Universiteit Leiden

nl en

Stefan Semrau

Assistant professor

Naam
Dr. S. Semrau
E-mail
semrau@physics.leidenuniv.nl

We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types. Using single-cell transcriptomics and single-molecule microscopy in combination with machine learning and mathematical modeling we seek to unravel the dynamics of the decision making process and understand the interplay of internal factors (epigenetics, cell cycle, stochastic gene expression) and external factors (signaling molecules, cell-cell contacts, mechanical cues). We believe that the basic principles discovered through our research will be of great value for applications in regenerative medicine and the eradication of cancer stem cells.

Meer informatie over Stefan Semrau

Semrau lab

Assistant professor

  • Wiskunde en Natuurwetenschappen
  • Leids Instituut Onderzoek Natuurkunde
  • LION - Biological & Soft Matter

Werkadres

Huygens Laboratorium
Niels Bohrweg 2
2333 CA Leiden
Kamernummer GW0309

Contact

  • Semrau S. (19 oktober 2015), Lineage decision-making in embryonic stem cells (Lezing). Amsterdam, the Netherlands.overig
  • Semrau S. (7 oktober 2015), Early lineage bifurcation during differentiation of embryonic stem cells revealed by single-cell transcriptomics (Lezing).overig
  • Semrau S. (28 september 2015), Early lineage bifurcation during differentiation of embryonic stem cells revealed by single-cell transcriptomics (Lezing). Veldhoven, the Netherlands.overig
  • Semrau S. (24 juni 2015), Early lineage bifurcation during differentiation of embryonic stem cells revealed by single-cell transcriptomics (Lezing). Stockholm, Sweden.overig
  • Semrau S. (20 mei 2015), Early lineage bifurcation during differentiation of embryonic stem cells revealed by single-cell transcriptomics (Lezing). Lunteren, the Netherlands.overig
  • Semrau S. (7 februari 2015), Early lineage bifurcation during differentiation of embryonic stem cells revealed by single-cell transcriptomics (Lezing). Baltimore, USA.overig
  • Slavov N., Semrau S., Airoldi E., Budnik B. & Oudenaarden A. van (2015), Differential Stoichiometry among Core Ribosomal Proteins., Cell reports 13(5): 865-873.'refereed' artikel in een tijdschrift
  • Semrau S. & Oudenaarden A. van (2015), Studying Lineage Decision-Making In Vitro: Emerging Concepts and Novel Tools., Annual review of cell and developmental biology 31(1): 317-345.'refereed' artikel in een tijdschrift
  • Semrau S. (2015), Initiator and co-organizer of the LION image award competition. [overig]overig
  • Semrau S. (2015), Co-developer of the “Aansluitingsmodule Natuurkunde”. [overig]overig
  • (2015), BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells, Stem Cell Reports 6(1): 85-94.'refereed' artikel in een tijdschrift

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