Cornelis Hokke
Hoogleraar Glycobiologie van gastheer-pathogeeninteractie
- Naam
- Prof.dr. C.H. Hokke
- Telefoon
- +31 71 526 5065
- c.h.hokke@lumc.nl
- ORCID iD
- 0000-0003-3545-7804
Cornelis H. (Ron) Hokke is hoogleraar Glycobiologie van Gastheer-Pathogeen Interactie en wetenschappelijk staflid van de afdeling Parasitologie van het Leids Universitair Medisch Centrum.
Glycobiologie van gastheer-pathogeen interactie
Alle pathogenen, van de kleinste microbe tot de grootste parasitaire worm, gaan interacties met ons aan door gebruik te maken van moleculaire suikerverbindingen, glycanen genoemd. Ons afweersysteem reageert op glycanen van bijvoorbeeld bacteriën en parasieten, en sommige virussen gebruiken de glycanen op onze cellen om aan te hechten. Glycanen en hun bindingspartners zoals lectines en antilichamen spelen daarom een essentiële rol in infecties. Ze vormen daarmee belangrijke aangrijpingspunten voor de ontwikkeling van geneesmiddelen, vaccins en diagnostische methoden. Centraal in mijn leerstoel staat het fascinerende, innovatieve onderzoeksveld dat zich hiermee bezighoudt: de glycobiologie van gastheer-pathogeen interactie. De belangrijkste onderzoekslijnen omvatten de ontwikkeling van op glycoconjugaten gebaseerde vaccins en diagnostica om wereldwijd zeer belangrijke wormeninfecties als schistosomiasis te kunnen bestrijden, en de identificatie van immunomodulatoire parasitaire glycoconjugaten als nieuwe therapeutica om allergische of ontstekingsziekten te bestrijden.
Wetenschappelijke carrière
Cornelis Hokke heeft zijn opleiding Scheikunde en zijn promotie onderzoek gedaan aan de Universiteit Utrecht. De titel van zijn proefschrift (1993) luidt ‘Structure determination of glycoprotein glycans’. Vervolgens ontwikkelde hij zich op basis van zijn biochemische achtergrond in de medische glycobiologie op de Vrije Universiteit Amsterdam. Vlak voor het jaar 2000 kwam hij naar de afdeling Parasitologie op het LUMC om zijn glycobiologische kennis te toe te passen in studies naar parasitaire infecties en een fascinatie te ontwikkelen voor de glycobiologie van gastheer-pathogeen interactie. Hij werd in maart 2017 benoemd tot hoogleraar bij het LUMC op de gelijknamige leerstoel.
Prijzen en eervolle benoemingen
Cornelis Hokke heeft inmiddels > 125 publicaties op het gebied van de glycobiologie en/of parasitologie op zijn naam staan. Van 2007 tot 2011 was Cornelis Hokke voorzitter van de Nederlandse Vereniging voor Glycobiologie. Hij is en was actief in de organisatie van meerdere nationale en internationale symposia op het gebied van glycobiologie en van de parasitologie. Op dit moment zit hij in de redactieraad van de vaktijdschriften Glycoconjugate Journal en Parasitology International, waarmee zijn bijzondere combinatie van expertise in de glycobiologie en de parasitologie nog eens wordt onderstreept.
Meer informatie
https://www.lumc.nl/org/parasitologie/research/glycobiology/
Hoogleraar Glycobiologie van gastheer-pathogeeninteractie
- Faculteit Geneeskunde
- Divisie 2
- Infectieziekten
- Parasitologie
- Meulah, B.; Bengtson, M.; Lieshout, L.V.; Hokke, C.H.; Kreidenweiss, A.; Diehl, J.C.; Adegnika, A.A. & Agbana, T.E. (2023), A review on innovative optical devices for the diagnosis of human soil-transmitted helminthiasis and schistosomiasis, Parasitology 150(2): 137-149.
- Kuipers, M.E.; Nguyen, D.L.; Diepen, A. van; Mes, L.; Bos, E.; Koning, R.I.; Nolte-'t Hoen, E.N.M.; Smits, H.H. & Hokke, C.H. (2023), Life stage-specific glycosylation of extracellular vesicles from Schistosoma mansoni schistosomula and adult worms drives differential interaction with C-type lectin receptors DC-SIGN and MGL, Frontiers in Molecular Biosciences 10.
- White, R.; Sotillo, J.; Ancarola, M.E.; Borup, A.; Boysen, A.T.; Brindley, P.J.; Buzas, E.I.; Cavallero, S.; Chaiyadet, S.; Chalmers, I.W.; Cucher, M.A.; Dagenais, M.; Davis, C.N.; Devaney, E.; Duque-Correa, M.A.; Eichenberger, R.M.; Fontenla, S.; Gasan, T.A.; Hokke, C.H.; Kosanovic, M.; Kuipers, M.E.; Laha, T.; Loukas, A.; Maizels, R.M.; Marcilla, A.; Mazanec, H.; Morphew, R.M.; Neophytou, K.; Nguyen, L.T.; Nolte-'t Hoen, E.; Povelones, M.; Robinson, M.W.; Rojas, A.; Schabussova, I.; Smits, H.H.; Sungpradit, S.; Tritten, L.; Whitehead, B.; Zakeri, A.; Nejsum, P.; Buck, A.H. & Hoffmann, K.F. (2023), Special considerations for studies of extracellular vesicles from parasitic helminths, Journal of Extracellular Vesicles 12(1).
