Johanna Meijer
Hoogleraar Neurofysiologie, in het bijzonder de regelmechanismen van biologische ritmen
- Naam
- Prof.dr. J.H. Meijer
- Telefoon
- +31 71 526 9760
- j.h.meijer@lumc.nl
Joke Meijer is hoogleraar en hoofd van de sectie Neurofysiologie, binnen de afdeling Cel en Chemische Biologie.
Meer informatie over Johanna Meijer
Zie ook
Biologische klok
De groep van Meijer onderzoekt de biologische klok en 24-uurs ritmen in onze hersen- en lichaamsfuncties. De biologische klok ligt aan de basis van de hersenen, in de hypothalamus en is zeer vroeg in de evolutie ontstaan. Individuele cellen in deze hersenkern zijn autonome oscillatoren, en zijn zelfstandig in staat zijn om ritmen te produceren. De cellen oscilleren onderling in fase, zodat er in het gehele netwerk van de biologische klok een krachtig ritme ontstaat, wat vervolgens doorgegeven wordt aan andere hersengebieden. Een gebrek aan communicatie binnen het klok-netwerk leidt tot verlies van klok-functie en vervolgens tot ziekten, zoals kanker, depressie en overgewicht. En omgekeerd gaan verschillende ziekten, en ook veroudering, gepaard met een verval van de functie van de klok. Herstel van de werking van de klok draagt wezenlijk bij aan een herstel van gezondheid.
Onderwerpen van de onderzoeksgroep van Meijer:
• Onze 24-uurs klok als een neuronaal netwerk
• Licht invloeden op de biologische klok
• Medisch: klok verstoringen en ziekten (veroudering, kanker, slaapstoornissen en depressie)
• Gezondheid en klokfunctie: versterking van de klok door lichamelijke activiteit en licht.
• Complexiteit: emergente eigenschappen in hiërarchische netwerken (Geheel is meer dan de som der delen)
• Chronofarmacologie: optimaliseren van de timing van geneesmiddelen
• Veldonderzoek, dierenwelzijn en populatie dynamica.
Wetenschappelijke carrière
Joke Meijer heeft haar master degree (cum laude) behaald in 1985 bij de afdelingen biologie, natuurkunde en geneeskunde van het Leids Universitair Medisch Centrum te Leiden. In 1989 heeft zij haar PhD-degree (cum laude) behaald bij de afdeling fysiologie van de Universiteit Leiden, gebaseerd op werk uitgevoerd aan de afdeling farmacologie, Nottingham University, UK, Halifax University, Canada en Biologisch Centrum, Groningen.
'Een Kwestie van Tijd', oratie uitgesproken bij aanvaarding van het ambt van hoogleraar in de Neurofysiologie in het bijzonder de Regelmechanismen van Biologische Ritmen aan de Universiteit Leiden op dinsdag 12 februari 2008
Prijzen en eervolle benoemingen
2019 ERC advanced grant “The circadian clock in day-active species: preserving our health in modern society”
2016 Aschoff and Honma Prijs in Biological Rhythm Research (meest prestigieuze internationale prijs in het dagelijks voorkomende onderzoeksgebied, tweejaarlijks toegekend)
2013 Gekozen lid van de Koninklijke Nederlandse Vereniging voor Wetenschap
1999 Beste Docent Award in Biofarmaceutische Wetenschappen (Faculteit Natuurlijke Wetenschappen, Universiteit Leiden)
1993 Aschoff’s Rule (prijs voor hoogwaardige contributies in chronobiologie ondersteuning de interdisciplinaire spirit van het wetenschapsgebied, toekenning van Jeff Hall)
1989 Fellowship, duur 3 jaar, van de KNAW
Hoogleraar Neurofysiologie, in het bijzonder de regelmechanismen van biologische ritmen
- Faculteit Geneeskunde
- Divisie 4
- Cel en Chemische biologie
- Beurden, A.W. van; Schoonderwoerd, R.A.; Tersteeg, M.M.H.; Gutierrez, P.D.; Michel, S.; Blommers, R.; Rohling, J.H.T. & Meijer, J.H. (2022), Single cell model for re-entrainment to a shifted light cycle, FASEB Journal 36(10).
- Schoonderwoerd, R.A.; Gutierrez, P.D.; Blommers, R.; Beurden, A.W. van; Coenen, T.C.J.J.; Klett, N.J.; Michel, S.H. & Meijer, J.H. (2022), Inhibitory responses to retinohypothalamic tract stimulation in the circadian clock of the diurnal rodent Rhabdomys pumilio, The FASEB Journal 36(8).
- Wang, Y.M.; Zanden, S.Y. van der; Leerdam, S. van; Tersteeg, M.M.H.; Kastelein, A.; Michel, S.; Neefjes, J.; Meijer, J.H. & Deboer, T. (2022), Induction of fatigue by specific anthracycline cancer drugs through disruption of the circadian pacemaker, Cancers 14(10).
- Caputo, R.; Poirel, V.J.; Challet, E.; Meijer, J.H. & Raison, S. (2022), Bimodal serotonin synthesis in the diurnal rodent, Arvicanthis ansorgei, The FASEB Journal 36(4).
- Schoonderwoerd, R.A.; Rover, M. de; Janse, J.A.M.; Hirschler, L.; Willemse, C.R.; Scholten, L.; Klop, I.; Berloo, S. van; Osch, M.J.P. van; Swaab, D.F. & Meijer, J.H. (2022), The photobiology of the human circadian clock, Proceedings of the National Academy of Sciences 119(13).
- Schoonderwoerd, R.A.; Buck, T.M.; Andriessen, C.A.; Wijnholds, J.; Hattar, S.; Meijer, J.H. & Deboer, T. (2022), Sleep Deprivation Does not Change the Flash Electroretinogram in Wild-type and Opn4(-/-)Gnat1(-/-) Mice, Journal of Biological Rhythms 37(2): 216-221.
