualized Experiments.
- Dadras, M.S.; Caja, L.; Mezheyeuski, A.; Liu, S.J.; Gelabert, C.; Gomez-Puerto, M.C.; Gallini, R.; Rubin, C.J.; Dijke, P. ten; Heldin, C.H. & Moustakas, A. (2021), The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma, Cell Death and Disease 12(10).
- Bulk, J. van den; Miranda, N.F.C.C. de & Dijke, P. ten (2021), Therapeutic targeting of TGF-beta in cancer: hacking a master switch of immune suppression, Clinical Science 135(1): 35-52.
- Prunier, C.; Alay, A.; Dijk, M. van; Ammerlaan, K.L.; Gelderen, S. van; Marvin, D.L.; Teunisse, A.; Slieker, R.C.; Szuhai, K.; Jochemsen, A.G.; Sole, X.; Dijke, P. ten & Ritsma, L. (2021), Breast cancer dormancy is associated with a 4NG1 state and not senescence, npj Breast Cancer 7(1).
- Caja, L.; Dadras, M.S.; Mezheyeuski, A.; Rodrigues-Junior, D.M.; Liu, S.J.; Webb, A.T.; Gomez-Puerto, M.C.; Dijke, P. ten; Heldin, C.H. & Moustakas, A. (2021), The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma, Journal of Cellular Physiology 237(1).
- Ma, J.; Ren, J.; Thorikay, M.; Dinther, M. van; Sanchez-Duffhues, G.; Caradec, J.; Benderitter, P.; Hoflack, J. & Dijke, P. ten (2021), Inhibiting endothelial cell function in normal and tumor angiogenesis using BMP type I receptor macrocyclic kinase inhibitors, Cancers 13(12).
- Hwang, J.; Suzuki, H.; Zhang, J.; Iyengar, P.V.; Dijke, P. ten & Kato, M. (2021), THG-1 overexpression stabilizes beta-catenin via antagonizing NRBP1 in esophageal squamous cell carcinoma, Cancer Science 112: 431-431.
- Dijke, P. ten & Baker, D. (2021), Fine-tuning ALK1 linear polyubiquitination to control angiogenesis, Trends in Cell Biology 31(9): 705-707.
- Li, L.; Ugalde, A.P.; Scheele, C.L.G.J.; Dieter, S.M.; Nagel, R.; Ma, J.; Pataskar, A.; Korkmaz, G.; Elkon, R.; Chien, M.P.; You, L.; Su, P.R.; Bleijerveld, O.B.; Altelaar, M.; Momchev, L.; Manber, Z.; Han, R.Q.; Breugel, P.C. van; Lopes, R.; Dijke, P. ten; Rheenen, J. van & Agami, R. (2021), A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis, Genome Biology 22(1).
- Kenswil, K.J.G.; Pisterzi, P.; Sanchez-Duffhues, G.; Dijk, C. van; Lolli, A.; Knuth, C.; Vanchin, B.; Jaramillo, A.C.; Hoogenboezem, R.M.; Sanders, M.A.; Feyen, J.; Cupedo, T.; Costa, I.G.; Li, R.H.; Bindels, E.M.J.; Lodder, K.; Blom, B.; Bos, P.K.; Goumans, M.J.; Dijke, P. ten; Farrell, E.; Krenning, G. & Raaijmakers, M.H.G.P. (2021), Endothelium-derived stromal cells contribute to hematopoietic bone marrow niche formation, Cell Stem Cell 28(4): 653-+.
- Vinuesa, A.G. de; Sanchez-Duffhues, G.; Blaney-Davidson, E.; Caam, A. van; Lodder, K.; Ramos, Y.; Kloppenburg, M.; Meulenbelt, I.; Kraan, P. van der; Goumans, M.J. & Dijke, P. ten (2021), Cripto favors chondrocyte hypertrophy via TGF-beta SMAD1/5 signaling during development of osteoarthritis, The Journal of Pathology 255(3).
- Ventura, F.; Williams, E.; Ikeya, M.; Bullock, A.N.; Dijke, P. ten; Goumans, M.J. & Sanchez-Duffhues, G. (2021), Challenges and opportunities for drug repositioning in fibrodysplasia ossificans progressiva, Biomedicines 9(2).
- Sanchez-Duffhues, G.; Williams, E.; Goumans, M.J.; Heldin, C.H. & Dijke, P. ten (2020), Bone morphogenetic protein receptors: structure, function and targeting by selective small molecule kinase inhibitors, Bone 138.
- Hoeksma, J.; Zon, G.C.M. van der; Dijke, P. ten & Hertog, J. den (2020), Cercosporamide inhibits bone morphogenetic protein receptor type I kinase activity in zebrafish, Disease Models and Mechanisms 13(9).
- Barone, M.; Muller, M.; Chiha, S.; Ren, J.; Albat, D.; Soicke, A.; Dohmen, S.; Klein, M.; Bruns, J.; Dinther, M. van; Opitz, R.; Lindemann, P.; Beerbaum, M.; Motzny, K.; Roske, Y.; Schmieder, P.; Volkmer, R.; Nazare, M.; Heinemann, U.; Oschkinat, H.; Dijke, P. ten; Schmalz, H.G. & Kuhne, R. (2020), Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells, Proceedings of the National Academy of Sciences 117(47): 29684-29690.
- Dijke, P. ten & Baker, D. (2020), Controlling smad4 signaling with a wip, EMBO Reports 21(5).
- Capelle, C.D. van; Spit, M. & Dijke, P. ten (2020), Current perspectives on inhibitory SMAD7 in health and disease, Critical Reviews in Biochemistry and Molecular Biology 55(6): 691-715.
- Zhang, T.; Madunic, K.; Holst, S.; Zhang, J.; Jin, C.S.; Dijke, P. ten; Karlsson, N.G.; Stavenhagen, K. & Wuhrer, M. (2020), Development of a 96-well plate sample preparation method for integratedN- andO-glycomics using porous graphitized carbon liquid chromatography-mass spectrometry, Molecular Omics 16(4): 355-363.
- Zhang, T.; , I. van die; Tefsen, B.; Vliet, S.J. van; Laan, L.C.; Zhang, J.; Dijke, P. ten; Wuhrer, M. & Belo, A.I. (2020), Differential O- and glycosphingolipid glycosylation in human pancreatic adenocarcinoma cells with opposite morphology and metastatic behavior, Frontiers in Oncology 10.
- Groeneveldt, C.; Hall, T. van; Burg, S.H. van der; Dijke, P. ten & Montfoort, N. van (2020), Immunotherapeutic Potential of TGF-beta Inhibition and Oncolytic Viruses, Trends in Immunology 41(5): 406-420.
- Vermeulen, S.; Roumans, N.; Honig, F.; Carlier, A.; Hebels, D.G.A.J.; Eren, A.D.; Dijke, P. ten; Vasilevich, A. & Boer, J. de (2020), Mechanotransduction is a context-dependent activator of TGF-beta signaling in mesenchymal stem cells, Biomaterials 259.
- Gomez-Puerto, M.C.; Sun, X.Q.; Schalij, I.; Orriols, M.; Pan, X.K.; Szulcek, R.; Goumans, M.J.; Bogaard, H.J.; Zhou, Q. & Dijke, P. ten (2020), MnTBAP reverses pulmonary vascular remodeling and improves cardiac function in experimentally induced pulmonary arterial hypertension, International Journal of Molecular Sciences 21(11).
- Fortin, J.; Tian, R.X.; Zarrabi, I.; Hill, G.; Williams, E.; Sanchez-Duffhues, G.; Thorikay, M.; Ramachandran, P.; Siddaway, R.; Wong, J.F.; Wu, A.; Apuzzo, L.N.; Haight, J.; You-Ten, A.; Snow, B.E.; Wakeham, A.; Goldhamer, D.J.; Schramek, D.; Bullock, A.N.; Dijke, P. ten; Hawkins, C. & Mak, T.W. (2020), Mutant ACVR1 arrests glial cell differentiation to drive tumorigenesis in pediatric gliomas, Cancer Cell 37(3): 308-+.
- Teixeira, A.F.; Dijke, P. ten & Zhu, H.J. (2020), On-target anti-TGF-beta therapies are not succeeding in clinical cancer treatments: what are remaining challenges?, Frontiers in Cell and Developmental Biology 8.
- Ren, J.; Wang, Y.H.; Ware, T.; Iaria, J.; Dijke, P. ten & Zhu, H.J. (2020), Reactivation of BMP signaling by suboptimal concentrations of MEK inhibitor and FK506 reduces organ-specific breast cancer metastasis, Cancer Letters 493: 41-54.
- Zhang, J.; Dijke, P. ten; Wuhrer, M. & Zhang, T. (2020), Role of glycosylation in TGF-beta signaling and epithelial-to-mesenchymal transition in cancer, Protein & Cell 12.
- Todd, G.M.; Gao, Z.C.; Hyvonen, M.; Brazil, D.P. & Dijke, P. ten (2020), Secreted BMP antagonists and their role in cancer and bone metastases, Bone 137.
- Kooij, R.; Liu, S.H.; Sapmaz, A.; Xin, B.T.; Janssen, G.M.C.; Veelen, P.A. van; Ovaa, H.; Dijke, P. ten & Geurink, P.P. (2020), Small-molecule activity-based probe for monitoring ubiquitin C-terminal hydrolase L1 (UCHL1) activity in live cells and zebrafish embryos, Journal of the American Chemical Society 142(39): 16825-16841.
- Sundqvist, A.; Vasilaki, E.; Voytyuk, O.; Bai, Y.; Morikawa, M.; Moustakas, A.; Miyazono, K.; Heldin, C.H.; Dijke, P. ten & Dam, H. van (2020), TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness, Oncogene 39(22): 4436-4449.
- Ma, J.; Sanchez-Duffhues, G.; Goumans, M.J. & Dijke, P. ten (2020), TGF-beta-induced endothelial to mesenchymal transition in disease and tissue engineering, Frontiers in Cell and Developmental Biology 8.
- Hua, W.; Dijke, P. ten; Kostidis, S.; Giera, M. & Hornsveld, M. (2020), TGF beta-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer, Cellular and Molecular Life Sciences 77(11): 2103-2123.
- Marvin, D.L.; Heijboer, R.; Dijke, P. ten & Ritsma, L. (2020), TGF-beta signaling in liver metastasis, Clinical and Translational Medicine 10(7).
- Addante, A.; Roncero, C.; Lazcanoiturburu, N.; Mendez, R.; Almale, L.; Garcia-Alvaro, M.; Dijke, P. ten; Fabregat, I.; Herrera, B. & Sanchez, A. (2020), A signaling crosstalk between BMP9 and HGF/c-met regulates mouse adult liver progenitor cell survival, Cells 9(3).
- Liu, S.J.; Gonzalez-Prieto, R.; Zhang, M.D.; Geurink, P.P.; Kooij, R.; Iyengar, P.V.; Dinther, M. van; Bos, E.; Zhang, X.B.; Devedec, S.E. le; Water, B. van de; Koning, R.I.; Zhu, H.J.; Mesker, W.E.; Vertegaal, A.C.O.; Ovaa, H.; Zhang, L.; Martens, J.W.M. & Dijke, P. ten (2020), Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGF beta-induced breast cancer metastasis, Clinical Cancer Research 26(6): 1460-1473.
- Trinanes, J.; Dijke, P. ten; Groen, N.; Hanegraaf, M.; Porrini, E.; Rodriguez-Rodriguez, A.E.; Drachenberg, C.; Rabelink, T.J.; Koning, E. de; Carlotti, F. & Vries, A.P.J. de (2020), Tacrolimus-Induced BMP/SMAD Signaling Associates With Metabolic Stress-Activated FOXO1 to Trigger beta-Cell Failure, Diabetes 69(2): 193-204.
- Hwang, J.C.; Haque, M.A.; Suzuki, H.; Dijke, P. ten & Kato, M. (2020), THG-1 suppresses SALL4 degradation to induce sternness genes and tumorsphere formation through antagonizing NRBP1 in squamous cell carcinoma cells, Biochemical and Biophysical Research Communications 523(2): 307-314.
- Li, Y.H.; Cui, C.; Xie, F.; Kielbasa, S.; Mei, H.L.; Dinther, M. van; Dam, H. van; Bauer, A.; Zhang, L. & Dijke, P. ten (2020), VprBP mitigates TGF-beta and Activin signaling by promoting Smurf1-mediated type I receptor degradation, Journal of Molecular Cell Biology 12(2): 138-151.
- Zhang, J.; Thorikay, M.; Zon, G. van der; Dinther, M. van & Dijke, P. ten (2020), Studying TGF-beta signaling and TGF-beta-induced epithelial-to-mesenchymal transition in breast cancer cells, Journal of Visualized Experiments.
- Marvin, D.L.; Heijboer, R.; Dijke, P. ten & Ritsma, L. (2020), TGF‐β signaling in liver metastasis, Clinical and Translational Medicine 10(7).
- Huynh, L.K.; Hipolito, C.J. & Dijke, P. ten (2019), A Perspective on the Development of TGF-beta Inhibitors for Cancer Treatment.
- Gomez-Puerto, M.C.; Zuijen, I. van; Huang, C.J.Z.; Szulcek, R.; Pan, X.K.; Dinther, M.A.H. van; Kurakula, K.; Wiesmeijer, C.C.; Goumans, M.J.; Bogaard, H.J.; Morrell, N.W.; Rana, A.A. & Dijke, P. ten (2019), Autophagy contributes to BMP type 2 receptor degradation and development of pulmonary arterial hypertension, Journal of Pathology 249(3): 356-367.
- Gomez-Puerto, M.C.; Iyengar, P.V.; Vinuesa, A.G. de; Dijke, P. ten & Sanchez-Duffhues, G. (2019), Bone morphogenetic protein receptor signal transduction in human disease, Journal of Pathology 247(1): 9-20.
- Ren, J.; Smid, M.; Iaria, J.; Salvatori, D.C.F.; Dam, H. van; Zhu, H.J.; Martens, J.W.M. & Dijke, P. ten (2019), Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression, Breast Cancer Research 21(1).
- Sim, W.J.; Iyengar, P.V.; Lama, D.; Lui, S.K.L.; Ng, H.C.; Haviv-Shapira, L.; Domany, E.; Kappei, D.; Tan, T.Z.; Saie, A.; Jaynes, P.W.; Verma, C.S.; Kumar, A.P.; Rouanne, M.; Ha, H.K.; Radulescu, C.; Dijke, P. ten; Eichhorn, P.J.A. & Thiery, J.P. (2019), c-Met activation leads to the establishment of a TGF beta-receptor regulatory network in bladder cancer progression, Nature Communications 10.
- Sow, H.S.; Ren, J.; Camps, M.; Ossendorp, F. & Dijke, P. ten (2019), Combined Inhibition of TGF- Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models.
- Rotteveel, L.; Poot, A.J.; Bogaard, H.J.; Dijke, P. ten; Lammertsma, A.A. & Windhorst, A.D. (2019), In vivo imaging of TGF beta signalling components using positron emission tomography, Drug Discovery Today 24(12): 2258-2272.
- Suriyamurthy, S.; Baker, D.; Dijke, P. ten & Iyengar, P.V. (2019), Epigenetic Reprogramming of TGF-beta Signaling in Breast Cancer, Cancers 11(5).
- Tran, S.T.P.; Hipolito, C.J.; Suzuki, H.; Xie, R.; Tuyen, H.D.K.; Dijke, P. ten; Terasaka, N.; Goto, Y.; Suga, H. & Kato, M. (2019), Generation of non-standard macrocyclic peptides specifically binding TSC-22 homologous gene-1, Biochemical and Biophysical Research Communications 516(2): 445-450.
