Thomas Hansen
Gastonderzoeker
- Naam
- Dr. T. Hansen
- Telefoon
- +31 71 527 2727
- t.hansen@lic.leidenuniv.nl
- ORCID iD
- 0000-0002-6291-1569
Gastonderzoeker
- Wiskunde en Natuurwetenschappen
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Bio-organic Synthesis
- Remmerswaal W.A., Elferink H., Houthuijs K.J., Hansen T., Braak F. ter, Berden G., Vorm S. van der, Martens J., Oomens J., Marel G.A. van der, Boltje T.J. & Codee J.D.C. (2024), Anomeric triflates versus dioxanium ions: different product-forming intermediates from 3-Acyl benzylidene mannosyl and glucosyl donors, Journal of Organic Chemistry (JOC) 89(3): 1618-1625.
- Hengst J.M.A. van, Hellemons R.J.C., Remmerswaal W.A., Vrande K.N.A. van de, Hansen T., Vorm S. van der, Overkleeft H.S., Marel G.A. van der & Codee J.D.C. (2023), Mapping the effect of configuration and protecting group pattern on glycosyl acceptor reactivity, Chemical Science 14(6): 1532-1542.
- Remmerswaal W.A., Hansen T., Hamlin T. & Codée J.D.C. (2023), Origin of stereoselectivity in SE2' reactions of six-membered ring oxocarbenium ions, Chemistry: a European Journal 29(14): e202203490.
- Elferink H., Remmerswaal W.A., Houthuijs K.J., Jansen O., Hansen T., Rijs A.M., Berden G., Martens J., Oomens J., Codée J.D.C. & Boltje T.J. (2022), Competing C‐4 and C‐5‐acyl stabilization of uronic acid glycosyl cations, Chemistry: a European Journal 28(63): e202201724.
- Hansen T., Sun X., Dalla Tiezza M., Zeist W.J., Poater J., Hamlin T.A. & Bickelhaupt F.M. (2022), C(spn)−X (n=1–3) bond activation by palladium, Chemistry: a European Journal 28(26): e202103953.
- Demkiw K.M., Remmerswaal W.A., Hansen T., Marel G.A. van der, Codee J.D.C. & Woerpel K.A. (2022), Halogen atom participation in guiding the stereochemical outcomes of acetal substitution reactions, Angewandte Chemie 134(42): e202209401.
- Hansen T., Nin-Hill A., Codée J.D.C., Hamlin T.A. & Rovira C. (2022), Rational tuning of the reactivity of three-membered heterocycle ring-openings via SN2 reactions, Chemistry: a European Journal 28(60): e202201649.
- Remmerswaal W.A., Houthuijs K.J., Ven R. van de, Elferink H., Hansen T., Berden G., Overkleeft H.S., Marel G.A. van der, Rutjes F., Filippov D.V., Boltje T.J., Martens J., Oomens J. & Codee J.D.C. (2022), Stabilization of glucosyl dioxolenium Ions by "dual participation" of the 2,2-dimethyl-2-(ortho-nitrophenyl)acetyl (DMNPA) protection group for 1,2-cis-glucosylation, Journal of Organic Chemistry (JOC) 87(14): 9139-9147.
- Hansen T., Roozee J.C., Bickelhaupt F.M. & Hamlin T.A. (2021), How solvation influences the S(N)2 versus E2 competition, Journal of Organic Chemistry (JOC) 87(3): 1805-1813.
- Hansen T., Vermeeren P., Bickelhaupt F.M. & Hamlin T.A. (2021), Origin of the alpha-effect in S(N)2 reactions, Angewandte Chemie (International Edition) 60(38): 20840-20848.
- Wander D.P.A., Zanden S.Y. van der, Vriends M.B.L. Veen B.C. van, Vlaming J.G.C., Bruyning T., Hansen T., Marel G.A. van der, Overkleeft H.S., Neefjes J.J.C. & Codée J.D.C. (2021), Synthetic (N,N-dimethyl)doxorubicin glycosyl diastereomers to dissect modes of action of anthracycline anticancer drugs, Journal of Organic Chemistry (JOC) 86(8): 5757-5770.
- Svatunek D., Hansen T., Houk K.N. & Hamlin T.A. (2021), How the Lewis Base F– Catalyzes the 1,3-Dipolar Cycloaddition between Carbon Dioxide and Nitrilimines, Journal of Organic Chemistry (JOC) 86(5): 4320–4325.
- Hansen T., Vermeeren P., Yoshisada R., Filippov D.V., Marel G.A. van der, Codee J.D.C. & Hamlin T.A. (2021), How Lewis acids catalyze ring-openings of cyclohexene oxide, Journal of Organic Chemistry (JOC) 86(4): 3565-3573.