- Panagiotou, M.; Michel, S.; Meijer, J.H. & Deboer, T. (2021), The aging brain: sleep, the circadian clock and exercise, Biochemical Pharmacology 191.
- Diepen, H.C. van; Schoonderwoerd, R.A.; Ramkisoensing, A.; Janse, J.A.M.; Hattar, S. & Meijer, J.H. (2021), Distinct contribution of cone photoreceptor subtypes to the mammalian biological clock, Proceedings of the National Academy of Sciences 118(22).
- Hazelhoff, E.M.; Dudink, J.; Meijer, J.H. & Kervezee, L. (2021), Beginning to see the light: lessons learned from the development of the circadian system for optimizing light conditions in the neonatal intensive care unit, Frontiers in Neuroscience 15.
- Robbers, Y.; Tersteeg, M.M.H.; Meijer, J.H. & Coomans, C.P. (2021), Group housing and social dominance hierarchy affect circadian activity patterns in mice, Royal Society Open Science 8(2).
- Schilperoort, M.; Berg, R. van den; Coomans, C.P.; Khedoe, P.P.S.J.; Ramkisoensing, A.; Boekestijn, S.; Wang, Y.A.; Berbee, J.F.P.; Meijer, J.H.; Biermasz, N.R.; Rensen, P.C.N. & Kooijman, S. (2020), Continuous light does not affect atherosclerosis in APOE*3-Leiden. CETP mice, Journal of Biological Rhythms 35(6): 598-611.
- Engberink, A.H.O.O.; Huisman, J.; Michel, S. & Meijer, J.H. (2020), Brief light exposure at dawn and dusk can encode day-length in the neuronal network of the mammalian circadian pacemaker, FASEB Journal 34(10): 13685-13695.
- Vrielink, T.J.C.O. & Meijer, J.H. (2020), Using surgical wrapping material for the fabrication of respirator masks, PLoS ONE 15(7).
- Ananthasubramaniam, B. & Meijer, J.H. (2020), Regulation of rest, rather than activity, underlies day-night activity differences in mice, Frontiers in Physiology 11.
- Buijink, M.R.; Engberink, A.H.O.O.; Wit, C.B.; Almog, A.; Meijer, J.H.; Rohling, J.H.T. & Michel, S. (2020), Aging affects the capacity of photoperiodic adaptation downstream from the central molecular clock, Journal of Biological Rhythms 35(2): 167-179.
- Buijink, M.R.; Engberink, A.H.O.O.; Wit, C.B.; Almog, A.; Meijer, J.H.; Rohling, J.H.T. & Michel, S. (2020), Aging affects the capacity of photoperiodic adaptation downstream from the central molecular clock., Journal of Biological Rhythms 35(2).
- Michel, S. & Meijer, J.H. (2020), From clock to functional pacemaker, European Journal of Neuroscience 51(1): 482-493.
- Roy, U.; Heredia-Munoz, M.T.; Stute, L.; Hofling, C.; Matysik, J.; Meijer, J.H.; Rossner, S. & Alia, A. (2019), Degeneration of the Suprachiasmatic Nucleus in an Alzheimer's Disease Mouse Model Monitored by in vivo Magnetic Resonance Relaxation Measurements and Immunohistochemistry, Journal of Alzheimer's Disease 69(2): 363-375.
- Naber, W.C.; Fronczek, R.; Haan, J.; Doesborg, P.; Colwell, C.S.; Ferrari, M.D. & Meijer, J.H. (2019), The biological clock in cluster headache: A review and hypothesis, Cephalalgia 39(14): 1855-1866.
- Schilperoort, M.; Berg, R. van den; Bosmans, L.A.; Os, B.W. van; Dolle, M.E.T.; Smits, N.A.M.; Guichelaar, T.; Baarle, D. van; Koemans, L.; Berbee, J.F.P.; Deboer, T.; Meijer, J.H.; Vries, M.R. de; Vreeken, D.; Gils, J.M. van; Dijk, K.W. van; Kerkhof, L.W.M. van; Lutgens, E.; Biermasz, N.R.; Rensen, P.C.N. & Kooijman, S. (2019), Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice, Journal of Pineal Research 68(1).
- Cederroth, C.R.; Albrecht, U.; Bass, J.; Brown, S.A.; Dyhrfjeld-Johnsen, J.; Gachon, F.; Green, C.B.; Hastings, M.H.; Helfrich-Forster, C.; Hogenesch, J.B.; Levi, F.; Loudon, A.; Lundkvist, G.B.; Meijer, J.H.; Rosbash, M.; Takahashi, J.S.; Young, M. & Canlon, B. (2019), Medicine in the Fourth Dimension, Cell Metabolism 30(2): 238-250.
- Almog, A.; Buijink, M.R.; Roethler, O.; Michel, S.; Meijer, J.H.; Rohling, J.H.T. & Garlaschelli, D. (2019), Uncovering functional signature in neural systems via random matrix theory, PLoS Computational Biology 15(5).
- Panagiotou, M.; Meijer, M.; Meijer, J.H. & Deboer, T. (2019), Effects of chronic caffeine consumption on sleep and the sleep electroencephalogram in mice, Journal of Psychopharmacology 33(1): 122-131.
- Joustra, S.D.; Gu, C.; Rohling, J.H.T.; Pickering, L.; Klose, M.; Hu, K.; Scheer, F.A.; Feldt-Rasmussen, U.; Jennum, P.J.; Pereira, A.M.; Biermasz, N.R. & Meijer, J.H. (2018), Decrease in scale invariance of activity fluctuations with aging and in patients with suprasellar tumors, Chronobiology International 35(3): 368-377.
