Menno Hoekstra
Universitair docent
- Naam
- Dr. M. Hoekstra
- Telefoon
- 071 5276582
- hoekstra@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0001-7463-2893
Meer informatie is beschikbaar op de Engelse profielpagina.
Oud-promovendi
Universitair docent
- Faculteit der Wiskunde en Natuurwetenschappen
- LACDR
- Divisie Systems Pharmacology and Pharmacy
- Hoekstra M. & Eck M. van (2024), Gene editing for the treatment of hypercholesterolemia, Current Atherosclerosis Reports 26: 139-146.
- Hoekstra M., Jong L.M. de, Geest R. van der, Leeuw L.R. de, Krinamurthi R., Geerling J.J. & Eck M. van (2024), LXR Agonist T0901317′s hepatic impact overrules its atheroprotective action in macrophages, driving early atherogenesis in cow-diet-fed male apolipoprotein E knockout mice, Biomolecules 14(4): 429.
- Hoekstra M., Snip O.S.C., Janusz P., Bernabé Kleijn M.N.A., Truitt E.R., Sullivan B.D., Schmidt T.A., Jay G.D. & Eck M. van (2024), Recombinant human proteoglycan 4 lowers inflammation and atherosclerosis susceptibility in female low-density lipoprotein receptor knockout mice, Journal of Physiology London 602(9): 1939-1951.
- Hoekstra M., Zhang Z., Lindenburg P.W. & Eck M. van (2024), Scavenger receptor BI deficiency in mice is associated with plasma ceramide and sphingomyelin accumulation and a reduced cholesteryl ester fatty acid length and unsaturation degree, Journal of Lipid and Atherosclerosis 13(1): 69-79.
- Jong L.M. de, Harpal C, Berg D. van den., Hoekstra M., Peter N.J., Rissmann R., Swen J.J. & Manson M.L. (2024), CYP and non-CYP drug metabolizing enzyme families exhibit differential sensitivities towards pro-inflammatory cytokine modulation, Drug Metabolism and Disposition 52(12): 1429-1437.
- Hoekstra M. (2024), Letter to the editor from Hoekstra: “adrenal Abcg1 controls cholesterol flux and steroidogenesis”, Endocrinology 165(9): bqae097.
- Verwilligen R.A.F., Mulder L., Araujo P.M., Carneiro M., Bussmann J., Hoekstra M. & Eck M. van (2023), Zebrafish as outgroup model to study evolution of scavenger receptor class B type I functions, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1868(6): 159308.
- Jong L.M. de, Boussallami S., Sánchez-López E., Giera M., Tushuizen M.E., Hoekstra M., Hawinkels L.J.A.C., Rissmann R., Swen J.J. & Manson M.L. (2023), The impact of CYP2C19 genotype on phenoconversion by concomitant medication, Frontiers in Pharmacology 14: 1201906.
- Hoekstra M. & Eck M. van (2023), High-density lipoproteins and non-alcoholic fatty liver disease, Atherosclerosis Plus 53: 33-41.
- Sluis R.J. van der, Aardweg T. van den, Sijsenaar T.J.P., Eck M. van & Hoekstra M. (2023), Metyrapone treatment protects low-density lipoprotein receptor knockout mice against hypercorticosteronemia development without changing atherosclerosis susceptibility, Biomolecules 13(9): 1287.
- Hoekstra M., Eck M. van & Berkel T.J.C. van (2023), Perspective : hepatocyte-directed base editing as novel treatment for human dyslipidemia-current status and remaining challenges, Arteriosclerosis, Thrombosis, and Vascular Biology 43(6): 832-835.
- Zhang Y., Verwilligen R.A.F., Eck M. van & Hoekstra M. (2023), PRMT5 inhibition induces pro-inflammatory macrophage polarization and increased hepatic triglyceride levels without affecting atherosclerosis in mice, Journal of Cellular and Molecular Medicine 27(8): 1056-1068.
- Kraaijenhof J.M., Tromp T.R., Nurmohamed N.S., Reeskamp L.F., Langenkamp M., Levels J. .H. .M., Boekholdt S.M., Wareham N.J., Hoekstra M., Stroes E.S.G., Hovingh G.K. & Grefhorst A. (2023), ANGPTL3 (angiopoietin‐Like 3) preferentially resides on high‐density lipoprotein in the human circulation, affecting its activity, Journal of the American Heart Association 12(21): .
- Schonke M., Ying Z.X., Kovynev A., Panhuis W.I.H., Binnendijk A., Poel S. van der, Pronk A.C.M., Streefland T.C.M., Hoekstra M., Kooijman S. & Rensen P.C.N. (2023), Time to run: late rather than early exercise training in mice remodels the gut microbiome and reduces atherosclerosis development, The FASEB Journal 37(1): e22719.
- Hoekstra M., Wel E.J. van der & Eck M. van (2022), Atherosclerosis regression is associated with both infiltration of new leukocytes into the plaque and a shift in macrophage polarization towards a more migratory phenotype, Atherosclerosis 356: 50-52.
- Jong L.M. de, Zhang Z., Hartog Y. de, Sijsenaar T.J.P., Martins Cardoso R., Manson M.L., Hankemeier T., Lindenburg P.W., Salvatori D.C.F., Eck M. van & Hoekstra M. (2022), PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice, Scientific Reports 12(1): 483.
- Verwilligen R.A.F., Mulder L., Rodenburg F.J., Dijke A. van, Hoekstra M., Bussmann J. & Eck M. van (2022), Stabilin 1 and 2 are important regulators for cellular uptake of apolipoprotein B-containing lipoproteins in zebrafish, Atherosclerosis 346: 18-25.
