Marta Artola Perez de Azanza

Universitair docent

Naam: Dr. M.E. Artola Perez de Azanza
Telefoon: +31 71 527 6458
E-mail: m.e.artola@lic.leidenuniv.nl
ORCID iD: 0000-0002-3051-3902

Promovendi

Universitair docent

Wiskunde en Natuurwetenschappen
Leiden Institute of Chemistry
LIC/Chemical Biology

Werkadres

Gorlaeus Gebouw
Einsteinweg 55
2333 CC Leiden
Kamernummer DE1.07

Contact

Gracht D. van der, Rowland R.J., Roig-Zamboni V., Guimaraes Da Lomba Ferraz M.J., Louwerse G.A.M., Geurink P.P., Aerts J.M.F.G., Sulzenbacher G., Davies G.J., Overkleeft H.S. & Artola Perez de Azanza M.E. (2023), Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases, Chemical Science 14(34): 9136-9144.
Su Q., Schroder S.P., Lelieveld L.T., Ferraz M.J., Verhoek M., Boot R.G., Overkleeft H.S., Aerts J.M.F.G., Artola M. & Kuo C.-L. (2023), Corrigendum: Xylose-Configured Cyclophellitols as Selective Inhibitors for Glucocerebrosidase, ChemBioChem 24(3): e202300728.
Su Q., Schroder S.P., Lelieveld L.T., Guimaraes Da Lomba Ferraz M.J., Verhoek M., Boot R.G., Overkleeft H.S., Aerts J.M.F.G., Artola Perez de Azanza M.E. & Kuo C.L. (2023), Corrigendum: xylose-configured cyclophellitols as selective inhibitors for glucocerebrosidase, ChemBioChem 24(3): e202300728. bijdrage in dag-/weekblad of tijdschrift
Su Q., Schröder S.P., Lelieveld L.T., Guimaraes Da Lomba Ferraz M.J., Verhoek M., Boot R.G., Overkleeft H.S., Aerts J.M.F.G., Artola M. & Kuo C.L. (2022), Corrigendum: Xylose-configured cyclophellitols as selective inhibitors for glucocerebrosidase, ChemBioChem 23: e202200728. bijdrage in dag-/weekblad of tijdschrift
Borlandelli V., Armstrong Z., Nin-Hill A., Codée J., Raich L., Artola M., Rovira C., Davies G. & Overkleeft H.S. (2023), 4-O-substituted glucuronic cyclophellitols are selective mechanism-based heparanase inhibitors, ChemMedChem 18(4): e202200580. 'refereed' artikel in een tijdschrift
Kok K., Kuo C.L., Katzy R.E., Lelieveld L.T., Wu L., Roig-Zamboni V., Marel G.A. van der, Codee J.D.C., Sulzenbacher G., Davies G.J., Overkleeft H.S., Aerts J.M.F.G. & Artola Perez de Azanza M.E. (2022), 1,6-epi-Cyclophellitol cyclosulfamidate is a bona fide lysosomal α-glucosidase stabilizer for the treatment of Pompe disease, Journal of the American Chemical Society 144(32): 14819-14827. 'refereed' artikel in een tijdschrift
Lelieveld L.T., Gerhardt S., Maas S., Zwiers K.C., Wit C. de, Beijk E.H., Guimaraes Da Lomba Ferraz M.J., Artola Perez de Azanza M.E., Meijer A.H., Tudorache C., Salvatori D., Boot R.G. & Aerts J.M.F.G. (2022), Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish, Journal of Lipid Research 63(5): 100199. 'refereed' artikel in een tijdschrift
Rowland R.J., Chen Y., Breen I., Wu L., Offen W.A., Beenakker T.J.M., Su Q., Nieuwendijk A.M.C.H. van den, Aerts J.M.F.G., Artola Perez de Azanza M.E., Overkleeft H.S. & Davies G.J. (2021), Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents, Chemistry-a European Journal 27: 1-13. 'refereed' artikel in een tijdschrift