- Tudorache, C.; Slabbekoorn, H.; Robbers, Y.; Hin, E.; Meijer, J.H.; Spaink, H.P. & Schaaf, M.J.M. (2018), Biological clock function is linked to proactive and reactive personality types, BMC Biology 16.
- Buijink M.R., Weeghel M. van, Gulersonmez M.C., Harms A.C., Rohling J.H.T., Meijer J.H., Hankemeier T. & Michel S. (2018), The influence of neuronal electrical activity on the mammalian central clock metabolome, Metabolomics 14: 122.
- Buijink, M.R.; Weeghel, M. van; Gulersonmez, M.C.; Harms, A.C.; Rohling, J.H.T.; Meijer, J.H.; Hankemeier, T. & Michel, S. (2018), The influence of neuronal electrical activity on the mammalian central clock metabolome, Metabolomics 14(10).
- Engberink, A.H.O.O.; Meijer, J.H. & Michel, S. (2018), Chloride cotransporter KCC2 is essential for GABAergic inhibition in the SCN, Neuropharmacology 138: 80-86.
- Mendoza, J.; Diepen, H.C. van; Pereira, R.R. & Meijer, J.H. (2018), Time-shifting effects of methylphenidate on daily rhythms in the diurnal rodent Arvicanthis ansorgei, Psychopharmacology 235(8): 2323-2333.
- Panagiotou, M.; Papagiannopoulos, K.; Rohling, J.H.T.; Meijer, J.H. & Deboer, T. (2018), How Old Is Your Brain? Slow-Wave Activity in Non-rapid-eye-movement Sleep as a Marker of Brain Rejuvenation After Long-Term Exercise in Mice, Frontiers in Aging Neuroscience 10.
- Panagiotou, M.; Meijer, J.H. & Deboer, T. (2018), Chronic high-caloric diet modifies sleep homeostasis in mice, European Journal of Neuroscience 47(11): 1339-1352.
- Schoonakker, M.; Meijer, J.H.; Deboer, T. & Fifel, K. (2018), Heterogeneity in the circadian and homeostatic modulation of multiunit activity in the lateral hypothalamus, SLEEP 41(6).
- Gu, C.G.; Yang, H.J.; Meijer, J.H. & Rohling, J.H.T. (2018), Dependence of the entrainment on the ratio of amplitudes between two subgroups in the suprachiasmatic nucleus, Physical Review E 97(6).
- Fifel, K.; Meijer, J.H. & Deboer, T. (2018), Circadian and Homeostatic Modulation of Multi-Unit Activity in Midbrain Dopaminergic Structures, Scientific Reports 8.
- Berg, R. van den; Kooijman, S.; Noordam, R.; Ramkisoensing, A.; Abreu-Vieira, G.; Tambyrajah, L.L.; Dijk, W.; Ruppert, P.; Mol, I.M.; Kramar, B.; Caputo, R.; Puig, L.S.; Ruiter, E.M. de; Kroon, J.; Hoekstra, M.; Sluis, R.J. van der; Meijer, O.C.; Dijk, K.W. van; Kerkhof, L.W.M. van; Christodoulides, C.; Karpe, F.; Gerhart-Hines, Z.; Kersten, S.; Meijer, J.H.; Coomans, C.P.; Heemst, D. van; Biermasz, N.R. & Rensen, P.C.N. (2018), A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening, Cell Reports 22(13): 3521-3533.
- Fifel, K.; Meijer, J.H. & Deboer, T. (2018), Long-term effects of sleep deprivation on neuronal activity in four hypothalamic areas, Neurobiology of Disease 109: 54-63.
- Kervezee, L.; Hartman, R.; Berg, D.J. van den; Meijer, J.H. & Lange, E.C.M. de (2017), Diurnal variation in the pharmacokinetics and brain distribution of morphine and its major metabolite, European Journal of Pharmaceutical Sciences 109: S132-S139.
- Houben, T.; Loonen, I.C.M.; Baca, S.M.; Schenke, M.; Meijer, J.H.; Ferrari, M.D.; Terwindt, G.M.; Voskuyl, R.A.; Charles, A.; Maagdenberg, A.M.J.M. van den & Tolner, E.A. (2017), Optogenetic induction of cortical spreading depression in anesthetized and freely behaving mice, Journal of Cerebral Blood Flow and Metabolism 37(5): 1641-1655.
- Kervezee L., Berg D.J. van den, Hartman R.J., Meijer J.H. & Lange E.C.M. de (2017), Diurnal variation in the pharmacokinetics and brain distribution of morphine and its major metabolite, European Journal of Pharmaceutical Sciences 109: S122-S130.
- Panagiotou, M.; Vyazovskiy, V.V.; Meijer, J.H. & Deboer, T. (2017), Differences in electroencephalographic non-rapid-eye movement sleep slow-wave characteristics between young and old mice, Scientific Reports 7.
- Buijink, M.R.; Almog, A.; Wit, C.B.; Roethler, O.; Engberink, A.H.O.O.; Meijer, J.H.; Garlaschelli, D.; Rohling, J.H.T. & Michel, S. (2016), Evidence for Weakened Intercellular Coupling in the Mammalian Circadian Clock under Long Photoperiod, PLoS ONE 11(12).
- Farajnia, S.; Meijer, J.H. & Michel, S. (2016), Photoperiod Modulates Fast Delayed Rectifier Potassium Currents in the Mammalian Circadian Clock, ASN NEURO 8(5).
- Stenvers, D.J.; Dorp, R. van; Foppen, E.; Mendoza, J.; Opperhuizen, A.L.; Fliers, E.; Bisschop, P.H.; Meijer, J.H.; Kalsbeek, A. & Deboer, T. (2016), Dim light at night disturbs the daily sleep-wake cycle in the rat, Scientific Reports 6.