- Chayé, M.A.M.; Gasan, T.A.; Ozir-Fazalalikhan, A.; Scheenstra, M.R.; Zawistowska-Deniziak, A.; Hengel, O.R.J. van; Gentenaar, M.; Manurung, M.D.; Harvey, M.R.; Codée, J.D.C.; Chiodo, F.; Heijke, A.M.; Kalinowska, A.; Diepen, A. van; Hensbergen, P.J.; Yazdanbakhsh, M.; Guigas, B.; Hokke, C.H. & Smits, H.H. (2023), Schistosoma mansoni egg-derived thioredoxin and Sm14 drive the development of IL-10 producing regulatory B cells, PLoS Neglected Tropical Diseases 17(6).
- Koopman, J.P.R.; Houlder, E.L.; Janse, J.J.; Casacuberta-Partal, M.; Lamers, O.A.C.; Sijtsma, J.C.; Dood, C. de; Hilt, S.T.; Ozir-Fazalalikhan, A.; Kuiper, V.P.; Roozen, G.V.T.; Bes-Roeleveld, L.M. de; Kruize, Y.C.M.; Wammes, L.J.; Smits, H.H.; Lieshout, L. van; Dam, G.J. van; Amerongen-Westra, I.M. van; Meij, P.; Corstjens, P.L.A.M.; Jochems, S.P.; Diepen, A. van; Yazdanbakhsh, M.; Hokke, C.H. & Roestenberg, M. (2023), Safety and infectivity of female cercariae in Schistosoma- naïve, healthy participants, EBioMedicine 97.
- Petralia, L.M.C.; Diepen, A. van; Nguyen, D.L.; Lokker, L.A.; Sartono, E.; Bennuru, S.; Nutman, T.B.; Pfarr, K.; Hoerauf, A.; Wanji, S.; Foster, J.M. & Hokke, C.H. (2023), Unraveling cross-reactivity of anti-glycan IgG responses in filarial nematode infections, Frontiers in Immunology 14.
- Kuipers, M.E.; Koning, R.I.; Bos, E.; Hokke, C.H.; Smits, H.H. & Nolte-'t Hoen, E.N.M. (2022), Optimized protocol for the isolation of extracellular vesicles from the parasitic worm Schistosoma mansoni with improved purity, concentration, and yield, Journal of Immunology Research 2022.
- Meulah, B.; Oyibo, P.; Bengtson, M.; Agbana, T.; Lontchi, R.A.L.; Adegnika, A.A.; Oyibo, W.; Hokke, C.H.; Diehl, J.C. & Lieshout, L. van (2022), Performance Evaluation of the Schistoscope 5.0 for (Semi-)automated Digital Detection and Quantification of Schistosoma haematobium Eggs in Urine: A Field-based Study in Nigeria, American Journal of Tropical Medicine and Hygiene 107(5): 1047-1054.
- Petralia, L.M.C.; Santha, E.; Behrens, A.J.; Nguyen, D.L.; Ganatra, M.B.; Taron, C.H.; Khatri, V.; Kalyanasundaram, R.; Diepen, A. van; Hokke, C.H. & Foster, J.M. (2022), Alteration of rhesus macaque serum N-glycome during infection with the human parasitic filarial nematode Brugia malayi, Scientific Reports 12(1).
- Huettner, I.; Krumm, S.A.; Serna, S.; Brzezicka, K.; Monaco, S.; Walpole, S.; Diepen, A. van; Allan, F.; Hicks, T.; Kimuda, S.; Emery, A.M.; Landais, E.; Hokke, C.H.; Angulo, J.; Reichardt, N.; Doores, K.J.; IAVI Protocol C Investigators & IAVI African HIV Res Network (2022), Cross-reactivity of glycan-reactive HIV-1 broadly neutralizing antibodies with parasite glycans, Cell Reports 38(13).
- Pongracz, T.; Nouta, J.; Wang, W.J.; Meijgaarden, K.E. van; Linty, F.; Vidarsson, G.; Joosten, S.A.; Ottenhoff, T.H.M.; Hokke, C.H.; Vries, J.J.C. de; Arbous, S.M.; Roukens, A.H.E.; Wuhrer, M.; BEAT-COVID Grp & COVID-19 Grp (2022), Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19, EBioMedicine 78.
- Petralia, L.M.C.; Diepen, A. van; Lokker, L.A.; Nguyen, D.L.; Sartono, E.; Khatri, V.; Kalyanasundaram, R.; Taron, C.H.; Foster, J.M. & Hokke, C.H. (2022), Mass spectrometric and glycan microarray-based characterization of the filarial nematode Brugia malayi glycome reveals anionic and zwitterionic glycan antigens, Molecular & Cellular Proteomics 21(5).
- Crosnier, C.; Hokke, C.H.; Protasio, A.V.; Brandt, C.; Rinaldi, G.; Langenberg, M.C.C.; Clare, S.; Janse, J.J.; Wilson, S.; Berriman, M.; Roestenberg, M. & Wright, G.J. (2022), Screening of a library of recombinant Schistosoma mansoni proteins with sera from murine and human controlled infections identifies early serological markers, The Journal of Infectious Diseases 225(8): 1435-1446.
- Meulah, B.; Bengtson, M.; Lieshout, L.V.; Hokke, C.H.; Kreidenweiss, A.; Diehl, J.C.; Adegnika, A.A. & Agbana, T.E. (2022), A review on innovative optical devices for the diagnosis of human soil-transmitted helminthiasis and schistosomiasis, Parasitology 150(2).
