Remus Dame investigates the coupling of genome organization and genome activity and the factors that fine-tune these processes in bacteria and archaea. He studies the proteins involved in vitro as well as in vivo using state-of-the-art biochemical and biophysical approaches.
Date of birth: 10 September 1974
2003 PhD, Leiden Institute of Chemistry, Leiden University, the Netherlands, 23 January 2003
Thesis title: “Architectural roles of H-NS and HU in DNA compaction and transcription regulation”
Advisors: Dr. N. Goosen and Prof. Dr. ir. P. van der Putte
1997 MSc in Chemistry, Department of Chemistry, University of Amsterdam, the Netherlands
Current and previous research positions
2015 – now Associate Professor, Leiden Institute of Chemistry, Leiden University, The Netherlands
2009 – 2015 Assistant Professor, Leiden Institute of Chemistry, Leiden University, The Netherlands
2007 Visiting scientist, Department of Physics, Cornell University, Ithaca, USA (Prof. M. Wang)
2006 Visiting scientist, Kavli Institute of Theoretical Physics, KITP, Santa Barbara, CA, USA
2004 Visiting scientist, European Laboratory for Non-linear Spectroscopy, LENS, Florence, Italy (Prof. F. Pavone)
2003 - 2009 Post-doctoral researcher (Veni), Department of Physics and Astronomy, VU University, Amsterdam, The Netherlands (Prof. G.J.L. Wuite)
Grants, awards, recognitions since 2010
2016 NWO-ALW Vici grant (k€ 1,500)
2014 HFSP grant (programme leader) with 4 partners (k$ 1,300)
2013 FOM programme grant with Prof. Wuite (VU) (k€ 330)
2010 FES-HTSM NanoNextNL grant (k€ 257)
Contribution to teaching and supervision
Current: undergraduate courses for BSc Life Science and Technology (Leiden/Delft): Physics, Cell Signalling and Biophysics, and Experimental Molecular Biophysics. One course for MSc Life Science and Technology at Leiden University: Cross-domain Chromatin Organisation. Guest lecturer: Dynamics of Biomolecules and Cells (VU University).
Previous: undergraduate course Molecular Genetics 2 for Biopharmaceutical Sciences (2014-2015) and Molecular Biophysics (2010-2014). Guest lecturer in Global Regulatory Networks in Bacteria (2010-2012) and Current Developments in Biophysics (VU University, 2009-2011).
Supervision of 9 PhD students and 4 postdoctoral fellows (one FEBS fellow) since 2009. Current employment of recent PhD students and postdocs: R.A. van der Valk, Leiden University; R.P.C. Driessen, Lumicks B.V.; M. Miqyass, TMC Chemical; R. Shahapure, Cambridge University
Other responsibilities since 2010
- Editorial board member for AIMS Microbiology (since 2015), Editor of ‘Bacterial chromatin’, Methods in Molecular Biology, Dame Ed., Springer (2018), Editor of the book ‘Bacterial chromatin, Dame & Dorman Eds., Springer (2010).
- Secretary of the Netherlands Society of Biochemistry and Molecular Biology (2013-2016), Secretary of the ‘Nora Baart Stichting’ (2013-2016), Secretary of the ‘Stichting Stimulering Biochemie Nederland’ (2013-2016).
- Member of the NWO-CW study group ‘Nucleic Acids’ (since 2010).
- Comité van Aanbeveling S.V. LIFE (Student union Life Science & Technology, Leiden University).
- Member of the organising committee of ‘The biology and physics of bacterial chromosome organization’ in the US (2018), Member of the organising committee of the Dutch Chromatin Meeting (2016), Member of the organising committee of ‘The biology and physics of bacterial chromosome organization’ meeting in Paris (2016), Member of the organising committee of the 2nd International Workshop on “The Biology and Physics of Bacterial Genome Organisation” in Birmingham, UK (2014), Member of the organising committee of the Joint Dutch Chromatin Meeting and NVBMB Fall Symposium (2013), Chair of the organising committee of the Lorentz workshop ‘The biology and physics of bacterial genome organization’ (2012), Member of the organising committee of the bimonthly KNAW Biophysics meeting (2010-2014).
- Organiser of the NVBMB Speaker of the Year lecture by Prof. Thomas Kirchhausen (2015), Organiser of the Mini-symposium ‘Bacterial chromatin organization and dynamics’ (2015), Organiser of the NVBMB Speaker of the Year lecture by Prof. Carlos Bustamante at the KNAW (2014).
- Grant reviewer for the Agence Nationale pour la Recherche, BBSRC, Deutsche Forschungsgemeinschaft, National Science Centre, National Science Foundation , National University of Singapore, Netherlands Organisation of Scientific Research, Royal Society of Chemistry, Science Foundation Ireland , UK India Education and Research Initiative, Wellcome Trust.
- Reviewer for Nature, Nature Chemical Biology, Nature Structural and Molecular Biology, Nature Microbiology, Nature Communications, Nature Reviews in Genetics, Nature Reviews in Microbiology, PNAS, EMBO Journal, EMBO Reports, Nucleic Acids Research, PLOS Genetics and various other biochemistry, biophysics and microbiology journals.
- Admission committee member of the MSc curriculum Molecular Science and Technology (Leiden/Delft).
- External member for PhD committees across The Netherlands, United Kingdom.
Publication record including five recent representative publications
Ca. 45 papers with ~2000 citations, H-index 19 (Web of Science)
- Driessen R.P.C., Lin S.N., Waterreus W.J., Meulen A.L.H van der, Valk R.A. van der, Moolenaar G.F., Laurens N., Wuite G.J.L., Pannu N.S., Goosen N., Dame R.T., Sso10a: a new member of archaeal chromatin proteins that exhibits diverse architectural properties. Scientific Reports. 2016, 6, 29422
- Peeters E., Driessen R.P.C., Werner F., Dame R.T., The interplay between nucleoid organization and transcription in archaeal genomes. Nature Reviews Microbiology. 2015, 13, 333-341.
- Driessen R.P.C., Sitters G., Laurens N., Moolenaar G.F., Wuite G.J.L., Goosen N., Dame R.T., Effect of temperature on the intrinsic flexibility of DNA and its interaction with architectural proteins. Biochemistry. 2014, 53, 6430-6438.
- Driessen R.P.C., Meng H., Suresh G., Shahapure R., Lanzani G., Priyakumar U.D., White M.F., Schiessel H., Noort J. van, Dame R.T., Crenarchaeal chromatin proteins Cren7 and Sul7 compact DNA by inducing rigid bends, Nucleic Acids Research. 2013 41, 196-205.
- Laurens N., Driessen R.P.C., Heller I., Vorselen D., Noom M.C., Hol F.J.H., White M.F., Dame R.T., Wuite G.J.L., Alba shapes the archaeal genome using a delicate balance of bridging and stiffening the DNA, Nature Communications. 2012, 3, 1328.
Presentations including five presentations at international conferences since 2010
34 invited presentations at universities, companies and institutes, and invited, keynote and plenary lectures at international conferences since 2010
- Biophysical Society thematic meeting: “Significance of Knotted Structures for Function of Proteins and Nucleic Acids”, September 2014, Warszaw, Poland
- Modeling biomolecular systems in cellular environments, October 2013, Kyoto, Japan
- Gordon Conference Chromosome Dynamics, May 2013, Italy
- Mechanobiology of Chromatin and Transcription, November 2012, Singapore
- Molecular biology of Archaea 3, July 2012, Marburg, Germany
- Consultancy t.a.v. assayontwikkeling