- Kervezee, L.; Gotta, V.; Stevens, J.; Birkhoff, W.; Kamerling, I.M.C.; Danhof, M.; Meijer, J.H. & Burggraaf, J. (2016), Levofloxacin-Induced QTc Prolongation Depends on the Time of Drug Administration, CPT: Pharmacometrics and Systems Pharmacology 5(9): 466-474.
- Lucassen E.A., Coomans C.P., Putten M. van, Kreij S.R. de, Genugten J.H.L.T. van, Sutorius R.P.M., Rooij K.E. de, Velde M. van der, Verhoeve S.L., Smit J.W.A., Lowik C.W.G.M., Smits H.H., Guigas B., Aartsma-Rus A.M. & Meijer J.H. (2016), Environmental 24-hr Cycles Are Essential for Health, Current Biology 26(14): 1843-1853.
- Lucassen, E.A.; Coomans, C.P.; Putten, M. van; Kreij, S.R. de; Genugten, J.H.L.T. van; Sutorius, R.P.M.; Rooij, K.E. de; Velde, M. van der; Verhoeve, S.L.; Smit, J.W.A.; Lowik, C.W.G.M.; Smits, H.H.; Guigas, B.; Aartsma-Rus, A.M. & Meijer, J.H. (2016), Environmental 24-hr Cycles Are Essential for Health, Current Biology 26(14): 1843-1853.
- Huang, N.E.; Hu, K.; Yang, A.C.C.; Chang, H.C.; Jia, D.; Liang, W.K.; Yeh, J.R.; Kao, C.L.; Juan, C.H.; Peng, C.K.; Meijer, J.H.; Wang, Y.H.; Long, S.R. & Wu, Z.H. (2016), On Holo-Hilbert spectral analysis: a full informational spectral representation for nonlinear and non-stationary data, Philosophical Transactions A: Mathematical, Physical and Engineering Sciences 374(2065).
- Kervezee, L.; Stevens, J.; Birkhoff, W.; Kamerling, I.M.C.; Boer, T. de; Droge, M.; Meijer, J.H. & Burggraaf, J. (2016), Identifying 24h variation in the pharmacokinetics of levofloxacin: a population pharmacokinetic approach, British Journal of Clinical Pharmacology 81(2): 256-268.
- Dattolo, T.; Coomans, C.P.; Diepen, H.C. van; Patton, D.F.; Power, S.; Antle, M.C.; Meijer, J.H. & Mistlberger, R.E. (2016), NEURAL ACTIVITY IN THE SUPRACHIASMATIC CIRCADIAN CLOCK OF NOCTURNAL MICE ANTICIPATING A DAYTIME MEAL, Neuroscience 315: 91-103.
- Buijink M.R., Almog A., Wit C.B., Roethler O., Olde Engberink A.H.O., Meijer J.H., Garlaschelli D., Rohling J.H.T. & Michel S. (2016), Evidence for Weakened Intercellular Coupling in the Mammalian Circadian Clock under Long Photoperiod, PLoS ONE 11(12): e0168954.
- Coomans, C.P.; Lucassen, E.A.; Kooijman, S.; Fifel, K.; Deboer, T.; Rensen, P.C.N.; Michel, S. & Meijer, J.H. (2015), Plasticity of circadian clocks and consequences for metabolism, Diabetes, Obesity and Metabolism 17: 65-75.
- Vosko, A.; Diepen, H.C. van; Kuljis, D.; Chiu, A.M.; Heyer, D.; Terra, H.; Carpenter, E.; Michel, S.; Meijer, J.H. & Colwell, C.S. (2015), Role of vasoactive intestinal peptide in the light input to the circadian system, European Journal of Neuroscience 42(2): 1839-1848.
- Farajnia, S.; Meijer, J.H. & Michel, S. (2015), Age-related changes in large-conductance calcium-activated potassium channels in mammalian circadian clock neurons, Neurobiology of Aging 36(6): 2176-2183.
- Ramkisoensing, A. & Meijer, J.H. (2015), Synchronization of biological clock neurons by light and peripheral feedback systems promotes circadian rhythms and health, Frontiers in Neurology 6.
- Diepen, H.C. van; Foster, R.G. & Meijer, J.H. (2015), A Colourful Clock.
- Coomans, C.P.; Ramkisoensing, A. & Meijer, J.H. (2015), The suprachiasmatic nuclei as a seasonal clock, Frontiers in Neuroendocrinology 37: 29-42.
- Kooijman, S.; Berg, R. van den; Ramkisoensing, A.; Boon, M.R.; Kuipers, E.N.; Loef, M.; Zonneveld, T.C.M.; Lucassen, E.A.; Sips, H.C.M.; Chatzispyrou, I.A.; Houtkooper, R.H.; Meijer, J.H.; Coomans, C.P.; Biermasz, N.R. & Rensen, P.C.N. (2015), Prolonged daily light exposure increases body fat mass through attenuation of brown adipose tissue activity, Proceedings of the National Academy of Sciences 112(21): 6748-6753.
- Robbers, Y.; Koster, E.A.S.; Krijbolder, D.I.; Ruijs, A.; Berloo, S. van & Meijer, J.H. (2015), Temporal behaviour profiles of Mus musculus in nature are affected by population activity, Physiology and Behavior 139: 351-360.
- Gu, C.G.; Coomans, C.P.; Hu, K.; Scheer, F.A.J.L.; Stanley, H.E. & Meijer, J.H. (2015), Lack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice, Proceedings of the National Academy of Sciences 112(8): 2320-2324.
- Diepen, H.C. van; Lucassen, E.A.; Yasenkov, R.; Groenen, I.; Ijzerman, A.P.; Meijer, J.H. & Deboer, T. (2014), Caffeine increases light responsiveness of the mouse circadian pacemaker, European Journal of Neuroscience 40(10): 3504-3511.