- Fossa, S.L.; Anton, B.P.; Boisvert, M.L.; Petralia, L.M.C.; Kneller, D.W.; Ganatra, M.B.; Hokke, C.H.; Foster, J.M. & Taron, C.H. (2022), A novel family of sugar-specific phosphodiesterases that remove zwitterionic modifications of N-acetylglucosamine, Glycobiology 32(11): 976-977.
- Hulme, B.J.; Geyer, K.K.; Forde-Thomas, J.E.; Padalino, G.; Phillips, D.W.; Ittiprasert, W.; Karinshak, S.E.; Mann, V.H.; Chalmers, I.W.; Brindley, P.J.; Hokke, C.H. & Hoffmann, K.F. (2022), Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production, PLoS Pathogens 18(1).
- Nkurunungi, G.; Mpairwe, H.; Versteeg, S.A.; Diepen, A. van; Nassuuna, J.; Kabagenyi, J.; Nambuya, I.; Sanya, R.E.; Nampijja, M.; Serna, S.; Reichardt, N.C.; Hokke, C.H.; Webb, E.L.; Ree, R. van; Yazdanbakhsh, M. & Elliott, A.M. (2021), Cross-reactive carbohydrate determinant-specific IgE obscures true atopy and exhibits alpha-1,3-fucose epitope-specific inverse associations with asthma, Allergy 76(1): 233-246.
- Tanaka, M.; Kildemoes, A.O.; Chadeka, E.A.; Cheruiyot, B.N.; Sassa, M.; Moriyasu, T.; Nakamura, R.; Kikuchi, M.; Fujii, Y.; Dood, C.J. de; Corstjens, P.L.A.M.; Kaneko, S.; Maruyama, H.; Njenga, S.M.; Vrueh, R. de; Hokke, C.H. & Hamano, S. (2021), Potential of antibody test using Schistosoma mansoni recombinant serpin and RP26 to detect light-intensity infections in endemic areas, Parasitology International 83.
- Pearson, M.S.; Tedla, B.A.; Mekonnen, G.G.; Proietti, C.; Becker, L.; Nakajima, R.; Jasinskas, A.; Doolan, D.L.; Amoah, A.S.; Knopp, S.; Rollinson, D.; Ali, S.M.; Kabole, F.; Hokke, C.H.; Adegnika, A.A.; Field, M.A.; Dam, G. van; Corstjens, P.L.A.M.; Mduluza, T.; Mutapi, F.; Oeuvray, C.; Greco, B.; Chaiyadet, S.; Laha, T.; Cai, P.F.; McManus, D.P.; Bottazzi, M.E.; Felgner, P.L.; Sotillo, J. & Loukas, A. (2021), Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis, The Lancet Microbe 2(11): E617-E626.
- Casacuberta-Partal, M.; Lieshout, L. van; Diepen, A. van; Sijtsma, J.C.; Ozir-Fazalalikhan, A.; Koopman, J.P.R.; Dood, C.J. de; Corstjens, P.L.A.M.; Dam, G.J. van; Hokke, C.H. & Roestenberg, M. (2021), Excretion patterns of Schistosoma mansoni antigens CCA and CAA by adult male and female worms, using a mouse model and ex vivo parasite cultures, Parasitology 149(3).
- Morelli, L.; Lay, L.; Santana-Mederos, D.; Valdes-Balbin, Y.; Bencomo, V.V.; Diepen, A. van; Hokke, C.H.; Chiodo, F. & Compostella, F. (2021), Glycan array evaluation of synthetic epitopes between the capsular polysaccharides from Streptococcus pneumoniae 19F and 19A, ACS Chemical Biology 16(9): 1671-1679.
- Huettner, I.; Krumm, S.; Landais, E.; Brzezicka, K.; Serna, S.; Diepen, A. van; Angulo, J.; Allan, F.; Emery, A.; Reichardt, N.; Hokke, R.; Poignard, P. & Doores, K. (2021), Cross-reactivity between HIV-1 bnAbs and parasite glycans, Journal of the International AIDS Society 24.
- Harvey, M.R.; Chiodo, F.; Noest, W.; Hokke, C.H.; Marel, G.A. van der & Codee, J.D.C. (2021), Synthesis and antibody binding studies of schistosome-derived oligo-alpha-(1-2)-l-fucosides, Molecules 26(8).
- Berni, F.; Wang, L.M.; Kalfopoulou, E.; Nguyen, D.L.; Es, D. van der; Huebner, J.; Overkleeft, H.S.; Hokke, C.H.; Marel, G.A. van der; Diepen, A. van & Codee, J.D.C. (2021), Generation of glucosylated sn-1-glycerolphosphate teichoic acids, RSC Chemical Biology 2(1): 187-191.
- Berni, F.; Kalfopoulou, E.; Cardells, A.M.G.; Carboni, F.; Es, D. van der; Romero-Saavedra, F.; Laverde, D.; Miklic, K.; Malic, S.; Rovis, T.L.; Jonjic, S.; Ali, S.; Overkleeft, H.S.; Hokke, C.H.; Diepen, A. van; Adamo, R.; Jimenez-Barbero, J.; Marel, G.A. van der; Huebner, J. & Codee, J.D.C. (2021), Epitope recognition of a monoclonal antibody raised against a synthetic glycerol phosphate based teichoic acid, ACS Chemical Biology 16(8): 1344-1349.
- Alvisi, N.; Noort, K. van; Dwiani, S.; Geschiere, N.; Sukarta, O.; Varossieau, K.; Nguyen, D.L.; Strasser, R.; Hokke, C.H.; Schots, A. & Wilbers, R.H.P. (2021), Beta-hexosaminidases along the secretory pathway of nicotiana benthamiana have distinct specificities toward engineered helminth N-glycans on recombinant glycoproteins, Frontiers in Plant Science 12.
