Universiteit Leiden

nl en

Proefschrift

Squaramide-based supramolecular polymers : from self-assembly to in vivo application

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

Auteur
Saez, Talens V.
Datum
10 december 2018
Links
Thesis in Leiden Repository

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water. For this purpose, I rely on the use of squaramides to provide directional interactions in order to drive the formation of one-dimensional aggregates through self-assembly. The interplay of hydrogen-bonding and aromaticity in the monomer self-assembly process is explored in the squaramide unit, by examining the consequence of aromatic gain on this process. Additionally, by systematic modification of the monomer structure, a library of supramolecular structures with different morphologies is developed and their use as future drug nanovehicles is studied in an in vivo model involving zebrafish embryos.

Deze website maakt gebruik van cookies. Meer informatie