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Mapping of bacterial genomes to combat infectious diseases

Mapping of bacterial genomes to combat infectious diseases

Dynamic folded chromosomes

We know that the chromosome of the bacterium Escherichia coli folded dynamic loops that are stabilized by "bridging" proteins. Researchers assume that the bacteria grow these loops in response to environmental stress, such as food shortages. Remodeling caused significant changes in the pool of DNA folding of proteins in a cell, and sometimes leads to changes in the shape and composition of the cell.
Analyze chromosome structure

The researchers want to test by examining the structure and reorganization of DNA during periods of abundant food and periods of food scarcity it. The team consists of researchers with expertise in chemical and physical biology, biochemistry, genetics, fluorescence and electron microscopy, and mathematical / physical modeling. It will analyze the bacterial chromosome structure in detail by an examination of the inner nucleus of cells at the nanoscale, and by modeling the way in which the DNA is folded up.

The knowledge thus obtained may eventually be used in the fight against bacterial infections.

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