- Neckmann, U.; Wolowczyk, C.; Hall, M.; Almaas, E.; Ren, J.; Zhao, S.; Johannessen, B.; Skotheim, R.I.; Bjorkoy, G.; Dijke, P. ten & Holien, T. (2019), GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients.
- Sanchez-Duffhues, G.; Vinuesa, A.G. de; Pol, V. van de; Geerts, M.E.; Vries, M.R. de; Janson, S.G.T.; Dam, H. van; Lindeman, J.H.; Goumans, M.J. & Dijke, P. ten (2019), Inflammation induces endothelial-to-mesenchymal transition and promotes vascular calcification through downregulation of BMPR2, Journal of Pathology 247(3): 333-346.
- Kurakula, K.; Sun, X.Q.; Happe, C.; Bos, D.D.G.; Szulcek, R.; Schalij, I.; Wiesmeijer, K.C.; Lodder, K.; Tu, L.; Guignabert, C.; Vries, C.J.M. de; Man, F.S. de; Noordegraaf, A.V.; Dijke, P. ten; Goumans, M.J. & Bogaard, H.J. (2019), Prevention of progression of pulmonary hypertension by the Nur77 agonist 6-mercaptopurine: role of BMP signalling, European Respiratory Journal 54(3).
- Sanchez-Duffhues, G.; Mikkers, H.; Jong, D. de; Szuhai, K.; Vries, T.J. de; Freund, C.; Bravenboer, N.; Es, R.J.J. van; Netelenbos, J.C.; Goumans, M.J.; Eekhoff, E.M.W. & Dijke, P. ten (2019), Generation of Fibrodysplasia ossificans progressiva and control integration free iPSC lines from periodontal ligament fibroblasts, Stem Cell Research 41.
- Lawera, A.; Tong, Z.; Thorikay, M.; Redgrave, R.E.; Cai, J.; Dinther, M. van; Morrell, N.W.; Afink, G.B.; Charnock-Jones, D.S.; Arthur, H.M.; Dijke, P. ten & Li, W. (2019), Role of soluble endoglin in BMP9 signaling, Proceedings of the National Academy of Sciences 116(36): 17800-17808.
- Trinanes, J.; Dijke, P. ten; Rabelink, T.J.; Koning, E.J. de; Carlotti, F. & Vries, A.P. de (2019), Tacrolimus Activated BMP Signaling Acts in Synergy with Stress-Activated FOXO1 to Induce Loss of Beta-Cell Function and Identity, American Journal of Transplantation 19: 960-961.
- Prunier, C.; Baker, D.; Dijke, P. ten & Ritsma, L. (2019), TGF-beta Family Signaling Pathways in Cellular Dormancy, TRENDS IN CANCER 5(1): 66-78.
- Hao, Y.; Baker, D. & Dijke, P. ten (2019), TGF--Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis.
- Hao, Y.; Baker, D. & Dijke, P. ten (2019), TGF-β-mediated epithelial-mesenchymal trransition and cancer metastasis, International Journal of Molecular Sciences 20(11).
- Man, S.; Duffhues, G.S.; Dijke, P. ten & Baker, D. (2019), The therapeutic potential of targeting the endothelial-to-mesenchymal transition, Angiogenesis 22(1): 3-13.
- Sundqvist, A.; Voytyuk, O.; Hamdi, M.; Popeijus, H.E.; Bijlsma-van der Burgt, C.; Janssen, J.; Martens, J.W.M.; Moustakas, A.; Heldin, C.H.; Dijke, P. ten & Dam, H. van (2019), JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses, Cells 8(12).
- Nickel, J.; Dijke, P. ten & Mueller, T.D. (2018), TGF-beta family co-receptor function and signaling, Acta Biochimica et Biophysica Sinica 50(1): 12-36.
- Staalduinen, J. van; Baker, D.; Dijke, P. ten & Dam, H. van (2018), Epithelial-mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?, Oncogene 37(48): 6195-6211.
- Paauwe, M.; Schoonderwoerd, M.J.A.; Helderman, R.F.C.P.; Harryvan, T.J.; Groenewoud, A.; Pelt, G.W. van; Bor, R.; Hemmer, D.M.; Versteeg, H.H.; Snaar-Jagalska, B.E.; Theuer, C.P.; Hardwick, J.C.H.; Sier, C.F.M.; Dijke, P. ten & Hawinkels, L.J.A.C. (2018), Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis, Clinical Cancer Research 24(24): 6331-6344.
- Sanchez-Duffhues, G.; Vinuesa, A.G. de & Dijke, P. ten (2018), Endothelial-to-mesenchymal transition in cardiovascular diseases: Developmental signaling pathways gone awry, Developmental Dynamics 247(3): 492-508.
- Goumans, M.J.; Zwijsen, A.; Dijke, P. ten & Bailly, S. (2018), Bone Morphogenetic Proteins in Vascular Homeostasis and Disease, Cold Spring Harbor perspectives in biology 10(2).
- Sundqvist, A.; Morikawa, M.; Ren, J.; Vasilaki, E.; Kawasaki, N.; Kobayashi, M.; Koinuma, D.; Aburatani, H.; Miyazono, K.; Heldin, C.H.; Dam, H. van & Dijke, P. ten (2018), JUNB governs a feed-forward network of TGF beta signaling that aggravates breast cancer invasion, Nucleic Acids Research 46(3): 1180-1195.
- Addante, A.; Roncero, C.; Almale, L.; Lazcanoiturburu, N.; Garcia-Alvaro, M.; Fernandez, M.; Sanz, J.; Hammad, S.; Nwosu, Z.C.; Lee, S.J.; Fabregat, I.; Dooley, S.; Dijke, P. ten; Herrera, B. & Sanchez, A. (2018), Bone morphogenetic protein 9 as a key regulator of liver progenitor cells in DDC-induced cholestatic liver injury, Liver International 38(9): 1664-1675.
- Goumans, M.J. & Dijke, P. ten (2018), TGF-beta Signaling in Control of Cardiovascular Function, Cold Spring Harbor perspectives in biology 10(2).
- Breitkopf-Heinlein, K.; Meyer, C.; Konig, C.; Gaitantzi, H.; Addante, A.; Thomas, M.; Wiercinska, E.; Cai, C.; Li, Q.; Wan, F.Q.; Hellerbrand, C.; Valous, N.A.; Hahnel, M.J.; Ehlting, C.; Bode, J.G.; Mueller-Bohl, S.; Klingmuller, U.; Altenoder, J.; Ilkavets, I.; Goumans, M.J.; Hawinkels, L.J.A.C.; Lee, S.J.; Wieland, M.; Mogler, C.; Ebert, M.P.; Herrera, B.; Augustin, H.G.; Sanchez, A.; Dooley, S. & Dijke, P. ten (2017), BMP-9 interferes with liver regeneration and promotes liver fibrosis, Gut 66(5): 939-954.
- Orriols, M.; Gomez-Puerto, M.C. & Dijke, P. ten (2017), BMP type II receptor as a therapeutic target in pulmonary arterial hypertension, Cellular and Molecular Life Sciences 74(16): 2979-2995.
- Chen, X.; Orriols, M.; Walther, F.J.; Laghmani, E.H.; Hoogeboom, A.M.; Hogen-Esch, A.C.B.; Hiemstra, P.S.; Folkerts, G.; Goumans, M.J.T.H.; Dijke, P. ten; Morrell, N.W. & Wagenaar, G.T.M. (2017), Bone Morphogenetic Protein 9 Protects against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation, Frontiers in Physiology 8.
- Zhang, Z.K.; Fan, Y.; Xie, F.; Zhou, H.; Jin, K.; Shao, L.; Shi, W.H.; Fang, P.F.; Yang, B.; Dam, H. van; Dijke, P. ten; Zheng, X.F.; Yan, X.H.; Jia, J.L.; Zheng, M.; Jin, J.; Ding, C.; Ye, S.; Zhou, F.F. & Zhang, L. (2017), Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7, Nature Communications 8.
- Thomse, L.H.; Fog-Tonnesen, M.; Fink, L.N.; Norlin, J.; Vinuesa, A.G. de; Hansen, T.K.; Heer, E.D.; Dijke, P. ten & Rosendahl, A. (2017), Disparate phospho-Smad2 levels in advanced type 2 diabetes patients with diabetic neuropathy and early experimental db/db mouse model, Renal Failure 39(1): 629-642.
- Xie, F.; Jin, K.; Shao, L.; Fan, Y.; Tu, Y.F.; Li, Y.H.; Yang, B.; Dam, H. van; Dijke, P. ten; Weng, H.L.; Dooley, S.; Wang, S.A.; Jia, J.L.; Jin, J.; Zhou, F.F. & Zhang, L. (2017), FAF1 phosphorylation by AKT accumulates TGF-beta type II receptor and drives breast cancer metastasis, Nature Communications 8.
- Drabsch, Y.; Snaar-Jagalska, B.E. & Dijke, P. ten (2017), Fish tales: The use of zebrafish xenograft human cancer cell models, Histology and Histopathology 32(7): 673-686.
- Kunnen, S.J.; Leonhard, W.N.; Semeins, C.; Hawinkels, L.J.A.C.; Poelma, C.; Dijke, P. ten; Bakker, A.; Hierck, B.P. & Peters, D.J.M. (2017), Fluid shear stress-induced TGF-beta/ALK5 signaling in renal epithelial cells is modulated by MEK1/2, Cellular and Molecular Life Sciences 74(12): 2283-2298.
- Feng, T.; Dzieran, J.; Yuan, X.; Dropmann, A.; Maass, T.; Teufel, A.; Marhenke, S.; Gaiser, T.; Ruckert, F.; Kleiter, I.; Kanzler, S.; Ebert, M.P.; Vogel, A.; Dijke, P. ten; Dooley, S. & Meindl-Beinker, N.M. (2017), Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice, Oncogenesis 6.
- Ren, J.; Liu, S.J.; Cui, C. & Dijke, P. ten (2017), Invasive Behavior of Human Breast Cancer Cells in Embryonic Zebrafish, Journal of Visualized Experiments.
- Pasteuning-Vuhman, S.; Boertje-van der Meulen, J.W.; Putten, M.M. van; Overzier, M.; Dijke, P. ten; Kielbasa, S.M.; Arindrarto, W.; Wolterbeek, R.; Lezhnina, K.V.; Ozerov, I.V.; Aliper, A.M.; Hoogaars, W.M.; Aartsma-Rus, A. & Loomans, C.J.M. (2017), New function of the myostatin/activin type I receptor (ALK4) as a mediator of muscle atrophy and muscle regeneration, FASEB Journal 31(1): 238-255.
- Thomsen, L.H.; Fog-Tonnesen, M.; Fink, L.N.; Norlin, J.; Vinuesa, A.G. de; Hansen, T.K.; Heer, E. de; Dijke, P. ten & Rosendahl, A. (2017), Smad2 Phosphorylation in Diabetic Kidney Tubule Epithelial Cells Is Associated with Modulation of Several Transforming Growth Factor-beta Family Members, Nephron 135(4): 291-306.
- Zhang, L.; Xie, F.; Zhang, J.; Dijke, P. ten & Zhou, F.F. (2017), SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death, Cell Death and Differentiation 24(9): 1530-1539.
- Caam, A. van; Madej, W.; Vinuesa, A.G. de; Goumans, M.J.; Dijke, P. ten; Davidson, E.B. & Kraan, P. van der (2017), TGF beta 1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity, Arthritis Research and Therapy 19.
- Pardali, E.; Sanchez-Duffhues, G.; Gomez-Puerto, M.C. & Dijke, P. ten (2017), TGF-beta-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases, International Journal of Molecular Sciences 18(10).
- Nakano, N.; Tsuchiya, Y.; Kako, K.; Umezaki, K.; Sano, K.; Ikeno, S.; Otsuka, E.; Shigeta, M.; Nakagawa, A.; Sakata, N.; Itoh, F.; Nakano, Y.; Iemura, S.; Dinther, M. van; Natsume, T.; Dijke, P. ten & Itoh, S. (2017), TMED10 Protein Interferes with Transforming Growth Factor (TGF)-beta Signaling by Disrupting TGF-beta Receptor Complex Formation, Journal of Biological Chemistry 292(10): 4099-4112.
- Zhou, F.F.; Xie, F.; Jin, K.; Zhang, Z.K.; Clerici, M.; Gao, R.; Dinther, M. van; Sixma, T.K.; Huang, H.Z.; Zhang, L. & Dijke, P. ten (2017), USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling, EMBO Journal 36(11): 1623-1639.
- Astrologo, L.; Zoni, E.; Karkampouna, S.; Gray, P.C.; Klima, I.; Grosjean, J.; Goumans, M.J.; Hawinkels, L.J.A.C.; Pluijm, G. van der; Spahn, M.; Thalmann, G.N.; Dijke, P. ten & Kruithof-de Julio, M. (2017), ALK1Fc Suppresses the Human Prostate Cancer Growth in in Vitro and in Vivo Preclinical Models, Frontiers in Cell and Developmental Biology 5.
- Colak, S. & Dijke, P. ten (2017), Targeting TGF-beta Signaling in Cancer, TRENDS IN CANCER 3(1): 56-71.
- Chen, W.J. & Dijke, P. ten (2016), Immunoregulation by members of the TGF beta superfamily, Nature Reviews Immunology 16(12): 723-740.
- Spender, L.C.; Ferguson, G.J.; Liu, S.J.; Cui, C.; Girotti, M.R.; Sibbet, G.; Higgs, E.B.; Shuttleworth, M.K.; Hamilton, T.; Lorigan, P.; Weller, M.; Vincent, D.F.; Sansom, O.J.; Frame, M.; Dijke, P. ten; Marais, R. & Inman, G.J. (2016), Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells, Oncotarget 7(50): 81995-82012.
- Vinuesa, A.G. de; Bocci, M.; Pietras, K. & Dijke, P. ten (2016), Targeting tumour vasculature by inhibiting activin receptor-like kinase (ALK)1 function, Biochemical Society Transactions 44: 1142-1149.
- Leenheer, D.; Dijke, P. ten & Hipolito, C.J. (2016), A current perspective on applications of macrocyclic-peptide-based high-affinity ligands, Biopolymers 106(6): 889-900.
- Sanchez-Duffhues, G.; Gorter, D.J.J. de & Dijke, P. ten (2016), Towards a cure for Fibrodysplasia ossificans progressiva, Annals of translational medicine 4.
- Giannelli, G.; Mikulits, W.; Dooley, S.; Fabregat, I.; Moustakas, A.; Dijke, P. ten; Portincasa, P.; Winter, P.; Janssen, R.; Leporatti, S.; Herrera, B. & Sanchez, A. (2016), The rationale for targeting TGF-beta in chronic liver diseases, European Journal of Clinical Investigation 46(4): 349-361.
- Morrell, N.W.; Bloch, D.B.; Dijke, P. ten; Goumans, M.J.T.H.; Hata, A.; Smith, J.; Yu, P.B. & Bloch, K.D. (2016), Targeting BMP signalling in cardiovascular disease and anaemia, Nature Reviews Cardiology 13(2): 106-120.
- Karkampouna, S.; Goumans, M.J.; Dijke, P. ten; Dooley, S. & Kruithof-de Julio, M. (2016), Inhibition of TGF beta type I receptor activity facilitates liver regeneration upon acute CCl4 intoxication in mice, Archives of Toxicology 90(2): 347-357.
- Sanchez-Duffhues, G.; Orlova, V. & Dijke, P. ten (2016), In Brief: Endothelial-to-mesenchymal transition, Journal of Pathology 238(3): 378-380.
