Universiteit Leiden

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Remus Dame

Associate professor

Dr. R.T. Dame
+31 71 527 5605

Remus Dame investigates the coupling of genome organization and genome activity and the factors that fine-tune these processes in bacteria and archaea. He studies the proteins involved in vitro as well as in vivo using state-of-the-art biochemical and biophysical approaches.

More information about Remus Dame

Curriculum Vitae

Personal information

Nationality:   Dutch
Date of birth:   10 September 1974


2003     PhD, Leiden Institute of Chemistry, Leiden University, the Netherlands, 23 January 2003
Thesis title: “Architectural roles of H-NS and HU in DNA compaction and transcription regulation”
Advisors: Dr. N. Goosen and Prof. Dr. ir. P. van der Putte
1997     MSc in Chemistry, Department of Chemistry, University of Amsterdam, the Netherlands

Current and previous research positions

2015 – now   Associate Professor, Leiden Institute of Chemistry, Leiden University, The Netherlands
2009 – 2015   Assistant Professor, Leiden Institute of Chemistry, Leiden University, The Netherlands
2007   Visiting scientist, Department of Physics, Cornell University, Ithaca, USA (Prof. M. Wang)
2006   Visiting scientist, Kavli Institute of Theoretical Physics, KITP, Santa Barbara, CA, USA
2004   Visiting scientist, European Laboratory for Non-linear Spectroscopy, LENS, Florence, Italy (Prof. F. Pavone)
2003 - 2009   Post-doctoral researcher (Veni), Department of Physics and Astronomy, VU University, Amsterdam, The Netherlands (Prof. G.J.L. Wuite)

Grants, awards, recognitions since 2010

2016   NWO-ALW Vici grant (k€ 1,500)
2014   HFSP grant (programme leader) with 4 partners (k$ 1,300)
2013   FOM programme grant with Prof. Wuite (VU) (k€ 330)
2010   FES-HTSM NanoNextNL grant (k€ 257)

Contribution to teaching and supervision

Current: undergraduate courses for BSc Life Science and Technology (Leiden/Delft): Physics, Cell Signalling and Biophysics, and Experimental Molecular Biophysics. One course for MSc Life Science and Technology at Leiden University: Cross-domain Chromatin Organisation. Guest lecturer: Dynamics of Biomolecules and Cells (VU University).

Previous: undergraduate course Molecular Genetics 2 for Biopharmaceutical Sciences (2014-2015) and Molecular Biophysics (2010-2014). Guest lecturer in Global Regulatory Networks in Bacteria (2010-2012) and Current Developments in Biophysics (VU University, 2009-2011).

Supervision of 9 PhD students and 4 postdoctoral fellows (one FEBS fellow) since 2009. Current employment of recent PhD students and postdocs: R.A. van der Valk, Leiden University; R.P.C. Driessen, Lumicks B.V.; M. Miqyass, TMC Chemical; R. Shahapure, Cambridge University