- Houben, T.; Coomans, C.P. & Meijer, J.H. (2014), Regulation of Circadian and Acute Activity Levels by the Murine Suprachiasmatic Nuclei, PLoS ONE 9(10).
- Diepen, H.C. van; Lucassen, E.A.; Yasenkov, R.; Groenen, I.; Ijzerman, A.P.; Meijer, J.H. & Deboer, T. (2014), Caffeine increases light responsiveness of the circadian pacemaker, Journal of Sleep Research 23: 192-193.
- Kervezee, L.; Hartman, R.; Berg, D.J. van den; Shimizu, S.; Emoto-Yamamoto, Y.; Meijer, J.H. & Lange, E.C.M. de (2014), Diurnal Variation in P-glycoprotein-Mediated Transport and Cerebrospinal Fluid Turnover in the Brain, AAPS Journal 16(5): 1029-1037.
- Kervezee L., Hartman R.J., Berg D.J. van den, Shimizu S., Yamamoto Y., Meijer J.H. & Lange E.C.M. de (2014), Diurnal variation in P-glycoprotein-mediated transport and cerebrospinal fluid turnover in the brain, AAPS Journal 16(5): 1029-1037.
- Meijer, J.H. & Robbers, Y. (2014), Wheel running in the wild, Proceedings of the Royal Society B: Biological Sciences 281(1786).
- Farajnia, S.; Westering, T.L.E. van; Meijer, J.H. & Michel, S. (2014), Seasonal induction of GABAergic excitation in the central mammalian clock, Proceedings of the National Academy of Sciences 111(26): 9627-9632.
- Farajnia, van Westering, Meijer & Michel (2014), Seasonal induction of GABAergic excitation in the central mammalian clock., Proceedings of the National Academy of Sciences 111(26): 9627-32.
- Farajnia, S.; Deboer, T.; Rohling, J.H.T.; Meijer, J.H. & Michel, S. (2014), Aging of the Suprachiasmatic Clock, Neuroscientist 20(1): 44-55.
- Ramkisoensing, A.; Gu, C.G.; Gastelaars, H.M.D.V.; Michel, S.; Deboer, T.; Rohling, J.H.T. & Meijer, J.H. (2014), Enhanced Phase Resetting in the Synchronized Suprachiasmatic Nucleus Network, Journal of Biological Rhythms 29(1): 4-15.
- Gu, C.G.; Ramkisoensing, A.; Liu, Z.H.; Meijer, J.H. & Rohling, J.H.T. (2014), The Proportion of Light-Responsive Neurons Determines the Limit Cycle Properties of the Suprachiasmatic Nucleus, Journal of Biological Rhythms 29(1): 16-27.
- Diepen, H.C. van; Ramkisoensing, A.; Peirson, S.N.; Foster, R.G. & Meijer, J.H. (2013), Irradiance encoding in the suprachiasmatic nuclei by rod and cone photoreceptors, FASEB Journal 27(10): 4204-4212.
- Monge, M.; Houben, T.; Boer, H. de; Aleksinskaya, M.; Massy, Z.; Rabelink, T.; Meijer, J.H. & Zonneveld, A.J. van (2013), Chronic renal failure does not affect the mouse locomotor activity in darkness conditions, Biological Rhythm Research 44(5): 771-777.
- Coomans, C.P.; Berg, S.A.A. van den; Houben, T.; Klinken, J.B. van; Berg, R. van den; Pronk, A.C.M.; Havekes, L.M.; Romijn, J.A.; Dijk, K.W. van; Biermasz, N.R. & Meijer, J.H. (2013), Detrimental effects of constant light exposure and high-fat diet on circadian energy metabolism and insulin sensitivity, FASEB Journal 27(4): 1721-1732.
- Coomans, C.P.; Berg, S.A.A. van den; Lucassen, E.A.; Houben, T.; Pronk, A.C.M.; Spek, R.D. van der; Kalsbeek, A.; Biermasz, N.R.; Dijk, K.W. van; Romijn, J.A. & Meijer, J.H. (2013), The Suprachiasmatic Nucleus Controls Circadian Energy Metabolism and Hepatic Insulin Sensitivity, Diabetes 62(4): 1102-1108.
- Michel, S.; Marek, R.; vanderLeest, H.T.; vanSteensel, M.J.; Schwartz, W.J.; Colwell, C.S. & Meijer, J.H. (2013), Mechanism of bilateral communication in the suprachiasmatic nucleus, European Journal of Neuroscience 37(6): 964-971.
- Deboer, T.; Diepen, H.C. van; Ferrari, M.D.; Maagdenberg, A.M.J.M. van den & Meijer, J.H. (2013), Reduced Sleep and Low Adenosinergic Sensitivity in Cacna1a R192Q Mutant Mice, SLEEP 36(1): 127-136.
- Hu, K.; Meijer, J.H.; Shea, S.A.; vanderLeest, H.T.; Pittman-Polletta, B.; Houben, T.; Oosterhout, F. van; Deboer, T. & Scheer, F.A.J.L. (2012), Fractal Patterns of Neural Activity Exist within the Suprachiasmatic Nucleus and Require Extrinsic Network Interactions, PLoS ONE 7(11): -.
- Antle, M.C.; Diepen, H.C. van; Deboer, T.; Pedram, P.; Pereira, R.R. & Meijer, J.H. (2012), Methylphenidate modifies the motion of the circadian clock., Neuropsychopharmacology 37(11): 2446-55.
- Oosterhout, F. van; Fisher, S.P.; Diepen, H.C. van; Watson, T.S.; Houben, T.; VanderLeest, H.T.; Thompson, S.; Peirson, S.N.; Foster, R.G. & Meijer, J.H. (2012), Ultraviolet Light Provides a Major Input to Non-Image-Forming Light Detection in Mice.
