Richard van den Berg
Docent
- Naam
- Dr. R.J.B.H.N. van den Berg
- Telefoon
- +31 71 527 4793
- r.j.vdberg@chem.leidenuniv.nl
- ORCID iD
- 0000-0002-8585-3904
Docent
- Wiskunde en Natuurwetenschappen
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Bio-organic Synthesis
- Li X., Chang H., Bouma J., Paus L.V. de, Mukhopadhyay P., Paloczi J., Mustafa M., Horst C. van der, Kumar S.S., Wu L., Yu Y., Berg R.J.B.H.N. van den, Janssen A.P.A., Lichtman A., Liu Z.J., Pacher P., Stelt M. van der, Heitman L.H. & Hua T. (2023), Structural basis of selective cannabinoid CB2 receptor activation, Nature Communications 14(1): 1447.
- Jiang M., Huizenga M.C.W., Wirth J.L., Paloczi J., Amedi A., Berg R.J.B.H.N. van den, Benz J., Collin L., Deng H., Di X., Driver W.F., Florea B.I., Grether U., Janssen A.P.A., Hankemeier T., Heitman L.H., Lam T.W., Mohr F., Pavlovic A., Ruf I., Hurk H. van den, Stevens A.F., Vliet D. van der, Wel T. van der, Wittwer M.B., Boeckel C.A.A. van, Pacher P., Hohmann A.G. & Stelt M. van der (2023), A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence, Nature Communications 14(1): 8039.
- Bakker A.T., Kotsogianni A.I., Mirenda L., Straub V.M., Avalos Garcia M., Berg R.J.B.H.N. van den, Florea B.I., Wezel G.P. van, Janssen A.P.A., Martin N.I. & Stelt M. van der (2023), Chemical proteomics reveals antibiotic targets of oxadiazolones in MRSA, Journal of the American Chemical Society 145(2): 1136-1143.
- Bakker A.T., Kotsogianni A.I., Mirenda L., Straub V.M., Avalos Garcia M., Berg R.J.B.H.N. van den, Florea B.I., Wezel G.P. van, Janssen A.P.A., Martin N.I. & Stelt M. van der (2022), Chemical proteomics reveals antibiotic targets of oxadiazolones in MRSA, Journal of the American Chemical Society 145(2): 1136-1143.
- Liu B., Mechelen J. van, Berg R.J.B.H.N. van den, Nieuwendijk A.M.C.H. van den, Aerts J.M.F.G., Marel G.A. van der, Codée J.D.C. & Overkleeft H.S. (2019), Synthesis of glycosylated 1-deoxynojirimycins starting from natural and synthetic disaccharides, European Journal of Organic Chemistry 2019(1): 118-129.
- Lelieveld L.T., Mirzaian M., Kuo C.L., Artola Perez de Azanza M.E., Guimaraes da Lomba Ferraz M.J., Peter R.E.A., Akiyama H., Greimel P., Berg R.J.B.H.N. van den, Overkleeft H.S., Boot R.G., Meijer A. & Aerts J.M.F.G. (2019), Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish, Journal of Lipid Research 60(11): 1851-1867.
- Rooden E.J. van, Kohsiek M.J.J., Kreekel R., Esbroeck A.C.M. van, Nieuwendijk A.M.C.H. van den, Janssen A.P.A., Berg R.J.B.H.N. van den, Overkleeft H.S. & Stelt M. van der (2018), Design and Synthesis of Quenched Activity-based Probes for Diacylglycerol Lipase and alpha,beta-Hydrolase Domain Containing Protein 6, Chemistry - An Asian Journal 13(22): 3491-3500.
- Rugen M.D., Vernet M.M.J.L., Hantouti L., Soenens A., Andriotis V.M.E., Rejzek M., Brett P., Berg R.J.B.H.N. van den, Aerts J.M.F.G., Overkleeft H.S. & Field R.A. (2018), A chemical genetic screen reveals that iminosugar inhibitors of plant glucosylceramide synthase inhibit root growth in Arabidopsis and cereals, Scientific Reports 8: 16421.
- Soethoudt M., Alachouzos G., Rooden E.J. van, Moya Garzón M.D., Berg R.J.B.H.N. van den, Heitman L.H. & Stelt M. van der (2018), Development of a Cannabinoid-Based Photoaffinity Probe to Determine the D8/9- Tetrahydrocannabinol Protein Interaction Landscape in Neuroblastoma Cells, Cannabis and Cannabinoid Research 3(1): 136-151.
