Anne-Laura van Harmelen
Hoogleraar Brein, Veiligheid en Veerkracht
- Naam
- Prof.dr. A. van Harmelen
- Telefoon
- +31 71 527 2727
- a.van.harmelen@fsw.leidenuniv.nl
- ORCID iD
- 0000-0003-1108-2921
Onderzoek
Een op de drie kinderen en adolescenten krijgen te maken met een traumatische ervaring in hun jeugd, zoals kindermishandeling of pesten. Jeugdtrauma is een van de sterkste voorspellers van een groot aantal gedragsmatige en mentale problemen in de adolescentie. Om deze problemen tegen te gaan richt het onderzoek van Anne-Laura van Harmelen zich op het beter begrijpen van de complexe sociale, psychologische en neurobiologische mechanismen van risico en veerkracht in de adolescentie. Zo heeft van Harmelen laten zien dat jeugdtrauma gerelateerd is in veranderingen in de structuur en functioneren van het brein, waardoor mensen kwetsbaar zijn voor mentale problemen en dat dezelfde neurobiologische mechanismen mensen kwetsbaar maken voor suicide. Ook heeft ze laten zien dat er belangrijke factoren zijn die veerkracht versterken bij jongeren met jeugdtrauma ervaringen, zoals vriendschappen en steun van de familie, het ophalen van positieve herinneringen en sterkere regulatie van stress responses in het brein. Ook heeft haar onderzoek laten zien dat deze factoren elkaar sterk beïnvloeden. Deze bevindingen hebben ertoe geleidt dat van Harmelen heeft voorgesteld dat veerkracht het best beschreven kan worden als een complex en dynamisch systeem.
Kort CV
- Sept 2020-heden: Hoogleraar Brein Veiligheid en Veerkracht, Instituut Pedagogische Wetenscappen, Universiteit Leiden.
Honorary Senior Affiliate, MRC CBU & Department of Psychiatry, University of Cambridge. - 2016-2020: Royal Society Dorothy Hodgkin Fellow/Senior Research Associate, Psychiatry, University of Cambridge
- 2015-2020: Fellow, Lucy Cavendish College Cambridge
- 2015-2017: Tutor and Director of Studies PBS, Lucy Cavendish College Cambridge
- 2014-2016: Rubicon Fellow, Department of Psychiatry, University of Cambridge
- 2008-2013: Promotie Psychologie (Klinische psychologie), Universiteit Leiden. Promotie datum: 10 December 2013
- 2006-2008: Master of Science (Cum Laude), Psychologie; VU Amsterdam
- 2003-2006: Bachelor of Science, Psychologie, Universiteit van Groningen
- 1999-2003: Bachelor of Physical Education, Windesheim College, Zwolle.
Subsidies
- 2019 Returning Carer’s scheme, University of Cambridge (£10K) (2019-2020)
- 2018 Royal Society Research Grant (£103K). The resilient adolescent brain (2018-2020)
- 2018 Royal Society Enhancement Award (£98K). The resilient adolescent brain (2018-2020)
- 2017 MQ Brighter Futures Award (£548K). Help overcome and prevent the emergence of suicide (2018-2020)
- 2016 Royal Society Dorothy Hodgkin Fellowship (£417K). The neurobiology of resilience after child maltreatment (2016-2020)
- 2015 Additionale Rubicon Fellowship (£12K) (2015-2016)
- 2014 Returning Carer’s Scheme, University of Cambridge (£7K) (2014-2016)
- 2013 Rubicon Fellowship, Netherlands Organization for Scientific Research (€140K). Verminderen vriendschappen de negatieve consequenties van emotionele mishandeling?
Prijzen en onderscheidingen
- 2020 Rising Star Award. Association for Psychological Science
- 2019 Society of Biological Psychiatry travel fellowship award ($2000)
- 2019 Master of Arts, University of Cambridge
- 2018 Emerging Leader in Adolescent Mental Health prize, Medical Research Foundation MRC (£5000)
- 2018 Nominatie voor the University of Cambridge Vice Chancellors award for Public engagement with research.