- Hawinkels, L.J.A.C.; Vinuesa, A.G. de; Paauwe, M.; Kruithof-de Julio, M.; Wiercinska, E.; Pardali, E.; Mezzanotte, L.; Keereweer, S.; Braumuller, T.M.; Heijkants, R.C.; Jonkers, J.; Lowik, C.W.; Goumans, M.J.; Hagen, T.L. ten & Dijke, P. ten (2016), Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors, Clinical Cancer Research 22(1): 96-106.
- Fabregat, I.; Moreno-Caceres, J.; Sanchez, A.; Dooley, S.; Dewidar, B.; Giannelli, G.; Dijke, P. ten & IT-LIVER Consortium (2016), TGF-beta signalling and liver disease, FEBS Journal 283(12): 2219-2232.
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- Seghers, L.; Vries, M.R. de; Pardali, E.; Hoefer, I.E.; Hierck, B.P.; Dijke, P. ten; Goumans, M.J. & Quax, P.H.A. (2012), Shear induced collateral artery growth modulated by endoglin but not by ALK1, Journal of Cellular and Molecular Medicine 16(10): 2440-2450.
- Meeteren, L.A. van; Thorikay, M.; Bergqvist, S.; Pardali, E.; Stampino, C.G.; Hu-Lowe, D.; Goumans, M.J. & Dijke, P. ten (2012), Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting, Journal of Biological Chemistry 287(22): 18551-18561.
- Zhang, L.; Huang, H.Z.; Zhou, F.F.; Schimmel, J.; Pardo, C.G.; Zhang, T.T.; Barakat, T.S.; Sheppard, K.A.; Mickanin, C.; Porter, J.A.; Vertegaal, A.C.O.; Dam, H. van; Gribnau, J.; Lu, C.X. & Dijke, P. ten (2012), RNF12 Controls Embryonic Stem Cell Fate and Morphogenesis in Zebrafish Embryos by Targeting Smad7 for Degradation, Molecular Cell 46(5): 650-661.
- Dijk, R.A. van; Engels, C.C.; Schaapherder, A.F.; Mulder-Stapel, A.; Dijke, P. ten; Hamming, J.F. & Lindeman, J.H.N. (2012), Visualizing TGF-beta and BMP signaling in human atherosclerosis: a histological evaluation based on Smad activation, Histology and Histopathology 27(3): 387-396.
- Zhou, F.F.; Zhang, X.F.; Dam, H. van; Dijke, P. ten; Huang, H.Z. & Zhang, L. (2012), Ubiquitin-specific Protease 4 Mitigates Toll-like/Interleukin-1 Receptor Signaling and Regulates Innate Immune Activation, Journal of Biological Chemistry 287(14): 11002-11010.
- Mohseny, A.B.; Cai, Y.P.; Kuijjer, M.; Xiao, W.; Akker, B. van den; Andrea, C.E. de; Jacobs, R.; Dijke, P. ten; Hogendoorn, P.C.W. & Cleton-Jansen, A.M. (2012), The activities of Smad and Gli mediated signalling pathways in high-grade conventional osteosarcoma, European Journal of Cancer 48(18): 3429-3438.
- Maring, J.A.; Trojanowska, M.; Dijke, P. ten & Jeon, K.W. (2012), ROLE OF ENDOGLIN IN FIBROSIS AND SCLERODERMA, INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 297 297: 295-308.
- Breitkopf-Heinlein K, Li Q, Mueller A, ten Dijke P & Dooley S (2012), HOW ARE HEPATOCYTES PRIMED FOR TGF-beta MEDIATED APOPTOSIS? BONE MORPHOGENETIC PROTEIN (BMP)-9 AS DEADLY CO-FACTOR IN VITRO AND IN VIVO, Journal of Hepatology 56: S9-S9.
- Antonov, A.S.; Antonova, G.N.; Fujii, M.; Dijke, P. ten; Handa, V.; Catravas, J.D. & Verin, A.D. (2012), Regulation of endothelial barrier function by TGF-beta type I receptor ALK5: Potential role of contractile mechanisms and heat shock protein 90, Journal of Cellular Physiology 227(2): 759-771.
- Meeteren, L.A. van & Dijke, P. ten (2012), Regulation of endothelial cell plasticity by TGF-beta, Cell and Tissue Research 347(1): 177-186.
- Kraan, P.M. van der; Goumans, M.J.; Davidson, E.B. & Dijke, P. ten (2012), Age-dependent alteration of TGF-beta signalling in osteoarthritis, Cell and Tissue Research 347(1): 257-265.
- Krieglstein, K.; Miyazono, K.; Dijke, P. ten & Unsicker, K. (2012), TGF-beta in aging and disease, Cell and Tissue Research 347(1): 5-9.
- Dooley, S. & Dijke, P. ten (2012), TGF-beta in progression of liver disease, Cell and Tissue Research 347(1): 245-256.
- Naber, H.P.H.; Wiercinska, E.; Pardali, E.; Laar, T. van; Nirmala, E.; Sundqvist, A.; Dam, H. van; Horst, G. van der; Pluijm, G. van der; Heckmann, B.; Danen, E.H.J. & Dijke, P. ten (2012), BMP-7 inhibits TGF-beta-induced invasion of breast cancer cells through inhibition of integrin beta(3) expression, Cellular Oncology 35(1): 19-28.
- Cai, J.; Pardali, E.; Sanchez-Duffhues, G. & Dijke, P. ten (2012), BMP signaling in vascular diseases, FEBS Letters 586(14): 1993-2002.
- Gorter, D.J.J. de; Jankipersadsing, V. & Dijke, P. ten (2012), Deregulated Bone Morphogenetic Protein Receptor Signaling Underlies Fibrodysplasia Ossificans Progressiva, Current Pharmaceutical Design 18(27): 4087-4092.
- Karkampouna, S.; Dijke, P. ten; Dooley, S. & Kruithof-de Julio, M. (2012), TGF beta Signaling in Liver Regeneration, Current Pharmaceutical Design 18(27): 4103-4113.
- Zhang, L.; Zhou, F.F.; Drabsch, Y.; Gao, R.; Snaar-Jagalska, B.E.; Mickanin, C.; Huang, H.Z.; Sheppard, K.A.; Porter, J.A.; Lu, C.X. & Dijke, P. ten (2012), USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-beta type I receptor, Nature Cell Biology 14(7): 717-726.
- Zhang, L.; Zhou, F.F.; Li, Y.H.; Drabsch, Y.; Zhang, J.; Dam, H. van & Dijke, P. ten (2012), Fas-associated Factor 1 Is a Scaffold Protein That Promotes beta-Transducin Repeat-containing Protein (beta-TrCP)-mediated beta-Catenin Ubiquitination and Degradation, Journal of Biological Chemistry 287(36): 30701-30710.
- Tan, H.L.; Glen, E.; Topf, A.; Hall, D.; O'Sulliyan, J.J.; Sneddon, L.; Wren, C.; Avery, P.; Lewis, R.J.; Dijke, P. ten; Arthur, H.M.; Goodship, J.A. & Keayney, B.D. (2012), Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation, Human Mutation 33(4): 720-727.
- Zhang, J.; Zhang, X.F.; Zhang, L.; Zhou, F.F.; Dinther, M. van & Dijke, P. ten (2012), LRP8 mediates Wnt/ss-catenin signaling and controls osteoblast differentiation.
- Drabsch, Y. & Dijke, P. ten (2012), TGF-beta signalling and its role in cancer progression and metastasis, Cancer and Metastasis Reviews 31(3-4): 553-568.
- Huang, S.D.; Holzel, M.; Knijnenburg, T.; Schlicker, A.; Roepman, P.; McDermott, U.; Garnett, M.; Grernrum, W.; Sun, C.; Prahallad, A.; Groenendijk, F.H.; Mittempergher, L.; Nijkamp, W.; Neefjes, J.; Salazar, R.; Dijke, P. ten; Uramoto, H.; Tanaka, F.; Beijersbergen, R.L.; Wessels, L.F.A. & Bernards, R. (2012), MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-beta Receptor Signaling, Cell 151(5): 937-950.
- Sundqvist, A.; Dijke, P. ten & Dam, H. van (2012), Key signaling nodes in mammary gland development and cancer: Smad signal integration in epithelial cell plasticity., Breast Cancer Research 14(1): 204.
- Boeck, M. de & Dijke, P. ten (2012), Key role for ubiquitin protein modification in TGF beta signal transduction, Upsala Journal of Medical Sciences 117(2): 153-165.
- Meeteren, L.A. van; Thorikay, M.; Bergqvist, S.; Pardali, E.; Stampino, C.G.; Hu-Lowe, D.; Goumans, M.J. & Dijke, P. ten (2012), An anti-human ALK1 antibody attenuates BMP9 induced ALK1 signaling and interferes with endothelial cell sprouting., Journal of Biological Chemistry.
- Pardali, E. & Dijke, P. ten (2012), TGF beta Signaling and Cardiovascular Diseases, International Journal of Biological Sciences 8(2): 195-213.
- Zhang, L.; Shi, S.T.; Zhang, J.; Zhou, F.F. & Dijke, P. ten (2012), Wnt/beta-catenin signaling changes C2C12 myoblast proliferation and differentiation by inducing Id3 expression, Biochemical and Biophysical Research Communications 419(1): 83-88.
- Naber, H.P.H.; Wiercinska, E.; Pardali, E.; Laar, T. van; Nirmala, E.; Sundqvist, A.; Dam, H. van; Horst, G. van der; Pluijm, G. van der; Heckmann, B.; Danen, E.H.J. & Dijke, P. ten (2012), BMP-7 inhibits TGF-β-induced invasion of breast cancer cells through inhibition of integrin β(3) expression.
- Dijke, P. ten; Egorova, A.D.; Goumans, M.J.T.H.; Poelmann, R.E. & Hierck, B.P. (2012), TGF-β signaling in endothelial-to-mesenchymal transition: the role of shear stress and primary cilia., Science Signaling 5(212): pt2.
- Kemaladewi, D.U.; Gorter, D.J.J. de; Aartsma-Rus, A.; Ommen, G.J. van; Dijke, P. ten; Hoen, P.A.C. 't & Hoogaars, W.M. (2012), Cell-type specific regulation of myostatin signaling.
- Vinuesa, A.G.; Sancho, R.; Garcia-Limones, C.; Behrens, A.; Dijke, P. ten; Calzado, M.A. & Munoz, E. (2012), Vanilloid receptor-1 regulates neurogenic inflammation in colon and protects mice from colon cancer.
- Dijke, P. ten; Egorova, A.D.; Goumans, M.J.T.H.; Poelmann, R.E. & Hierck, B.P. (2012), TGF-beta Signaling in Endothelial-to-Mesenchymal Transition: The Role of Shear Stress and Primary Cilia, Science Signaling 5(212): -.
- Pulkki, M.M.; Mottershead, D.G.; Pasternack, A.H.; Muggalla, P.; Ludlow, H.; Dinther, M. van; Myllymaa, S.; Koli, K.; Dijke, P. ten; Laitinen, M. & Ritvos, O. (2012), A Covalently Dimerized Recombinant Human Bone Morphogenetic Protein-15 Variant Identifies Bone Morphogenetic Protein Receptor Type 1B as a Key Cell Surface Receptor on Ovarian Granulosa Cells, Endocrinology 153(3): 1509-1518.
- Dijk, R.A. van; Engels, C.C.; Schaapherder, A.F.; Mulder-Stapel, A.; Dijke, P. ten; Hamming, J.F. & Lindeman, J.H.N. (2012), Visualizing TGF-β and BMP signaling in human atherosclerosis: a histological evaluation based on Smad activation., Histology and Histopathology 27(3): 387-96.
- Lissenberg-Thunnissen, S.N.; Gorter, D.J.J. de; Sier, C.F.M. & Schipper, I.B. (2011), Use and efficacy of bone morphogenetic proteins in fracture healing, International Orthopaedics 35(9): 1271-1280.
- Egorova, A.D.; Heiden, K. van der; Pas, S. van de; Vennemann, P.; Poelma, C.; DeRuiter, M.C.; Goumans, M.J.T.H.; Gittenberger-de Groot, A.C.; Dijke, P. ten; Poelmann, R.E. & Hierck, B.P. (2011), Tgf beta/Alk5 Signaling Is Required for Shear Stress Induced Klf2 Expression in Embryonic Endothelial Cells, Developmental Dynamics 240(7): 1670-1680.
- Koeck, T.; Olsson, A.H.; Nitert, M.D.; Sharoyko, V.V.; Ladenvall, C.; Kotova, O.; Reiling, E.; Ronn, T.; Parikh, H.; Taneera, J.; Eriksson, J.G.; Metodiev, M.D.; Larsson, N.G.; Balhuizen, A.; Luthman, H.; Stancakova, A.; Kuusisto, J.; Laakso, M.; Poulsen, P.; Vaag, A.; Groop, L.; Lyssenko, V.; Mulder, H. & Ling, C. (2011), A Common Variant in TFB1M Is Associated with Reduced Insulin Secretion and Increased Future Risk of Type 2 Diabetes, Cell Metabolism 13(1): 80-91.
- Meulmeester, E. & Dijke, P. ten (2011), The dynamic roles of TGF-beta in cancer, Journal of Pathology 223(2): 205-218.
- Groenendijk, B.C.W.; Benus, G.F.J.D.; Klous, A.; Pacheco, Y.M.; Volger, O.L.; Fledderus, J.O.; Ferreira, V.; Engelse, M.A.; Pannekoek, H.; Dijke, P. ten; Horrevoets, A.J.G. & Vries, C.J.M. de (2011), Activin A induces a non-fibrotic phenotype in smooth muscle cells in contrast to TGF-beta, Experimental Cell Research 317(2): 131-142.
- Wiercinska, E.; Naber, H.P.H.; Pardali, E.; Pluijm, G. van der; Dam, H. van & Dijke, P. ten (2011), The TGF-beta/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system, Breast Cancer Research and Treatment 128(3): 657-666.
- Zhang, L.; Zhou, F.F.; Laar, T. van; Zhang, J.; Dam, H. van & Dijke, P. ten (2011), Fas-associated factor 1 antagonizes Wnt signaling by promoting beta-catenin degradation, Molecular Biology of the Cell 22(9): 1617-1624.
- Egorova, A.D.; Khedoe, P.P.S.J.; Goumans, M.J.T.H.; Nauli, S.M.; Dijke, P. ten; Poelmann, R.E. & Hierck, B.P. (2011), Lack of Primary Cilia Primes Shear-Induced Endothelial-to-Mesenchymal Transition, Circulation Research 108(9): 1093U142.
- Olieslagers, S.; Pardali, E.; Tchaikovski, V.; Dijke, P. ten & Waltenberger, J. (2011), TGF-beta 1/ALK5-induced monocyte migration involves PI3K and p38 pathways and is not negatively affected by diabetes mellitus, Cardiovascular Research 91(3): 510-518.
- Shi, S.; Hoogaars, W.M.H.; Gorter, D.J.J. de; Heiningen, S.H. van; Lin, H.Y.; Hong, C.C.; Kernaladewi, D.U.; Aartsma-Rus, A.; Dijke, P. ten & Hoen, P.A.C. 't (2011), BMP antagonists enhance myogenic differentiation and ameliorate the dystrophic phenotype in a DMD mouse model, Neurobiology of Disease 41(2): 353-360.
