Squaramide-based supramolecular polymers: from self-assembly to in vivo application
The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.
- Saez, Talens V.
- 10 December 2018
- Thesis in Leiden Repository
The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water. For this purpose, I rely on the use of squaramides to provide directional interactions in order to drive the formation of one-dimensional aggregates through self-assembly. The interplay of hydrogen-bonding and aromaticity in the monomer self-assembly process is explored in the squaramide unit, by examining the consequence of aromatic gain on this process. Additionally, by systematic modification of the monomer structure, a library of supramolecular structures with different morphologies is developed and their use as future drug nanovehicles is studied in an in vivo model involving zebrafish embryos.