Hoogleraar Brein, Veiligheid en Veerkracht
- Faculteit der Sociale Wetenschappen
- Instituut Pedagogische Wetenschappen
- Forensische gezinsped. en Jeugdhulpverl.
- Steenbergen H. van, Bruijn E.R.A de, Duijvenvoorde A.C.K. van & Harmelen A. van (2021), How positive affect buffers stress responses, Current Opinion in Behavioral Sciences 39: 153-160.
- Smith A.J., Moreno-López L., Davidson E., Dauvermann M., Orellana S., Soneson E., Ioannidis K., Kaser M. & Harmelen A. van (2021), REACT study protocol: resilience after the COVID-19 threat (REACT) in adolescents, BMJ Open 11(1).
- Moreno-López L., Sallie S.N., Ioannidis K., Kaser M., Schueler K., Askelund A.D, Turner L., van Harmelen A.L. & RAISE Consortium (2021), RAISE study protocol: a cross-sectional, multilevel, neurobiological study of resilience after individual stress exposure, BMJ Open 11(1).
- van Harmelen A.L., Schmaal L. & Blumberg H.P. (2020), Imaging suicidal thoughts and behavior: the promise of computational models, NEUROPSYCHOPHARMACOL 46: pages219–220.
- Cassels M., Neufeld S., Harmelen A. van, Goodyer I. & Wilkinson P. (2020), Prospective pathways from impulsivity to non-suicidal self-injury among youth, ARCH SUICIDE RES .
- Fritz J., Stochl J., Goodyer I.M., Harmelen A.L. van & Wilkinson P.O. (2020), Embracing the positive: an examination of how well resilience factors at age 14 can predict distress at age 17, Translational Psychiatry 10: 272.
- Ioannidis K., Askelund A.D., Kievit R.A. & Harmelen A. van (2020), Correction to: The complex neurobiology of resilient functioning after childhood maltreatment, BMC Medicine 18: 202.
- Ioannidis K., Askelund A.D., Kievit R.A. & Harmelen A.L. van (2020), The complex neurobiology of resilient functioning after childhood maltreatment (vol 18, 32, 2020), BMC Medicine 18(1): .
- Gonzalez-Garcia N., Moreno-Lopez L., Vasa F. & Van Harmelen A.L. (2020), Adolescent Resilient Functioning After Childhood Adversity is Associated With More Efficient Social Information Processing Structural Brain Network Topology, BIOL PSYCHIAT 87(9): S106-S106.
- Chatzi V., White S., Sun L.N., Suckling J. & Van Harmelen A.L. (2020), An Integrative Social Neurocognitive Model for Suicidal Ideation in Adolescents, BIOL PSYCHIAT 87(9): S23-S24.
- Fritz J., Stretton J., Askelund A.D., Schweizer S., Walsh N.D., Elzinga B.M., Goodyer I.M., Wilkinson P.O. & van Harmelen A.L. (2020), Mood and neural responses to social rejection do not seem to be altered in resilient adolescents with a history of adversity, Development and Psychopathology 32(2): 411-423.
- Moreno-Lopez L., Ioannidis K., Askelund A.D., Smith A.J., Schueler K. & Van Harmelen A.L. (2020), The Resilient Emotional Brain: A Scoping Review of the Medial Prefrontal Cortex and Limbic Structure and Function in Resilient Adults With a History of Childhood Maltreatment, BIOL PSYCHIAT-COGN N 5(4): 392-402.
- Ioannidis K., Askelund A.D., Kievit R.A. & Van Harmelen A.L. (2020), The complex neurobiology of resilient functioning after childhood maltreatment, BMC Medicine 18: e32.
- Schmaal L., Harmelen A.L. van, Chatzi V., Lippard E.T.C., Toenders Y.J., Averill L.A., Mazure C.M. & Blumberg H.P. (2020), Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies, Molecular Psychiatry 25: 408-427.