Su Q., Schröder S.P., Lelieveld L.T., Ferraz M.J., Verhoek M., Boot R.G., Overkleeft H.S., Aerts J.M.F.G., Artola M. & Kuo C.L. (2021), Xylose-configured cyclophellitols as selective inhibitors for glucocerebrosidase, Chembiochem 22(21): 3090-3098. 'refereed' artikel in een tijdschrift
Huecas S., Araujo-Bazan L., Ruiz F.M., Ruiz-Avila L.B., Martinez R.F., Escobar-Pena A., Artola Perez de Azanza M.E., Vazquez-Villa H., Martin-Fontecha M., Fernandez-Tornero C., Lopez-Rodriguez M.L. & Andreu J.M. (2021), Targeting the FtsZ allosteric binding site with a novel fluorescence polarization screen, cytological and structural approaches for antibacterial discovery, Journal of Medicinal Chemistry 64(9): 5730-5745. 'refereed' artikel in een tijdschrift
Kok K., Zwiers K.C., Boot R.G., Overkleeft H.S., Aerts J.M.F.G. & Artola M. (2021), Fabry disease: molecular basis, pathophysiology, diagnostics and potential therapeutic directions, Biomolecules 11(2): 271.
McGregor N.G.S., Coines J., Borlandelli V.B., Amaki S., Artola M., Nin-Hill A., Linzel D., Yamada C., Arakawa T., Ishiwata A., Ito Y., Marel G.A. van der, Codee J.D.C., Fushinobu S., Overkleeft H.S., Rovira C. & Davies G.J. (2021), Cysteine nucleophiles in glycosidase catalysis: application of a covalent β‐l‐arabinofuranosidase inhibitor, Angewandte Chemie (International Edition) 60(11): 5754-5758.
Chen Y., Armstrong Z., Artola M., Florea B.I., Kuo C.L., Boer C. de, Rasmussen M.S., Abou Hachem M., Marel G.A. van der, Codee J.D.C., Aerts J.M.F.G., Davies G.J. & Overkleeft H.S. (2021), Activity-based protein profiling of retaining alpha-amylases in complex biological samples, Journal of the American Chemical Society 143(5): 2423-2432.
Boer D.E., Mirzaian M., Ferraz M.J., Zwiers K.C., Baks M.V., Hazeu M.D., Ottenhoff R., Marques A.R.A., Meijer R., Roos J.C.P., Cox T.M., Boot R.G., Pannu N., Overkleeft H.S., Artola M. & Aerts J.M.F.G. (2021), Human glucocerebrosidase mediates formation of xylosyl-cholesterol by beta-xylosidase and transxylosidase reactions, Journal of Lipid Research 62. 'refereed' artikel in een tijdschrift
Boer D.E.C., Mirzaian M., Ferraz M.J., Zwiers K.C., Baks M.V., Hazeu M.D., Ottenhoff R., Marques A.R.A., Meijer R., Roos J.P.C., Cox T.M., Boot R.G., Pannu N., Overkleeft H.S., Artola M. & Aerts J.M.F.G. (2020), Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions, Journal of Lipid Research 61(12): jlr.RA120001043.
McGregor N.G.S., Turkenburg J.P., Krogh K.B.R.M., Nielsen J.E., Artola M., Stubbs K.A., Overkleeft H.S. & Davies G.J. (2020), Structure of a GH51 α-L-arabinofuranosidase from Meripilus giganteus: conserved substrate recognition from bacteria to fungi, Acta Crystallographica Section D Structural Biology 76(11): 1124-1133.
Kytidou K., Artola M., Overkleeft H.S. & Aerts J.M.F.G. (2020), Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics, Frontiers in Plant Science 11: 357.
McGregor N.G.S., Artola M., Nin-Hill A., Linzel D., Haon M., Reijngoud J., Ram A., Rosso M.N., Marel G.A. van der, Codée J.D.C., Wezel G.P. van, Berrin J.G., Rovira C., Overkleeft H.S. & Davies G.J. (2020), Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining α-l-Arabinofuranosidases, Journal of the American Chemical Society 142(10): 4648-4662.