- Hansen T. (25 november 2020), Glycosyl cations in glycosylation reactions (Dissertatie. Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University). Promotor(en) en copromotor(en): Codée J.D.C., Marel G.A. van der.
- Vermeeren P., Hansen T., Grasser M., Silva D.R., Hamlin T.A. & Bickelhaupt F.M. (2020), S(N)2 versus E2 competition of F- and PH2- revisited, Journal of Organic Chemistry (JOC) 85(21): 14087-14093.
- Vermeeren P., Hansen T., Jansen P., Swart M., Hamlin T.A. & Bickelhaupt F.M. (2020), A unified framework for understanding nucleophilicity and protophilicity in the SN2/E2 competition, Chemistry: a European Journal 26(67): 15538-15548.
- Hansen T., Ofman T.P., Vlaming J.G.C., Gagarinov I.A., Beek J. van, Goté T.A., Tichem J.M., Ruijgrok G., Overkleeft H.S., Filippov D.V., Marel G.A. van der & Codée J.D.C. (2020), Reactivity-stereoselectivity mapping for the assembly of Mycobacterium marinum lipooligosaccharides, Angewandte Chemie (International Edition) 60(2): 937-945.
- Hansen T., Vermeeren P., Haim A., Dorp M.J.H. van, Codee J.D.C., Bickelhaupt F.M. & Hamlin T.A. (2020), Regioselectivity of Epoxide Ring-Openings via S(N)2 Reactions Under Basic and Acidic Conditions, European Journal of Organic Chemistry 2020(25): 3822-3828.
- Geus M.A.R. de, Maurits E., Sarris A.J.C., Hansen T., Kloet M.S., Kamphorst K., Hoeve W. ten, Robillard M.S., Pannwitz A., Bonnet S.A., Codée J.D.C., Filippov D.V., Overkleeft H.S. & Kasteren S.I. van (2020), Fluorogenic Bifunctional Trans-cyclooctenes as Efficient Tools for Investigating Click-to-Release Kinetics, Chemistry: a European Journal 26(44): 9900-9904.
- Hansen T. Elferink H. Hengst J.M.A. van Houthuijs K.J. Remmerswaal W.A. Kromm A. Berden G. Vorm S. van der Rijs A.M. Overkleeft H.S. Filippov D.V. Rutjes F.P.J.T. Marel G.A. van der Martens J. Oomens J. Codée J.D.C. Boltje T.J. (2020), Characterization of glycosyl dioxolenium ions and their role in glycosylation reactions, Nature Communications 11(1): 2664.
- Sun J.S., Chen J., Hansen T., Zhang Q.J., Liu D.Y., Sun Y., Yan H., Codee J.D.C. & Schmidt R.R. (2019), 1‐Picolinyl‐5‐azido Thiosialosides: Versatile donors for the stereoselective construction of Sialyl Linkages, Angewandte Chemie (International Edition) 58(47): 17000-17008.
- Vorm S. van der, Hansen T., Hengst J.M.A. van, Overkleeft H.S., Marel G.A. van der & Codée J.D.C. (2019), Acceptor reactivity in glycosylation reactions, Chemical Society Reviews 48(17): 4688-4706.
- Liu H., Hansen T., Zhou S.Y., Wen G.E., Liu X.X., Zhang Q.J., Codée J.D.C., Schmidt R.R. & Sun J.S. (2019), Dual-Participation Protecting Group Solves the Anomeric Stereocontrol Problems in Glycosylation Reactions, Organic Letters 21(21): 8713-8717.
- Zhang Q., Gimeno A., Santana D., Wang Z., Valdés-Balbin Y., Rodríguez-Noda L.M., Hansen T., Kong L., Shen M., Overkleeft H.S., Vérez-Bencomo V., Marel G.A. van der, Jiménez-Barbero J., Chiodo F. & Codée J.D.C. (2019), Synthetic, Zwitterionic Sp1 Oligosaccharides Adopt a Helical Structure Crucial for Antibody Interaction, ACS Central Science 5(8): 1407-1416.
- Ham A. van der, Hansen T., Lodder G., Codée J.D.C., Hamlin T.A. & Filippov D.V. (2019), Computational and NMR Studies on the Complexation of Lithium Ion to 8‐Crown‐4, ChemPhysChem 20(16): 2103-2109.
- Hansen T., Lebedel L., Remmerswaal W.A., Vorm S. van der, Wander D.P.A., Somers M., Overkleeft H.S., Filippov D.V., Désiré J., Mingot A., Bleriot Y., Marel G.A. van der, Thibaudeau S. & Codée J.D.C. (2019), Defining the SN1 Side of Glycosylation Reactions: Stereoselectivity of Glycopyranosyl Cations, ACS Central Science 5(5): 781-788.