- Davies S.E., Neufeld S.A.S., Sprang E. van, Schweren L., Keivit R., Fonagy P., Dubicka B., Kelvin R., Midgley N., Reynolds S., Target M., Wilkinson P., Harmelen A.L. van & Goodyer I.M. (2020), Trajectories of depression symptom change during and following treatment in adolescents with unipolar major depression, J CHILD PSYCHOL PSYC 61(5): 565-574.
- Askelund A.D., Schweizer S., Goodyer I.M. & Harmelen A. van (2019), Author correction: Positive memory specificity is associated with reduced vulnerability to depression, Nature Human Behaviour 3(7): 758.
- Kalisch R., Cramer A.O.J., Binder H., Fritz J., Leertouwer I., Lunansk G., Meyer B., Timiner J., Veer I.M. & Van Harmelen A.L. (2019), Deconstructing and Reconstructing Resilience: A Dynamic Network Approach, Perspectives on Psychological Science 14(5): 765-777.
- Van Harmelen AL Schmaal L Blumberg HP (2019), Journal of Affective Disorders Special Issue on Suicide-Related Research: Hopeful progress but much research urgently needed Redactielid Journal of Affective Disorders 251: 39-41.
- Van Harmelen A.L., Schmaal L. & Blumberg H.P. (2019), Journal of Affective Disorders Special Issue on Suicide-Related Research: hopeful progress but much research urgently needed, Journal of Affective Disorders 251: 39-41.
- Askelund A.D., Schweizer S., Goodyer I.M. & Harmelen A. van (2019), Positive memory specificity is associated with reduced vulnerability to depression, Nature Human Behaviour 3: 265-273.
- Fritz J., Fried E.I., Goodyer I.M., Wilkinson P.O. & Harmelen A.L. van (2018), A network model of resilience factors for adolescents with and without exposure to childhood adversity, Scientific Reports 8: 15774.
- Kievit R.A., Brandmaier A.M., Ziegler G., Harmelen A.L. van, Mooij S.M.M. de, Moutoussis M., Goodyer I.M., Bullmore E., Jones P.B., Fonagy P., Lindenberger U. & Dolan R.J. (2018), Developmental cognitive neuroscience using latent change score models: A tutorial and applications, Developmental Cognitive Neuroscience 33: 99-117.
- Kievit R.A., Brandmaier A.M., Ziegler G., Harmelen A.L. van, Mooij S.M.M. de, Moutoussis M., Goodyer I.M., Bullmore E., Jones P.B., Fonagy P., Lindenberger U. & Dolan R.J. (2018), Developmental cognitive neuroscience using latent change score models: a tutorial and applications, Developmental Cognitive Neuroscience 33: 99-117.
- Winpenny E.M., Harmelen A.L. van, White M., Sluijs E.M.F. van & Goodyer I.M. (2018), Diet quality and depressive symptoms in adolescence: no cross-sectional or prospective associations following adjustment for covariates, PUBLIC HEALTH NUTR 21(13): 2376-2384.
- Winpenny E.M., Harmelen A.L. van, White M., Sluijs E.M.F. van & Goodyer I.M. (2018), Diet quality and depressive symptoms in adolescence: no cross-sectional or prospective associations following adjustment for covariates, Public Health Nutrition 21(13): 2376-2384.
- Cassels M., Harmelen A.L. van, Neufeld S., Goodyer I., Jones P.B. & Wilkinson P. (2018), Poor family functioning mediates the link between childhood adversity and adolescent nonsuicidal self-injury, Journal of Child Psychology and Psychiatry 59(8): 881-887.
- Fritz J., Graaff A.M. de, Caisley H., Harmelen A.L. van & Wilkinson P.O. (2018), A systematic review of amenable resilience factors that moderate and/or mediate the relationship between childhood adversity and mental health in young people, Frontiers in Psychiatry 9: 230.