- Hoekstra M., Liu Q., Zhang Y.H., Wel E.J. van der, Le Devedec S.E. & Eck M. van (2022), Hypocholesterolemic phospholipid transfer protein knockout mice exhibit a normal glucocorticoid response to food deprivation, American Journal of Translational Research 14(3): 1884-1891.
- Snip O.S.C., Hoekstra M., Zhang Y., Geerling J.J. & Eck M. van (2022), 2-Hydroxypropyl-beta-cyclodextrin treatment does not induce atherosclerotic lesion regression in Western-type diet-fed apolipoprotein E knockout mice, Biomolecules 12(9): 1205.
- Tromp T.R., Reeskamp L.F., Langenkamp M., Levels J.H.M., Hoekstra M., Hovingh G.K. & Grefhorst A. (2022), Angiopoietin-like 3 (ANGPTL3) resides on HDL and LDL with the latter form having the highest lipase inhibitory activity, Atherosclerosis 355: 10.
- Ouweneel A.B., Reiche M.E., Snip O.S.C., Wever R., Wel E.J. van der, Schaftenaar F.H., Kauerova S., Lutgens E., Eck M. van & Hoekstra M. (2022), Apolipoprotein A1 deficiency in mice primes bone marrow stem cells for T cell lymphopoiesis, Journal of Cell Science 135(5): jcs.258901.
- Korporaal S.J.A., Sluis R.J. van der, Eck M. van & Hoekstra M. (2021), Bone marrow Ts65Dn trisomy-induced changes in platelet functionality and lymphocytopenia do not impact atherosclerosis susceptibility in mice, Journal of Cardiovascular Development and Disease 8(9): 110.
- Hoekstra M., Ren B., Laurila P.P., Hildebrand R.B., Soronen J., Frodermann V., Li Z., Boon M.R., Geerling J.J., Rensen P.C.N., Jauhiainen M. & Eck M. van (2021), Hematopoietic upstream stimulating factor 1 deficiency is associated with increased atherosclerosis susceptibility in LDL receptor knockout mice, Scientific Reports 11: 16419.
- Hommes J.W., Kratofil R.M., Wahlen S., Haas C.J.C. de, Hildebrand R.B., Hovingh G.K., Otto M., Eck M. van, Hoekstra M., Korporaal S.J.A. & Surewaard B.G.J. (2021), High density lipoproteins mediate in vivo protection against staphylococcal phenol-soluble modulins, Scientific Reports 11: 15357.
- Ouweneel A.B., Zhao Y., Calpe-Berdiel L., Lammers B., Hoekstra M., Berkel T.J.C. van & Eck M. van (2021), Impact of bone marrow ATP-binding cassette transporter A1 deficiency on atherogenesis is independent of the presence of the low-density lipoprotein receptor, Atherosclerosis 319: 79-85.
- Zhang Y., Boer M. de, Wel E.J. van der, Eck M. van & Hoekstra M. (2021), PRMT4 inhibitor TP-064 inhibits the pro-inflammatory macrophage lipopolysaccharide response in vitro and ex vivo and induces peritonitis-associated neutrophilia in vivo, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1867(11): 166212.
- Ouweneel A.B., Reiche M.E., Snip O.S.C., Wever R., Wel E.J. van der, Schaftenaar F.H. & Kauerova S.: Lutgens E.: Eck M. van Hoekstra M. (2021), Apolipoprotein A1 deficiency in mice primes bone marrow stem cells for T cell lymphopoiesis, Journal of Cell Science 135(5): jcs258901.
- Zhang Y., Verwilligen R.A.F., Boer M. de, Sijsenaar T.J.P., Eck M. van & Hoekstra M. (2021), PRMT4 inhibitor TP-064 impacts both inflammatory and metabolic processes without changing the susceptibility for early atherosclerotic lesions in male apolipoprotein E knockout mice, Atherosclerosis 338: 23-29.
- Martins Cardoso R., Creemers E., Absalah S., Hoekstra M., Gooris G.S., Bouwstra J.A. & Eck M. van (2020), Hyperalphalipoproteinemic scavenger receptor BI knockout mice exhibit a disrupted epidermal lipid barrier, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865(3): 158592.
- Hoekstra M., Sluis R.J. van der, Hildebrand R.B., Lammers B., Zhao Y., Praticò D., Berkel T.J.C. van, Rensen P.C.N., Kooijman S., Jauhiainen M. & Eck M. van (2020), Disruption of PLTP (phospholipid transfer protein)-mediated HDL (high-density lipoprotein) maturation reduces SR-BI (scavenger receptor BI) deficiency-driven atherosclerosis susceptibility despite unexpected metabolic complications, Arteriosclerosis, Thrombosis, and Vascular Biology 40(3): 611-623.
- Sluis R.J. van der & Hoekstra M. (2020), Glucocorticoids are active players and therapeutic targets in atherosclerotic cardiovascular disease, Molecular and Cellular Endocrinology 504: 110728.
- Hoekstra M. & Eck M. van (2020), Correspondence to Probucol-induced hypocholesterolemia is not associated with exacerbated foam cell formation in ABCG1 knockout mice, Atherosclerosis 296: 91-92.
- Hoekstra M. (2020), Identification of scavenger receptor BI as a potential screening candidate for congenital primary adrenal insufficiency in humans, AJP - Endocrinology and Metabolism 319(1): E102-E104.