- Vorm S. van der, Hansen T., Rijssel E.R. van, Dekkers R., Madern J.M., Overkleeft H.S., Filippov D.V., Marel G.A. van der & Codée J.D.C. (2019), Furanosyl oxocarbenium ion Conformational Energy Landscape maps as a tool to study the glycosylation stereoselectivity of 2-azidofuranoses, 2-fluorofuranoses and methyl furanosyl uronates, Chemistry: a European Journal 25(29): 7149-7157.
- Madern J.M., Hansen T., Rijssel E.R. van, Kistemaker H.A.V., Vorm S. van der, Overkleeft H.S., Marel G.A. van der, Filippov D.V. & Codee J.D.C. (2019), Synthesis, Reactivity, and Stereoselectivity of 4-Thiofuranosides, Journal of Organic Chemistry (JOC) 84(3): 1218-1227.
- Rooden E.J. van, Kreekel R., Hansen T., Janssen A.P.A., Esbroeck A.C.M. van, Dulk H. den, Berg R.J.B.H.N. van den, Codee J.D.C. & Stelt M. van der (2018), Two-step activity-based protein profiling of diacylglycerol lipase, Organic and Biomolecular Chemistry 16: 5250-5253.
- Artola M., Kuo C.L., McMahon S.A., Oehler V., Hansen T., Lienden M.J.C. van der, He X., Elst H. van den, Florea B.I., Kermode A.R., Marel G.A. van der, Gloster T.M., Codée J.D.C., Overkleeft H.S. & Aerts J.M.F.G. (2018), New Irreversible alpha-l-Iduronidase Inhibitors and Activity-Based Probes, Chemistry: a European Journal 24(71): 19081-19088.
- Sarris A.J.C., Hansen T., Geus M.A.R. de, Maurits E., Doelman W., Overkleeft H.S., Codée J.D.C., Filippov D.V. & Kasteren S.I. van (2018), Fast and pH-Independent Elimination of trans-Cyclooctene by Using Aminoethyl-Functionalized Tetrazines, Chemistry: a European Journal 24(68): 18075-18081.
- Schröder S.P., Wu L., Artola Perez de Azanza M.E., Hansen T., Offen W.A., Guimaraes da Lomba Ferraz M.J., Li K.-Y., Aerts J.M.F.G., Marel G.A. van der, Codee J.D.C., Davies G.J. & Overkleeft H.S. (2018), Gluco-1H-imidazole: A New Class of Azole-Type beta-Glucosidase Inhibitor, Journal of the American Chemical Society 140(15): 5045-5048.
- Schröder S.P., Kallemeijn W.W., Debets M.F., Hansen T., Sobala L.F., Hakki Z., Williams S.J., Beenakker T.J.M., Aerts J.M.F.G., Marel G.A. van der, Codée J.D.C., Davies G.J. & Overkleeft H.S. (2018), Spiro-epoxyglycosides as activity-based probes for glycoside hydrolase family 99 endomannosidase/endomannanase, Chemistry: a European Journal 24(39): 9983-9992.
- Hagen B., Vorm S. van der, Hansen T., Marel G.A. van der & Codée J.D.C. (2017), Stereoselective glycosylations - Additions to oxocarbenium ions. In: Bennett C. (red.), Selective Glycosylations – Synthetic Methods and Catalysts: Wiley.
- Vorm S. van der, Hansen T., Overkleeft H.S., Marel G.A. van der & Codee J.D.C. (2017), The Influence of Acceptor Nucleophilicity on the Glycosylation Reaction Mechanism, Chemical Science 2017(8): 1867-1875.
- Beenakker T.J.M., Wander D.P.A., Offen W.A., Artola Perez de Azanza M.E., Raich L., Guimaraes da Lomba Ferraz M.J., Li K.Y., Houben J.H.P.M., Rijssel E.R. van, Hansen T., Marel G.A. van der, Codee J.D.C., Aerts J.M.F.G., Rovira C., Davies G.J. & Overkleeft H.S. (2017), Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors, Journal of the American Chemical Society 139(19): 6534-6537.
- Mukhopadhyay P., Baggelaar M., Erdelyi K., Cao Z., Cinar R., Fezza F., Ignatowska-Jankowska B., Wilkerson J., Gils N. van, Hansen T., Ruben M., Soethoudt M., Heitman L., Kunos G., Maccarrone M., Lichtman A., Pacher P. & Stelt M. van der (2016), The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity, British Journal of Pharmacology 173(3): 446–458.