- Casacuberta-Partal, M.; Beenakker, M.; Dood, C. de; Hoekstra, P.; Kroon, L.; Kornelis, D.; Corstjens, P.; Hokke, C.H.; Dam, G. van; Roestenberg, M. & Lieshout, L. van (2021), Specificity of the point-of-care urine strip test for schistosoma circulating cathodic antigen (POC-CCA) tested in non-endemic pregnant women and young children, American Journal of Tropical Medicine and Hygiene 104(4): 1412--1417.
- Zande, H.J.P. van der; Gonzalez, M.A.; Ruiter, K. de; Wilbers, R.H.P.; Garcia-Tardon, N.; Huizen, M. van; Noort, K. van; Pelgrom, L.R.; Lambooij, J.M.; Zawistowska-Deniziak, A.; Otto, F.; Ozir-Fazalalikhan, A.; Willigen, D. van; Welling, M.; Poles, J.; Leeuwen, F. van; Hokke, C.H.; Schots, A.; Yazdanbakhsh, M.; Loke, P. & Guigas, B. (2021), The helminth glycoprotein omega-1 improves metabolic homeostasis in obese mice through type 2 immunity-independent inhibition of food intake, The FASEB Journal 35(2).
- Kildemoes, A.O.; Veldhuizen, T.; Tanaka, M.; Lieshout, L. van; Camprubí-Ferrer, D.; Munoz, J.; Clerinx, J.; Visser, L.; Hamano, S.; Njenga, S.M.; Roestenberg, M.; Diepen, A. van & Hokke, C.H. (2021), DIMINISHING CROSS-REACTIVITY IN SCHISTOSOMIASIS SEROLOGY BY APPLYING A SINGLE GLYCAN TARGET APPROACH, American Journal of Tropical Medicine and Hygiene 105(5): 412-412.
- Quik, M.; Hokke, C.H. & Everts, B. (2020), The role of O-GlcNAcylation in immunity against infections, Immunology 161(3): 175-185.
- Hoffmann, K.F.; Hokke, C.H.; Loukas, A. & Buck, A.H. (2020), Helminth extracellular vesicles: great balls of wonder, International Journal for Parasitology 50(9): 621-622.
- Kuipers, M.E.; Nolte-'t Hoen, E.N.M.; Ham, A.J. van der; Ozir-Fazalalikhan, A.; Nguyen, D.L.; Korne, C.M. de; Koning, R.I.; Tomes, J.J.; Hoffmann, K.F.; Smits, H.H. & Hokke, C.H. (2020), DC-SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte-derived dendritic cells, Journal of Extracellular Vesicles 9(1).
- Ta, B.T.T.; Nguyen, D.L.; Jala, I.; Dontumprai, R.; Plumworasawat, S.; Aighewi, O.; Ong, E.; Shawley, A.; Potriquet, J.; Saichua, P.; Diepen, A. van; Sripa, B.; Hokke, C.H. & Suttiprapa, S. (2020), Identification, recombinant protein production, and functional analysis of a M60-like metallopeptidase, secreted by the liver fluke Opisthorchis viverrini, Parasitology International 75.
- Langenberg, M.C.C.; Hoogerwerf, M.A.; Koopman, J.P.R.; Janse, J.J.; Oosterhoud, J.K.V.; Feijt, C.; Jochems, S.P.; Dood, C.J. de; Schuijlenburg, R. van; Ozir-Fazalalikhan, A.; Manurung, M.D.; Sartono, E.; Beek, M.T. van der; Winkel, B.M.F.; Verbeek-Menken, P.H.; Stam, K.A.; Leeuwen, F.W.B. van; Meij, P.; Diepen, A. van; Lieshout, L. van; Dam, G.J. van; Corstjens, P.L.A.M.; Hokke, C.H.; Yazdanbakhsh, M.; Visser, L.G. & Roestenberg, M. (2020), A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics, Nature Medicine 26(3): 326-+.
- Kuipers, M.E.; Nolte-'t Hoen, E.N.M.; Ham, A.J. van der; Ozir-Fazalalikhan, A.; Nguyen, D.L.; Korne, C.M. de; Koning, R.I.; Tomes, J.J.; Hoffmann, K.F.; Smits, H.H. & Hokke, C.H. (2020), DC-SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte-derived dendritic cells, Journal of Extracellular Vesicles 9(1).
- Noort, K. van; Nguyen, D.L.; Kriechbaumer, V.; Hawes, C.; Hokke, C.H.; Schots, A. & Wilbers, R.H.P. (2020), Functional characterization of Schistosoma mansoni fucosyltransferases in Nicotiana benthamiana plants, Scientific Reports 10(1).
- Kildemoes, A.O.; Diepen, A. van; Veldhuizen, T.; Nguyen, L.; Tanaka, M.; Dam, G.J. van; Roestenberg, M.; Hamano, S. & Hokke, C.H. (2019), THE DIAGNOSTIC POTENTIAL OF GLYCAN SPECIFIC ANTIBODIES IN SCHISTOSOMIASIS ASSESSED BY GLYCAN MICROARRAYS, American Journal of Tropical Medicine and Hygiene 101: 214-214.
