Natalia Ortiz Zacarias
Universitair docent
- Naam
- Dr. N.V. Ortiz Zacarias Ph.D.
- Telefoon
- 071 5272727
- n.v.ortiz.zacarias@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0001-7470-5546
Universitair docent
- Faculteit der Wiskunde en Natuurwetenschappen
- LACDR
- Divisie Medicinal Chemistry
- Essa K.T.S.E.M., Noorman Dussen K. van der, Yao Y., Bleijs B.T.M., Ortiz Zacarias N.V., Heitman L.H., Westen G.J.P. van, Jespers W., Es D. van der & Sicho M. (2025), Combining AlphaFold with focused virtual library design in the development of novel CCR2 and CCR5 antagonists, Journal of Chemical Information and Modeling 65(22): 12398-12409.
- Essa K., Ortiz Zacarías N.V., Roth S., Xin B.T., Winter S. de, Horst C. van der, Bleijs B., Heiden R.A. de, Voulgaraki R., Neubert E., Ovaa H., Danen E.H.J., Mulder M.P.C., Moreau K., Es D. van der & Heitman L.H. (2025), Leveraging targeted protein degradation for G protein-coupled receptors: the development of CCR2 molecular degraders, Journal of Medicinal Chemistry 68(24): 26525-26546.
- Hollander L.S. den, Beerkens B.L.H., Dekkers S., Veldhoven J.P.D. van, Ortiz Zacarías N.V., Horst C. van der, Sieders E.G., Valk B. de, Wang J., IJzerman A.P., Es D. van der & Heitman L.H. (2024), Labeling of CC chemokine receptor 2 with a versatile intracellular allosteric probe, ACS Chemical Biology 19(9): 2070-2080.
- Toy L., Huber M.E., Lee M., Bartolomé A.A., Ortiz Zacarías N.V., Nasser S., Scholl S., Zlotos D.P., Mandour Y.M., Heitman L.H., Szpakowska M., Chevigné A. & Schiedel M. (2024), Fluorophore-labeled pyrrolones targeting the intracellular allosteric binding site of the chemokine receptor CCR1, ACS Pharmacology & Translational Science 7(7): 2080-2092.
- Ortiz Zacarías N.V., RöthS., Broekhuis J.D., Es D. van der, Moreau K. & Heitman L.H. (2024), Inducing receptor degradation as a novel approach to target cc chemokine receptor 2 (CCR2), International Journal of Molecular Sciences 25(16): 8984.
- Wagner S., Moura Gatti F., Silva D.G. de, Ortiz Zacarias N.V., Zweemer A.J.M., Hermann S., Maria M. de, Koch M., Weiss C., Schepmann D., Heitman L.H., Tschammer N., Kopka K. & Junker A. (2021), Development of the first potential nonpeptidic positron emission tomography tracer for the imaging of CCR2 receptors, ChemMedChem 16(4): 640-645.
- Ortiz Zacarías N.V., Chahal K.K., Šimková T., Horst C. van der, Zheng Y., Inoue A., Theunissen E., Mallee L., Es D. van der, Louvel J., IJzerman A.P., Handel T.M., Kufareva I. & Heitman L.H. (2021), Design and characterization of an intracellular covalent ligand for CC chemokine receptor 2, Journal of Medicinal Chemistry 64(5): 2608-2621.
- Ortiz Zacarías N.V., Bemelmans M.P., Handel T.M., Visser K.E. de & Heitman L.H. (2021), Anticancer opportunities at every stage of chemokine function, Trends in Pharmacological Sciences 42(11): 912-928.
- Patberg M., Isaak A., Füsser F., Ortiz Zacarías N.V., Vinnenberg L., Schulte J., Michetti L., Grey L., Horst C. van der, Hundehege P., Koch O., Heitman L.H., Budde T. & Junker A. (2021), Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists, European Journal of Medicinal Chemistry 226: 113838.
- Sommer F., Ortiz Zacarías N.V., Heitman L.H. & Meijer A.H. (2020), Inhibition of macrophage migration in zebrafish larvae demonstrates in vivo efficacy of human CCR2 inhibitors, Developmental and Comparative Immunology 116: 103932.
- Ortiz Zacarías N.V. (4 december 2019), The road to Insurmountability: Novel avenues to better target CC Chemokine Receptors (Dissertatie. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University). Promotor(en): IJzerman A. & Heitman L.
- Ortiz Zacarías N.V., Veldhoven J.P.D. van, Hollander L.S. den, Dogan B., Openy J., Hsiao Y.Y., Lenselink E.B., Heitman L.H. & IJzerman A.P. (2019), Synthesis and Pharmacological Evaluation of Triazolopyrimidinone Derivatives as Noncompetitive, Intracellular Antagonists for CC Chemokine Receptors 2 and 5, Journal of Medicinal Chemistry 62(24): 11035-11053.
- Ortiz Zacarías N.V., Lenselink E.B., IJzerman A.P., Handel T.M. & Heitman L.H. (2018), Intracellular Receptor Modulation: Novel Approach to Target GPCRs, Trends in Pharmacological Sciences 39(6): 547-559.
- Zacarias N.V.O., Veldhoven J.P.D. van, Portner L., Spronsen E. van, Ullo S, Veenhuizen M., Velden W.J.C. van der, Zweemer A.J.M., Kreekel R.M., Oenema K., Lenselink E.B., Heitman L.H.I & IJzerman A.P. (2018), Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2, Journal of Medicinal Chemistry 61(20): 9146-9161.
- Bot I., Ortiz Zacarias N.V., Witte W.E. de, Vries H. de, Santbrink P.J. van, Velden D. van der, Kroener M.J., Berg D.J. van den, Stamos D., Lange E.C.M. de, Kuiper J., IJzerman A.P. & Heitman L.H. (2017), A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy, Scientific Reports 2017(7): 52.
- Thum S., Kokornaczyk A.K., Seki T., De Maria M., Ortiz Zacarias N.V., Vries H. de, Weiss C., Koch M.l., Schepmann D., Kitamura M., Tschammer N., Heitman L.H., Junker A. & Wuensch B. (2017), Synthesis and biological evaluation of chemokine receptor ligands with 2-benzazepine scaffold, European Journal of Medicinal Chemistry 135: 401-413.
- Zheng Y., Qin L., Ortiz Zacarias N.V., Vries H. de, Han G.W., Gustavsson M., Dabros M., Zhao C., Cherney R.J., Carter P., Stamos D., Abagyan R., Cherezov V., Stevens R.C., IJzerman A.P., Heitman L.H., Tebben A., Kufareva I. & Handel T.M. (2016), Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists, Nature 540(7633): 458-461.
- Massink A., Gutiérrez-de-Terán H., Lenselink E.B., Ortiz Zacarías N.V., Xia L., Heitman L.H., Katritch V., Stevens R.C. & IJzerman A.P. (2015), Sodium Ion Binding Pocket Mutations and Adenosine A2A Receptor Function, Molecular Pharmacology 87(2): 305-13.