- Oosterhout, F. van; Lucassen, E.A.; Houben, T.; vanderLeest, H.T.; Antle, M.C. & Meijer, J.H. (2012), Amplitude of the SCN Clock Enhanced by the Behavioral Activity Rhythm, PLoS ONE 7(6).
- Lucassen, E.A.; Diepen, H.C. van; Houben, T.; Michel, S.; Colwell, C.S. & Meijer, J.H. (2012), Role of vasoactive intestinal peptide in seasonal encoding by the suprachiasmatic nucleus clock, European Journal of Neuroscience 35(9): 1466-1474.
- Farajnia, S.; Michel, S.; Deboer, T.; vanderLeest, H.T.; Houben, T.; Rohling, J.H.T.; Ramkisoensing, A.; Yasenkov, R. & Meijer, J.H. (2012), Evidence for Neuronal Desynchrony in the Aged Suprachiasmatic Nucleus Clock, Journal of Neuroscience 32(17): 5891-5899.
- Rohling, J.H.T.; Vanderleest, H.T.; Michel, S.; Vansteensel, M.J. & Meijer, J.H. (2011), Phase Resetting of the Mammalian Circadian Clock Relies on a Rapid Shift of a Small Population of Pacemaker Neurons, PLoS ONE 6(9): -.
- Meijer, J.H.; Michel, S.; vanderLeest, H.T. & Rohling, J.H.T. (2010), Daily and seasonal adaptation of the circadian clock requires plasticity of the SCN neuronal network, European Journal of Neuroscience 32(12): 2143-2151.
- Houben T, Deboer T, van Oosterhout F & Meijer JH (2009), Correlation with Behavioral Activity and Rest Implies Circadian Regulation by SCN Neuronal Activity Levels, Journal of Biological Rhythms 24(6): 477-487.
- vanderLeest HT, Vansteensel MJ, Duindam H, Michel S & Meijer JH (2009), Phase of the Electrical Activity Rhythm in the SCN in Vitro Not Influenced by Preparation Time, Chronobiology International 26(6): 1075-1089.
- vanderLeest HT, Rohling JH, Michel S & Meijer JH (2009), Phase shifting capacity of the circadian pacemaker determined by the SCN neuronal network organization., PLoS ONE 4(3): e4976.
- vanderLeest HT, Vansteensel MJ, Duindam H, Michel S & Meijer JH (2009), Phase of the electrical activity rhythm in the SCN in vitro not influenced by preparation time.
- VanderLeest HT, Rohling JHT, Michel S & Meijer JH (2009), Phase Shifting Capacity of the Circadian Pacemaker Determined by the SCN Neuronal Network Organization, PLoS ONE 4(3).
- van Oosterhout F, Michel S, Deboer T, Houben T, van de Ven RCG, Albus H, Westerhout J, Vansteensel MJ, Ferrari MD, van den Maagdenberg AMJM & Meijer JH (2008), Enhanced circadian phase resetting in R192Q Ca(v)2.1 calcium channel migraine mice, Annals of Neurology 64(3).
- van Oosterhout F, Michel S, Deboer T, Houben T, van de Ven RCG, Albus H, Westerhout J, Vansteensel MJ, Ferrari MD, van den Maagdenberg AMJM & Meijer JH (2008), Enhanced circadian phase resetting in R192Q Ca(v)2.1 calcium channel migraine mice, Annals of Neurology 64(3): 315-324.
- van Oosterhout F, Michel S, Deboer T, Houben T, van de Ven RC, Albus H, Westerhout J, Vansteensel MJ, Ferrari MD, van den Maagdenberg AM & Meijer JH (2008), Enhanced circadian phase resetting in R192Q Cav2.1 calcium channel migraine mice.
- Meijer JH, Deboer T & Michel S (2008), [In time for Beijing: influence of the biological clock on athletic performance]., Nederlands Tijdschrift voor Geneeskunde 152(33): 1809-12.
- Zhang J, Fang Z, Jud C, Vansteensel MJ, Kaasik K, Lee CC, Albrecht U, Tamanini F, Meijer JH, Oostra BA & Nelson DL (2008), Fragile X-related proteins regulate mammalian circadian behavioral rhythms, American Journal of Human Genetics 83(1).
- Vansteensel MJ, Michel S & Meijer JH (2008), Organization of cell and tissue circadian pacemakers: A comparison among species, Brain Research Reviews 58(1).
- Hampp G, Ripperger JA, Houben T, Schmutz I, Blex C, Perreau-Lenz S, Brunk I, Spanagel R, Ahnert-Hilger G, Meijer JH & Albrecht U (2008), Regulation of monoamine oxidase a by circadian-clock components implies clock influence on mood, Current Biology 18(9).
- Deboer T, Ruijgrok G & Meijer JH (2007), Short light-dark cycles affect sleep in mice, European Journal of Neuroscience 26(12).
- Deboer T, Ruijgrok G & Meijer JH (2007), Short light-dark cycles affect sleep in mice, European Journal of Neuroscience 26(12): 3518-3523.
- Meijer JH, Michel S & Vansteensel MJ (2007), Processing of daily and seasonal light information in the mammalian circadian clock, General and Comparative Endocrinology 152(2-3).
- VanderLeest HT, Houben T, Michel S, Deboer T, Albus H, Vansteensel MJ, Block GD & Meijer JH (2007), Seasonal encoding by the circadian pacemaker of the SCN.
- Deboer T, Detari L & Meijer JH (2007), Long term effects of sleep deprivation on the mammalian circadian pacemaker, SLEEP 30(3): 257-262.
- Rohling J, Meijer JH, VanderLeest HT & Admiraal J (2006), Phase differences between SCN neurons and their role in photoperiodic encoding; a simulation of ensemble patterns using recorded single unit electrical activity patterns, Journal of Physiology - Paris 100(5-6): 261-270.
