Stephan Hacker
Universitair docent
- Naam
- Dr. S.M. Hacker
- Telefoon
- +31 71 527 4362
- s.m.hacker@lic.leidenuniv.nl
Meer informatie is beschikbaar op de Engelse profielpagina.
Nieuws
-
Zwaartekracht-subsidies voor vijf projecten met Leidse onderzoekers -
Antibiotica van de toekomst: op zoek naar een nieuwe manier om bacteriën te doden -
Vidi-financiering voor twaalf wetenschappers Universiteit Leiden -
Samenwerking van instituten tegen TBC in het Leidsch Dagblad -
Leidse onderzoekers slaan handen ineen tegen tuberculose
Universitair docent
- Wiskunde en Natuurwetenschappen
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Molecular Physiology
- Dienemann J.N., Chen S.Y., Hitzenberger M., Sievert M.L., Hacker S.M., Prigge S.T., Zacharias M., Groll M. & Sieber S.A. (2023), A chemical proteomic strategy reveals inhibitors of lipoate salvage in bacteria and parasites, Angewandte Chemie (International Edition) 62(31): e202304533.
- Munoz A.W., Meighen-Berger K.M., Hacker S.M., Feige M.J. & Sieber S.A. (2023), A chemical probe unravels the reactive proteome of health-associated catechols, Chemical Science 14(32): 8635-8643.
- Weerapana E. & Hacker S.M. (2023), Activity-based protein profiling - celebrating the groundbreaking contributions of Benjamin Cravatt, Israel Journal of Chemistry 63(3-4): e202300059.
- Weigert Muñoz A., Hoyer E., Schumacher K., Grognot M., Taute K.M., Hacker S.M., Sieber S.A. & Jung K. (2022), Eukaryotic catecholamine hormones influence the chemotactic control of Vibrio campbellii by binding to the coupling protein CheW, Proceedings of the National Academy of Sciences 119(10): e2118227119.
- Schmidt C., Zollo M., Bonsignore R., Casini A. & Hacker S.M. (2022), Competitive profiling of ligandable cysteines in Staphylococcus aureus with an organogold compound, Chemical Communications 58(36): 5526-5529.
- Hacker S.M. & Jessen-Trefzer C. (2022), Chemical biology in drug discovery, Biological Chemistry 403(4): 361-362.
- Svenningsen E.B., Ottosen R.N., Jorgensen K.H., Nisavic M., Larsen C.K., Hansen B.K., Wang Y., Lindorff-Larsen K., Torring T., Hacker S.M., Palmfeldt J. & Poulsen T.B. (2022), The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21, RSC Chemical Biology 3(10): 1216-1229.
- Hacker S.M. (2022), Reversible protein inhibitors kept on target, Nature 603(7902): 583-584.
- Demange P., Joly E., Marcoux J., Zanon P.R.A., Listunov D., Rullière P., Barthes C., Noirot C., Izquierdo J.B., Rozié A., Pradines K., Hee R., Brito M.V. de, Marcellin M., Serre R.F., Bouchez O., Burlet-Schiltz O., Oliveira M.C.F., Ballereau S., Bernardes-Génisson V., Maraval V., Calsou P., Hacker S.M., Génisson Y., Chauvin R. & Britton S. (2022), SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species, eLife 11: e73913.
- Hubner I., Shapiro J.A., Hossmann J., Drechsel J., Hacker S.M., Rather P.N., Pieper D.H., Wuest W.M. & Sieber S.A. (2021), Broad spectrum antibiotic xanthocillin X effectively kills acinetobacter baumannii via dysregulation of heme biosynthesis, ACS Central Science 7(3): 488-498.
- Allihn P.W.A., Hackl M.W., Ludwig C., Hacker S.M. & Sieber S.A. (2021), A tailored phosphoaspartate probe unravels CprR as a response regulator in Pseudomonas aeruginosa interkingdom signaling, Chemical Science 12: 4763-4770.
- Abbasov M.E. Kavanagh M.E., Ichu T.A., Lazear M.R., Tao Y.F., Crowley V.M., Ende C.W..A., Hacker S.M., Ho J., Dix M.M., Suciu R., Hayward M.M., Kiessling L.L. & Cravatt B.F. (2021), A proteome-wide atlas of lysine-reactive chemistry, Nature Chemistry 13(11): 1081-+.
- Sima S., Barkovits K., Marcus K., Schmauder L., Hacker S.M., Hellwig N., Morgner N. & Richter K. (2021), HSP-90/kinase complexes are stabilized by the large PPIase FKB-6, Scientific Reports 11: 12347.
- Lee K.M., Le P., Sieber S.A. & Hacker S.M. (2020), Degrasyn exhibits antibiotic activity against multi-resistant Staphylococcus aureus by modifying several essential cysteines, Chemical Communications 56: 2929-2932.
- Le P.L., Kunold E., Macsics R., Rox K., Jennings M.C., Ugur I., Reinecke M., Chaves-Moreno D., Hackl M.W., Fetzer C., Mandl F.A.M., Lehmann J., Korotkov V.S., Hacker S.M., Kuster B., Antes I., Pieper D.H., Rohde M., Wuest W.M., Medina E. & Sieber S.A. (2020), Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms, Nature Chemistry 12: 145-+.
