Universiteit Leiden Universiteit Leiden

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The use of activity based protein profiling to study proteasome biology

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

Auteur Guillem Paniagua Soriano
Links Thesis in Leiden Repository

The work described in this thesis focuses on the characterization of proteasome directed activity-based probes (ABPs) as well as on the adaptation mechanisms that make multiple myeloma derived cell lines resistant against proteasome inhibitors (PIs).