- Egorova, A.D.; Khedoe, P.P.S.J.; Goumans, M.J.T.H.; Yoder, B.K.; Nauli, S.M.; Dijke, P. ten; Poelmann, R.E. & Hierck, B.P. (2011), Lack of Primary Cilia Primes Shear-Induced Endothelial-to-Mesenchymal Transition, Circulation Research 108(9): 1093-U142.
- Vries, M.R. de; Seghers, L.; Hoefer, I.E.; Pardali, E.; Hierck, B.P. van der; Goumans, M.J.; Dijke, P. ten & Quax, P.H. (2011), Endoglin and ALK1 Act Differently of Ischemia and Shear Stress Induced Neovascularization, Circulation 124(21).
- Pardali, E.; Schaft, D.W.J. van der; Wiercinska, E.; Gorter, A.; Hogendoorn, P.C.W.; Griffioen, A.W. & Dijke, P. ten (2011), Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma, Oncogene 30(3): 334-345.
- Zhou, F.F.; Zhang, L.; Laar, T. van; Dam, H. van & Dijke, P. ten (2011), GSK3 beta inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb, Molecular Biology of the Cell 22(18): 3533-3540.
- Gorter, D.J.J. de; Dinther, M. van; Korchynskyi, O. & Dijke, P. ten (2011), Biphasic Effects of Transforming Growth Factor beta on Bone Morphogenetic Protein-Induced Osteoblast Differentiation, Journal of Bone and Mineral Research 26(6): 1178-1187.
- Meeteren, L.A. van; Goumans, M.J. & Dijke, P. ten (2011), TGF-beta Receptor Signaling Pathways in Angiogenesis; Emerging Targets for Anti-Angiogenesis Therapy, Current Pharmaceutical Biotechnology 12(12): 2108-2120.
- Heide, L.P. van der; Dinther, M. van; Moustakas, A. & Dijke, P. ten (2011), TGF beta Activates Mitogen- and Stress-activated Protein Kinase-1 (MSK1) to Attenuate Cell Death, Journal of Biological Chemistry 286(7): 5003-5011.
- Han, G.W.; Li, F.L.; Dijke, P. ten & Wang, X.J. (2011), Temporal Smad7 Transgene Induction in Mouse Epidermis Accelerates Skin Wound Healing, American Journal of Pathology 179(4): 1768-1779.
- Hawinkels, L.J.A.C. & Dijke, P. ten (2011), Exploring anti-TGF-beta beta therapies in cancer and fibrosis, Growth Factors 29(4): 140-152.
- Drabsch, Y. & Dijke, P. ten (2011), TGF-beta Signaling in Breast Cancer Cell Invasion and Bone Metastasis, Journal of Mammary Gland Biology and Neoplasia 16(2): 97-108.
- Kraan, P.M. van der; Goumans, M.J.; Davidson, E.B. & Dijke, P. ten (2011), Age-dependent alteration of TGF-β signalling in osteoarthritis., Cell and Tissue Research.
- van der Heide LP, van Dinther M, Moustakas A & Ten Dijke P (2011), TGF{beta} Activates Mitogen- and Stress-activated Protein Kinase-1 (MSK1) to Attenuate Cell Death., Journal of Biological Chemistry 286(7): 5003-11.
- Kemaladewi, D.U.; Heiningen, S.H. van; Aartsma-Rus, A.; Ommen, G.J.B. van; Dijke, P. ten; Hoen, P.A.C. 't & Hoogaars, W.M.H. (2011), Interference of myostatin and TGF-beta signaling by antisense-mediated exon skipping in ALK4/5 receptors.
- de Gorter DJ, van Dinther M, Korchynskyi O & Ten Dijke P (2011), Biphasic effects of transforming growth factor β on bone morphogenetic protein-induced osteoblast differentiation., Journal of Bone and Mineral Research 26(6): 1178-87.
- Morris, E.; Chrobak, I.; Bujor, A.; Hant, F.; Mummery, C.; Dijke, P. ten & Trojanowska, M. (2011), Endoglin Promotes TGF-beta/Smad1 Signaling in Scleroderma Fibroblasts, Journal of Cellular Physiology 226(12): 3340-3348.
- Orlova, V.V.; Liu, Z.; Goumans, M.J. & Dijke, P. ten (2011), Controlling angiogenesis by two unique TGF-beta type I receptor signaling pathways, Histology and Histopathology 26(9): 1219-1230.
- Kemaladewi, D.U.; Hoogaars, W.M.H.; Heiningen, S.H. van; Terlouw, S.; Gorter, D.J.J. de; Dunnen, J.T. den; Ommen, G.J.B. van; Aartsma-Rus, A.; Dijke, P. ten & Hoen, P.A.C. 't (2011), Dual exon skipping in myostatin and dystrophin for Duchenne muscular dystrophy., BMC Medical Genomics 4(1): 36.
- Morris E, Chrobak I, Bujor A, Hant F, Mummery C, Ten Dijke P & Trojanowska M (2011), Endoglin promotes TGF-β/Smad1 signaling in scleroderma fibroblasts., Journal of Cellular Physiology.
- Stephenne, X.; Foretz, M.; Taleux, N.; Zon, G.C. van der; Sokal, E.; Hue, L.; Viollet, B. & Guigas, B. (2011), Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status, Diabetologia 54(12): 3101-3110.
- Zhang L, Zhou F, van Laar T, Zhang J, van Dam H & Ten Dijke P (2011), Fas-associated factor 1 antagonizes Wnt signaling by promoting {beta}-catenin degradation., Molecular Biology of the Cell 22(9): 1617-24.
- Krause C, Kloen P & Ten Dijke P (2011), Elevated transforming growth factor β and mitogen-activated protein kinase pathways mediate fibrotic traits of Dupuytren's disease fibroblasts., Fibrogenesis && Tissue Repair 4(1): 14.
- Orlova, V.V.; Liu, Z.; Goumans, M.J. & Dijke, P. ten (2011), Controlling angiogenesis by two unique TGF-β type I receptor signaling pathways., Histology and Histopathology 26(9): 1219-30.
- Naber, H.P.H.; Wiercinska, E.; Dijke, P. ten & Laar, T. van (2011), Spheroid assay to measure TGF-β-induced invasion., Journal of Visualized Experiments.
- Joziasse, I.C.; Smith, K.A.; Chocron, S.; Dinther, M. van; Guryev, V.; Smagt, J.J. van de; Cuppen, E.; Dijke, P. ten; Mulder, B.J.M.; Maslen, C.L.; Reshey, B.; Doevendans, P.A. & Bakkers, J. (2011), ALK2 mutation in a patient with Down's syndrome and a congenital heart defect, European Journal of Human Genetics 19(4): 389-393.
- Olieslagers S, Pardali E, Tchaikovski V, Ten Dijke P & Waltenberger J (2011), TGF-{beta}1/ALK5-induced monocyte migration involves PI3K and p38 pathways and is not negatively affected by diabetes mellitus., Cardiovascular Research.
- Egorova, A.D.; Heiden, K. van der; Pas, S. van de; Vennemann, P.; Poelma, C.; DeRuiter, M.C.; Goumans, M.J.T.H.; Gittenberger-de Groot, A.C.; Dijke, P. ten; Poelmann, R.E. & Hierck, B.P. (2011), Tgfβ/Alk5 signaling is required for shear stress induced klf2 expression in embryonic endothelial cells., Developmental Dynamics.
- van Meeteren LA, Goumans MJ & Ten Dijke P (2011), TGF-β Receptor Signaling Pathways in Angiogenesis; Emerging Targets for Anti-Angiogenesis Therapy., Current Pharmaceutical Biotechnology.
- Watanabe, Y.; Itoh, S.; Goto, T.; Ohnishi, E.; Inamitsu, M.; Itoh, F.; Satoh, K.; Wiercinska, E.; Yang, W.W.; Shi, L.; Tanaka, A.; Nakano, N.; Mommaas, A.M.; Shibuya, H.; Dijke, P. ten & Kato, M. (2010), TMEPAI, a Transmembrane TGF-beta-Inducible Protein, Sequesters Smad Proteins from Active Participation in TGF-beta Signaling, Molecular Cell 37(1): 123-134.
- Dinther, M. van; Visser, N.; Gorter, D.J.J. de; Doorn, J.; Goumans, M.J.; Boer, J. de & Dijke, P. ten (2010), ALK2 R206H Mutation Linked to Fibrodysplasia Ossificans Progressiva Confers Constitutive Activity to the BMP Type I Receptor and Sensitizes Mesenchymal Cells to BMP-Induced Osteoblast Differentiation and Bone Formation, Journal of Bone and Mineral Research 25(6): 1208-1215.
- Petersen, M.; Pardali, E.; Horst, G. van der; Cheung, H.; Hoogen, C. van den; Pluijm, G. van der & Dijke, P. ten (2010), Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis, Oncogene 29(9): 1351-1361.
- Hassane, S.; Leonhard, W.N.; Wal, A. van der; Hawinkels, L.J.A.C.; Lantinga-van Leeuwen, I.S.; Dijke, P. ten; Breuning, M.H.; Heer, E. de & Peters, D.J.M. (2010), Elevated TGF beta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease, Journal of Pathology 222(1): 21-31.
- Baan B, Pardali E, Ten Dijke P & van Dam H (2010), In situ proximity ligation detection of cJun/AP-1 dimers reveals increased levels of cJun/Fra1 complexes in aggressive breast cancer cell lines in vitro and in vivo.
- Olieslagers S, Pardali L, Tchaikovski V, Ten Dijke P & Waltenberger J (2010), Unraveling downstream TGF-beta1 signaling required for monocyte motility and the effect of diabetes mellitus hereon., Cardiovascular Research 87: S95S95.
- Cunha, S.I.; Pardali, E.; Thorikay, M.; Anderberg, C.; Hawinkels, L.; Goumans, M.J.; Seehra, J.; Heldin, C.H.; Dijke, P. ten & Pietras, K. (2010), Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis, Journal of Experimental Medicine 207(1): 85-100.
- Krause, C.; Korchynskyi, O.; Rooij, K. de; Weidauer, S.E.; Gorter, D.J.J. de; Bezooijen, R.L. van; Hatsell, S.; Economides, A.N.; Mueller, T.D.; Lowik, C.W.G.M. & Dijke, P. ten (2010), Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways., Journal of Biological Chemistry 285(53): 41614-26.
- Pardali, E.; Goumans, M.J. & Dijke, P. ten (2010), Signaling by members of the TGF-beta family in vascular morphogenesis and disease, Trends in Cell Biology 20(9): 556-567.
- Boer, T.P. de; Veen, T.A.B. van; Jonsson, M.K.B.; Kok, B.G.J.M.; Metz, C.H.G.; Sluijter, J.P.G.; Doevendans, P.A.; Bakker, J.M.T. de; Goumans, M.J. & Heyden, M.A.G. van der (2010), Human cardiomyocyte progenitor cell-derived cardiomyocytes display a maturated electrical phenotype, Journal of Molecular and Cellular Cardiology 48(1): 254-260.
- Baan, B.; Pardali, E.; Dijke, P. ten & Dam, H. van (2010), In Situ Proximity Ligation Detection of c-Jun/AP-1 Dimers Reveals Increased Levels of c-Jun/Fra1 Complexes in Aggressive Breast Cancer Cell Lines in Vitro and in Vivo, Molecular and Cellular Proteomics 9(9): 1982-1990.
- Song, K.N.; Krause, C.; Shi, S.T.; Patterson, M.; Suto, R.; Grgurevic, L.; Vukicevic, S.; Dinther, M. van; Falb, D.; Dijke, P. ten & Alaoui-Ismaili, M.H. (2010), Identification of a Key Residue Mediating Bone Morphogenetic Protein (BMP)-6 Resistance to Noggin Inhibition Allows for Engineered BMPs with Superior Agonist Activity, Journal of Biological Chemistry 285(16): 12169-12180.
- Graauw, M. de; Miltenburg, M.H. van; Schmidt, M.K.; Pont, C.; Lalai, R.; Kartopawiro, J.; Pardali, E.; Devedec, S.E. le; Smit, V.T.; Wal, A. van der; Van't Veer, L.J.; Cleton-Jansen, A.M.; Dijke, P. ten & Water, B. van de (2010), Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells, Proceedings of the National Academy of Sciences 107(14): 6340-6345.
- Hawinkels, L.J.A.C.; Kuiper, P.; Wiercinska, E.; Verspaget, H.W.; Liu, Z.; Pardali, E.; Sier, C.F.M. & Dijke, P. ten (2010), Matrix Metalloproteinase-14 (MT1-MMP)-Mediated Endoglin Shedding Inhibits Tumor Angiogenesis, Cancer Research 70(10): 4141-4150.
- Meulmeester E & Ten Dijke P (2010), The dynamic roles of TGF-β in cancer., Journal of Pathology.
- Shi S, Hoogaars WM, de Gorter DJ, van Heiningen SH, Lin HY, Hong CC, Kemaladewi DU, Aartsma-Rus A, Ten Dijke P & 't Hoen PA (2010), BMP antagonists enhance myogenic differentiation and ameliorate the dystrophic phenotype in a DMD mouse model.
- van Dinther M, Visser N, de Gorter DJ, Doorn J, Goumans MJ, de Boer J & ten Dijke P (2010), ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation., Journal of Bone and Mineral Research 25(6): 1208-15.
- Koelink, P.J.; Hawinkels, L.J.A.C.; Wiercinska, E.; Sier, C.F.M.; Dijke, P. ten; Lamers, C.B.H.W.; Hommes, D.W. & Verspaget, H.W. (2010), 5-Aminosalicylic acid inhibits TGF-beta 1 signalling in colorectal cancer cells.
- de Graauw M, van Miltenburg MH, Schmidt MK, Pont C, Lalai R, Kartopawiro J, Pardali E, Le Dévédec SE, Smit VT, van der Wal A, Van't Veer LJ, Cleton-Jansen AM, ten Dijke P & van de Water B (2010), Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells., Proceedings of the National Academy of Sciences 107(14): 6340-5.
- Pardali E, van der Schaft DW, Wiercinska E, Gorter A, Hogendoorn PC, Griffioen AW & Ten Dijke P (2010), Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma., Oncogene.
- Meulmeester E & Ten Dijke P (2010), Integration of transcriptional signals at the tumor cell invasive front.
- Pardali E, Goumans MJ & ten Dijke P (2010), Signaling by members of the TGF-beta family in vascular morphogenesis and disease., Trends in Cell Biology 20(9): 556-67.
- Wiercinska, E.; Naber, H.P.H.; Pardali, E.; Pluijm, G. van der; Dam, H. van & Dijke, P. ten (2010), The TGF-beta/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system.
- Bijkerk, R.; Duijs, J.; Kobayashi, K.; Solingen, C. van; Roeten, M.K.; Veer, E.P. van der; Dijke, P. ten; Boer, H.C. de; Rabelink, T.J.; Goumans, M.J. & Zonneveld, A.J. van (2010), MicroRNA-155 Functions as a Suppressor of Endothelial to Mesenchymal Transition, Arteriosclerosis, Thrombosis, and Vascular Biology 30(11): E236E237.
- Petersen, M.; Pardali, E.; Horst, G. van der; Cheung, H.; Hoogen, C. van den; Pluijm, G. van der & Dijke, P. ten (2010), Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis., Oncogene 29(9): 1351-61.
- Gorter, D.J.J. de; Dinther, M. van; Dijke, P. ten & Conn, P.M. (2010), MEASUREMENT OF CONSTITUTIVE ACTIVITY OF BMP TYPE I RECEPTORS, Methods in Enzymology 484: 281-293.
- de Gorter DJ, van Dinther M, Korchynskyi O & Ten Dijke P (2010), Biphasic effects of transforming growth factor-β on bone morphogenetic protein-induced osteoblast differentiation., Journal of Bone and Mineral Research.