- Bach K., Beerkens B.L.H., Zanon P.R.A. & Hacker S.M. (2020), Light-Activatable, 2,5-Disubstituted Tetrazoles for the Proteome-wide Profiling of Aspartates and Glutamates in Living Bacteria, ACS CENTRAL SCI 6(4): 546-554.
- Zanon P.R.A., Lewald L. & Hacker S.M. (2020), Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome, ANGEW CHEM INT EDIT 59(7): 2829-2836.
- Gleissner C.M.L., Pyka C.L., Heydenreuter W., Gronauer T.F., Atzberger C., Korotkov V.S., Cheng W.T., Hacker S.M., Vollmar A.M., Braig S. & Sieber S.A. (2019), Neocarzilin A Is a Potent Inhibitor of Cancer Cell Motility Targeting VAT-1 Controlled Pathways, ACS Central Science 5(7): 1170-1178.
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- Ermert S., Hacker S.M., Buntru A., Scheffner M., Hauck C.R. & Marx A. (2017), Different Enzymatic Processing of gamma-Phosphoramidate and gamma-Phosphoester-Modified ATP Analogues, ChemBioChem 18(4): 378-381.
- Lange S., Hacker S.M., Schmid P., Scheffner M. & Marx A. (2017), Small-Molecule Inhibitors of the Tumor Suppressor Fhit, ChemBioChem 18(17): 1707-1711.
- Ermert S., Marx A. & Hacker S.M. (2017), Phosphate-Modified Nucleotides for Monitoring Enzyme Activity, Topics in Current Chemistry 375: 28.
- Gotz K.H., Hacker S.M., Mayer D., Durig J.N., Stenger S. & Marx A. (2017), Inhibitors of the Diadenosine Tetraphosphate Phosphorylase Rv2613c of Mycobacterium tuberculosis, ACS Chemical Biology 12(10): 2682-2689.
- Hacker S.M., Backus K.M., Lazear M.R., Forli S., Correia B.E. & Cravatt B.F. (2017), Global profiling of lysine reactivity and ligandability in the human proteome, Nature Chemistry 9: 1181-1190.
- Hacker S.M., Buntz A., Zumbusch A. & Marx A. (2015), Direct Monitoring of Nucleotide Turnover in Human Cell Extracts and Cells by Fluorogenic ATP Analogs, ACS Chemical Biology 10(11): 2544-2552.
- Hacker S.M., Welter M. & Marx A. (2015), Synthesis of γ‐Phosphate‐Labeled and Doubly Labeled Adenosine Triphosphate Analogs, Current Protocols in Nucleic Acid Chemistry 60: .
- Hacker S.M., Mortensen F., Scheffner M. & Marx A. (2014), Selektive Beobachtung der enzymatischen Aktivität des Tumorsuppressors Fhit, Angewandte Chemie 126(38): 10413-10416.
- Hacker S.M., Mortensen F., Scheffner M. & Marx A. (2014), Selective Monitoring of the Enzymatic Activity of the Tumor Suppressor Fhit, Angewandte Chemie (International Edition) 53(38): 10247-10250.
- Acosta O.B.G., Hardt N., Hacker S.M., Strittmatter T., Schink B. & Marx A. (2014), Thiamine Pyrophosphate Stimulates Acetone Activation by Desulfococcus biacutus As Monitored by a Fluorogenic ATP Analogue, ACS Chemical Biology 9: 1263-1266.
- Hacker S.M., Hintze C., Marx A. & Drescher M. (2014), Monitoring enzymatic ATP hydrolysis by EPR spectroscopy, Chemical Communications 50: 7262-7264.
- Hacker S.M., Pagliarini D., Tischer T., Hardt N., Schneider D., Mex M., Mayer T.U., Scheffner M. & Marx A. (2013), Fluorogene ATP-Analoga zur Detektion von ATP-Verbrauch: Beobachtung der Aktivierung von Ubiquitin in Echtzeit, Angewandte Chemie 125(45): 12133-12137.
- Hacker S.M., Pagliarini D., Tischer T., Hardt N., Schneider D., Mex M., Mayer T.U., Scheffner M. & Marx A. (2013), Fluorogenic ATP Analogues for Online Monitoring of ATP Consumption: Observing Ubiquitin Activation in Real Time, Angewandte Chemie (International Edition) 52(45): 11916-11919.
- Hardt N., Hacker S.M. & Marx A. (2013), Synthesis and fluorescence characteristics of ATP-based FRET probes, Organic and Biomolecular Chemistry 11(48): 8298-8305.
- Hacker S.M., Hardt N., Buntru A., Pagliarini D., Mockel M., Mayer T.U., Scheffner M., Hauck C.R. & Marx A. (2013), Fingerprinting differential active site constraints of ATPases, Chemical Science 4: 1588-1596.
- Hacker S.M., Mex M. & Marx A. (2012), Synthesis and Stability of Phosphate Modified ATP Analogues, Journal of Organic Chemistry (JOC) 77(22): 10450-10454.
- Consultant Drug Discovery Activities