Other responsibilities since 2010

  • ŸEditorial board member for AIMS Microbiology (since 2015), Editor of ‘Bacterial chromatin’, Methods in Molecular Biology, Dame Ed., Springer (2018), Editor of the book ‘Bacterial chromatin, Dame & Dorman Eds., Springer (2010).
  • Secretary of the Netherlands Society of Biochemistry and Molecular Biology (2013-2016), Secretary of the ‘Nora Baart Stichting’ (2013-2016), Secretary of the ‘Stichting Stimulering Biochemie Nederland’ (2013-2016).
  • Member of the NWO-CW study group ‘Nucleic Acids’ (since 2010).
  • Comité van Aanbeveling S.V. LIFE (Student union Life Science & Technology, Leiden University).
  • Member of the organising committee of ‘The biology and physics of bacterial chromosome organization’ in the US (2018), Member of the organising committee of  the Dutch Chromatin Meeting (2016), Member of the organising committee of ‘The biology and physics of bacterial chromosome organization’ meeting in Paris (2016), Member of the organising committee of the 2nd International Workshop on “The Biology and Physics of Bacterial Genome Organisation” in Birmingham, UK (2014), Member of the organising committee of the Joint Dutch Chromatin Meeting and NVBMB Fall Symposium (2013), Chair of the organising committee of the Lorentz workshop ‘The biology and physics of bacterial genome organization’ (2012), Member of the organising committee of the bimonthly KNAW Biophysics meeting (2010-2014).
  • Organiser of the NVBMB Speaker of the Year lecture by Prof. Thomas Kirchhausen (2015), Organiser of the Mini-symposium ‘Bacterial chromatin organization and dynamics’ (2015), Organiser of the NVBMB Speaker of the Year lecture by Prof. Carlos Bustamante at the KNAW (2014).
  • Grant reviewer for the Agence Nationale pour la Recherche, BBSRC, Deutsche Forschungsgemeinschaft, National Science Centre, National Science Foundation , National University of Singapore, Netherlands Organisation of Scientific Research, Royal Society of Chemistry, Science Foundation Ireland , UK India Education and Research Initiative, Wellcome Trust.
  • Reviewer for Nature, Nature Chemical Biology, Nature Structural and Molecular Biology, Nature Microbiology, Nature Communications, Nature Reviews in Genetics, Nature Reviews in Microbiology, PNAS, EMBO Journal, EMBO Reports, Nucleic Acids Research, PLOS Genetics and various other biochemistry, biophysics and microbiology journals.
  • Admission committee member of the MSc curriculum Molecular Science and Technology (Leiden/Delft).
  • External member for PhD committees across The Netherlands, United Kingdom.

Publication record including five recent representative publications

Ca. 45 papers with ~2000 citations, H-index 19 (Web of Science)

Full publication record: ResearcherID, or Leiden University

  • ŸDriessen R.P.C., Lin S.N., Waterreus W.J., Meulen A.L.H van der, Valk R.A. van der, Moolenaar G.F., Laurens N., Wuite G.J.L., Pannu N.S., Goosen N., Dame R.T., Sso10a: a new member of archaeal chromatin proteins that exhibits diverse architectural properties. Scientific Reports. 2016, 6, 29422
  • ŸPeeters E., Driessen R.P.C., Werner F., Dame R.T., The interplay between nucleoid organization and transcription in archaeal genomes. Nature Reviews Microbiology. 2015, 13, 333-341.
  • ŸDriessen R.P.C., Sitters G., Laurens N., Moolenaar G.F., Wuite G.J.L., Goosen N., Dame R.T., Effect of temperature on the intrinsic flexibility of DNA and its interaction with architectural proteins. Biochemistry. 2014, 53, 6430-6438.
  • ŸDriessen R.P.C., Meng H., Suresh G., Shahapure R., Lanzani G., Priyakumar U.D., White M.F., Schiessel H., Noort J. van, Dame R.T., Crenarchaeal chromatin proteins Cren7 and Sul7 compact DNA by inducing rigid bends, Nucleic Acids Research. 2013 41, 196-205.
  • ŸLaurens N., Driessen R.P.C., Heller I., Vorselen D., Noom M.C., Hol F.J.H., White M.F., Dame R.T., Wuite G.J.L., Alba shapes the archaeal genome using a delicate balance of bridging and stiffening the DNA, Nature Communications. 2012, 3, 1328.

Presentations including five presentations at international conferences since 2010

34 invited presentations at universities, companies and institutes, and invited, keynote and plenary lectures at international conferences since 2010

  • ŸBiophysical Society thematic meeting: “Significance of Knotted Structures for Function of Proteins and Nucleic Acids”, September 2014, Warszaw, Poland
  • Modeling biomolecular systems in cellular environments, October 2013, Kyoto, Japan
  • Gordon Conference Chromosome Dynamics, May 2013, Italy
  • Mechanobiology of Chromatin and Transcription, November 2012, Singapore
  • ŸMolecular biology of Archaea 3, July 2012, Marburg, Germany

Associate professor

  • Wiskunde en Natuurwetenschappen
  • Leiden Institute of Chemistry
  • LIC/Protein Chemistry

Work address

Science Campus
Einsteinweg 55
2333 CC Leiden
Room number EE217



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