- Deng H., Kooijman S., Nieuwendijk A.M.C.H. van den, Ogasawara D., Wel T. van der, Dalen F. van, Baggelaar M.P., Janssen F.J., Berg R.J.B.H.N. van der, Dulk J. den, Cravatt B.F., Overkleeft H.S., Rensen P.C. & Stelt M. van der (2017), Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding, Journal of Medicinal Chemistry 60(1): 428-440.
- Lahav D., Liu B., Berg R.J.B.H.N. van den, Nieuwendijk A.M.C.H. van den, Wennekes T., Ghisaidoobe A.T., Breen I., Ferraz M.J., Kuo C.L., Wu L., Geurink P.P., Ovaa H., Marel G.A. van der, Stelt M. van der, Boot R.G., Davies G.J., Aerts J.M.F.G. & Overkleeft H.S. (2017), A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase, Journal of the American Chemical Society 138(40): 14192-14197.
- Deng H., Wel T. van der, Berg R.J.B.H.N. van den, Nieuwendijk A.M.C.H. van den, Janssen F.J., Baggelaar M.P., Overkleeft H.S. & Stelt M. van der (2017), Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-alpha and ABHD6 inhibitors, MEDCHEMCOMM 8(5): 982-988.
- Wisse P., Gold H., Mirzaian M., Guimaraes Da Lomba Ferraz M.J., Lutteke G., Berg R.J.B.H.N. van den, Elst H. van den, Lugtenburg J., Marel G.A. van der, Aerts J.M.F.G., Codee J.D.C. & Overkleeft H.S. (2015), Synthesis of a panel of carbon-13-labelled (glyco)sphingolipids, European Journal of Organic Chemistry 2015(12): 2661-2677.
- Wisse P., Geus M.A.R. de, Cross G., Nieuwendijk A.M.C.H. van den, Rooden E.J. van, Berg R.J.B.H.N. van den, Aerts J.M.F.G., Marel G.A. van der, Codée J.D.C. & Overkleeft H.S. (2015), Synthesis of 6-Hydroxysphingosine and α-Hydroxy Ceramide Using a Cross-Metathesis Strategy, Journal of Organic Chemistry (JOC) 80(14): 7258-65.
- Berg R.J.B.H.N. van der, Rijssel E.R. van, Ferraz M.J., Houben J., Strijland A., Donker-Koopman W.E., Wennekes T., Bonger K.M., Ghisaidoobe A.B.T., Hoogendoorn S., Marel G.A. van der, Codee J.D.C., Overkleeft H.S. & Aerts J.M.F.G. (2015), Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors, ChemMedChem 10(12): 2042-2062.
- Hoogendoorn S., Mock E.D., Strijland A., Donker-Koopman W.E., Elst H. van den, Berg R.J.B.H.N. van den, Aerts J.M.F.G., Marel G.A. van der & Overkleeft H.S. (2015), Ortho-Carborane-modified N-substituted Deoxynojirimycins, European Journal of Organic Chemistry 2015(20): 4437-4446.
- Ghisaidoobe Amar T., Van den Berg Richard J.B.H.N., Butt Saleem S., Strijland Anneke, Donker-Koopman Wilma E., Scheij Saskia, Van den Nieuwendijk Adrianus M.C.H., Koomen Gerrit-Jan, Van Loevezijn Arnold, Leemhuis Mark, Wennekes Tom, Van der Stelt Mario, Van der Marel Gijsbert A., Van Boeckel Constant A.A., Aerts Johannes M.F.G. & Overkleeft Herman S. (2014), Identification and Development of Biphenyl Substituted Iminosugars as Improved Dual Glucosylceramide Synthase/Neutral Glucosylceramidase Inhibitors, Journal of Medicinal Chemistry 57(21): 9096-9104.
- Nieuwendijk A.M.C.H. van den, Berg R.J.B.H.N. van den, Ruben M., Witte M.D., Brussee J., Boot R.G., Marel G.A. van der, Aerts J.M.F.G. & Overkleeft H.S. (2012), Synthesis of Eight 1-Deoxynojirimycin Isomers from a Single Chiral Cyanohydrin, European Journal of Organic Chemistry 2012(18): 3437-3446.
