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Essentiality of conserved amino acid residues in β-lactamase

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

Chikunova, A.
31 mei 2022
Thesis in Leiden Repository

Thus, the number of essential residues is limited by evolutionary pressure. The roles of all non-catalytic essential residues in class A β-lactamases are described with a large-scale experiments, as well as specific functions of a few residues. The results show that residues close to the active site and farther away have different reasons for being essentia

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