- Kemaladewi DU, Hoogaars WMH, van Heiningen SH, van Deutekom JCT, den Dunnen JT, van Ommen GJB, Aartsma-Rus AR, ten Dijke P & 't Hoen PAC (2009), Dual exon skipping in myostatin and dystrophin as a potential therapy for Duchenne muscular dystrophy, Neuromuscular Disorders 19(8-9): 577-577.
- Scharpfenecker M, Floot B, Russell NS, ten Dijke P & Stewart FA (2009), Endoglin haploinsufficiency reduces radiation-induced fibrosis and telangiectasia formation in mouse kidneys, Radiotherapy and Oncology 92(3): 484-491.
- Tabata T, Kokura K, ten Dijke P & Ishii S (2009), Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5, Genes to Cells 14(1): 17-28.
- Dzwonek J, Preobrazhenska O, Cazzola S, Conidi A, Schellens A, van Dinther M, Stubbs A, Klippel A, Huylebroeck D & ten Dijke P (2009), Smad3 Is a Key Nonredundant Mediator of Transforming Growth Factor beta Signaling in Nme Mouse Mammary Epithelial Cells, Molecular Cancer Research 7(8): 1342-1353.
- Pardali E & ten Dijke P (2009), Transforming growth factor-beta signaling and tumor angiogenesis.
- Herrera B, van Dinther M, ten Dijke P & Inman GJ (2009), Autocrine Bone Morphogenetic Protein-9 Signals through Activin Receptor-like Kinase-2/Smad1/Smad4 to Promote Ovarian Cancer Cell Proliferation, Cancer Research 69(24): 9254-9262.
- Smith KA, Joziasse IC, Chocron S, van Dinther M, Guryev V, Verhoeven MC, Rehmann H, van der Smagt JJ, Doevendans PA & Cuppen E (2009), Dominant-Negative ALK2 Allele Associates With Congenital Heart Defects, Circulation 119(24): 3062U42.
- Scharpfenecker M, Kruse JJCM, Sprong D, Russell NS, Dijke PT & Stewart FA (2009), IONIZING RADIATION SHIFTS THE PAI-1/ID-1 BALANCE AND ACTIVATES NOTCH SIGNALING IN ENDOTHELIAL CELLS, International Journal of Radiation Oncology - Biology - Physics 73(2): 506-513.
- Smits AM, van Laake LW, den Ouden K, Schreurs C, Szuhai K, van Echteld CJ, Mummery CL, Doevendans PA & Goumans MJ (2009), Human cardiomyocyte progenitor cell transplantation preserves long-term function of the infarcted mouse myocardium, Cardiovascular Research 83(3): 527-535.
- Liu Z, Kobayashi K, van Dinther M, van Heiningen SH, Valdimarsdottir G, van Laar T, Scharpfenecker M, Lowik CWGM, Goumans MJ & ten Dijke P (2009), VEGF and inhibitors of TGF beta type-I receptor kinase synergistically promote blood-vessel formation by inducing alpha 5-integrin expression, Journal of Cell Science 122(18): 3294-3302.
- Goumans MJ, Liu Z & ten Dijke P (2009), TGF-beta signaling in vascular biology and dysfunction, Cell Research 19(1): 116-127.
- Smits AM, van Vliet P, Metz CH, Korfage T, Sluijter JPG, Doevendans PA & Goumans MJ (2009), Human cardiomyocyte progenitor cells differentiate into functional mature cardiomyocytes: an in vitro model for studying human cardiac physiology and pathophysiology, Nature Protocols 4(2): 232-243.
- Noort WA, Sluijter JPG, Goumans MJ, Chamuleau SAJ & Doevendans PA (2009), Stem Cells from In- or Outside of the Heart: Isolation, Characterization, and Potential for Myocardial Tissue Regeneration, Pediatric Cardiology 30(5): 699-709.
- Itoh F, Itoh S, Carvalho RLC, Adachi T, Ema M, Goumans MJ, Larsson J, Karlsson S, Takahashi S & Mummery CL (2009), Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation, Laboratory Investigation 89(7): 800-810.
- Goumans MJ, Liu Z & ten Dijke P (2009), TGF-beta signaling in vascular biology and dysfunction., Cell Research 19(1): 116-27.
- Davidson, E.N.B.; Remst, D.F.G.; Vitters, E.L.; Beuningen, H.M. van; Blom, A.B.; Goumans, M.J.; Berg, W.B. van den & Kraan, P.M. van der (2009), Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice, Journal of Immunology 182(12): 7937-7945.
- Jonsson MKB, van Veen TAB, Goumans MJ, Vos MA, Duker G & Sartipy P (2009), Improvement of cardiac efficacy and safety models in drug discovery by the use of stem cell-derived cardiomyocytes, Expert Opinion on Drug Discovery 4(4): 357-372.
- Kodach LL, Wiercinska E, de Miranda NFCC, Bleuming SA, Peppelenbosch MP, Dekker E, van den Brink GR, van Noesel CJM, Morreau H, ten Dijke P, Offerhaus GJA & Hardwick JCH (2009), The Bone Morphogenetic Protein Pathway is inactivated in the majority of sporadic colorectal cancers, European Journal of Gastroenterology and Hepatology 21(3): A41A41.
- Naber HPH, ten Dijke P & Pardali E (2008), Role of TGF-beta in the Tumor Stroma, Current Cancer Drug Targets 8(6): 466-472.
- Kodach LL, Wiercinska E, De Miranda NFCC, Bleuming SA, Musler AR, Peppelenbosch MP, Dekker E, van den Brink GR, Van Noesel CJM, Morreau H, Hommes DW, Ten Dijke P, Offerhaus GJA & Hardwick JCH (2008), The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers, Gastroenterology 134(5).
- Korchynskyi O & ten Dijke P (2008), TGF beta Inhibits BMP Signaling and Osteogenesis Through the TGF beta and BMP R-Smad Direct Interaction, Journal of Bone and Mineral Research 23: S24S24.
- Pannu J, Asano Y, Nakerakanti S, Smith E, Jablonska S, Blaszczyk M, ten Dijke P & Trojanowska M (2008), Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate, Arthritis and Rheumatism 58(8).
- de Gorter DJJ, van Bezooijen RL, Lowik CWGM & ten Dijke P (2008), The Interplay Between BMP and TGF-beta Signaling in Osteoblast Differentiation, Journal of Bone and Mineral Research 23: S140S140.
- Huisman MA, de Heer E, Ten Dijke P & Grote JJ (2008), Transforming Growth Factor beta and Wound Healing in Human Cholesteatoma, Laryngoscope 118(1): 94-98.
- Goumans MJ, van Zonneveld AJ & ten Dijke P (2008), Transforming Growth Factor beta-Induced Endothelial-to-Mesenchymal Transition: A Switch to Cardiac Fibrosis?, Trends in Cardiovascular Medicine 18(8): 293-298.
- ten Dijke P, Krause C, de Gorter DJJ, Lowik CWGM & van Bezooijen RL (2008), Osteocyte-derived sclerostin inhibits bone formation: Its role in bone morphogenetic protein and Wnt signaling, Journal of Bone and Joint Surgery, American Volume 90A.
- Velasco S, Alvarez-Munoz P, Pericacho M, ten Dijke P, Bernabeu C, Lopez-Novoa JM & Rodriguez-Barbero A (2008), L- and S-endoglin differentially modulate TGF beta 1 signaling mediated by ALK1 and ALK5 in L6E9 myoblasts, Journal of Cell Science 121(6).
- Petersen M, Thorikay M, Deckers M, van Dinther M, Grygielko ET, Gellibert F, de Gouville A, Huet S, ten Dijke P & Laping N (2008), Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis, Kidney International 73(6).
- Monteiro R, van Dinther M, Bakkers J, Wilkinson R, Patient R, ten Dijke P & Mummery C (2008), Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish, Developmental Biology 315(1).
- ten Dijke P, Goumans MJ & Pardali E (2008), Endoglin in angiogenesis and vascular diseases, Angiogenesis 11(1).
- Hawinkels L, Goumans M & ten Dijke P (2008), TGF-beta Receptor Signal Transduction in Vascular Development, ICCB 2008: PROCEEDINGS OF THE 9TH INTERNATIONAL CONGRESS ON CELL BIOLOGY: 1-6.
- Finnson KW, Parker WL, ten Dijke P, Thorikay M & Philip A (2008), ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes, Journal of Bone and Mineral Research 23(6).
- ten Dijke P, Krause C, de Gorter DJ, Löwik CW & van Bezooijen RL (2008), Osteocyte-derived sclerostin inhibits bone formation: its role in bone morphogenetic protein and Wnt signaling., Journal of Bone and Joint Surgery, American Volume 90 Suppl 1: 31-5.
- Rudini N, Felici A, Giampietro C, Lampugnani M, Corada M, Swirsding K, Garre M, Liebner S, Letarte M, ten Dijke P & Dejana E (2008), VE-cadherin is a critical endothelial regulator of TGF-beta signalling, EMBO Journal 27(7).
- Buijs JT, Henriquez NV, van Overveld PG, van der Horst G, ten Dijke P & van der Pluijm G (2007), TGF-beta and BMP7 interactions in tumour progression and bone metastasis., Clinical and Experimental Metastasis 24(8): 609-17.
- Buijs JT, Henriquez NV, van Overveld PG, van der Horst G, Que I, Schwaninger R, Rentsch C, Ten Dijke P, Cleton-Jansen AM, Driouch K, Lidereau R, Bachelier R, Vukicevic S, Clézardin P, Papapoulos SE, Cecchini MG, Löwik CW & van der Pluijm G (2007), Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer., Cancer Research 67(18): 8742-51.
- Buijs JT, Rentsch CA, van der Horst G, van Overveld PG, Wetterwald A, Schwaninger R, Henriquez NV, Ten Dijke P, Borovecki F, Markwalder R, Thalmann GN, Papapoulos SE, Pelger RC, Vukicevic S, Cecchini MG, Löwik CW & van der Pluijm G (2007), BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo., American Journal of Pathology 171(3): 1047-57.
- Buijs J, Henriquez N, van Overveld P, van der Horsy G, Que I, Schwaninger R, Rentsch C, ten Dijke P, Cleton A, Lidereau R, Bachelier R, Vukicevics S, Clezardin P, Papapoulos S, Cecchini M, Lowik C & van der Pluijm G (2007), Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer, BONE 40(6).
- Bezooijen, R.L. van; DeRuiter, M.C.; Vilain, N.; Monteiro, R.M.; Visser, A.; Wee-Pals, L. van der; Munsteren, C.J. van; Hogendoorn, P.C.W.; Aguet, M.; Mummery, C.L.; Papapoulos, S.E.; Dijke, P. ten & Lowik, C.W.G.M. (2007), SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development, Developmental Dynamics 236(2).
- ten Dijke P & Arthur HM (2007), Extracellular control of TGF beta signalling in vascular development and disease, Nature Reviews Molecular Cell Biology 8(11).
- Carvalho RLC, Itoh F, Goumans MJ, Lebrin F, Kato M, Takahashi S, Ema M, Itoh S, van Rooijen M, Bertolino P, ten Dijke P & Mummery CL (2007), Compensatory signalling induced in the yolk sac vasculature by deletion of TGF beta receptors in mice, Journal of Cell Science 120(24).
- Pannu J, Nakerakanti S, Smith E, ten Dijke P & Trojanowska M (2007), Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways, Journal of Biological Chemistry 282(14).
- van Bezooijen RL, Svensson JP, Eefting D, Visser A, van der Horst G, Karperien M, Quax PH, Vrieling H, Papapoulos SE, ten Dijke P & Lowik CW (2007), Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation, Journal of Bone and Mineral Research 22(1).
- Itoh S & ten Dijke P (2007), Negative regulation of TGF-beta receptor/Smad signal transduction, Current Opinion in Cell Biology 19(2).
- Heldin CH & ten Dijke P (2007), Editorial overview: Cellular signaling, Current Opinion in Cell Biology 19(2).
- Li Y, Ying LT, Ten Dijke P & Chiang C (2007), Aberrant bmp signaling and notochord delamination in the pathogenesis of esophageal atresia, Developmental Dynamics 236(3).
- Dennler S, Andre J, Alexaki I, Li A, Magnaldo T, ten Dijke P, Wang XJ, Verrecchia F & Mauviel A (2007), Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo, Cancer Research 67(14).
- Carvalho RL, Itoh F, Goumans MJ, Lebrin F, Kato M, Takahashi S, Ema M, Itoh S, van Rooijen M, Bertolino P, Ten Dijke P & Mummery CL (2007), Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice., Journal of Cell Science 120(Pt 24): 4269-77.
- Castanares C, Redondo-Horcajo M, Magan-Marchal N, ten Dijke P, Lamas S & Rodriguez-Pascual F (2007), Signaling by ALK5 mediates TGF-beta-induced ET-1 expression in endothelial cells: a role for migration and proliferation, Journal of Cell Science 120(7).
- Scharpfenecker M, van Dinther M, Liu Z, van Bezooijen RL, Zhao QH, Pukac L, Lowik CWGM & ten Dijke P (2007), BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis, Journal of Cell Science 120(6).
- ten Dijke P & Arthur HM (2007), Extracellular control of TGFbeta signalling in vascular development and disease., Nature Reviews Molecular Cell Biology 8(11): 857-69.
- Zilberberg L, ten Dijke P, Sakai LY & Rifkin DB (2007), A rapid and sensitive bioassay to measure bone morphogenetic protein activity, BMC Cell Biology 8.
- Buijs JT, Rentsch CA, van der Horst G, van Civerveld PGM, Wetterwald A, Schwaninger R, Henriquez NV, ten Dijke P, Borovecki F, Markwalder R, Thalmann GN, Papapoulos SE, Pelger RCM, Vukicevic S, Cecchini MG, Lowik CWGM & van der Pluijm G (2007), BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo, American Journal of Pathology 171(3).
- Itoh S & ten Dijke P (2007), Negative regulation of TGF-beta receptor/Smad signal transduction., Current Opinion in Cell Biology 19(2): 176-84.
- Boon RA, Fledderus JO, Volger OL, van Wanrooij EJA, Pardali E, Weesie F, Kuiper J, Pannekoek H, ten Dijke P & Horrevoets AJG (2007), KLF2 suppresses TGF-beta signaling in endothelium through induction of Smad7 and inhibition of AP-1, Arteriosclerosis, Thrombosis, and Vascular Biology 27(3).
- Buijs JT, Henriquez NV, van Overveld PGM, van der Horst G, ten Dijke P & van der Pluijm G (2007), TGF-beta and BMP7 interactions in tumour progression and bone metastasis, Clinical and Experimental Metastasis 24(8).
- Buijs JT, Henriquez NV, Van Overveld PGM, Van der Horst G, Que I, Schwaninger R, Rentsch C, Ten Dijke P, Cleton-Jansen AM, Driouch K, Lidereau R, Bachelier R, Vukicevic S, Clezardin P, Papapoulos SE, Cecchini MG, Lowik CWGM & Van der Pluijm G (2007), Bone morphogenetic protein 7 in the development and treatment of bone Metastases from breast cancer, Cancer Research 67(18).
- Deckers M, van Dinther M, Buijs J, Que N, Lowik C, van der Pluijm G & ten Dijke P (2006), The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells, Cancer Research 66(4).
- Logeart-Avramoglou D, Bourguignon M, Oudina K, Ten Dijke P & Petite H (2006), An assay for the determination of biologically active bone morphogenetic proteins using cells transfected with an inhibitor of differentiation promoter-luciferase construct, Analytical Biochemistry 349(1).