- Berg R.J.B.H.N. van den, Wennekes T., Ghisaidoobe A., Donker-Koopman W.E., Strijland A., Boot R.G., Marel G.A. van der, Aerts J.M.F.G. & Overkleeft H.S. (2011), Assessment of Partially Deoxygenated Deoxynojirimycin Derivatives as Glucosylceramide Synthase Inhibitors, Acs Medicinal Chemistry Letters 2(7): 519-522.
- Ghisaidoobe A., Bikker P., Bruijn A.C.J. de, Godschalk F.D., Rogaar E., Guijt M.C., Hagens P., Halma J.M., Hart S.M. van 't, Luitjens S.B., Rixel V.H.S. van, Wijzenbroek M., Zweegers T., Donker-Koopman W.E., Strijland A., Boot R.G., Marel G.A. van der, Overkleeft H.S., Aerts J.M.F.G. & Berg R.J.B.H.N. van den (2011), Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars, Acs Medicinal Chemistry Letters 2(2): 119-123.
- Berg R.J.B.H.N. van den., Elst H. van den., Korevaar C.G.N., Aerts J.M.F.G., Marel G.A. van der. & Overkleeft H.S. (2011), A Rapid and Efficient Synthesis of D-erythro-Sphingosine from D-ribo-Phytosphingosine, European Journal of Organic Chemistry 2011(33): 6685-6689.
- Wennekes T., Meijer A.J., Groen A.K., Boot R.G., Groener J.E., Eijk M.C. van, Ottenhoff R., Bijl N., Ghauharali K., Song H., O'Shea T.J., Liu H., Yew N., Copeland D., Berg R.J.B.H.N. van den, Marel G.A. van der, Overkleeft H.S. & Aerts J.M.F.G. (2010), Dual-Action Lipophilic Iminosugar Improves Glycemic Control in Obese Rodents by Reduction of Visceral Glycosphingolipids and Buffering of Carbohydrate Assimilation, Journal of Medicinal Chemistry 53(2): 689-698.
- Wennekes T., Van den Berg R.J.B.H.N., Boltje T.J., Donker-Koopman W.E., Kuijper B., Van der Marel G.A., Strijland A., Verhagen C.P., Aerts J.M.F.G. & Overkleeft H.S. (2010), Synthesis and Evaluation of Lipophilic Aza-C-glycosides as Inhibitors of Glucosylceramide Metabolism, European Journal of Organic Chemistry (7): 1258-1283.
- Nieuwendijk A.M.C.H. van, Ruben M., Engelsma S.E., Risseeuw M.D.P., Berg R.J.B.H.N. van den, Boot R.G., Aerts J.M.F.G., Brussee J., Marel G.A. van der & Overkleeft H.S. (2010), Synthesis of L-altro-1-Deoxynoprimycin, D-allo-1-Deoxynoprimycin, and D-galacto-1-Deoxynojirimycin from a Single Chiral Cyanohydrin, 12(17): 3957-3959.
- Wennekes T., Berg R.J.B.H.N. van den, Boot R.G., Marel G.A. van der, Overkleeft H.S. & Aerts J.M.F.G. (2009), Glycosphingolipids-Nature, Function, and Pharmacological Modulation, Angewandte Chemie (International Edition) 48(47): 8848-8869.
- Ali A., Berg R.J.B.H.N. van den, Overkleeft H.S., Filippov D.V., Marel G.A. van der & Codee J.D.C. (2009), Methylsulfonylethoxycarbonyl (Msc) and fluorous propylsulfonylethoxycarbonyl (FPsc) as hydroxy-protecting groups in carbohydrate chemistry, Tetrahedron Letters 50(19): 2185-2188.
- Bonger K.M., Berg R.J.B.H.N. van den, Knijnenburg A.D., Heitman L.H., IJzerman A.P., Oosterom J., Timmers C.M., Overkleeft H.S. & Marel G.A. van der (2008), Synthesis and evaluation of homodimeric GnRHR antagonists having a rigid bis-propargylated benzene core, Bioorganic & Medicinal Chemistry 16(7): 3744-3758.