- Farias, L.P.; Chalmers, L.W.; Perally, S.; Rofatto, H.K.; Jackson, C.J.; Brown, M.; Khouri, M.I.; Barbosa, M.M.F.; Hensbergen, P.J.; Hokke, C.H.; Leite, L.C.C. & Hoffmann, K.F. (2019), Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity, International Journal for Parasitology 49(8): 593-599.
- Langenberg, M.C.C.; Hoogerwerf, M.A.; Janse, J.J.; Lieshout, L. van; Corstjens, P.L.A.M.; Roestenberg, M.; Dam, G.J. van; Diepen, A. van; Dood, C.J. de; Feijt, C.; Ganesh, M.S.; Gerritsma, H.; Hardeman, G.; Hokke, C.H.; Koopman, J.P.R.; Kos-van Oosterhoud, J.; Kruize, Y.C.M.; Meij, P.; Ozir-Fazalalikhan, A.; Schuijlenburg, R. van; Smits, H.H.; Verbeek-Menken, P.H.; Visser, L.G.; Vries, J.J.C. de; Winkel, B.M.F.; Yazdanbakhsh, M. & CoHSI Clinical Trial Team (2019), Katayama Syndrome Without Schistosoma mansoni Eggs, Annals of Internal Medicine 170(10): 732-+.
- Nkurunungi, G.; Diepen, A. van; Nassuuna, J.; Sanya, R.E.; Nampijja, M.; Nambuya, I.; Kabagenyi, J.; Serna, S.; Reichardt, N.C.; Ree, R. van; Webb, E.L.; Elliott, A.M.; Yazdanbakhsh, M. & Hokke, C.H. (2019), Microarray assessment of N-glycan-specific IgE and IgG profiles associated with Schistosoma mansoni infection in rural and urban Uganda, Scientific Reports 9.
- Yang, Y.Y.M.; Wilson, R.A.; Thomas, S.R.L.; Kariuki, T.M.; Diepen, A. van & Hokke, C.H. (2019), Micro Array-Assisted Analysis of Anti-Schistosome Glycan Antibodies Elicited by Protective Vaccination With Irradiated Cercariae, Journal of Infectious Diseases 219(10): 1671-1680.
- Ittiprasert, W.; Mann, V.H.; Karinshak, S.E.; Coghlan, A.; Rinaldi, G.; Sankaranarayanan, G.; Chaidee, A.; Tanno, T.; Kumkhaek, C.; Prangtaworn, P.; Mentink-Kane, M.M.; Cochran, C.J.; Driguez, P.; Holroyd, N.; Tracey, A.; Rodpai, R.; Everts, B.; Hokke, C.H.; Hoffmann, K.F.; Berriman, M. & Brindley, P.J. (2019), Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni, eLife 8.
- Es D. van der, Berni F., Hogendorf W.F.J., Meeuwenoord N., Laverde D., Diepen A. van, Overkleeft H.S., Filippov D.V., Hokke C.H., Huebner J., Marel G.A. van der & Codée J.D.C. (2018), Streamlined Synthesis and Evaluation of Teichoic Acid Fragments, Chemistry: a European Journal 24(16): 4014-4018.
- Kytidou K., Beekwilder J., Artola M., Meel E. van, Wilbers R.H.P., Moolenaar G.F., Goosen N., Ferraz M.J., Katzy R., Voskamp P., Florea B.I., Hokke C.H., Overkleeft H.S., Schots A., Bosch D., Pannu N. & Aerts J.M.F.G. (2018), Nicotiana benthamiana α-galactosidase A1.1 can functionally complement human α-galactosidase A deficiency associated with Fabry disease, Journal of Biological Chemistry 293(26): 10042-10058.
- Egesa, M.; Lubyayi, L.; Jones, F.M.; Diepen, A. van; Chalmers, I.W.; Tukahebwa, E.M.; Bagaya, B.S.; Hokke, C.H.; Hoffmann, K.F.; Dunne, D.W.; Elliott, A.M.; Yazdanbakhsh, M.; Wilson, S. & Cose, S. (2018), Antibody responses to Schistosoma mansoni schistosomula antigens, Parasite Immunology 40(12).
- Winkel, B.M.F.; Dalenberg, M.R.; Korne, C.M. de; Feijt, C.; Langenberg, M.C.C.; Pelgrom, L.; Ganesh, M.S.; Yazdanbakhsh, M.; Smits, H.H.; Jong, E.C. de; Everts, B.; Leeuwen, F.W.B. van; Hokke, C.H. & Roestenberg, M. (2018), Early Induction of Human Regulatory Dermal Antigen Presenting Cells by Skin-Penetrating Schistosoma Mansoni Cercariae, Frontiers in Immunology 9.
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Langenberg, M.; Hoogerwerf, M.A.; Janse, J.; Kos-van Oosterhoud, J.; Feijt, C.; Dood, C. de; Ganesh, M.; Ozir-Fazalakhan, A.; Kruize, Y.; Winkel, B.; Hardeman, G.; Verbeek-Menken, P.; Beek, M. van der; Brienen, E.; Diepen, A. van; Corstjens, P.; Visser, L.; Lieshout, L. van; Smits, H.; Meij, P.; Dam, G. van; Hokke, R.; Yazdanbakhsh, M. & Roestenberg, M. (2018), CONTROLLED HUMAN INFECTION WITH SINGLE-SEX
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- Johswich, A.; Kraft, B.; Wuhrer, M.; Berger, M.; Deelder, A.M.; Hokke, C.H.; Gerardy-Schahn, R. & Bakker, H. (2009), Golgi targeting of Drosophila melanogaster beta 4GalNAcTB requires a DHHC protein family-related protein as a pilot, Journal of Cell Biology 184(1): 173-183.