Aerts J.M.F.G., Artola M.E., Eijk M.C. van, Ferraz M.J. & Boot R.G. (2019), Glycosphingolipids and infection. Potential new therapeutic avenues, Frontiers in Cell and Developmental Biology 7: 324.
Jariwala P.B., Pellock S.J., Goldfarb D., Cloer E.W., Artola M., Simpson J.B., Bhatt A.P., Walton W.G., Roberts L.R., Major M.B., Davies G.J., Overkleeft H.S. & Redinbo M.R. (2019), Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling, ACS Chemical Biology 15(1): 217-225.
Lelieveld L.T., Mirzaian M., Kuo C.L., Artola Perez de Azanza M.E., Guimaraes da Lomba Ferraz M.J., Peter R.E.A., Akiyama H., Greimel P., Berg R.J.B.H.N. van den, Overkleeft H.S., Boot R.G., Meijer A. & Aerts J.M.F.G. (2019), Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish, Journal of Lipid Research 60(11): 1851-1867.
Artola M., Hedberg C., Rowland R.J., Raich L., Kytidou K., Wu L., Schaaf A., Ferraz M.J., Marel G.A. van der, Codee J.D.C., Rovira C., Aerts J.M.F.G., Davies G.J. & Overkleeft H.S. (2019), Alpha-d-Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal alpha-galactosidase A in Fabry disease, Chemical Science 10(40): 9233-9243.
Wu L., Armstrong Z., Schröder S.P., Boer C. de, Artola M., Aerts J.M.F.G., Overkleeft H.S. & Davies G.J. (2019), An overview of activity-based probes for glycosidases, Current Opinion in Chemical Biology 53: 25-36.
Artola M., Kuo C.L., Lelieveld L.T., Rowland R.J., Marel G.A. van der, Codée J.D.C., Boot R.G., Davies G.J., Aerts J.M.F.G. & Overkleeft H.S. (2019), Functionalized cyclophellitols are selective glucocerebrosidase inhibitors and induce a bona fide neuropathic Gaucher model in zebrafish, Journal of the American Chemical Society 141(10): 4214-4218.
Kuo C.L., Kallemeijn W.W., Lelieveld L.T., Mirzaian M., Zoutendijk I., Vardi A., Futerman A.H., Meijer A.H., Spaink H.P., Overkleeft H.S., Aerts J.M.F.G. & Artola Perez de Azanza M.E. (2019), In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity‐based protein profiling, FEBS Journal 286(3): 584-600.
Kuo C.L., Kallemeijn W.W., Lelieveld L.T., Mirzaian M., Zoutendijk I., Vardi A., Futerman A.H., Meijer A.H., Spaink H.P., Overkleeft H.S., Aerts J.M.F.G. & Artola M. (2019), In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling, FEBS Journal 286(3): 584-600.
Kuo C.L., Meel H.M.M. van, Kytidou K., Kallemeijn W.W., Witte M., Overkleeft H.S., Artola Pérez de Azanza M.E. & Aerts J.M.F.G. (2018), Activity-Based Probes for Glycosidases: Profiling and Other Applications. In: Imperiali B. (red.), Chemical Glycobiology Part B. Monitoring Glycans and their Interactions. Methods in Enzymology nr. 598: Elsevier: Monograph Series. 217-235.
Ben Bdira F., Artola Perez de Azana M.E., Overkleeft H.S., Ubbink M. & Aerts J.M.F.G. (2018), Distinguishing the differences in beta-glycosylceramidase folds, dynamics, and actions informs therapeutic uses, Journal of Lipids 59(12): 2262-2276.
