Marco van Eijk
Universitair docent / opleidingsdirecteur
- Naam
- Dr. M.C. van Eijk
- Telefoon
- +31 71 527 4771
- m.c.van.eijk@lic.leidenuniv.nl
- ORCID iD
- 0000-0001-7751-4112
Universitair docent / opleidingsdirecteur
- Wiskunde en Natuurwetenschappen
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- Lienden M.J.C. van der, Aten J., Boot R.G., Eijk M.C. van, Aarts J.M.F.G. & Kuo C.L. (2022), HEPES‐buffering of bicarbonate‐containing culture medium perturbs lysosomal glucocerebrosidase activity, Journal of Cellular Biochemistry 123(5): 893-905.
- Eijk M.C. van & Aerts J.M.F.G. (2021), The unique phenotype of lipid-laden macrophages, International Journal of Molecular Sciences 22(8): 4039.
- Lienden M.J.C. van der, Aten J., Marques A.R.A., Waas I.S.E., Larsen P.W.B., Claessen N., Wel N.N. van der, Ottenhoff R., Eijk M.C. van & Aerts J.M.F.G. (2021), GCase and LIMP2 abnormalities in the liver of Niemann Pick type C mice, International Journal of Molecular Sciences 22(5): 2532.
- Eijk M. van, Ferraz M.J., Boot R.G. & Aerts J.M.F.G. (2020), Lyso-glycosphingolipids: presence and consequences, Essays in Biochemistry 64(3): 565-578.
- Moro Chao D.H., Wang Y., Foppen E., Ottenhoff R., Roomen C. van, Parlevliet E.T., Eijk M.C. van, Verhoek M., Boot R.G., Marques A.R., Scheij S., Mirzaian M., Kooijman S., Jansen K., Wang D., Mergen C., Seeley R.J., Tschöp M.H., Overkleeft H.S., Rensen P.C.N., Kalsbeek A., Aerts J.M.F.G. & Yi C.X. (2019), The iminosugar AMP-DNM improves satiety and activates brown adipose tissue through GLP1, Diabetes 68(12): 2223-2234.
- Aerts J.M.F.G., Artola M.E., Eijk M.C. van, Ferraz M.J. & Boot R.G. (2019), Glycosphingolipids and infection. Potential new therapeutic avenues, Frontiers in Cell and Developmental Biology 7: 324.
- Rakhshandehroo M., Eijkeren R.J. van, Gabriel T.L., Haar C. de, Gijzel S.M.W., Hamers N., Ferraz M.J., Aerts J.M.F.G., Schipper H.S., Eijk M.C. van, Boes M. & Kalkhoven E. (2019), Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1864(8): 1157-1167.
- Lienden M.J.C. van der, Gaspar P., Boot R.G., Aerts J.M.F.G. & Eijk M.C. van (2018), Glycoprotein Non-Metastatic Protein B: An Emerging Biomarker for Lysosomal Dysfunction in Macrophages, International Journal of Molecular Sciences 20(1): 66.
- Tol M.J., Lienden M.J.C. van der, Gabriel T.L., Hagen J.J., Scheij S., Veenendaal T., Klumperman J., Donker-Koopman W.E., Verhoeven A.J., Overkleeft H.S., Aerts J.M.F.G., Argmann C.A. & Eijk M.C. van (2018), HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution, Autophagy 14(3): 437-449.
- Aerts J.M.F.G., Guimaraes da Lomba Ferraz M.J., Mirzaian M., Gaspar P., Oussoren S.V., Wisse P., Kuo C.L., Lelieveld L.T., Kytidou K., Hazeu M.D., Boer D.E.C., Meijer R., Lienden M.J.C. van der, Herrera D., Gabriel T.L., Aten J., Overkleeft H.S., Eijk M.C. van, Boot R.G. & Rosa Alcalde Marques A. (2017), Lysosomal Storage Diseases. For Better or Worse: Adapting to Defective Lysosomal Glycosphingolipid Breakdown. In: , eLS. eLS: John Wiley & Sons, Ltd.. 1-13.
- Wu L., Jiang J., Jin Y., Kallemeijn W.W., Kuo C.-L., Artola M., Dai W., Elk C. van, Eijk M. van, Marel G.A. van der, Codee J.D.C., Florea B.I., Aerts J.M.F.G., Overkleeft H.S. & Davies G.J. (2017), Activity-based probes for functional interrogation of retaining beta-glucuronidases, Nature Chemical Biology 13(8): 867-873.