- de Geus DC, van Roon AMM, Thomassen EAJ, Hokke CH, Deelder AM & Abrahams JP (2009), Characterization of a diagnostic Fab fragment binding trimeric Lewis X, Proteins 76(2): 439-447.
- Peterson NA, Hokke CH, Deelder AM & Yoshino TP (2009), Glycotope analysis in miracidia and primary sporocysts of Schistosoma mansoni: Differential expression during the miracidium-to-sporocyst transformation, International Journal for Parasitology 39(12): 1331-1344.
- Schramm G, Hamilton JV, Balog CIA, Wuhrer M, Gronow A, Beckmann S, Wippersteg V, Grevelding CG, Goldmann T & Weber E (2009), Molecular characterisation of kappa-5, a major antigenic glycoprotein from Schistosoma mansoni eggs, Molecular and Biochemical Parasitology 166(1): 4-14.
- Everts B, Perona-Wright G, Smits HH, Hokke CH, van der Ham AJ, Fitzsimmons CM, Doenhoff MJ, van der Bosch J, Mohrs K & Haas H (2009), Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses, Journal of Experimental Medicine 206(8): 1673-1680.
- Stolz A., Haines N., Pich A., Irvine K.D., Hokke C.H., Deelder A.M., Gerardy-Schahn R., Wuhrer M. & Bakker H. (2008), Distinct contributions of beta4GalNAcTA and beta4GalNAcTB to Drosophila glycosphingolipid biosynthesis, Glycoconjugate Journal : .
- Bakker H, Johswich A, Kraft B, Wuhrer M, Hokke CH & Gerardy-Schahn R (2008), Mechanism of Interaction between Drosophila beta 4GalNAcTB and the beta 4GalNAcTB Pilot Protein (GABPI), Glycobiology 18(11): 993-993.
- Yoshino TP, Dinguirard N, Kunert J & Hokke CH (2008), Molecular and functional characterization of a tandem-repeat galectin from the freshwater snail Biomphalaria glabrata, intermediate host of the human blood fluke Schistosoma mansoni, Gene 411(1-2).
- Ruhaak LR, Huhn C, Waterreus WJ, de Boer AR, Neususs C, Hokke CH, Deelder AM & Wuhrer M (2008), Hydrophilic interaction chromatography-based high-throughput sample preparation method for N-glycan analysis from total human plasma glycoproteins, Analytical Chemistry 80(15).
- Hokke C (2008), Parasite glycobiology: Schistosome glycans in parasite-host interaction and development, Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology 150(3).
- Robijn MLM, Planken J, Kornelis D, Hokke CH & Deelder AM (2008), Mass spectrometric detection of urinary oligosaccharides as markers of Schistosoma mansoni infection, Transactions of The Royal Society of Tropical Medicine and Hygiene 102(1).
- de Boer AR, Hokke CH, Deelder AM & Wuhrer M (2008), Serum antibody screening by surface plasmon resonance using a natural glycan microarray, Glycoconjugate Journal 25(1).
- Stolz A, Haines N, Pich A, Irvine KD, Hokke CH, Deelder AM, Gerardy-Schahn R, Wuhrer M & Bakker H (2008), Distinct contributions of beta 4GalNAcTA and beta 4GalNAcTB to Drosophila glycosphingolipid biosynthesis, Glycoconjugate Journal 25(2).
- Hokke C.H., Deelder A.M., Hoffmann K.F. & Wuhrer M. (2007), Glycomics-driven discoveries in schistosome research, Experimental Parasitology 117(3): 275-83.
- Boer B.A. de, Hokke C.H., Deelder A.M. & Wuhrer M. (2007), General microarray technique for immobilization and screening of natural glycans, Analytical Chemistry 79(21): 8107-13.
- de Boer AR, Hokke CH, Deelder AM & Wuhrer M (2007), General microarray technique for immobilization and screening of natural glycans, Analytical Chemistry 79(21).
- Wuhrer M, Stam JC, van de Geijn FE, Koeleman CAM, Verrips CT, Dolhain RJEM, Hokke CH & Deelder AM (2007), Glycosylation profiling of immunoglobulin G (IgG) subclasses from human serum, Proteomics 7(22).
- Rouwendal GJA, Wuhrer M, Florack DEA, Koeleman CAM, Deelder AM, Bakker H, Stoopen GM, van Die I, Helsper JPFG, Hokke CH & Bosch D (2007), Efficient introduction of a bisecting GlcNAc residue in tobacco N-glycans by expression of the gene encoding human N-acetylglucosaminyltransferase III, Glycobiology 17(3).
- Robijn MLM, Koeleman CAM, Wuhrer M, Royle L, Geyer R, Dwek RA, Rudd PM, Deelder AM & Hokke CH (2007), Targeted identification of a unique glycan epitope of Schistosoma mansoni egg antigens using a diagnostic antibody, Molecular and Biochemical Parasitology 151(2).
- Hokke CH, Fitzpatrick JM & Hoffmann KF (2007), Integrating transcriptome, proteome and glycome analyses of Schistosoma biology, Trends in Parasitology 23(4).
- Wuhrer M, Catalina MI, Deelder AM & Hokke CH (2007), Glycoproteomics based on tandem mass spectrometry of glycopeptides, Journal of Chromatography B 849(1-2).
- Robijn MLM, Koeleman CAM, Hokke CH & Deelder AM (2007), Schistosoma mansoni eggs excrete specific free oligosaccharides that are detectable in the urine of the human host, Molecular and Biochemical Parasitology 151(2).