- Hoekstra M., Ouweneel A.B., Price J., Geest R. van der, Sluis R.J. van der, Geerling J.J., Nahon J.E. & Eck M. van (2020), SR-BI deficiency disassociates obesity from hepatic steatosis and glucose intolerance development in high fat diet-fed mice, Journal of Nutritional Biochemistry 89: 108564.
- Sluis R.J. van der, Depuydt M.A.C., Eck M. van & Hoekstra M. (2020), VLDL/LDL serves as the primary source of cholesterol in the adrenal glucocorticoid response to food deprivation, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865(7): 158682.
- Koorneef L.L., Kroon J., Viho E.M.G., Wahl L.F., Heckmans K.M.L., Dorst M.M.A.R. van, Hoekstra M., Houtman R., Hunt H. & Meijer O.C. (2020), The selective glucocorticoid receptor antagonist CORT125281 has tissue-specific activity, Journal of Endocrinology 246(1): 79-92.
- Hoekstra M., Nahon J.E., Jong L.M. de, Kröner M.J., Leeuw L.R. de & Eck M. van (2019), Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865(6): 1402-1409.
- Cardoso R.M., Creemers E., Absalah S., Gooris G.S., Hoekstra M., Eck M. van & Bouwstra J.A. (2019), Hypercholesterolemia in young adult APOE−/− mice alters epidermal lipid composition and impairs barrier function, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864(7): 976-984.
- Sluis R.J. van der, Depuydt M.A.C., Verwilligen R.A.F., Hoekstra M. & Eck M. van (2019), Elimination of adrenocortical apolipoprotein E production does not impact glucocorticoid output in wild-type mice, Molecular and Cellular Endocrinology 490: 21-27.
- Hoekstra M., Snip O.S.C. & Eck M. van (2019), Letter by Hoekstra et al Regarding Article, "Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages", Circulation 139(16): 1981-1982.
- Geest R. van der, Sluis R.J. van der, Groen A.K., Eck M. van & Hoekstra M. (2019), Cholestasis-associated glucocorticoid overexposure does not increase atherogenesis, Journal of Endocrinology 242(2): 1-12.
- Snip O.S.C., Ouweneel A.B., Wever R., Schaftenaar F.H., Cejkova S., Eck M. van & Hoekstra M. (2019), Apolipoprotein A1 modulates the ability of bone marrow to facilitate lymphocyte production after transplantation into Ldl receptor knockout mice, Atherosclerosis 287: E107-E107.
- Hoekstra M., Ouweneel A.B., Nahon J.E., Geerling J.J. & Eck M. van (2019), Sr-Bi deficiency uncouples the development of hypertriglyceridemia and atherosclerosis from hepatic steatosis aand glucose intolerance in obese mice, Atherosclerosis 287: E121-E121.
- Verwilligen R.A.F., Dijke A. van, Hoekstra M., Bussmann J. & Eck M. van (2019), The role of endothelial and macrophage scavenger receptor stabilin 1 and 2 in early atherosclerosis development in zebrafish, Atherosclerosis 287: E101-E102.
- Hoekstra M., Ouweneel A.B., Nahon J.E., Geest R. van der, Kröner M.J., Sluis R.J. van der & Eck M. van (2019), ATP-binding cassette transporter G1 deficiency is associated with mild glucocorticoid insufficiency in mice, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864(4): 443-451.
- Nahon J.E., Hoekstra M., Harmelen V. van, Rensen P.C.N., Willems Van Dijk K., Kooijman S. & Eck M. van (2019), Proteoglycan 4 deficiency protects against glucose intolerance and fatty liver disease in diet-induced obese mice, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865(2): 494-501.
- Nahon J.E., Groeneveldt C., Geerling J.J., Eck M. van & Hoekstra M. (2018), Inhibition of protein arginine methyltransferase 3 activity selectively impairs liver X receptor-driven transcription of hepatic lipogenic genes in vivo, British Journal of Pharmacology 175(15): 3175-3183.
- Nahon J.E., Hoekstra M., Havik S.R., Santbrink P.J. van., Dallinga-Thie G.M., Kuivenhoven J.A., Geerling J.J. & Eck M. van (2018), Proteoglycan 4 regulates macrophage function without altering atherosclerotic lesion formation in a murine bone marrow-specific deletion model, Atherosclerosis 274: 120-127.
- Nahon J.E., Hoekstra M., Havik S.R., Santbrink P.J. van, Dallinga-Thie G.M., Kuivenhoven J.A., Geerling J.J. & Eck M. van (2018), Corrigendum to "Proteoglycan 4 regulates macrophage function without altering atherosclerotic lesion formation in a murine bone marrow-specific deletion model", Atherosclerosis 279: 132-132.
- Sluis R.J. van der, Verwilligen R.A.F., Lendvai Z., Wever R., Hoekstra M. & Eck M. van (2018), HDL is essential for atherosclerotic lesion regression in Apoe knockout mice by bone marrow Apoe reconstitution, Atherosclerosis 278: 240-249.
- Ouweneel A.B., Hoekstra M., Wel E.J. van der, Schaftenaar F.H., Snip O.S.C., Hassan J., Korporaal S.J.A. & Eck M. van (2018), Hypercholesterolemia impairs megakaryopoiesis and platelet production in scavenger receptor BI knockout mice, Atherosclerosis 282: 176-182.
- Nahon J.E., Hoekstra M. & Eck M. van (2018), Total body proteoglycan 4 (Prg4) deficiency increases atherosclerosis susceptibility in apolipoprotein E knockout and low-density lipoprotein receptor knockout mice, Atherosclerosis 278: 315-316.