- Gabriel T.L., Mirzaian M., Hooibrink B., Ottenhof R., Roomen C. van, Aerts J.M.F.G. & Eijk M.C. van (2017), Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival, PLoS ONE 12(7): 0182075.
- Marques A.R., Mirzaian M., Akiyama H., Wisse P., Ferraz M.J., Gaspar P., Ghauharali-Van der Vlugt K., Meijer R., Giraldo P., Alfonso P., Irún P., Dahl M., Karlsson S., Pavlova E.V., Cox T.M., Scheij S., Verhoek M., Ottenhoff R., Roomen C.P. van, Pannu N.S., Van Eijk M., Dekker N., Boot R.G., Overkleeft H.S., Blommaart E., Hirabayashi Y. & Aerts J.M. (2016), Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases, 57: 451-463.
- Marques A.R., Gabriel T.L., Aten J., Roomen C.P. van, Ottenhoff R., Claessen N., Alfonso P., Irún P., Giraldo P., Aerts J.M.F.G. & Eijk M.C. van (2016), Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease, PLoS ONE 11(1): e0147208.
- Tol M.J., Ottenhoff R., Eijk M. van, Zelcer N., Aten J., Houten S.M., Geerts D., Roomen C. van, Bierlaagh M.C., Scheij S., Hoeksema M.A., Aerts J.M., Bogan J.S., Dorn G.W., Argmann C.A. & Verhoeven A.J. (2016), A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity, Diabetes 65(9): 2591-605.
- Kramer G., Wegdam W., Donker-Koopman W., Ottenhoff R., Gaspar P., Verhoek M., Nelson J., Gabriel T., Kallemeijn W.W., Boot R.G., Laman J.D., Vissers J.P., Cox T., Pavlova E., Moran M.T., Aerts J.M.F.G. & Eijk M.C. van (2016), Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models, FEBS Open Bio 6(9): 902-913.
- Mirzaian M., Wisse P., Ferraz M.J., Marques A.R., Gabriel T.L., Roomen C.P. van, Ottenhoff R., Eijk M. van, Codée J.D., Marel G.A. van der, Overkleeft H.S. & Aerts J.M. (2016), Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard, Clinica Chimica Acta 459: 36-44.
- Herrera Moro Chao D., Argmann C., Eijk M. van, Boot R.G., Ottenhoff R., Roomen C. van, Foppen E., Siljee J.E., Unmehopa U.A., Kalsbeek A. & Aerts J.M.F.G. (2016), Impact of obesity on taste receptor expression in extra-oral tissues: emphasis on hypothalamus and brainstem, Scientific Reports 6: 29094.
- Virtue S., Masoodi M., Weijer B.A.M. de, Eijk M. van, Mok C.Y.L., Eiden M., Dale M., Pirraco A., Serlie M.J., Griffin J.L. & Vidal-Puig A. (2015), Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans, International Journal of Obesity 39(7): 1151-1160.
- Chao D.H.M., Kallemeijn W.W., Marques A.R.A., Orre M., Ottenhoff R., Roomen C. van, Foppen E., Renner M.C., Moeton M., Eijk M. van, Boot R.G., Kamphuis W., Hol E.M., Aten J., Overkleeft H.S., Kalsbeek A. & Aerts J.M.F.G. (2015), Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes, PLoS ONE 10(9): e0138107.
- Franken R., Radonic T., Hartog A.W. den, Groenink M., Pals G., Eijk M. van, Lutter R., Mulder B.J., Zwinderman A.H. & Waard V. de (2015), The revised role of TGF-β in aortic aneurysms in Marfan syndrome, Netherlands Heart Journal 23(2): 116-21.
- Dessing M.C., Tammaro A., Pulskens W.P., Teske G.J., Butter L.M., Claessen N., Eijk M. van, Poll T. van der, Vogl T., Roth J., Florquin S. & Leemans J.C. (2015), The calcium-binding protein complex S100A8/A9 has a crucial role in controlling macrophage-mediated renal repair following ischemia/reperfusion, Kidney International 87(1): 85-94.
- Kurakula K., Vos M., Eijk M. van, Smits H.H. & Vries C.J.M. de (2015), LIM-only protein FHL2 regulates experimental pulmonary Schistosoma mansoni egg granuloma formation, European Journal of Immunology 45(11): 3098-3106.
- Gabriel Tanit L., Tol Marc J., Ottenhof Roelof, Van Roomen Cindy, Aten Jan, Claessen Nike, Hooibrink Berend, De Weijer Barbara, Serlie Mireille J., Argmann Carmen, Van Elsenburg Leonie, Aerts Johannes M.P.G. & Van Eijk Marco (2014), Lysosomal Stress in Obese Adipose Tissue Macrophages Contributes to MITF-Dependent Gpnmb Induction, Diabetes 63(10): 3310-3323.