Artola Perez de Azanza M.E., Wouters S., Schröder S.P., Boer C. de, Chen Y., Petracca R., Nieuwendijk A.M.C.H. van den, Aerts J.M.F.G., Marel G.A. van der, Codée J.D.C. & Overkleeft H.S. (2019), Direct Stereoselective Aziridination of Cyclohexenols with 3-Amino-2-(trifluoromethyl)quinazolin-4(3H)-one in the Synthesis of Cyclitol Aziridine Glycosidase Inhibitors, European Journal of Organic Chemistry 2019(6): 1397-1404.
Artola M., Kuo C.L., McMahon S.A., Oehler V., Hansen T., Lienden M.J.C. van der, He X., Elst H. van den, Florea B.I., Kermode A.R., Marel G.A. van der, Gloster T.M., Codée J.D.C., Overkleeft H.S. & Aerts J.M.F.G. (2018), New Irreversible alpha-l-Iduronidase Inhibitors and Activity-Based Probes, Chemistry: a European Journal 24(71): 19081-19088.
Breen I.Z., Artola Perez de Azanza M.E., Wu L., Beenakker T.J.M., Offen W.A., Aerts J.M.F.G., Davies G.J. & Overkleeft H.S. (2018), Competitive and covalent inhibitors of human lysosomal retaining exoglucosidases. In: Maccarrone M. (red.), eLS: Wiley Online Library.
Schröder S.P., Wu L., Artola Perez de Azanza M.E., Hansen T., Offen W.A., Guimaraes da Lomba Ferraz M.J., Li K.-Y., Aerts J.M.F.G., Marel G.A. van der, Codee J.D.C., Davies G.J. & Overkleeft H.S. (2018), Gluco-1H-imidazole: A New Class of Azole-Type beta-Glucosidase Inhibitor, Journal of the American Chemical Society 140(15): 5045-5048.
Parker C.G., Kuttruff C.A., Galmozzi A., Jorgensen L., Yeh C.-H., Hermanson D.J., Wang Y., Artola M., McKerrall S.J., Josyln C.M., Norremark B., Dunstl G., Felding J., Saez E., Baran P.S. & Cravatt B.F. (2017), Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs, ACS Central Science 3(12): 1276-1285.
Schröder S.P., Sande J.W. van de, Kallemeijn W.W., Kuo C.L., Artola Perez de Azanza M.E., Rooden E.J. van, Jiang J., Beenakker T.J.M., Florea B.I., Offen W.A., Davies G.J., Minnaard A.J., Aerts J.M.F.G., Codee J.D.C., Marel G.A. van der & Overkleeft H.S. (2017), Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines, Chemical Communications 53(93): 12528-12531.
Petracca R., Romeo E., Baggelaar M.P., Artola M., Pontis S., Ponzano S., Overkleeft H.S., Stelt M. van der & Piomelli D. (2017), Novel activity-based probes for N-acylethanolamine acid amidase, Chemical Communications 53(86): 11810-11813.
Artola Perez de Azanza M.E., Wu L., Guimaraes da Lomba Ferraz M.J., Kuo C.L., Raich L., Breen I.Z., Offen W.A., Codee J.D.C., Marel G.A. van der, Rovira C., Aerts J.M.F.G., Davies G.J. & Overkleeft H.S. (2017), 1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor, ACS Central Science 3(7): 784-793.
Wu L., Jiang J., Jin Y., Kallemeijn W.W., Kuo C.-L., Artola M., Dai W., Elk C. van, Eijk M. van, Marel G.A. van der, Codee J.D.C., Florea B.I., Aerts J.M.F.G., Overkleeft H.S. & Davies G.J. (2017), Activity-based probes for functional interrogation of retaining beta-glucuronidases, Nature Chemical Biology 13(8): 867-873.
Beenakker T.J.M., Wander D.P.A., Offen W.A., Artola Perez de Azanza M.E., Raich L., Guimaraes da Lomba Ferraz M.J., Li K.Y., Houben J.H.P.M., Rijssel E.R. van, Hansen T., Marel G.A. van der, Codee J.D.C., Aerts J.M.F.G., Rovira C., Davies G.J. & Overkleeft H.S. (2017), Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors, Journal of the American Chemical Society 139(19): 6534-6537.