- Nahon J.E., Hoekstra M., Hulst S. van, Manta C., Goerdt S., Geerling J.J., Géraud C. & Eck M. van (2018), Hematopoietic Stabilin-1 deficiency does not influence atherosclerosis susceptibility in LDL receptor knockout mice, Atherosclerosis 281: 47-55.
- Snip O.S.C., Hoekstra M., Zhao Y., Calpe-Berdiel L., Vulve J., Carles Escola-Gil J., Foks A., Sluis R.J. van der, Blanco-Vaca F., Berkel T.J.C. van, Kuivenhoven J. & Eck M. van (2018), Reduced systemic inflammation and increased reverse cholesterol transport together drive leukocyte ABCA1-mediated protection against atherosclerosis, Atherosclerosis 275: e43-e44.
- Hoekstra M., Geerling J.J., Jiskoot W. & Eck M. van (2018), The Anti-atherogenic Potential of Liposome-mediated Delivery of LXR Agonists to Macrophages: a Preclinical Validation Study, Atherosclerosis Supplements 32: 7.
- Berg R. van den, Kooijman S., Noordam R., Ramkisoensing A., Abreu-Vieira G., Tambyrajah L.L., Dijk W., Ruppert P., Mol I.M., Kramar B., Caputo R., Puig L.S., Ruiter E.M. de, Kroon J., Hoekstra M., Sluis R.J. van der, Meijer O.C., Dijk Willems K. van, Kerkhof L.W.M. van, Christodoulides C., Karpe F., Gerhart-Hines Z., Kersten S., Meijer J.H., Coomans C.P., Heemst D. van, Biermasz N.R. & Rensen P.C.N. (2018), A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening, Cell Reports 22(13): 3521-3533.
- Nahon J.E., Groeneveldt C., Eck M. van & Hoekstra M. (2018), Inhibition of PRMT3 activity selectively prevents LXR-driven transcription of hepatic lipogenic genes in vivo , Atherosclerosis Supplements 32: 36-36.
- Nahon J., Hoekstra M., Kooijman S. & Eck M. van (2018), PRG4 KO mice are protected from high fat diet-induced metabolic disruptions , Atherosclerosis Supplements 32: 36-37.
- Ouweneel A.B., Sluis R.J. van der, Nahon J.E., Eck M. van & Hoekstra M. (2017), Simvastatin treatment aggravates the glucocorticoid insufficiency associated with hypocholesterolemia in mice, Atherosclerosis 261: 99-104.
- Geest R. van der, Ouweneel A.B., Sluis R.J. van der, Groen A.K., Eck M. van & Hoekstra M. (2016), Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice, Toxicology and Applied Pharmacology 306: 1-7.
- Hoekstra M. & Berkel T.J.C. van (2016), Functionality of High-Density Lipoprotein as Antiatherosclerotic Therapeutic Target, Arteriosclerosis, Thrombosis, and Vascular Biology 36(11): E87-E94.
- Hoekstra M. & Eck M. van (2016), HDL is redundant for adrenal steroidogenesis in LDLR knockout mice with a human-like lipoprotein profile, Journal of Lipid Research 57(4): 631-637.
- Van der Sluis Ronald J., Van den Aardweg Tim, Reuwer Anne Q., Twickler Marcel T., Boutillon Florence, Van Eck Miranda, Goffin Vincent & Hoekstra Menno (2014), Prolactin receptor antagonism uncouples lipids from atherosclerosis susceptibility, Journal of Endocrinology 222(3): 341-350.
- Nair Jayaprakash K., Willoughby Jennifer L.S., Chan Amy, Charisse Klaus, Rowshon Alam M.D., Wang Qianfan, Hoekstra Menno, Kandasamy Pachamuthu, Kel'in Alexander V., Milstein Stuart, Taneja Nate, O'Shea Jonathan, Shaikh Sarfraz, Zhang Ligang, Van der Sluis Ronald J., Jung Michael E., Akinc Akin, Hutabarat Renta, Kuchimanchi Satya, Fitzgerald Kevin, Zimmermann Tracy, Van Berkel Theo J.C., Maier Martin A., Rajeev Kallanthottathil G. & Manoharan Muthiah (2014), Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing, Journal of the American Chemical Society 136(49): 16958-16961.
- Hoekstra M., Frodermann V., Aardweg T. van den, Sluis R.J. van der & Kuiper J. (2013), Leukocytosis and Enhanced Susceptibility to Endotoxemia but Not Atherosclerotic in Adrenalectomized APOE Knockout Mice, PLoS ONE 8(11): e80441.
- Hoekstra M., Sluis R.J. van der, Eck M. van & Berkel T.J.C. van (2013), Adrenal-Specific Scavenger Receptor BI Deficiency Induces Glucocorticoid Insufficiency and Lowers Plasma Very-Low-Density and Low-Density Lipprotein Levels in Mice, Arteriosclerosis, Thrombosis, and Vascular Biology 33(2): e39-46.
- Hoekstra Menno, Korporaal Suzanne J.A., Van der Sluis Ronald J., Hirsch-Reinshagen Veronica, Bochem Andrea E., Wellington Cheryl L., Van Berkel Theo J.C., Kuivenhoven Jan Albert & Van Eck Miranda (2013), LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function, 54(2): 358-364.