- Leenders JJ, Pokharel S, Creemers EE, Herias V, de Windt LJ, ten Dijke P, Molkentin JD, van Bilsen M, van Leeuwen RE, Jain MK, Heymans S & Pinto YM (2006), Down regulation of the novel transcriptional regulator of cardiac hypertrophy, Kruppel-like factor 15, is mediated by TGF-beta induced p38 activation in vivo and in vitro., Circulation 114(18): 13-13.
- Leenders JJ, Polkharel S, Creemers EE, Herias V, de Windt LJ, ten Dijke P, Molkentin JD, van Bilsen M, Hoydal M, van Leeuwen REW, Jain MK, Heymans S & Pinto YM (2006), Down regulation of the novel transcriptional regulator of cardiac hypertrophy, Kruppel-like factor 15, is mediated by TGF-beta induced p38 activation in vivo and in vitro., Hypertension 48(4): 761-761.
- Han GW, Li AG, Liang YY, Owens P, He W, Lu SL, Yoshimatsu Y, Wang D, ten Dijke P, Lin X & Wang XJ (2006), Smad7-induced beta-catenin degradation alters epidermal appendage development, Developmental Cell 11(3).
- Noda D, Itoh S, Watanabe Y, Inamitsu M, Dennler S, Itoh F, Koike S, Danielpour D, ten Dijke P & Kato M (2006), ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-beta/Smad-induced growth arrest of prostate cells, Oncogene 25(41).
- Han G, Li A, Liang Y, Owens P, Yoshimatsu Y, Wang D, ten Dijke P, Lin X & Wang X (2006), Smad7 overexpression in keratinocytes induces beta-catenin degradation that contributes to developmental abnormalities in hair follicles and sebaceous glands, Journal of Investigative Dermatology 126: 106-106.
- Wiercinska E, Wickert L, Denecke B, Said HM, Hamzavi J, Gressner AM, Thorikay M, ten Dijke P, Mertens PR, Breitkopf K & Dooley S (2006), Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells, Hepatology 43(5).
- Melke P, Jonsson H, Pardali E, ten Dijke P & Peterson C (2006), A rate equation approach to elucidate the kinetics and robustness of the TGF-beta pathway, Biophysical Journal 91(12).
- Wicks SJ, Grocott T, Haros K, Maillard M, ten Dijke P & Chantry A (2006), Reversible ubiquitination regulates the Smad/TGF-beta signalling pathway, Biochemical Society Transactions 34.
- Inamitsu M, Itoh S, Hellman U, ten Dijke P & Kato M (2006), Methylation of Smad6 by protein arginine N-methyltransferase 1, FEBS Letters 580(28-29).
- van Laake LW, van den Driesche S, Post S, Feijen A, Jansen MA, Driessens MH, Mager JJ, Snijder RJ, Westermann CJJ, Doevendans PA, van Echteld CJA, ten Dijke P, Arthur HM, Goumans MJ, Lebrin F & Mummery CL (2006), Endoglin has a crucial role in blood cell-mediated vascular repair, Circulation 114(21).
- ten Dijke P (2006), Bone morphogenetic protein signal transduction in bone., Current Medical Research and Opinion 22 Suppl 1: S7-11.
- Valdimarsdottir G, Goumans MJ, Itoh F, Itoh S, Heldin CH & ten Dijke P (2006), Smad7 and protein phosphatase 1 alpha are critical determinants in the duration of TGF-beta/ALKI signaling in endothelial cells, BMC Cell Biology 7.
- ten Dijke P (2006), Bone morphogenetic protein signal transduction in bone, Current Medical Research and Opinion 22.
- Valdimarsdottir G, Goumans MJ, Itoh F, Itoh S, Heldin CH & ten Dijke P (2006), Smad7 and protein phosphatase 1alpha are critical determinants in the duration of TGF-beta/ALK1 signaling in endothelial cells., BMC Cell Biology 7: 16.
- Janssens K, ten Dijke P, Janssens S & Van Hul W (2005), Transforming growth factor-beta1 to the bone., Endocrine Reviews 26(6): 743-74.
- Bertolino P, Deckers M, Lebrin F & ten Dijke P (2005), Transforming growth factor-beta signal transduction in angiogenesis and vascular disorders., Chest 128(6 Suppl): 585S-590S.
- Sayama K, Komatsuzawa H, Yamasaki K, Shirakata Y, Hanakawa Y, Ouhara K, Tokumaru S, Dai XJ, Tohyama M, ten Dijke P, Sugai M, Ichijo H & Hashimoto K (2005), New mechanisms of skin innate immunity: ASK1-mediated keratinocyte differentiation regulates the expression of beta-defensins, LL37, and TLR2, European Journal of Immunology 35(6): 1886-1895.
- van Bezooijen RL, Visser A, van der Horst G, Karperien M, Papaloulos SE, ten Dijke P & Lowik CWGM (2005), Sclerostin inhibits BMP-stimulated bone formation by antagonizing Wnt signaling, Journal of Bone and Mineral Research 20(9): S9S9.
- Wicks SJ, Haros K, Maillard M, Song L, Cohen RE, ten Dijke P & Chantry A (2005), The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling, Oncogene 24(54).
- ten Dijke P, Carvalho R, Goumans MJ, Lebrin F, Arthur H & Mummery C (2005), TGF-beta in endothelial cell function and vascular development., Journal of Vascular Research 42: 10-11.
- Lebrin F, Deckers M, Bertolino P & ten Dijke P (2005), TGF-beta receptor function in the endothelium, Cardiovascular Research 65(3): 599-608.
- Bertolino P, Deckers M, Lebrin F & ten Dijke P (2005), Transforming growth factor-beta signal transduction in angiogenesis and vascular disorders, Chest 128(6): 585S590S.
- van der Pluijm G, Buijs J, Henriquez N, Wetterwald A, Rentsch C, Schwaninger R, ten Dijke P, Borovecki F, Thalmann G, Pelger R, Cecchini M & Lowik C (2005), Epithelium-mesenchyme transition in bone metastasis: New therapeutic opportunities?, Journal of Bone and Mineral Research 20: P38P38.
- Janssens K, ten Dijke P, Janssens S & Van Hul W (2005), Transforming growth factor-beta 1 to the bone, Endocrine Reviews 26(6).
- Bezooijen RL, ten Dijke P, Papapoulos SE & Lowik CWGM (2005), SOST/sclerostin, an osteocyte-derived negative regulator of bone formation, Cytokine and Growth Factor Reviews 16(3).
- Lin AH, Luo J, Mondshein LH, ten Dijke P, Vivien D, Contag CH & Wyss-Coray T (2005), Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury., Journal of Immunology 175(1): 547-54.
- Lopes SMCDS, Feijen A, Korving J, Korchynskyi O, Larsson J, Karlsson S, Ten Dijke P, Lyons KM, Goldschmeding R, Doevendans P & Mummery CL (2004), Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction, Developmental Dynamics 231(3): 542-550.
- Carvalho RLC, Jonker L, Goumans MJ, Larsson J, Bouwman P, Karisson S, ten Dijke P, Arthur HM & Mummery CL (2004), Defective paracrine signalling by TGF beta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia, Development 131(24): 6237-6247.
- Lebrin F, Goumans MJ, Jonker L, Carvalho RLC, Valdimarsdottir G, Thorikay M, Mummery C, Arthur HM & ten Dijke P (2004), Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction, EMBO Journal 23(20): 4018-4028.
- Lutz M, Krieglstein K, Schmitt S, ten Dijke P, Sebald W, Wizenmann A & Knaus P (2004), Nerve growth factor mediates activation of the Smad pathway in PC12 cells, European Journal of Biochemistry 271(5): 920-931.
- ten Dijke P & Hill CS (2004), New insights into TGF-beta-Smad signalling, Trends in Biochemical Sciences 29(5): 265-273.
- Piek E, Van Dinther M, Parks WT, Sallee JM, Bottinger EP, Roberts AB & Ten Dijke P (2004), RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta, Biochemical Journal 383: 187-199.
- Lowik C, Ten Dijke P & Van Bezooijen R (2004), SCLEROSTIN IS AN OSTEOCYTE-EXPRESSED NEGATIVE REGULATOR OF BONE FORMATION, BUT NOT A CLASSICAL BMP ANTAGONIST, Calcified Tissue International 74: S22S22.
- Monteiro RM, Lopes SMCD, Korchynskyl O, ten Dijke P & Mummery CL (2004), Spatio-temporal activation of Smad1 and Smad5 in vivo: monitoring transcriptional activity of Smad proteins, Journal of Cell Science 117(20): 4653-4663.
- Itoh F, Itoh S, Goumans MJ, Valdimarsdottir G, Iso T, Dotto GP, Hamamori Y, Kedes L, Kato M & ten Dijke P (2004), Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells, EMBO Journal 23(3): 541-551.
- van Bezooijen RL, Roelen BAJ, Visser A, van der Wee-Pals L, de Wilt E, Karperien M, Hamersma H, Papapoulos SE, ten Dijke P & Lowik CWGM (2004), Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist, Journal of Experimental Medicine 199(6).
- Edlund S, Bu S, Schuster N, Aspenström P, Heuchel R, Heldin NE, ten Dijke P, Heldin CH & Landström M (2003), Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3., Molecular Biology of the Cell 14(2): 529-44.
- Goumans MJ, Valdimarsdottir G, Itoh S, Lebrin F, Larsson J, Mummery C, Karlsson S & ten Dijke P (2003), Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFP/ALK5 signaling, Molecular Cell 12(4): 817-828.
- ten Dijke P, Korchynskyi E, Valdimarsdottir G & Goumans MJ (2003), Controlling cell fate by bone morphogenetic protein receptors, Molecular and Cellular Endocrinology 211(1-2): 105-113.
- ten Dijke P, Fu JY, Schaap P & Roelen BAJ (2003), Signal transduction of bone morphogenetic proteins in osteoblast differentiation, Journal of Bone and Joint Surgery, American Volume 85A: 34-38.
- Lowik C, ten Dijke P & van Bezooijen R (2003), Sclerostin is an osteocyte-expressed negative regulator of bone formation., BONE 33(5): S19S19.
- Itoh S, Thorikay M, Kowanetz M, Moustakas A, Itoh F, Heldin CH & ten Dijke P (2003), Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses, Journal of Biological Chemistry 278(6): 3751-3761.
- Kurisaki K, Kurisaki A, Valcourt U, Terentiev AA, Pardali K, ten Dijke P, Heldin CH, Ericsson J & Moustakas A (2003), Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation, Molecular and Cellular Biology 23(13): 4494-4510.
- Dooley S, Hamzavi J, Breitkopf K, Wiercinska E, Said HM, Lorenzen J, Ten Dijke P & Gressner AM (2003), Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats, Gastroenterology 125(1): 178-191.
- Ikedo H, Tamaki K, Ueda S, Kato S, Fujii M, Ten Dijke P & Okuda S (2003), Smad protein and TGF-beta signaling in vascular smooth muscle cells, International Journal of Molecular Medicine 11(5): 645-650.
- Edlund S, Bu SH, Schuster N, Aspenstrom P, Heuchel R, Heldin NE, ten Dijke P, Heldin CH & Landstrom M (2003), Transforming growth factor-beta 1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3, Molecular Biology of the Cell 14(2): 529-544.
- Janssens K, ten Dijke P, Ralston SH, Bergmann C & Van Hul W (2003), Transforming growth factor-beta 1 mutations in Camurati-Engelmann disease lead to increased signaling by altering either activation or secretion of the mutant protein, Journal of Biological Chemistry 278(9): 7718-7724.
- Goumans MJ, Valdimarsdottir G, Itoh S, Lebrin F, Larsson J, Mummery C, Karlsson S & ten Dijke P (2003), Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling., Molecular Cell 12(4): 817-28.
- Althini S, Usoskin D, Kylberg A, ten Dijke P & Ebendal T (2003), Bone morphogenetic protein signalling in NGF-stimulated PC12 cells., Biochemical and Biophysical Research Communications 307(3): 632-9.
- ten Dijke P, Korchynskyi O, Valdimarsdottir G & Goumans MJ (2003), Controlling cell fate by bone morphogenetic protein receptors., Molecular and Cellular Endocrinology 211(1-2): 105-13.
- Roelen BA & Dijke P (2003), Controlling mesenchymal stem cell differentiation by TGFBeta family members., Journal of Orthopaedic Science 8(5): 740-8.
- de Sousa Lopes SM, Carvalho RL, van den Driesche S, Goumans MJ, ten Dijke P & Mummery CL (2003), Distribution of phosphorylated Smad2 identifies target tissues of TGF beta ligands in mouse development., Gene Expression Patterns 3(3): 355-60.
- Liang YY, Lin X, Liang M, Brunicardi FC, ten Dijke P, Chen Z, Choi KW & Feng XH (2003), dSmurf selectively degrades decapentaplegic-activated MAD, and its overexpression disrupts imaginal disc development., Journal of Biological Chemistry 278(29): 26307-10.
- Korchynskyi O, Dechering KJ, Sijbers AM, Olijve W & ten Dijke P (2003), Gene array analysis of bone morphogenetic protein type I receptor-induced osteoblast differentiation., Journal of Bone and Mineral Research 18(7): 1177-85.
- Kaivo-Oja N, Bondestam J, Kämäräinen M, Koskimies J, Vitt U, Cranfield M, Vuojolainen K, Kallio JP, Olkkonen VM, Hayashi M, Moustakas A, Groome NP, ten Dijke P, Hsueh AJ & Ritvos O (2003), Growth differentiation factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells., Journal of Clinical Endocrinology and Metabolism 88(2): 755-62.
- ten Dijke P, Fu J, Schaap P & Roelen BA (2003), Signal transduction of bone morphogenetic proteins in osteoblast differentiation., Journal of Bone and Joint Surgery, American Volume 85-A Suppl 3: 34-8.
- Suh N, Roberts AB, Birkey Reffey S, Miyazono K, Itoh S, ten Dijke P, Heiss EH, Place AE, Risingsong R, Williams CR, Honda T, Gribble GW & Sporn MB (2003), Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling., Cancer Research 63(6): 1371-6.
- Fan X, Valdimarsdottir G, Larsson J, Brun A, Magnusson M, Jacobsen SE, ten Dijke P & Karlsson S (2002), Transient disruption of autocrine TGF-beta signaling leads to enhanced survival and proliferation potential in single primitive human hemopoietic progenitor cells., Journal of Immunology 168(2): 755-62.
- Dennler S, Goumans MJ & ten Dijke P (2002), Transforming growth factor beta signal transduction, Journal of Leukocyte Biology 71(5): 731-740.
- Itoh F, Divecha N, Brocks L, Oomen L, Janssen H, Calafat J, Itoh S & ten Dijke P (2002), The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-beta/Smad signalling, Genes to Cells 7(3): 321-331.
- Suh N, Roberts A, Heiss E, Place A, Williams C, Risingsong R, Reffey S, Honda T, Gribble G, Miyazono K, Itoh S, ten Dijke P & Sporn M (2002), Synthetic triterpenoids activate TGF-beta/SMAD signalling, Cancer Epidemiology, Biomarkers and Prevention 11(10): 1230S1230S.
- Ikedo H, Tamaki K, Ueda S, Kato S, Fujii M, ten Dijke P & Okuda S (2002), Smad protein and TGF-beta signaling in vascular smooth muscle cells., Journal of the American Society of Nephrology 13: 738A738A.