- Gaspar P., Kallemeijn W.W., Strijland A., Scheij S., Eijk M. van, Aten J., Overkleeft H.S., Balreira A., Zunke F., Schwake M., Sa Miranda M.C. & Aerts J.M.F.G. (2014), Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis, 55(1): 138-145.
- Melief J., Schuurman K.G., Garde M.D.B. van de, Smolders J., Eijk M. van, Hamann J. & Huitinga I. (2013), Microglia in Normal Appearing White Matter of Multiple Sclerosis are Alerted but Immunosuppressed, Glia 61(11): 1848-1861.
- Xu X., Grijalva A., Skowronski A., Eijk M. van, Serlie M.J. & Ferrante A.W.Jr. (2013), Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation, Cell Metabolism 18(6): 816-830.
- Radonic T., Witte P. de, Groenink M., Waard V. de, Lutter R., Eijk M. van, Jansen M., Timmermans J., Kempers M., Scholte A.J., Hilhorst-Hofstee Y., Berg M.P. van den, Tintelen J.P. van, Pals G., Baars M.J.H., Mulder B.J.M. & Zwinderman A.H. (2012), Inflammation Aggravates Disease Severity in Marfan Syndrome Patients, PLOS ONE 7(3): e0032963.
- Ambarus C.A., Krausz S., Eijk M. van, Hamann J., Radstake T.R.D.J., Reedquist K.A., Tak P.P. & Baeten D.L.P. (2012), Systematic validation of specific phenotypic markers for in vitro polarized human macrophages, Journal of Immunological Methods 375(1-2): 196-206.
- Melief J., Koning N., Schuurman K.G., Garde M.D.B. van de, Smolders J., Hoek R.M., Eijk M. van, Hamann J. & Huitinga I. (2012), Phenotyping primary human microglia: Tight regulation of LPS responsiveness, Glia 60(10): 1506-1517.
- Aerts J.M.F.G., Boot R.G., Eijk M.C. van, Groener J., Bijl N., Lombardo E., Bietrix F.M., Dekker N., Groen A.K., Ottenhoff R., Roomen C. van, Aten J., Serlie M., Langeveld M., Wennekes T. & Overkleeft H.S. (2011), Glycosphingolipids and insulin resistance. In: Cowart L.A. (red.), Sphingolipids and Metabolic Disease. Advances in Experimental Medicine and Biology nr. 721. New York, NY, U.S.A.: Springer. 20-41.
- Reuwer A.Q., Eijk M. van, Houttuijn-Bloemendaal F.M., Loos C.M. van der, Claessen N., Teeling P., Kastelein J.J.P., Hamann J., Goffin V., Thusen J.H. von der, Twickler M.T.B. & Aten J. (2011), The prolactin receptor is expressed in macrophages within human carotid atherosclerotic plaques: a role for prolactin in atherogenesis?, Journal of Endocrinology 208(2): 107-117.
- Aerts J.M.F.G., Boot R.G., Eijk M.C. van, Groener J., Bijl N., Lombardo E., Bietrix F.M., Dekker N., Groen A.K., Ottenhoff R., Roomen C. van, Aten J., Serlie M., Langeveld M., Wennekes T. & Overkleeft H.S. (2011), Glycosphingolipids and insulin resistance, Advances in Experimental Medicine and Biology 721: 99-119.
- Wennekes T., Meijer A.J., Groen A.K., Boot R.G., Groener J.E., Eijk M.C. van, Ottenhoff R., Bijl N., Ghauharali K., Song H., O'Shea T.J., Liu H., Yew N., Copeland D., Berg R.J.B.H.N. van den, Marel G.A. van der, Overkleeft H.S. & Aerts J.M.F.G. (2010), Dual-Action Lipophilic Iminosugar Improves Glycemic Control in Obese Rodents by Reduction of Visceral Glycosphingolipids and Buffering of Carbohydrate Assimilation, Journal of Medicinal Chemistry 53(2): 689-698.
- Eijk M.C. van, Aust G., Brouwer M.S.M., Meurs M. van, Voerman J.S.A., Dijke I.E., Pouwels W., Saendig I., Wandel E., Aerts J.M.F.G., Boot R.G., Laman J.D. & Hamann J. (2010), Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease, Immunology Letters 129(2): 64-71.