- Wennekes T., Berg R.J.B.H.N. van den, Donker W., Marel G.A. van der, Donker W., Marel G.A. van der, Strijland A., Aerts J.M.F.G. & Overkleeft H.S. (2007), Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man, Journal of Organic Chemistry (JOC) 72(4): 1088-1097.
- Wennekes T., Berg R.J.B.H.N. van den & et al (2007), Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivates as selective inhibitors of glucosylceramide in man, Journal of Organic Chemistry (JOC) 72(4): 1088-1097.
- Bonger K.M., Berg R.J.B.H.N. van den, Heitman L.H., IJzerman A.P., Oosterom J., Timmers C.M., Overkleeft H.S. & Marel G.A. van der (2007), Synthesis and evaluation of homo-bivalent GnRHR ligands, Bioorganic & Medicinal Chemistry 15(14): 4841-4856.
- Bonger K.M., Wennekes T., Lavoir S.V.P., Esposito D., Berg R.J.B.H.N. van den, Litjens R.E.J.N., Marel G.A. van der & Overkleeft H.S. (2006), Transformation of carbohydrate derived 4-azidopentanals into highly functionalized pyrrolidines via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction, QSAR & Combinatorial Science 25: 491-503.
- Berg R.J.B.H.N. van den, Boltje T.J., Verhagen C.P., Litjens R.E.J.N., Marel G.A. van der & Overkleeft H.S. (2006), An efficient synthesis of the natural tetrahydrofuran pachastrissamine starting from D-ribo-phytosphingosine, Journal of Organic Chemistry (JOC) 71: 836-839.
- Litjens R.E.J.N., Bos L.J. van den, Codee J.D.C., Berg R.J.B.H.N. van den, Overkleeft H.S. & Marel G.A. van der (2005), Sulfonium triflate mediated glycosidations of aryl 2-azido-2-deoxy-1-thio-D-mannosides, European Journal of Organic Chemistry (5): 918-924.
- Litjens R.E.J.N., Hoogerhout P., Filippov D.V., Codee J.D.C., Bos L.J. van den, Berg R.J.B.H.N. van den, Overkleeft H.S. & Marel G.A. van der (2005), Synthesis of an alpha-Gal epitope alpha-D-Galp-(1 -> 3)-beta-D-Galp-(1 -> 4)-beta-D-Glcp NAc-lipid conjugate, Journal of Carbohydrate Chemistry 24(7): 755-769.
- Litjens R.E.J.N., Bos L.J. van den, Codee J.D.C., Berg R.J.B.H.N. van den, Overkleeft H.S. & Marel G.A. van der (2005), Sulfonium triflate mediated glycosidations of aryl 2-azido-2-deoxy-1-thio-D-mannosides, European Journal of Organic Chemistry (5): 918-924.
- Bos L.J. van den, Litjens R.E.J.N., Berg R.J.B.H.N. van den, Overkleeft H.S. & Marel G.A. van der (2005), Preparation of 1-thio uronic acid lactones and their use in oligosaccharide synthesis, 7: 2007-2010.
- Litjens R.E.J.N., Bos L.J. van den, Codée J.D.C., Berg R.J.B.H.N. van den, Overkleeft H.S. & Marel G.A. van der (2005), Sulfonium triflate mediated glycosidations of aryl 2-azido-2-deoxy-1-thio-D-mannosides, European Journal of Organic Chemistry : 918-924.
- Berg R.J.B.H.N. van den, Donker-Koopman W., Boom J.H. van, Aerts H.M.F.G. & Noort D. (2004), Design and synthesis of 2-acetamidomethyl derivatives of isofagomine as potential inhibitors of human lysosomal beta-hexosaminidases, Bioorganic & Medicinal Chemistry 12(5): 891-902.
- Berg R.J.B.H.N. van den, Korevaar C.G.N., Marel G.A. van der, Overkleeft H.S. & Boom J.H. van (2002), A simple and low cost synthesis of D-erythro-sphingosine and D-erythro-azidosphingosine from D-ribo-phytosphingosine: glycosphingolipid precursors, Tetrahedron Letters 43: 8409-8412.
- Berg R.J.B.H.N. van den, Noort D., Marel G.A. van der, Boom J.H. van & Benschop H.P. (2002), Synthesis of pseudo-disaccharide analogues of lipid A: haptens for the generation of antibodies with glycosidase activity towards lipid A, Journal of Carbohydrate Chemistry 21(3): 167-188.