- Goselink HM, Nijmeijer BA, Hokke CH, van der Heijden R, Willemze R & Falkenburg JHF (2007), Proliferation of acute lymphoblastic leukemic (ALL) cells is dependent on exogenous purine administration, Blood 110(11).
- Hokke CH, Deelder AM, Hoffmann KF & Wuhrer M (2007), Glycomics-driven discoveries in schistosome research, Experimental Parasitology 117(3).
- Wuhrer M, Koeleman CAM, Fitzpatrick JM, Hoffmann KF, Deelder AM & Hokke CH (2006), Gender-specific expression of complex-type N-glycans in schistosomes, Glycobiology 16(10).
- Wuhrer M, Balog CIA, Catalina MI, Jones FM, Schramm G, Haas H, Doenhoff MJ, Dunne DW, Deelder AM & Hokke CH (2006), IPSE/alpha-1, a major secretory glycoprotein antigen from schistosome eggs, expresses the Lewis X motif on core-difucosylated N-glycans, FEBS Journal 273(10).
- Van de Vijver KK, Deelder AM, Jacobs W, Van Marck EA & Hokke CH (2006), LacdiNAc- and LacNAc-containing glycans induce granulomas in an in vivo model for schistosome egg-induced hepatic granuloma formation, Glycobiology 16(3).
- Van de Vijver KK, Colpaert CG, Jacobs W, Kuypers K, Hokke CH, Deelder AM & Van Marck EA (2006), The host's genetic background determines the extent of angiogenesis induced by schistosome egg antigens, Acta Tropica 99(2-3).
- Wuhrer M, Koeleman CAM, Deelder AM & Hokke CH (2006), Repeats of LacdiNAc and fucosylated LacdiNAc on N-glycans of the human parasite Schistosoma mansoni, FEBS Journal 273(2).
- Wuhrer M, Koeleman CAM, Hokke CH & Deelder AM (2006), Mass spectrometry of proton adducts of fucosylated N-glycans: fucose transfer between antennae gives rise to misleading fragments, Rapid Communications in Mass Spectrometry 20(11).
- Tong M, Jacobi CE, van de Rijke FM, Kuijper S, van de Werken S, Lowary TL, Hokke CH, Appelmelk BJ, Nagelkerke NJD, Tanke HJ, van Gijlswijkh RPM, Veuskens J, Kolk AHJ & Raap AK (2005), A multiplexed and miniaturized serological tuberculosis assay identifies antigens that discriminate maximally between TB and non-TB sera, Journal of Immunological Methods 301(1-2).
- Wuhrer M, Koeleman CAM, Hokke CH & Deelder AM (2005), Protein glycosylation analyzed by normal-phase nano-liquid chromatography-mass spectrometry of glycopeptides, Analytical Chemistry 77(3).
- Robijn MLM, Wuhrer M, Kornelis D, Deelder AM, Geyer R & Hokke CH (2005), Mapping fucosylated epitopes on glycoproteins and glycolipids of Schistosoma mansoni cercariae, adult worms and eggs, Parasitology 130.
- van Roon AMM, Aguilera B, Cuenca F, van Remoortere A, van der Marel GA, Deelder AM, Overkleeft HS & Hokke CH (2005), Synthesis and antibody-binding studies of a series of parasite fuco-oligosaccharides, Bioorganic and Medicinal Chemistry 13(10).
- Wuhrer M, Balog CIA, Koeleman CAM, Deelder AM & Hokke CH (2005), New features of site-specific horseradish peroxidase (HRP) glycosylation uncovered by nano-LC-MS with repeated ion-isolation/fragmentation cycles, BBA - General Subjects 1723(1-3).
- Hokke CH & Yazdanbakhsh M (2005), Schistosome glycans and innate immunity, Parasite Immunology 27(7-8).
- de Souza AC, van Remoortere A, Hokke CH, Deelder AM, Vliegenthart JFG & Kamerling JR (2005), Determination of the specificity of monoclonal antibodies against Schistosoma mansoni CAA glycoprotein antigen using neoglycoconjugate variants, Biological Chemistry 386(9).
- Wuhrer M, Deelder AM & Hokke CH (2005), Protein glycosylation analysis by liquid chromatography-mass spectrometry, Journal of Chromatography B 825(2).
- Fitzsimmons CM, Schramm G, Jones FM, Chalmers IW, Hoffmann KE, Grevelding CG, Wuhrer M, Hokke CH, Haas H, Doenhoff MJ & Dunne DW (2005), Molecular characterization of omega-1: A hepatotoxic ribonuclease from Schistosoma mansoni eggs, Molecular and Biochemical Parasitology 144(1).
- Bruggink C, Wuhrer M, Koeleman CAM, Barreto V, Liu Y, Pohl C, Ingendoh A, Hokke CH & Deelder AM (2005), Oligosaccharide analysis by capillary-scale high-pH anion-exchange chromatography with on-line ion-trap mass spectrometry, Journal of Chromatography B 829(1-2).
- Wuhrer M, Koeleman CAM, Hokke CH & Deelder AM (2004), Nano-scale liquid chromatography-mass spectrometry of 2-aminobenzamide-labeled oligosaccharides at low femtomole sensitivity, International Journal of Mass Spectrometry 232(1).
- de Vijver KKV, Hokke CH, van Remoortere A, Jacobs W, Deelder AM & Van Marck EA (2004), Glycans of Schistosoma mansoni and keyhole limpet haemocyanin induce hepatic granulomas in vivo, International Journal for Parasitology 34(8).