- Koning N., Eijk M. van, Pouwels W., Brouwer M.S.M., Voehringer D., Huitinga I., Hoek R.M., Raes G. & Hamann J. (2010), Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation, Journal of Innate Immunity 2(2): 195-200.
- Pols T.W.H., Bonta P.I., Pires N.M.M., Otermin I., Vos M., Vries M.R. de, Eijk M. van, Roelofsen J., Havekes L.M., Quax P.H.A., Kuilenburg A.B.P. van, Waard V. de, Pannekoek H. & Vries C.J.M. de (2010), 6-Mercaptopurine Inhibits Atherosclerosis in Apolipoprotein E*3-Leiden Transgenic Mice Through Atheroprotective Actions on Monocytes and Macrophages, Arteriosclerosis, Thrombosis, and Vascular Biology 30(8): 1591-U184.
- Eijk M.C. van, Voorn-Brouwer T., Scheij S.S., Verhoeven A.J., Boot R.G. & Aerts J.M.F.G. (2010), Curdlan-mediated regulation of human phagocyte-specific chitotriosidase, FEBS Letters 584(14): 3165-3169.
- Eijk M.C. van, Aten J., Bijl N., Ottenhoff R., Roomen C.P.A.A. van, Dubbelhuis P.F., Seeman I., Ghauharali-Vlugt van der K., Overkleeft H.S., Arbeeny C., Groen A.K. & Aerts J.M.F.G. (2009), Reducing Glycosphingolipid Content in Adipose Tissue of Obese Mice Restores Insulin Sensitivity, Adipogenesis and Reduces Inflammation, PLoS ONE 4(3): e4723.
- Iyer A., Eijk M. van, Silva E., Hatta M., Faber W., Aerts J.M.F.G. & Das P.K. (2009), Increased chitotriosidase activity in serum of leprosy patients: Association with bacillary leprosy, Clinical Immunology 131(3): 501-509.
- Bijl N., Sokolovic M., Vrins C., Langeveld M., Moerland P.D., Ottenhoff R., Roomen C.P.A.A. van, Claessen N., Boot R.G., Aten J., Groen A.K., Aerts J.M.F.G. & Eijk M.C. van (2009), Modulation of Glycosphingolipid Metabolism Significantly Improves Hepatic Insulin Sensitivity and Reverses Hepatic Steatosis in Mice, Hepatology 50(5): 1431-1441.
- Bijl N., Roomen C.P.A.A. van, Triantis V., Sokolovic M., Ottenhoff R., Scheij S., Eijk M. van, Boot R.G., Aerts J.M.F.G. & Groen A.K. (2009), Reduction of Glycosphingolipid Biosynthesis Stimulates Biliary Lipid Secretion In Mice, Hepatology 49(2): 637-645.
- Aerts J.M.F.G., Ottenhoff R., Powlson A.S., Grefhorst A., Eijk M. van, Dubbelhuis P.F., Aten J., Kuipers F., Serlie M.J., Wennekes T., Sethi J.K., O'Rahilly S. & Overkleeft H.S. (2007), Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity, Diabetes 56(5): 1341-1349.
- Bussink A.P., Swieten P.F. van, Ghauharali K., Scheij S., Eijk M.C. van, Wennekes T., Marel G.A. van der, Boot R.G., Aerts J.M.F.G. & Overkleeft H.S. (2007), N-Azidoacetylmannosamine-mediated chemical tagging of gangliosides, Journal of Lipid Research 48(6): 1417-1421.
- Eijk M.C. van, Scheij S.S., Roomen C.P.A.A. van, Speijer D., Boot R.G. & Aerts J.M.F.G. (2007), TLR- and NOD2-dependent regulation of human phagocyte-specific chitotriosidase, FEBS Letters 581(28): 5389-5395.
- Hamann J., Koning N., Pouwels W., Ulfman L.H., Eijk M. van, Stacey M., Lin H.-H., Gordon S. & Kwakkenbos M.J. (2007), EMR1, the human homolog of F4/80, is an eosinophil-specific receptor, European Journal of Immunology 37(10): 2797-2802.
- Nierop K. van, Muller F.J.M., Stap J., Noorden C.J.F. van, Eijk M. van & Groot C. de (2006), Lysosomal destabilization contributes to apoptosis of germinal center B-lymphocytes, Journal of Histochemistry and Cytochemistry 54(12): 1425-1435.
- Eijk M.C. van, Roomen C.P.A.A. van, Renkema G.H., Bussink A.P., Andrews L., Blommaart E.F.C., Sugar A., Verhoeven A.J., Boot R.G. & Aerts J.M.F.G. (2005), Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity, International Immunology 17(11): 1505-1512.