- He W, Wang D, Goumans M, Dijke P, Sundberg JP & Wang X (2002), Smad7 transgenic mice exhibit a severe delay in hair follicle development, aberrant follicle morphogenesis and differentiation, and cyclical balding, Journal of Investigative Dermatology 119(1): 286-286.
- Dooley S, Delvoux B, Hamzavi J, Breitkopf K, Goldberg G, Denecke B, Jahnen-Dechent W, Lorenzen J, ten Dijke P & Gressner AM (2002), Smad7 prevents activation of hepatic stellate cells and experimentally induced fibrosis in rat liver, Hepatology 36(4): 224A224A.
- Ohkawara B, Iemura S, ten Dijke P & Ueno N (2002), Action range of BMP is defined by its N-terminal basic amino acid core., Current Biology 12(3): 205-9.
- Rosendahl A, Pardali E, Speletas M, Ten Dijke P, Heldin CH & Sideras P (2002), Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation., American Journal of Respiratory Cell and Molecular Biology 27(2): 160-9.
- Goumans MJ, Valdimarsdottir G, Itoh S, Rosendahl A, Sideras P & ten Dijke P (2002), Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors., EMBO Journal 21(7): 1743-53.
- Chang W, ten Dijke P & Wu DK (2002), BMP pathways are involved in otic capsule formation and epithelial-mesenchymal signaling in the developing chicken inner ear., Developmental Biology 251(2): 380-94.
- Dong C, Zhu S, Wang T, Yoon W, Li Z, Alvarez RJ, ten Dijke P, White B, Wigley FM & Goldschmidt-Clermont PJ (2002), Deficient Smad7 expression: a putative molecular defect in scleroderma., Proceedings of the National Academy of Sciences 99(6): 3908-13.
- Bondestam J, Kaivo-oja N, Kallio J, Groome N, Hydén-Granskog C, Fujii M, Moustakas A, Jalanko A, ten Dijke P & Ritvos O (2002), Engagement of activin and bone morphogenetic protein signaling pathway Smad proteins in the induction of inhibin B production in ovarian granulosa cells., Molecular and Cellular Endocrinology 195(1-2): 79-88.
- Korchynskyi O & ten Dijke P (2002), Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter., Journal of Biological Chemistry 277(7): 4883-91.
- Muehleman C, Kuettner KE, Rueger DC, Ten Dijke P & Chubinskaya S (2002), Immunohistochemical localization of osteogenetic protein (OP-1) and its receptors in rabbit articular cartilage., Journal of Histochemistry and Cytochemistry 50(10): 1341-50.
- He W, Li AG, Wang D, Han S, Zheng B, Goumans MJ, Ten Dijke P & Wang XJ (2002), Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues., EMBO Journal 21(11): 2580-90.
- Blokzijl A, ten Dijke P & Ibáñez CF (2002), Physical and functional interaction between GATA-3 and Smad3 allows TGF-beta regulation of GATA target genes., Current Biology 12(1): 35-45.
- Ten Dijke P, Goumans MJ, Itoh F & Itoh S (2002), Regulation of cell proliferation by Smad proteins., Journal of Cellular Physiology 191(1): 1-16.
- Valdimarsdottir G, Goumans MJ, Rosendahl A, Brugman M, Itoh S, Lebrin F, Sideras P & ten Dijke P (2002), Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells., Circulation 106(17): 2263-70.
- Olsson N, Piek E, Sundström M, ten Dijke P & Nilsson G (2001), Transforming growth factor-beta-mediated mast cell migration depends on mitogen-activated protein kinase activity., Cellular Signalling 13(7): 483-90.
- Dooley S, Delvoux B, Streckert M, Bonzel L, Stopa M, ten Dijke P & Gressner AM (2001), Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFbeta signal transduction during transdifferentiation of hepatic stellate cells., FEBS Letters 502(1-2): 4-10.
- Dooley S, Delvoux B, Streckert M, Bonzel L, Stopa M, ten Dijke P & Gressner AM (2001), Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts - TGF beta signal transduction during transdifferentiation of hepatic stellate cells, FEBS Letters 502(1-2): 4-10.
- Stopa M, Steckert M, Bonzel L, Delvoux B, ten Dijke P, Gressner AM & Dooley S (2001), Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts, Journal of Hepatology 34: 83-83.
- Schiffer M, Bitzer M, Roberts ISD, Kopp JB, ten Dijke P, Mundel P & Bottinger EP (2001), Apoptosis in podocytes induced by TGF-beta and Smad7, Journal of Clinical Investigation 108(6): 807-816.
- Chang W, ten Dijke P & Wu DK (2001), Chondrogenesis of the otic capsule during the chicken inner ear development., Developmental Biology 235(1): 193-193.
- Inagaki Y, Nemoto T, Nakao A, ten Dijke P, Kobayashi K, Takehara K & Greenwel P (2001), Interaction between GC box binding factors and smad proteins modulates cell lineage-specific alpha 2(I) collagen gene transcription, Journal of Biological Chemistry 276(19): 16573-16579.
- He W, Wang D, Dijke P & Wang X (2001), Overexpression of Smad7 in the epidermis of transgenic mice results in developmental defects in the epidermis and its appendages, Journal of Investigative Dermatology 117(2): 409-409.
- Larsson J, Goumans MJ, Sjöstrand LJ, van Rooijen MA, Ward D, Levéen P, Xu X, ten Dijke P, Mummery CL & Karlsson S (2001), Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice., EMBO Journal 20(7): 1663-73.
- Rosendahl A, Checchin D, Fehniger TE, ten Dijke P, Heldin CH & Sideras P (2001), Activation of the TGF-beta/activin-Smad2 pathway during allergic airway inflammation., American Journal of Respiratory Cell and Molecular Biology 25(1): 60-8.
- Bondestam J, Huotari MA, Morén A, Ustinov J, Kaivo-Oja N, Kallio J, Horelli-Kuitunen N, Aaltonen J, Fujii M, Moustakas A, Ten Dijke P, Otonkoski T & Ritvos O (2001), cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)., Cytogenetics and Cell Genetics 95(3-4): 157-62.
- Inagaki Y, Mamura M, Kanamaru Y, Greenwel P, Nemoto T, Takehara K, Ten Dijke P & Nakao A (2001), Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells., Journal of Cellular Physiology 187(1): 117-23.
- Meno C, Takeuchi J, Sakuma R, Koshiba-Takeuchi K, Ohishi S, Saijoh Y, Miyazaki J, ten Dijke P, Ogura T & Hamada H (2001), Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2., Developmental Cell 1(1): 127-38.
- Kato S, Ueda S, Tamaki K, Fujii M, Miyazono K, ten Dijke P, Morimatsu M & Okuda S (2001), Ectopic expression of Smad7 inhibits transforming growth factor-beta responses in vascular smooth muscle cells., Life Sciences 69(22): 2641-52.
- Kumar A, Novoselov V, Celeste AJ, Wolfman NM, ten Dijke P & Kuehn MR (2001), Nodal signaling uses activin and transforming growth factor-beta receptor-regulated Smads., Journal of Biological Chemistry 276(1): 656-61.
- Souchelnytskyi S, Rönnstrand L, Heldin CH & ten Dijke P (2001), Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases., Methods in Molecular Biology 124: 107-20.
- Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P & Itoh S (2001), Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads., EMBO Journal 20(15): 4132-42.
- Yakymovych I, Ten Dijke P, Heldin CH & Souchelnytskyi S (2001), Regulation of Smad signaling by protein kinase C., FASEB Journal 15(3): 553-5.
- Hayes SA, Zarnegar M, Sharma M, Yang F, Peehl DM, ten Dijke P & Sun Z (2001), SMAD3 represses androgen receptor-mediated transcription., Cancer Research 61(5): 2112-8.
- Jörnvall H, Blokzijl A, ten Dijke P & Ibáñez CF (2001), The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line., Journal of Biological Chemistry 276(7): 5140-6.
- Larsson J, Goumans MJ, Sjostrand LJ, van Rooijen MA, Ward D, Leveen P, Xu XF, ten Dijke P, Mummery CL & Karlsson S (2000), Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor deficient mice., Blood 96(11): 676A676A.
- Pardali E, Xie XQ, Tsapogas P, Itoh S, Arvanitidis K, Heldin CH, ten Dijke P, Grundstrom T & Sideras P (2000), Smad and AML proteins synergistically confer transforming growth factor beta 1 responsiveness to human germ-line IgA genes, Journal of Biological Chemistry 275(5): 3552-3560.
- Faure S, Lee MA, Keller T, ten Dijke P & Whitman M (2000), Endogenous patterns of TGF beta superfamily signaling during early Xenopus development, Development 127(13): 2917-2931.
- ten Dijke P, Miyazono K & Heldin CH (2000), Signaling inputs converge on nuclear effecters in TGF-beta signaling, Trends in Biochemical Sciences 25(2): 64-70.
- Oh SP, Seki T, Goss KA, Imamura T, Yi Y, Donahoe PK, Li L, Miyazono K, ten Dijke P, Kim S & Li E (2000), Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis., Proceedings of the National Academy of Sciences 97(6): 2626-31.
- Haaijman A, Burger EH, Goei SW, Nelles L, ten Dijke P, Huylebroeck D & Bronckers AL (2000), Correlation between ALK-6 (BMPR-IB) distribution and responsiveness to osteogenic protein-1 (BMP-7) in embryonic mouse bone rudiments., Growth Factors 17(3): 177-92.
- Brodin G, Ahgren A, ten Dijke P, Heldin CH & Heuchel R (2000), Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter., Journal of Biological Chemistry 275(37): 29023-30.
- Faure S, Lee MA, Keller T, ten Dijke P & Whitman M (2000), Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development., Development 127(13): 2917-31.
- Zwijsen A, van Rooijen MA, Goumans MJ, Dewulf N, Bosman EA, ten Dijke P, Mummery CL & Huylebroeck D (2000), Expression of the inhibitory Smad7 in early mouse development and upregulation during embryonic vasculogenesis., Developmental Dynamics 218(4): 663-70.
- Morén A, Itoh S, Moustakas A, Dijke P & Heldin CH (2000), Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4., Oncogene 19(38): 4396-404.
- Tanimoto H, Itoh S, ten Dijke P & Tabata T (2000), Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs., Molecular Cell 5(1): 59-71.
- Olsson N, Piek E, ten Dijke P & Nilsson G (2000), Human mast cell migration in response to members of the transforming growth factor-beta family., Journal of Leukocyte Biology 67(3): 350-6.
- Pardali K, Kurisaki A, Moren A, ten Dijke P, Kardassis D & Moustakas A (2000), Role of smad proteins and transcription factor Sp1 in p21(Wafl/Cip1) regulation by transforming growth factor-beta, Journal of Biological Chemistry 275(38): 29244-29256.
- Pardali K, Kurisaki A, Morén A, ten Dijke P, Kardassis D & Moustakas A (2000), Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta., Journal of Biological Chemistry 275(38): 29244-56.
- ten Dijke P, Miyazono K & Heldin CH (2000), Signaling inputs converge on nuclear effectors in TGF-beta signaling., Trends in Biochemical Sciences 25(2): 64-70.
- Itoh S, Itoh F, Goumans MJ & Ten Dijke P (2000), Signaling of transforming growth factor-beta family members through Smad proteins., European Journal of Biochemistry 267(24): 6954-67.
- Landström M, Heldin NE, Bu S, Hermansson A, Itoh S, ten Dijke P & Heldin CH (2000), Smad7 mediates apoptosis induced by transforming growth factor beta in prostatic carcinoma cells., Current Biology 10(9): 535-8.
- Pardali E, Xie XQ, Tsapogas P, Itoh S, Arvanitidis K, Heldin CH, ten Dijke P, Grundström T & Sideras P (2000), Smad and AML proteins synergistically confer transforming growth factor beta1 responsiveness to human germ-line IgA genes., Journal of Biological Chemistry 275(5): 3552-60.
- Miyazono K, ten Dijke P & Heldin CH (2000), TGF-beta signaling by Smad proteins., Advances in Immunology 75: 115-57.
- Itoh S, Ericsson J, Nishikawa J, Heldin CH & ten Dijke P (2000), The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling.
- Howell M, Itoh F, Pierreux CE, Valgeirsdottir S, Itoh S, ten Dijke P & Hill CS (1999), Xenopus Smad4beta is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes., Developmental Biology 214(2): 354-69.
- Piek E, Moustakas A, Kurisaki A, Heldin CM & ten Dijke P (1999), TGF-beta type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells, Journal of Cell Science 112(24): 4557-4568.
- Mikkola H, Valdimarsdottir G, Andersson E, Larsson J, Jacobsen SE, ten Dijke P & Karlsson S (1999), Tetracycline regulatable transgenic mouse model for TGF-beta signalling: Inhibition of TGF-beta pathway in hematopoietic cells by dominant negative TGF-beta receptor II., Blood 94(10): 686A686A.
- Aström AK, Jin D, Imamura T, Röijer E, Rosenzweig B, Miyazono K, ten Dijke P & Stenman G (1999), Chromosomal localization of three human genes encoding bone morphogenetic protein receptors., Mammalian Genome 10(3): 299-302.
- Ishisaki A, Yamato K, Hashimoto S, Nakao A, Tamaki K, Nonaka K, ten Dijke P, Sugino H & Nishihara T (1999), Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells., Journal of Biological Chemistry 274(19): 13637-42.
- Wollina U, Lange D, Ten Dijke P, Heldin CH & Funa K (1999), Eccrine sweat glands: expression of transforming growth factor-beta and bone morphogenetic protein type I receptors and their intracellular signalling Smad proteins., Acta Dermato-Venereologica 79(3): 183-6.
- Korchynskyi O, Landström M, Stoika R, Funa K, Heldin CH, ten Dijke P & Souchelnytskyi S (1999), Expression of Smad proteins in human colorectal cancer., International Journal of Cancer 82(2): 197-202.
- Lange D, Persson U, Wollina U, ten Dijke P, Castelli E, Heldin CH & Funa K (1999), Expression of TGF-beta related Smad proteins in human epithelial skin tumors., International Journal of Oncology 14(6): 1049-56.
- Piek E, Westermark U, Kastemar M, Heldin CH, van Zoelen EJ, Nistér M & Ten Dijke P (1999), Expression of transforming-growth-factor (TGF)-beta receptors and Smad proteins in glioblastoma cell lines with distinct responses to TGF-beta1., International Journal of Cancer 80(5): 756-63.
- Franzén A, Piek E, Westermark B, ten Dijke P & Heldin NE (1999), Expression of transforming growth factor-beta1, activin A, and their receptors in thyroid follicle cells: negative regulation of thyrocyte growth and function., Endocrinology 140(9): 4300-10.
- Piek E, Afrakhte M, Sampath K, van Zoelen EJ, Heldin CH & ten Dijke P (1999), Functional antagonism between activin and osteogenic protein-1 in human embryonal carcinoma cells., Journal of Cellular Physiology 180(2): 141-9.
- Brodin G, ten Dijke P, Funa K, Heldin CH & Landström M (1999), Increased smad expression and activation are associated with apoptosis in normal and malignant prostate after castration., Cancer Research 59(11): 2731-8.
- Heldin NE, Bergström D, Hermansson A, Bergenstråhle A, Nakao A, Westermark B & ten Dijke P (1999), Lack of responsiveness to TGF-beta1 in a thyroid carcinoma cell line with functional type I and type II TGF-beta receptors and Smad proteins, suggests a novel mechanism for TGF-beta insensitivity in carcinoma cells., Molecular and Cellular Endocrinology 153(1-2): 79-90.