Artola M., Ruiz-Avila L.B., Ramirez-Aportela E., Fernando Martinez R., Araujo-Bazan L., Vazquez-Villa H., Martin-Fontecha M., Oliva M.A., Martin-Galiano A.J., Chacon P., Lopez-Rodriguez M.L., Andreu J.M. & Huecas S. (2017), The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors, Chemical Science 8(2): 1525-1534.
Jiang J., Artola Perez de Azanza M.E., Beenakker T.J.M., Schröder S.P., Petracca R., Boer C. de, Aerts J.M.F.G., Marel G.A. van der, Codée J.D.C. & Overkleeft H.S. (2016), The synthesis of cyclophellitol-aziridine and its configurational and functional isomers, European Journal of Organic Chemistry 2016(22): 3671-3678.
Schroder S., Petracca R., Minnee H., Artola M., Aerts J.M.F.G., Codée J.D.C., Marel G.A. van der & Overkleeft H.S. (2016), A Divergent Synthesis of L-arabino- and D-xylo-configured Cyclophellitol Epoxides and Aziridines, European Journal of Organic Chemistry : .
Perez-Gomez E., Andradas C., Blasco-Benito S., Caffarel M.M., Garcia-Taboada E., Villa-Morales M., Moreno E., Hamann S., Martin-Villar E., Flores J.M., Wenners A., Alkatout I., Klapper W., Roecken C., Bronsert P., Stickeler E., Staebler A., Bauer M., Arnold N., Soriano J., Perez-Martinez M., Megias D., Moreno-Bueno G., Ortega-Gutierrez S., Artola M., Vazquez-Villa H., Quintanilla M., Fernandez-Piqueras J., Canela E.I., McCormick P.J., Guzman M. & Sanchez C. (2015), Role of Cannabinoid Receptor CB2 in HER2 Pro-oncogenic Signaling in Breast Cancer, Journal of the National Cancer Institute 107(6): djv077.
Artola Perez de Azanza M., Ruiz-Avila L.B., Vergonos A., Huecas S., Araujo-Bazan L., Martin-Fontecha M., Vazquez-Villa H., Turrado C., Ramirez-Aportela E., Hoegl A., Nodwell M., Barasoain I., Chacon P., Sieber S.A., Andreu J.M. & Lopez-Rodriguez M.L. (2015), Effective GTP-Replacing FtsZ Inhibitors and Antibacterial Mechanism of Action, ACS Chemical Biology 10(3): 834-843.
Bartolome-Nebreda J.M., Alonso de Diego S.A., Artola M., Delgado F., Delgado O., Luz Martin-Martin M., Martinez-Viturro C.M., Ángel Pena M., Min Tong H., Gool M. van, Manuel Alonso J., Fontana A., Macdonald G.J., Megens A., Langlois X., Somers M., Vanhoof G. & Conde-Ceide S. (2015), Identification of a Novel Orally Bioavailable Phosphodiesterase 10A (PDE10A) Inhibitor with Efficacy in Animal Models of Schizophrenia, Journal of Medicinal Chemistry 58(2): 978-993.
Ruiz-Ayila L.B., Huecas S., Artola M., Vergonos A., Ramirez-Aportela E., Cercenado E., Barasoain I., Vazquez-Villa H., Martin-Fontecha M., Chacon P., Lopez-Rodriguez M.L. & Andreu J.M. (2013), Synthetic Inhibitors of Bacterial Cell Division Targeting the GTP-Binding Site of FtsZ, ACS Chemical Biology 8(9): 2072-2083.
Turrado C., Puig T., Garcia-Carceles J., Artola Perez de Azanza M., Benhamu B., Ortega-Gutierrez S., Relat J., Oliveras G., Blancafort A., Haro D., Marrero P.F., Colomer R. & Lopez-Rodriguez M.L. (2012), New Synthetic Inhibitors of Fatty Acid Synthase with Anticancer Activity, Journal of Medicinal Chemistry 55(11): 5013-5023.

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