- Rohling J, Wolters L & Meijer JH (2006), Simulation of day-length encoding in the SCN: From single-cell to tissue-level organization, Journal of Biological Rhythms 21(4).
- Vansteensel MJ, Magnone MC, van Oosterhout F, Baeriswyl S, Albrecht U, Albus H, Dahan A & Meijer JH (2005), The opioid fentanyl affects light input, electrical activity and Per gene expression in the hamster suprachiasmatic nuclei, European Journal of Neuroscience 21(11).
- Itri JN, Michel S, Vansteensel MJ, Meijer JH & Colwell CS (2005), Fast delayed rectifier potassium current is required for circadian neural activity, Nature Neuroscience 8(5).
- Albus H, Vansteensel MJ, Michel S, Block GD & Meijer JH (2005), A GABAergic mechanism is necessary for coupling dissociable ventral and dorsal regional oscillators within the circadian clock, Current Biology 15(10).
- Deboer T, Overeem S, Visser NAH, Duindam H, Frolich M, Lammers GJ & Meijer JH (2004), Convergence of circadian and sleep regulatory mechanisms on hypocretin-1, Neuroscience 129(3): 727-732.
- Schwartz WJ & Meijer JH (2004), Real-time imaging reveals spatiotemporal dynamics of cellular circadian clocks, Trends in Neurosciences 27(9).
- Deboer T, Overeem S, Visser NAH, Duindam H, Frolich M, Lammers GJ & Meijer JH (2004), Convergence of circadian and sleep regulatory mechanisms on hypocretin-1, Neuroscience 129(3).
- Schaap J, Albus H, Vanderleest HT, Eilers PHC, Detari L & Meijer JH (2003), Heterogeneity of rhythmic suprachiasmatic nucleus neurons: Implications, for circadian waveform and photoperiodic encoding, Proceedings of the National Academy of Sciences 100(26): 15994-15999.
- Deboer T, Vansteensel MJ, Detari L & Meijer JH (2003), Sleep states alter activity of suprachiasmatic nucleus neurons, Nature Neuroscience 6(10): 1086-1090.
- Vansteensel MJ, Yamazaki S, Albus H, Deboer T, Block GD & Meijer JH (2003), Dissociation between circadian Per1 and neuronal and behavioral rhythms following a shifted environmental cycle, Current Biology 13(17).
- Vansteensel MJ, Yamazaki S, Albus H, Deboer T, Block GD & Meijer JH (2003), Dissociation between circadian Per1 and neuronal and behavioral rhythms following a shifted environmental cycle.
- Vansteensel MJ, Deboer T, Dahan A & Meijer JH (2003), Differential responses of circadian activity onset and offset following GABA-ergic and opioid receptor activation.
- Vansteensel MJ, Deboer T, Dahan A & Meijer JH (2003), Differential responses of circadian activity onset and offset following GABA-ergic and opioid receptor activation, Journal of Biological Rhythms 18(4): 297-306.
- Meijer JH & Schwartz WJ (2003), In search of the pathways for light-induced pacemaker resetting in the suprachiasmatic nucleus, Journal of Biological Rhythms 18(3).
- Schaap J, Pennartz CMA & Meijer JH (2003), Electrophysiology of the circadian pacemaker in mammals.
- Albus H, Bonnefont X, Chaves I, Yasui A, Doczy J, van der Horst GTJ & Meijer JH (2002), Cryptochrome-deficient mice lack circadian electrical activity in the suprachiasmatic nuclei, Current Biology 12(13): 1130-1133.
- Albus H, Bonnefont X, Chaves I, Yasui A, Doczy J, van der Horst GTJ & Meijer JH (2002), Cryptochrome-deficient mice lack circadian electrical activity in the suprachiasmatic nuclei, Current Biology 12(13): 1130-1133.
- Watanabe K, Deboer T & Meijer JH (2001), Light-Induced resetting of the circadian pacemaker: quantitative analysis of transient versus steady-state phase shifts., Journal of Biological Rhythms 16(6): 564-73.
- Schaap J & Meijer JH (2001), Opposing effects of behavioural activity and light on neurons of the suprachiasmatic nucleus, European Journal of Neuroscience 13(10): 1955-1962.
- Schaap J, Albus H, Eilers PHC, Detari L & Meijer JH (2001), Phase differences in electrical discharge rhythms between neuronal populations of the left and right suprachiasmatic nuclei, Neuroscience 108(3).
- Meijer JH, Ruijs ACJ, Albus H, van de Geest B, Duindam H, Zwinderman AH & Dahan A (2000), Fentanyl, a mu-opioid receptor agonist, phase shifts the hamster circadian pacemaker.
- Meijer JH, Thio B, Albus H, Schaap J & Ruijs ACJ (1999), Functional absence of extraocular photoreception in hamster circadian rhythm entrainment, Brain Research 831(1-2): 337-339.
- Meijer JH, Watanabe K, Schaap J, Albus H & Detari L (1998), Light responsiveness of the suprachiasmatic nucleus: Long-term multiunit and single-unit recordings in freely moving rats, Journal of Neuroscience 18(21): 9078-9087.
- Meijer JH, Schaap J, Watanabe K & Albus H (1997), Multiunit activity recordings in the suprachiasmatic nuclei: In vivo versus in vitro models, Brain Research 753(2): 322-327.
- Meijer JH, Watanabe K, Detari L, deVries MJ, Albus H, Treep JA, Schaap J & Rietveld WJ (1996), Light entrainment of the mammalian biological clock, HYPOTHALAMIC INTEGRATION OF CIRCADIAN RHYTHMS 111: 175-190.