- Van der Stoep Marco, Li Zhaosha, Calpe-Berdiel Laura, Van der Sluis Ronald J., Saleh Peshtiwan, McKinnon Heather J., Smit Martin J., Korporaal Suzanne J.A., Van Berkel Theo J.C., Van Eck Miranda & Hoekstra Menno (2013), Elimination of macrophages drives LXR-induced regression both in initial and advanced stages of atherosclerotic lesion development, Biochemical Pharmacology 86(11): 1594-1602.
- Li Zhaosha, Kruijt J. Kar, Van der Sluis Ronald J., Van Berkel Theo J.C. & Hoekstra Menno (2013), Nuclear receptor atlas of female mouse liver parenchymal, endothelial, and Kupffer cells, 45(7): 268-275.
- Stoep M. van der, Li Z., Calpe-Berdiel L., Sluis R.J. van der, McKinnon H.J., Smit M.J., Berkel T.J.C. van, Van Eck M., Hoekstra M. & Korporaal S.J.A. (2013), Liver X receptor (LXR) agonist T0901317 induces regression of early and advanced atherosclerotic lesions under normolipidemic conditions in mice: PB 1.32-1, Journal of Thrombosis and Haemostasis 11(s2): 520-520.
- Korporaal S.J.A., Angelis V. de, Hoekstra M., Gitz E., Bochem A.E., Sjouke B., Hovingh K., Groot P.G. de & Eck M. van (2013), Disturbed glycoprotein VI-mediated signaling in platelets from hypercholesterolemic mice and humans, Journal of Thrombosis and Haemostasis 11: 280-280.
- Stoep M. van der, Li Z., Sluis R.J. van der, Berkel T.J.C. van, Eck M. van, Hoekstra M. & Korporaal S.J.A. (2013), Liver X receptor (LXR) activation influences murine platelet count only under normolipidemic conditions, Journal of Thrombosis and Haemostasis 11: 910-910.
- Bochem Andrea E., Holleboom Adriaan G., Romijn Johannes A., Hoekstra Menno, Dallinga-Thie Geesje M., Motazacker Mahdi M., Hovingh G. Kees, Kuivenhoven Jan A. & Stroes Erik S.G. (2013), High density lipoprotein as a source of cholesterol for adrenal steroidogenesis: a study in individuals with low plasma HDL-C, 54(6): 1698-1704.
- Hoekstra M., Sluis R.J. van der, Li Z., Oosterveer M.H., Groen A.K. & Berkel T.J.C. van (2012), FXR agonist GW4064 increases plasma glucocorticoid levels in C57BL/6 mice, Molecular and Cellular Endocrinology 362(1-2): 69-75.
- Hoekstra M., Sluis R.J. van der, Kuiper J. & Berkel T.J.C. van (2012), Nonalcoholic fatty liver disease is associated with an altered hepatocyte microRNA profile in LDL receptor knockout mice, Journal of Nutritional Biochemistry 23(6): 622-628.
- Meurs I., Lammers B., Zhao Y., Out R., Hildebrand R.B., Hoekstra M., Berkel T.J.C. van & Eck M. van (2012), The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis, Atherosclerosis 221(1): 41-47.
- Li Zhaosha, Blad Clara C., Van der Sluis Ronald J., De Vries Henk, Van Berkel Theo J.C., IJzerman Adriaan P. & Hoekstra Menno (2012), Effects of pyrazole partial agonists on HCA2-mediated flushing and VLDL-triglyceride levels in mice, British Journal of Pharmacology 167(4): 818-825.
- Hoekstra M., Eck M. van & Korporaal S.J.A. (2012), Genetic studies in mice and humans reveal new physiological roles for the high-density lipoprotein receptor scavenger receptor class B type I, Current Opinion in Lipidology 23(2): 127-132.
- Li Z., Wang Y., Sluis R.J. van der, Hoorn J.W.A. van der, Princen H.M.G., Eck M. van, Berkel T.J.C. van, Rensen P.C.N. & Hoekstra M. (2012), Niacin reduces plasma CETP levels by diminishing liver macrophage content in CETP transgenic mice, Biochemical Pharmacology 84(6): 821-829.
- Sluis Ronald J. van der, Puijvelde G.H. van, Berkel T.J.C. van & Hoekstra M. (2012), Adrenalectomy stimulates the formation of initial atherosclerotic lesions: Reversal by adrenal transplantation, Atherosclerosis 221(1): 76-83.
- Zhao Y., Pennings M., Vrins C.L., Calpe-Berdiel L., Hoekstra M., Kruijt J.K., Ottenhoff R., Hildebrand R.B., Van der Sluis R., Jessup W., Le Goff W., Chapman M.J., Huby T., Groen A.K., Van Berkel T.J. & Van Eck M. (2011), Hypocholesterolemia, foam cell accumulation, but no atherosclerosis in mice lacking ABC-transporter A1 and scavenger receptor BI, Atherosclerosis 218(2): .
- Lammers B., Zhao Y., Hoekstra M., Hildebrand R.B., Ye D., Meurs I., Berkel T.J.C. van & Eck M. van (2011), Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1and ApoE, PLoS ONE 6(10): e26095.
- Wang Y., Li Z., Hoekstra M., Bieghs V., Shiri-Sverdlov R., Berkel T.J.C. van, Smit J.W.A., Princen H.M.G., Romijn J.A., Havekes L.M. & Rensen P.C.N. (2011), Niacin, atorvastatin and fenofibrate decrease plasma CETP by reduction of the hepatic macrophage content in APOE*3-Leiden.CETP mice, Atherosclerosis Supplements 12(1): 38-38.
