Macromolecular Biochemistry
Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Lars Jeuken, Anne Wentink, Anjali Pandit, René Olsthoorn,Alia Matysik, Sebastian Geibel and Steffen Brünle.
The research is aimed at understanding peptide, protein & nucleic acid structure, function and interactions. Particular interests comprise protein-protein interactions & enzyme function (Prof. Ubbink), biophysical aspects of protein - DNA interactions (Prof. Dame), protein - nanoparticle interactions for applicationd in light-driven redox catalysis (Prof. Jeuken) and protein aggregation in neurodegenerative diseases (Dr. Wentink).
The section houses equipment for recombinant protein production and a variety biophysical characterisation methods.
News
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Grants for fundamental research in Leiden -
Leiden chemists discover new ways in which single-celled organisms organise their DNA -
Not wrapping but folding: Bacteria also organise their DNA (but they do it a bit differently) -
How cells determine the fate of proteins (and can we do it too?) -
Caught in living cells: how bacteria regulate their genes to defend themselves
Recent dissertations
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Microstructural and Metabolic Alterations in the Zebrafish Brain Induced by Toll-Like Receptor 2 Deficiency -
Thermostable Nanodiscs for the development of novel biopharmaceuticals -
Design and synthesis of metal-based chemotherapeutic agents for targeted DNA interactions or DNA repair pathway modulation