- Meijer JH, Watanabe K, Detari L & Schaap J (1996), Circadian rhythm in light response in suprachiasmatic nucleus neurons of freely moving rats, Brain Research 741(1-2): 352-355.
- MEIJER JH & DEVRIES MJ (1995), LIGHT-INDUCED PHASE-SHIFTS IN ONSET AND OFFSET OF RUNNING-WHEEL ACTIVITY IN THE SYRIAN-HAMSTER, Journal of Biological Rhythms 10(1): 4-16.
- DEVRIES MJ, TREEP JA & MEIJER JH (1994), ELECTRICAL-STIMULATION OF THE ANTERIOR OPTIC CHIASM MIMICS THE PHASE-SHIFTING EFFECTS OF LIGHT ON THE CIRCADIAN ACTIVITY RHYTHM OF THE SYRIAN-HAMSTER, Biological Rhythm Research 25(2): 211-213.
- DEVRIES MJ, TREEP JA, DEPAUW ESD & MEIJER JH (1994), THE EFFECTS OF ELECTRICAL-STIMULATION OF THE OPTIC NERVES AND ANTERIOR OPTIC CHIASM ON THE CIRCADIAN ACTIVITY RHYTHM OF THE SYRIAN-HAMSTER - INVOLVEMENT OF EXCITATORY AMINO-ACIDS, Brain Research 642(1-2): 206-212.
- DEVRIES MJ, CARDOZO BN, VANDERWANT J, DEWOLF A & MEIJER JH (1993), GLUTAMATE IMMUNOREACTIVITY IN TERMINALS OF THE RETINOHYPOTHALAMIC TRACT OF THE BROWN NORWEGIAN RAT, Brain Research 612(1-2): 231-237.
- MEIJER JH, ALBUS H, WEIDEMA F & RAVESLOOT JH (1993), THE EFFECTS OF GLUTAMATE ON MEMBRANE-POTENTIAL AND DISCHARGE RATE OF SUPRACHIASMATIC NEURONS, Brain Research 603(2): 284-288.
- MEIJER JH, RUSAK B & GANSHIRT G (1992), THE RELATION BETWEEN LIGHT-INDUCED DISCHARGE IN THE SUPRACHIASMATIC NUCLEUS AND PHASE-SHIFTS OF HAMSTER CIRCADIAN-RHYTHMS, Brain Research 598(1-2): 257-263.
- MEIJER JH (1992), ENTRAINMENT OF THE CIRCADIAN PACEMAKER BY LIGHT, Journal of interdisciplinary cycle research 23(3): 152-154.
- DEVRIES MJ & MEIJER JH (1991), ASPARTATE INJECTIONS INTO THE SUPRACHIASMATIC REGION OF THE SYRIAN-HAMSTER DO NOT MIMIC THE EFFECTS OF LIGHT ON THE CIRCADIAN ACTIVITY RHYTHM, Neuroscience Letters 127(2): 215-218.
- MEIJER JH (1990), PHYSIOLOGICAL-BASIS FOR PHOTIC ENTRAINMENT, European Journal of Morphology 28(2-4): 308-316.
- MEIJER JH, DAAN S, OVERKAMP GJF & HERMANN PM (1990), THE 2-OSCILLATOR CIRCADIAN SYSTEM OF TREE SHREWS (TUPAIA-BELANGERI) AND ITS RESPONSE TO LIGHT AND DARK PULSES, Journal of Biological Rhythms 5(1): 1-16.
- MEIJER JH, RUSAK B & HARRINGTON ME (1989), PHOTICALLY RESPONSIVE NEURONS IN THE HYPOTHALAMUS OF A DIURNAL GROUND-SQUIRREL, Brain Research 501(2): 315-323.
- RUSAK B, MEIJER JH & HARRINGTON ME (1989), HAMSTER CIRCADIAN-RHYTHMS ARE PHASE-SHIFTED BY ELECTRICAL-STIMULATION OF THE GENICULO-HYPOTHALAMIC TRACT, Brain Research 493(2): 283-291.
- MEIJER JH & RIETVELD WJ (1989), NEUROPHYSIOLOGY OF THE SUPRACHIASMATIC CIRCADIAN PACEMAKER IN RODENTS, Physiological Reviews 69(3): 671-707.
- MEIJER JH, RUSAK B & HARRINGTON ME (1988), LUMINANCE CODING IN THE CIRCADIAN PACEMAKER OF THE 13-LINED GROUND-SQUIRREL, Pfl�gers Archiv European Journal of Physiology 412(1-2): S2-S2.
- MEIJER JH, VANDERZEE EA & DIETZ M (1988), GLUTAMATE PHASE-SHIFTS CIRCADIAN ACTIVITY RHYTHMS IN HAMSTERS, Neuroscience Letters 86(2): 177-183.
- MEIJER JH & GROOS GA (1988), RESPONSIVENESS OF SUPRACHIASMATIC AND VENTRAL LATERAL GENICULATE NEURONS TO SEROTONIN AND IMIPRAMINE - A MICROIONTOPHORETIC STUDY IN NORMAL AND IMIPRAMINE-TREATED RATS, Brain Research Bulletin 20(1): 89-96.
- MEIJER JH & GROOS GA (1986), LUMINANCE CODING OF THE CIRCADIAN SYSTEM, Experientia 42(11-12): 1309-1309.
- MEIJER JH, GROOS GA & RUSAK B (1986), LUMINANCE CODING IN A CIRCADIAN PACEMAKER - THE SUPRACHIASMATIC NUCLEUS OF THE RAT AND THE HAMSTER, Brain Research 382(1): 109-118.
- GROOS GA & MEIJER JH (1985), EFFECTS OF ILLUMINATION ON SUPRACHIASMATIC NUCLEUS ELECTRICAL-DISCHARGE, Annals of the New York Academy of Sciences 453: 134-146.
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