- Fritz J., Graaff A.M. de, Caisley H., Harmelen A.L. van & Wilkinson P.O. (2018), A Systematic Review of Amenable Resilience Factors That Moderate and/or Mediate the Relationship Between Childhood Adversity and Mental Health in Young People, Frontiers in Psychiatry 9: .
- Lewis G Ioannidis K van Harmelen AL Neufeld S Stochl J Lewis G Jones PB Goodyer I (2018), The association between pubertal status and depressive symptoms and diagnoses in adolescent females: A population-based cohort study, PLoS ONE 13(6): .
- Lewis G., Ioannidis K., Harmelen A.L. van, Neufeld S., Stochl J., Lewis G., Jones P.B. & Goodyer I. (2018), The association between pubertal status and depressive symptoms and diagnoses in adolescent females: a population-based cohort study, PLoS ONE 13(6).
- Lakens D., Adolfi F.G., Albers C.J., Anvari F., Apps M.A.J, Argamon S.E., Baguley T., Becker R.B., Benning S.D., Bradford D.E., Buchanan E.M., Caldwell A.R., Van Calster B., Carlsson R., Chen S.C., Chung B., Colling L.J., Collins G.S., Crook Z., Cross E.S., Daniels S., Danielsson H., DeBruine L., Dunleavy D.J., Earp B.D., Feist M.I., Ferrell J.D., Field J.G., Fox N.W., Friesen A., Gomes C., Gonzalez-Marquez M., Grange J.A., Grieve A.P., Guggenberger R., Grist J., van Harmelen A.L., Hasselman F., Hochard .KD., Hoffarth M.R., Holmes N.P., Ingre M., Isager P.M., Isotalus H.K., Johansson C., Juszczyk K., Kenny D.A., Khalil A.A. Konat B., Lao J.P. Larsen E.G., Lodder G.M.A., Lukavsky J., Madan C.R., Manheim D., Martin S.R., Martin A.E., Mayo D.G., McCarthy R.J., McConway K., McFarland C., Nio A.Q.X., Nilsonne G., de Oliveira C.L., de Xivry J.J.O., Parsons S., Pfuhl G., Quinn K.A., Sakon J.J., Saribay S.A., Schneider I.K., Selvaraju M., Sjoerds Z., Smith S.G., Smits T., Spies J.R., Sreekumar V., Steltenpohl C.N., Stenhouse N., Swiatkowski W., Vadillo M.A., Van Assen M.A.L.M., Williams M.N., Williams S.E., Williams D.R., Yarkoni T., Ziano I. & Zwaan R.A. (2018), Justify your alpha, Nature Human Behaviour 2: 168-171.
- Kalisch R., Baker D.G., Basten U., Boks M.P., Bonanno G.A., Brummelman E., Chmitorz A., Fernandez G., Fiebach C.J., Galatzer-Levy I., Geuze E., Groppa S., Helmreich I., Hendler T., Hermans E.J., Jovanovic T., Kubiak T., Lieb K., Lutz B., Muller M.B., Murray R.J., Nievergelt C.M., Reif A., Roelofs K., Rutten B.P.F., Sander D., Schick A., Tuscher O., Diest I. van, Harmelen A. van, Veer I.M., Vermetten E., Vinkers C.H., Wager T.D., Walter H., Wessa M., Wibral M. & Kleim B. (2017), The resilience framework as a strategy to combat stress-related disorders, Nature Human Behaviour 1: 784-790.
- Danese A. & Harmelen A.L. van (2017), The hidden wounds of childhood trauma, European journal of psychotraumatology 8(sup7).
- Harmelen A.L. van, Kievit R.A., Ioannidis K., Neufeld S., Jones P.B., Bullmore E., Dolan R., Fonagy P. & Goodyer I. (2017), Adolescent friendships predict later resilient functioning across psychosocial domains in a healthy community cohort, Psychological Medicine 47(13): 2312-2322.