- Mayboroda OA, van Remoortere A, Tanke HJ, Hokke CH & Deelder AM (2004), A new approach for fluorescence correlation spectroscopy (FCS) based immunoassays, Journal of Biotechnology 107(2).
- van de Wetering JK, van Remoortere A, Vaandrager AB, Batenburg JJ, van Golde LMG, Hokke CH & van Hellemond JJ (2004), Surfactant protein D binding to terminal alpha 1-3-linked fucose residues and to Schistosoma mansoni, American Journal of Respiratory Cell and Molecular Biology 31(5).
- van Roon AMM, Pannu NS, de Vrind JPM, van der Marel GA, van Boom JH, Hokke CH, Deelder AM & Abrahams JP (2004), Structure of an anti-Lewis X fab fragment in complex with its Lewis X antigen, Structure 12(7).
- Wuhrer M, Robijn MLM, Koeleman CAM, Balog CIA, Geyer R, Deelder AM & Hokke CH (2004), A novel Gal(beta 1-4)Gal(beta 1-4)Fuc(alpha 1-6)-core modification attached to the proximal N-acetylglucosamine of keyhole limpet haemocyanin (KLH) N-glycans, Biochemical Journal 378.
- van den Berg TK, Honing H, Franke N, van Remoortere A, Schiphorst WECM, Liu FT, Deelder AM, Cummings RD, Hokke CH & van Die I (2004), LacdiNAc-glycans constitute a parasite pattern for galectin-3-mediated immune recognition, Journal of Immunology 173(3).
- Wuhrer M, Hokke CH & Deelder AM (2004), Glycopeptide analysis by matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry reveals novel features of horseradish peroxidase glycosylation, Rapid Communications in Mass Spectrometry 18(15).
- Van Roon AMM, Van de Vijver KK, Jacobs W, Van Marck EA, Van Dam GJ, Hokke CH & Deelder AM (2004), Discrimination between the anti-monomeric and the anti-multimeric Lewis X response in murine schistosomiasis, Microbes and Infection 6(13).
- van der Boog PJM, van Kooten C, van Zandbergen G, Klar-Mohamad N, Oortwijn B, Bos NA, van Remoortere A, Hokke CH, de Fijter JW & Daha MR (2004), Injection of recombinant Fc alpha RI/CD89 in mice does not induce mesangial IgA deposition, Nephrology Dialysis Transplantation 19(11).
- Wuhrer M, Koeleman CAM, Deelder AM & Hokke CN (2004), Normal-phase nanoscale liquid chromatography - Mass spectrometry of underivatized oligosaccharides at low-femtomole sensitivity, Analytical Chemistry 76(3).
- van Roon AMM, Pannu NS, Hokke CH, Deelder AM & Abrahams JP (2003), Crystallization and preliminary X-ray analysis of an anti-LewisX Fab fragment with and without its LewisX antigen, Acta Crystallographica Section D: Biological Crystallography 59.
- Vermeer HJ, van Dam GJ, Halkes KM, Kamerling JP, Vliegenthart JFG, Hokke CH & Deelder AM (2003), Immunodiagnostically applicable monoclonal antibodies to the circulating anodic antigen of Schistosoma mansoni bind to small, defined oligosaccharide epitopes, Parasitology Research 90(4).
- Naus CWA, van Remoortere A, Ouma JH, Kimani G, Dunne DW, Kamerling JP, Deelder AM & Hokke CH (2003), Specific antibody responses to three schistosome-related carbohydrate structures in recently exposed immigrants and established residents in an area of Schistosoma mansoni endemicity, Infection and Immunity 71(10).
- van Remoortere A, Vermeer HJ, van Roon AM, Langermans JA, Thomas AW, Wilson RA, van Die I, van den Eijnden DH, Agoston K, Kerekgyarto J, Vliegenthart JFG, Kamerling JP, van Dam GJ, Hokke CH & Deelder AM (2003), Dominant antibody responses to Fuc alpha 1-3GalNAc and Fuc alpha 1-2Fuc alpha 1-3GlcNAc containing carbohydrate epitopes in Pan troglodytes vaccinated and infected with Schistosoma mansoni, Experimental Parasitology 105(3-4).
- Van der Kleij D, Van Remoortere A, Schuitemaker JHN, Kapsenberg ML, Deelder AM, Tielens AGM, Hokke CH & Yazdanbakhsh M (2002), Triggering of innate immune responses by schistosome egg glycolipids and their carbohydrate epitope GalNAc beta 1-4(Fuc alpha 1-2Fuc alpha 1-3)GlcNAc, Journal of Infectious Diseases 185(4).
- van Remoortere A, van Dam GJ, Hokke CH, van den Eijnden DH, van Die I & Deelder AM (2001), Profiles of immunoglobulin M (IgM) and IgG antibodies against defined carbohydrate epitopes in sera of Schistosoma-infected individuals determined by surface plasmon resonance, Infection and Immunity 69(4).
- van Remoortere A, Hokke CH, van Dam GJ, van Die I, Deelder AM & van den Eijnden DH (2000), Various stages of Schistosoma express Lewis(x), LacdiNAc, GalNAc beta 1-4 (Fuc alpha 1-3)GlcNAc and GalNAc beta 1-4(Fuc alpha 1-2Fuc alpha 1-3)GlcNAc carbohydrate epitopes: detection with monoclonal antibodies that are characterized by enzymatically synthesized neoglycoproteins.
- Editorial Board Member 'Parasitology International'
- Editorial Board Member 'Glycoconjugate Journal'