- Hoekstra M., Van der Sluis R.J., Kuiper J. & Van Berkel T.J. (2011), Nonalcoholic fatty liver disease is associated with an altered hepatocyte microRNA profile in LDL receptor knockout mice, Journal of Nutritional Biochemistry : .
- Vergeer M., Korporaal S.J., Franssen R., Meurs I. van, Out R., Hovingh G.K., Hoekstra M., Sierts J.A., Dallinga-Thie G.M., Motazacker M.M., Holleboom A.G., Van Berkel T.J., Kastelein J.J., Van Eck M. & Kuivenhoven J.A. (2011), Genetic variant of the scavenger receptor BI in humans, The New England Journal of Medicine 364(2): .
- Korporaal S.J.A., Meurs I., Hauer A.D., Hildebrand R.B., Hoekstra M., Ten Cate H., Pratico D., Akkerman J.W.N., Berkel T.J.C. van, Kuiper J. & Eck M. van (2011), Deletion of the HDL receptor SR-BI in mice modulates thrombosis susceptibility and indirectly affects platelet function by elevation of plasma free cholesterol, Arteriosclerosis, Thrombosis, and Vascular Biology 31(1): 34-42.
- Hoekstra M., Van der Lans C.A., Halvorsen B., Gullestad L., Kuiper J., Aukrust P., Van Berkel T.J. & Biessen E.A. (2010), The peripheral blood mononuclear cell microRNA signature of coronary artery disease, Biochemical and Biophysical Research Communications 394(3): .
- Hoekstra M., Van Berkel T.J. & Van Eck M. (2010), Scavenger receptor BI: a multi-purpose player in cholesterol and steroid metabolism, World Journal of Gastroenterology 16(47): .
- Korporaal S.J., Meurs I. van, Hauer A.D., Hildebrand R.B., Hoekstra M., Cate H.T., Pratico D., Akkerman J.W., Van Berkel T.J., Kuiper J. & Van Eck M. (2010), Deletion of the high-density lipoprotein receptor scavenger receptor BI in mice modulates thrombosis susceptibility and indirectly affects platelet function by elevation of plasma free cholesterol, Arteriosclerosis, Thrombosis, and Vascular Biology 31(1): .
- Hildebrand R.B., Lammers B., Meurs I. van, Korporaal S.J., De Haan W., Zhao Y., Kruijt J.K., Pratico D., Schimmel A.W., Holleboom A.G., Hoekstra M., Kuivenhoven J.A., Van Berkel T.J., Rensen P.C. & Van Eck M. (2010), Restoration of high-density lipoprotein levels by cholesteryl ester transfer protein expression in scavenger receptor class B type I (SR-BI) knockout mice does not normalize pathologies associated with SR-BI deficiency, Arteriosclerosis, Thrombosis, and Vascular Biology 30(7): .
- Hoekstra M., Korporaal S.J., Li Z., Zhao Y., Eck M. van & Berkel T.J. van (2010), Plasma lipoproteins are required for both basal and stress-induced adrenal glucocorticoid synthesis and protection against endotoxemia in mice, AJP - Endocrinology and Metabolism 299(6): E1038-1043.
- Zhao Y., Pennings M., Hildebrand R.B., Ye D., Calpe-Berdiel L., Out R., Kjerrulf M., Hurt-Camejo E., Groen A.K., Hoekstra M., Jessup W., Chimini G., Van Berkel T.J. & Van Eck M. (2010), Enhanced foam cell formation, atherosclerotic lesion development, and inflammation by combined deletion of ABCA1 and SR-BI in Bone marrow-derived cells in LDL receptor knockout mice on western-type diet, Circulation Research 107(12): .
- Hoekstra M., Van Berkel T.J. & Van Eck M. (2010), Scavenger receptor BI: a multi-purpose player in cholesterol and steroid metabolism, World Journal of Gastroenterology 16(47): .
- Feng Y., Lievens J., Jacobs F., Hoekstra M., Van Craeyveld E., Gordts S.C., Snoeys J. & De Geest B. (2010), Hepatocyte-specific ABCA1 transfer increases HDL cholesterol but impairs HDL function and accelerates atherosclerosis, Cardiovascular Research 88(2): .
- Hoekstra M., Korporaal S.J., Li Z., Zhao Y., Van Eck M. & Van Berkel T.J. (2010), Plasma lipoproteins are required for both basal and stress-induced adrenal glucocorticoid synthesis and protection against endotoxemia in mice, AJP - Endocrinology and Metabolism 299(6): .
- Hildebrand R.B., Lammers B., Meurs I., Korporaal S.J., De Haan W., Zhao Y., Kruijt J.K., Pratico D., Schimmel A.W., Holleboom A.G., Hoekstra M., Kuivenhoven J.A., Van Berkel T.J., Rensen P.C. & Van Eck M. (2010), Restoration of High-Density Lipoprotein Levels by Cholesteryl Ester Transfer Protein Expression in Scavenger Receptor Class B Type I (SR-BI) Knockout Mice Does not Normalize Pathologies Associated with SR-BI Deficiency, Arteriosclerosis, Thrombosis, and Vascular Biology 30(7): 1439-39.
- Hoekstra M., Li Z., Kruijt J.K., Van Eck M., Van Berkel T.J. & Kuiper J. (2010), The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status, Journal of Hepatology 52(2): .
- Hoekstra M., Ye D., Hildebrand R.B., Zhao Y., Lammers B., Stitzinger M., Kuiper J., Berkel T.J.C. van & Eck M. van (2009), Scavenger receptor class B type I-mediated uptake of serum cholesterol is essential for optimal adrenal glucocorticoid production, Journal of Lipid Research 50(6): 1039-1046.