- Dalgleish T., Walsh N.D., Mobbs D., Schweizer S., Harmelen A.L. van, Dunn B., Dunn V., Goodyer I. & Stretton J. (2017), Social pain and social gain in the adolescent brain: A common neural circuitry underlying both positive and negative social evaluation, Nature Scientific Reports 7: .
- Dalgleish T., Walsh N.D., Mobbs D., Schweizer S., Harmelen A.L. van, Dunn B., Dunn V., Goodyer I. & Stretton J. (2017), Social pain and social gain in the adolescent brain: a common neural circuitry underlying both positive and negative social evaluation, Nature Scientific Reports 7.
- Schie C.C. van, Harmelen A.L. van, Hauber K., Boon A., Crone E.A. & Elzinga B.M. (2017), The neural correlates of childhood maltreatment and the ability to understand mental states of others, European Journal of Psychotraumatology 8(1).
- Harmelen A.L. van, Gibson J.L., St Clair M.C., Owens M., Brodbeck J., Dunn V., Lewis G., Croudace T., Jones P.B., Kievit R.A. & Goodyer I.M. (2016), Friendships and family support reduce subsequent depressive symptoms in at-risk adolescents, PLoS ONE 11(5).
- Harpur L.J., Polek E. & Harmelen A. van (2015), The role of timing of maltreatment and child intelligence in pathways to low symptoms of depression and anxiety in adolescence, Child Abuse and Neglect 47: 24-37.
- Harmelen A.L. van, Tol M.J. van, Dalgleish T., Wee N.J.A. van der, Veltman D.J., Aleman A., Spinhoven P., Penninx B.W.J.H. & Elzinga B.M. (2014), Hypoactive medial prefrontal cortex functioning in adults reporting childhood emotional maltreatment, Social cognitive and affective neuroscience 9(12): 2026-2033.
- Harmelen A.L. van, Hauber K., Moor B.G., Spinhoven P., Boon A.E., Crone E.A. & Elzinga B.M. (2014), Childhood emotional maltreatment severity is associated with dorsal medial prefrontal cortex responsivity to social exclusion in young adults, PLoS ONE 9(1).
- Walsh N.D., Dalgleish T., Lombardo M.V., Dunn V.J., Harmelen A.L. van, Ban M. & Goodyer I.M. (2014), General and specific effects of early-life psychosocial adversities on adolescent grey matter volume, NeuroImage: Clinical 4: 308-318.
- Harmelen A.L. van, Tol M.J. van, Demenescu L.R., Wee N.J.A. van der, Veltman D.J., Aleman A., Buchem M.A. van, Spinhoven P., Penninx B.W.J.H. & Elzinga B.M. (2013), Enhanced amygdala reactivity to emotional faces in adults reporting childhood emotional maltreatment, Social cognitive and affective neuroscience 8(4): 362-369.
- Moors A., Houwer J. de, Hermans D., Wanmaker S., Schie K. van, Harmelen A.L. van, Schryver M. de, Winne J. de & Brysbaert M. (2013), Norms of valence, arousal, dominance, and age of acquisition for 4,300 Dutch words, Behavior Research Methods 45: 169-177.
- Van Harmelen A.L., Van Tol M.J., Van der WeeN.J.A., Veltman D.J., Aleman A., Spinhoven P., Van Buchem M.A., Zitman F.G., Penninx B.W.J.H. & Elzinga B.M. (2010), Reduced Medial Prefrontal Cortex Volume in Adults Reporting Childhood Emotional Maltreatment, BIOL PSYCHIAT 68(9): 832-838.
- Van Harmelen A.L., De Jong P.J., Glashouwer K.A., Spinhoven P., Penninx B.W.J.H. & Elzinga B.M. (2010), Child abuse and negative explicit and automatic self-associations: The cognitive scars of emotional maltreatment, BEHAV RES THER 48: 486-494.
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