- Sakou T, Onishi T, Yamamoto T, Nagamine T, Sampath T & Ten Dijke P (1999), Localization of Smads, the TGF-beta family intracellular signaling components during endochondral ossification., Journal of Bone and Mineral Research 14(7): 1145-52.
- Jonson T, Gorunova L, Dawiskiba S, Andrén-Sandberg A, Stenman G, ten Dijke P, Johansson B & Höglund M (1999), Molecular analyses of the 15q and 18q SMAD genes in pancreatic cancer., Genes, Chromosomes and Cancer 24(1): 62-71.
- ten Dijke P & Heldin CH (1999), Signal transduction. An anchor for activation., Nature 397(6715): 109, 111.
- Heldin CH & ten Dijke P (1999), SMAD destruction turns off signalling., Nature Cell Biology 1(8): E195-7.
- Piek E, Heldin CH & Ten Dijke P (1999), Specificity, diversity, and regulation in TGF-beta superfamily signaling., FASEB Journal 13(15): 2105-24.
- Röijer E, Morén A, ten Dijke P & Stenman G (1998), Assignment1 of the Smad7 gene (MADH7) to human chromosome 18q21.1 by fluorescence in situ hybridization., Cytogenetics and Cell Genetics 81(3-4): 189-90.
- Erlacher L, McCartney J, Piek E, ten Dijke P, Yanagishita M, Oppermann H & Luyten FP (1998), Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis., Journal of Bone and Mineral Research 13(3): 383-92.
- Röijer E, Miyazono K, Aström AK, Geurts van Kessel A, ten Dijke P & Stenman G (1998), Chromosomal localization of three human genes encoding members of the TGF-beta superfamily of type I serine/threonine kinase receptors., Mammalian Genome 9(3): 266-8.
- Saitoh M, ten Dijke P, Miyazono K & Ichijo H (1998), Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases., Biochemical and Biophysical Research Communications 253(2): 470-6.
- Dennler S, Itoh S, Vivien D, ten Dijke P, Huet S & Gauthier JM (1998), Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene., EMBO Journal 17(11): 3091-100.
- Onishi T, Ishidou Y, Nagamine T, Yone K, Imamura T, Kato M, Sampath TK, ten Dijke P & Sakou T (1998), Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats., BONE 22(6): 605-12.
- Jonk LJ, Itoh S, Heldin CH, ten Dijke P & Kruijer W (1998), Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer., Journal of Biological Chemistry 273(33): 21145-52.
- Shimizu A, Kato M, Nakao A, Imamura T, ten Dijke P, Heldin CH, Kawabata M, Shimada S & Miyazono K (1998), Identification of receptors and Smad proteins involved in activin signalling in a human epidermal keratinocyte cell line., Genes to Cells 3(2): 125-34.
- Nagamine T, Imamura T, Ishidou Y, Kato M, Murata F, ten Dijke P & Sakou T (1998), Immunohistochemical detection of activin A, follistatin, and activin receptors during fracture healing in the rat., Journal of Orthopaedic Research 16(3): 314-21.
- Afrakhte M, Morén A, Jossan S, Itoh S, Sampath K, Westermark B, Heldin CH, Heldin NE & ten Dijke P (1998), Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members., Biochemical and Biophysical Research Communications 249(2): 505-11.
- Tamaki K, Souchelnytskyi S, Itoh S, Nakao A, Sampath K, Heldin CH & ten Dijke P (1998), Intracellular signaling of osteogenic protein-1 through Smad5 activation., Journal of Cellular Physiology 177(2): 355-63.
- Souchelnytskyi S, Nakayama T, Nakao A, Morén A, Heldin CH, Christian JL & ten Dijke P (1998), Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors., Journal of Biological Chemistry 273(39): 25364-70.
- Ishisaki A, Yamato K, Nakao A, Nonaka K, Ohguchi M, ten Dijke P & Nishihara T (1998), Smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse B cells., Journal of Biological Chemistry 273(38): 24293-6.
- Persson U, Izumi H, Souchelnytskyi S, Itoh S, Grimsby S, Engström U, Heldin CH, Funa K & ten Dijke P (1998), The L45 loop in type I receptors for TGF-beta family members is a critical determinant in specifying Smad isoform activation., FEBS Letters 434(1-2): 83-7.
- Persson U, Souchelnytskyi S, Franzén P, Miyazono K, ten Dijke P & Heldin CH (1997), Transforming growth factor (TGF-beta)-specific signaling by chimeric TGF-beta type II receptor with intracellular domain of activin type IIB receptor., Journal of Biological Chemistry 272(34): 21187-94.
- Yonemori K, Imamura T, Ishidou Y, Okano T, Matsunaga S, Yoshida H, Kato M, Sampath TK, Miyazono K, ten Dijke P & Sakou T (1997), Bone morphogenetic protein receptors and activin receptors are highly expressed in ossified ligament tissues of patients with ossification of the posterior longitudinal ligament.
- Piek E, Franzén P, Heldin CH & ten Dijke P (1997), Characterization of a 60-kDa cell surface-associated transforming growth factor-beta binding protein that can interfere with transforming growth factor-beta receptor binding., Journal of Cellular Physiology 173(3): 447-59.
- de Winter JP, Roelen BA, ten Dijke P, van der Burg B & van den Eijnden-van Raaij AJ (1997), DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells., Oncogene 14(16): 1891-9.
- Hayashi K, Ishidou Y, Yonemori K, Nagamine T, Origuchi N, Maeda S, Imamura T, Kato M, Yoshida H, Sampath TK, ten Dijke P & Sakou T (1997), Expression and localization of bone morphogenetic proteins (BMPs) and BMP receptors in ossification of the ligamentum flavum., BONE 21(1): 23-30.
- Nakao A, Röijer E, Imamura T, Souchelnytskyi S, Stenman G, Heldin CH & ten Dijke P (1997), Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway., Journal of Biological Chemistry 272(5): 2896-900.
- Nakao A, Afrakhte M, Morén A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH & ten Dijke P (1997), Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling., Nature 389(6651): 631-5.
- Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K & Gotoh Y (1997), Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways., Science 275(5296): 90-4.
- Olofsson A, Hellman U, Ten Dijke P, Grimsby S, Ichijo H, Morén A, Miyazono K & Heldin CH (1997), Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160., Biochemical Journal 324 ( Pt 2): 427-34.
- Okano T, Ishidou Y, Kato M, Imamura T, Yonemori K, Origuchi N, Matsunaga S, Yoshida H, ten Dijke P & Sakou T (1997), Orthotopic ossification of the spinal ligaments of Zucker fatty rats: a possible animal model for ossification of the human posterior longitudinal ligament., Journal of Orthopaedic Research 15(6): 820-9.
- Souchelnytskyi S, Tamaki K, Engström U, Wernstedt C, ten Dijke P & Heldin CH (1997), Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling., Journal of Biological Chemistry 272(44): 28107-15.
- Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K & ten Dijke P (1997), TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4., EMBO Journal 16(17): 5353-62.
- Heldin CH, Miyazono K & ten Dijke P (1997), TGF-beta signalling from cell membrane to nucleus through SMAD proteins., Nature 390(6659): 465-71.
- Rydén M, Imamura T, Jörnvall H, Belluardo N, Neveu I, Trupp M, Okadome T, ten Dijke P & Ibáñez CF (1996), A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system., Journal of Biological Chemistry 271(48): 30603-9.
- Yamashita H, Ten Dijke P, Heldin CH & Miyazono K (1996), Bone morphogenetic protein receptors., BONE 19(6): 569-74.
- Yamada N, Kato M, ten Dijke P, Yamashita H, Sampath TK, Heldin CH, Miyazono K & Funa K (1996), Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours., British Journal of Cancer 73(5): 624-9.
- de Winter JP, ten Dijke P, de Vries CJ, van Achterberg TA, Sugino H, de Waele P, Huylebroeck D, Verschueren K & van den Eijnden-van Raaij AJ (1996), Follistatins neutralize activin bioactivity by inhibition of activin binding to its type II receptors., Molecular and Cellular Endocrinology 116(1): 105-14.
- Souchelnytskyi S, ten Dijke P, Miyazono K & Heldin CH (1996), Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses., EMBO Journal 15(22): 6231-40.
- ten Dijke P, Miyazono K & Heldin CH (1996), Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors., Current Opinion in Cell Biology 8(2): 139-45.
- Yamashita H, Okadome T, Franzén P, ten Dijke P, Heldin CH & Miyazono K (1995), A rat pituitary tumor cell line (GH3) expresses type I and type II receptors and other cell surface binding protein(s) for transforming growth factor-beta., Journal of Biological Chemistry 270(2): 770-4.
- Rosenzweig BL, Imamura T, Okadome T, Cox GN, Yamashita H, ten Dijke P, Heldin CH & Miyazono K (1995), Cloning and characterization of a human type II receptor for bone morphogenetic proteins., Proceedings of the National Academy of Sciences 92(17): 7632-6.
- Dewulf N, Verschueren K, Lonnoy O, Morén A, Grimsby S, Vande Spiegle K, Miyazono K, Huylebroeck D & Ten Dijke P (1995), Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis., Endocrinology 136(6): 2652-63.
- Olofsson A, Ichijo H, Morén A, ten Dijke P, Miyazono K & Heldin CH (1995), Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix., Journal of Biological Chemistry 270(52): 31294-7.
- Ishidou Y, Kitajima I, Obama H, Maruyama I, Murata F, Imamura T, Yamada N, ten Dijke P, Miyazono K & Sakou T (1995), Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation., Journal of Bone and Mineral Research 10(11): 1651-9.
- Verschueren K, Dewulf N, Goumans MJ, Lonnoy O, Feijen A, Grimsby S, Vandi Spiegle K, ten Dijke P, Morén A, Vanscheeuwijck P, Heldin CH, Miyazono K, Mummery C, Van Den Eijnden-Van Raaij J & Huylebroeck D (1995), Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis., Mechanisms of Development 52(1): 109-23.
- Yamashita H, ten Dijke P, Huylebroeck D, Sampath TK, Andries M, Smith JC, Heldin CH & Miyazono K (1995), Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.
- Miyazono K, Ten Dijke P, Ichijo H & Heldin CH (1994), Receptors for transforming growth factor-beta., Advances in Immunology 55: 181-220.
- ten Dijke P, Yamashita H, Ichijo H, Franzén P, Laiho M, Miyazono K & Heldin CH (1994), Characterization of type I receptors for transforming growth factor-beta and activin., Science 264(5155): 101-4.
- Yamashita H, Ichijo H, Grimsby S, Morén A, ten Dijke P & Miyazono K (1994), Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta., Journal of Biological Chemistry 269(3): 1995-2001.
- Taketazu F, Kato M, Gobl A, Ichijo H, ten Dijke P, Itoh J, Kyogoku M, Rönnelid J, Miyazono K & Heldin CH (1994), Enhanced expression of transforming growth factor-beta s and transforming growth factor-beta type II receptor in the synovial tissues of patients with rheumatoid arthritis., Laboratory Investigation 70(5): 620-30.
- Yamashita H, ten Dijke P, Franzén P, Miyazono K & Heldin CH (1994), Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta., Journal of Biological Chemistry 269(31): 20172-8.
- Morén A, Olofsson A, Stenman G, Sahlin P, Kanzaki T, Claesson-Welsh L, ten Dijke P, Miyazono K & Heldin CH (1994), Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein., Journal of Biological Chemistry 269(51): 32469-78.
- ten Dijke P, Yamashita H, Sampath TK, Reddi AH, Estevez M, Riddle DL, Ichijo H, Heldin CH & Miyazono K (1994), Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4., Journal of Biological Chemistry 269(25): 16985-8.
- ten Dijke P, Franzén P, Yamashita H, Ichijo H, Heldin CH & Miyazono K (1994), Serine/threonine kinase receptors., Progress in growth factor research 5(1): 55-72.
- Miyazono K, ten Dijke P, Yamashita H & Heldin CH (1994), Signal transduction via serine/threonine kinase receptors., Seminars in cell biology 5(6): 389-98.
- ten Dijke P, Ichijo H, Franzén P, Schulz P, Saras J, Toyoshima H, Heldin CH & Miyazono K (1993), Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity., Oncogene 8(10): 2879-87.
- Ichijo H, Yamashita H, ten Dijke P, Eto Y, Heldin CH & Miyazono K (1993), Characterization of in vivo phosphorylation of activin type II receptor., Biochemical and Biophysical Research Communications 194(3): 1508-14.
- Franzén P, ten Dijke P, Ichijo H, Yamashita H, Schulz P, Heldin CH & Miyazono K (1993), Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor., Cell 75(4): 681-92.
- Villiger PM, Kusari AB, ten Dijke P & Lotz M (1993), IL-1 beta and IL-6 selectively induce transforming growth factor-beta isoforms in human articular chondrocytes., Journal of Immunology 151(6): 3337-44.
- Jeng MH, ten Dijke P, Iwata KK & Jordan VC (1993), Regulation of the levels of three transforming growth factor beta mRNAs by estrogen and their effects on the proliferation of human breast cancer cells., Molecular and Cellular Endocrinology 97(1-2): 115-23.
- Miller DM, Ogawa Y, Iwata KK, ten Dijke P, Purchio AF, Soloff MS & Gentry LE (1992), Characterization of the binding of transforming growth factor-beta 1, -beta 2, and -beta 3 to recombinant beta 1-latency-associated peptide., Molecular Endocrinology -Baltimore- 6(5): 694-702.
- Constam DB, Philipp J, Malipiero UV, ten Dijke P, Schachner M & Fontana A (1992), Differential expression of transforming growth factor-beta 1, -beta 2, and -beta 3 by glioblastoma cells, astrocytes, and microglia., Journal of Immunology 148(5): 1404-10.
- Strife A, Lambek C, Perez A, Darzynkiewicz Z, Skierski J, Gulati S, Haley JD, ten Dijke P, Iwata KK & Clarkson BD (1991), The effects of transforming growth factor beta 3 on the growth of highly enriched hematopoietic progenitor cells derived from normal human bone marrow and peripheral blood., Cancer Research 51(18): 4828-36.
- Cheifetz S, Hernandez H, Laiho M, ten Dijke P, Iwata KK & Massagué J (1990), Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms., Journal of Biological Chemistry 265(33): 20533-8.
- Gatherer D, Ten Dijke P, Baird DT & Akhurst RJ (1990), Expression of TGF-beta isoforms during first trimester human embryogenesis., Development 110(2): 445-60.
- ten Dijke P, Iwata KK, Thorikay M, Schwedes J, Stewart A & Pieler C (1990), Molecular characterization of transforming growth factor type beta 3., Annals of the New York Academy of Sciences 593: 26-42.
- ten Dijke P, Iwata KK, Goddard C, Pieler C, Canalis E, McCarthy TL & Centrella M (1990), Recombinant transforming growth factor type beta 3: biological activities and receptor-binding properties in isolated bone cells., Molecular and Cellular Biology 10(9): 4473-9.
- ten Dijke P, Geurts van Kessel AH, Foulkes JG & Le Beau MM (1988), Transforming growth factor type beta 3 maps to human chromosome 14, region q23-q24., Oncogene 3(6): 721-4.
- ten Dijke P, Hansen P, Iwata KK, Pieler C & Foulkes JG (1988), Identification of another member of the transforming growth factor type beta gene family., Proceedings of the National Academy of Sciences 85(13): 4715-9.
- van Duin M, Koken MH, van den Tol J, ten Dijke P, Odijk H, Westerveld A, Bootsma D & Hoeijmakers JH (1987), Genomic characterization of the human DNA excision repair gene ERCC-1., Nucleic Acids Research 15(22): 9195-213.
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- Consultant
- Consultant
- Guest professor
- Guest professor
- Guest professor