- Hoekstra M., Lammers B., Out R., Li Z., Van Eck M. & Van Berkel T.J.C. (2009), Activation of the nuclear receptor PXR decreases plasma LDL-cholesterol levels and induces hepatic steatosis in LDL receptor knockout mice, Molecular Pharmaceutics 6(1): 182-9.
- De Haan W., De Vries-Van der Weij J., Mol I., Hoekstra M., Romijn J., Jukema J.W., Havekes L., Princen H. & Rensen P.C. (2009), PXR agonism decreases plasma HDL levels in ApoE3-Leiden.CETP mice, Biochimica et Biophysica Acta 1791(3): 191-7.
- Hoekstra M., Meurs I., Koenders M., Out R., Hildebrand R.B., Kruijt J.K., Eck M. van & Berkel T.J.C. van (2008), Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fasting, Journal of Lipid Research 49: 738-745.
- Eck M. van, Hoekstra M., Out R., Ros I.X., Kruijt J.K., Hildebrand R.B. & Berkel T.J.C. van (2008), Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo, 49(1): 136-146.
- Out R., Jessup W., Goff L.J., Hoekstra M., Gelissen I.C., Zhao Y., Kritharides L., Chimini G., Kuiper J., Chapman M.J., Huby T., Berkel T.J.C. van & Eck M. van (2008), Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC, Circulation Research 102(1): 113-120.
- Ye Dan, Hoekstra Menno, Out Ruud, Meurs Illiana, Kruijt J. Kar, Hildebrand Reeni B., Van Berkel Theo J.C. & Van Eck Miranda (2008), Hepatic cell-specific ATP-binding cassette (ABC) transporter profiling identifies putative novel candidates for lipid homeostasis in mice, Atherosclerosis 196(2): 650-658.
- Haan W. de, Hoogt C.C. van der, Westerterp M., Hoekstra M., Dallinga-Thie G.M., Princen H.M.G., Romijn J.A., Jukema J.W., Havekes L.M. & Rensen P.C.N. (2008), Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden. CETP mice, Atherosclerosis 197(1): 57-63.
- Out R., Hoekstra M., Habets K.L., Meurs I., Waard V. de, Hildebrand R.B., Wang Y., Chimini G., Kuiper J., Berkel T.J.C. van & Eck M. van (2008), Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophagesand distinct atherosclerosis at relatively low plasma cholesterol levels, Arteriosclerosis, Thrombosis, and Vascular Biology 28(2): 258-264.
- Hoogt C.C. van der, Haan W. de, Westerterp M., Hoekstra M., Dallinga-Thie G.M., Romijn J.A., Princen H.M., Jukema J.W., Havekes L.M. & Rensen P.C.N. (2007), Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice, 48: 1763-1771.
- Out R., Hoekstra M., Meurs I., Vos P. de, Kuiper J., Eck M. van & Berkel T.J.C. van (2007), Total body ABCG1 expression protects against early atherosclerotic lesion development in mice, Arteriosclerosis, Thrombosis, and Vascular Biology 27: 594-599.
- Eck M. van, Hoekstra M., Hildebrand R.B., Yaong Y., Stengel D., Kruijt J.K., Sattler W., Tietge U.J., Ninio E., Berkel T.J.C. van & Praticò D. (2007), Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL, Arteriosclerosis, Thrombosis, and Vascular Biology 27: 2413-2419.
- Hoogt C.C. van der, Haan W. de, Westerterp M., Hoekstra M., Dallinga-Thie G.M., Romijn J.A., Princen H.M.G., Jukema J.W., Havekes L.M. & Rensen P.C.N. (2007), Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression, 48: 1763-1771.
- Eck M. van, Ye D., Hildebrand R.B., Kruijt J.K., Haan W. de, Hoekstra M., Rensen P.C.N., Ehnholm C., Jauhiainen M. & Berkel T.J.C. van (2007), Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice, Circulation Research 100: 678-685.
- Ye D., Hoekstra M., Out R., Meurs I., Kruijt J.K., Hildebrand R.B., Berkel T.J.C. van & Eck M. van (2007), Hepatic cell-specific atp-binding cassette (ABC) transporter profiling identifies putative novel candidates for macrophage cholesterol homeostasis in mice, Atherosclerosis Supplements 8(1): 24-24.
- Hoekstra M., Stitzinger M., Out R., Van Eck M., Van Berkel T.J. & Kuiper J. (2007), Nutrition-induced changes in adiponutrin gene expression implicate a role for adiponutrin in hepatic lipogenesis, Atherosclerosis Supplements 8(1): 211-211.
- Hoogt C.C. van der, Haan W. de, Westerterp M., Hoekstra M., Dallinga-Thie G.M., Romijn J.A., Princen H.M., Jukema J.W., Havekes L.M. & Rensen P.C.N. (2007), Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression, 48: 1763-1771.
- Pennings M., Meurs I., Ye D., Out R., Hoekstra M., Berkel T.J.C. van & Eck M. van (2006), Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion development, 580: 5588-5596.
- Van Eck Miranda, Ye Dan, Hildebrand Reeni B., Kruijt J.K., Hoekstra Menno & Van Berkel Theo J. (2006), Importance of macrophage cholesteryl ester transfer protein (CETP) for determining serum cholesteryl ester transfer activity and atherosclerosis, Circulation 114(18): 188-188.
- Out R., Hoekstra M., Hildebrand RB, Kruit J.K., Meurs I., Li Z., Kuipers F., Berkel T.J.C. van & Eck M. van (2006), Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice, Arteriosclerosis, Thrombosis, and Vascular Biology 26: 2295-2300.
- Post S.M., Groenendijk M., Hoogt C.C. van der, Fievet C., Luc G., Hoekstra M., Princen H.M., .Staels B. & Rensen P.C.N. (2006), Cholesterol 7alpha-hydroxylase deficiency in mice on an APOE*3-Leiden background increases hepatic ABCA1 mRNA expression and HDL-cholesterol, Arteriosclerosis, Thrombosis, and Vascular Biology 26: 2724-2730.
- Hoekstra Menno, Stitzinger Miranda, Out Ruud, Van Eck Miranda, Van Berkel Theo J. & Kuiper Johan (2006), The obesity-linked gene adiponutrin is highly regulated by a western-type diet in liver parenchymal cells of LDL receptor deficient mice, Circulation 114(18): 111-111.
- Van Eck Miranda, Hoekstra Menno, Hildebrand Reeni B., Yao Yuemang, Stengel Dominique, Tietge Uwe J., Ninio Ewa, Van Berkel Theo J. & Pratico Domenico (2006), Increased oxidative stress due to dysfunctional HDL in scavenger receptor BI knockout mice, Circulation 114(18): 226-226.
- Hoekstra M., Stitzinger M., Wanrooij E.J.A. van, Michon I.N., Kruijt J.K., Kamphorst J.T., Eck M. van, Vreugdenhil E., Berkel T.J.C. van & Kuiper J. (2006), Microarray analysis indicates an important role for FABP5 and putative novel FABPs on a Western-type diet, Journal of Lipid Research 47: 2198-2207.
- Out Ruud, Hoekstra Menno, Meurs Illiana, De Vos Paula, Kuiper Johan, Van Eck Miranda & Van Berkel Theo J.J. (2006), ABCG1 protects against atherosclerotic lesion development, Circulation Research 99(11): 1281-1281.
- Post S.M., Groenendijk M., Hoogt C.C. van der, Fievet C., Luc G., Hoekstra M., Princen H.M.G., Staels B. & Rensen P.C.N. (2006), Cholesterol 7alpha-hydroxylase deficiency on an APOE*3-Leiden background increases hepatic ABCA1 mRNA expression and HDL-cholesterol, Arteriosclerosis, Thrombosis, and Vascular Biology 26: 2724-2730.
- Eck M. van, Oost J., Goudriaan J.R., Hoekstra M., Hildebrand M., Bos IST, Willems Van Dijk K. & Berkel T.J.C. van (2005), Role of the macrophage very-low-density lipoprotein receptor in atherosclerotic lesion development, Atherosclerosis 83: 230-237.
- Eck MV, Oost J., Goudriaan J.R., Hoekstra M, Hildebrand RB, Bos IS, Willems Van Dijk J.A.P. & Berkel T.J.C. van (2005), Role of the macrophage very-low-density lipoprotein receptor in atherosclerotic lesion development, Atherosclerosis 183: 230-237.
- Hoekstra M. (8 september 2005), Modulation of hepatic gene expression: implications for lipid metabolism (Dissertatie, Faculty of Science, Leiden University). Promotor(en) en copromotor(en): Berkel T.J.C. van, Eck M. van.
- Out R., Hoekstra M., Jager S.C.A. de, Vos P. de, Westhuyzen D.R. van der, Webb N.R., Eck M. van, Biessen E.A.L. & Berkel T.J.C. van (2005), Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice, 46: 1172-1181.
- Berkel T.J.C. van, Out R., Hoekstra M., Kuiper J., Biessen E.A.L. & Eck M. van (2005), Scavenger receptors: friend or foe in atherosclerosis?, Current Opinion in Lipidology 16: 525-535.
- Hoekstra M., Out R., Kruijt J.K., Eck M. van & Berkel T.J.C. van (2005), Diet induced regulation of genes involved in cholesterol metabolism in rat liver parenchymal and Kupffer cells, Journal of Hepatology 42: 400-407.
- Meurs I., Hoekstra M., Wanrooij E.J.A. van, Hildebrand RB, Kuiper J., Kuipers F., Hardeman M.R., Berkel T.J.C. van & Eck M. van (2005), HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes, Experimental Hematology 33: 1309-1319.
- Eck M. van, Pennings M., Hoekstra M., Out R. & Berkel T.J.C. van (2005), Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis, Current Opinion in Lipidology 16: 307-315.
- Berkel T. van, Out R., Hoekstra M., Hildebrand R.B., Kruijt K., Singaraja R., Kaminski W.E., Schmitz G., Hayden M. & Eck M. van (2005), W10 regulation of plasma HDL levels and metabolism, Atherosclerosis Supplements 6(1): 46-46.
- Out R., Hoekstra M., Spijkers J.A., Kruijt J.K., Eck M. van, Bos I.S.T., Twisk J. & Berkel T.J.C. van (2004), Scavenger receptor class B type I is solely reponsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice, 45: 2088-2095.
- Eck M. van, Twisk J., Hoekstra M., Rij B.T., Lans C. van der, Bos I.S., Kruijt J.K., Kuipers F. & Berkel T.J.C. van (2003), Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver, Journal of Biological Chemistry 278(26): 23699-23705.
- Eck M. van, Twisk J., Rij B. van, Lans C. van der, Hoekstra M., Bos S., Kuipers F. & Berkel T.J.C. van (2002), Differential effects of scavenger receptor BI (SRBI) deficiency on the arterial wall and the liver, Circulation 106: II-77.
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