Marije Niemeijer
Universitair docent
- Naam
- Dr. M.C. Niemeijer
- Telefoon
- 071 5276105
- m.c.niemeijer@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0003-0045-2317
Voor meer informatie zie de Engelse profielpagina.
Universitair docent
- Faculteit der Wiskunde en Natuurwetenschappen
- LACDR
- Divisie Cell systems and Drug Safety
- Petersen A.B., Bredsdorff L., Tahir N., Niemeijer M.C., Kass G.E.N., Vitkauskaite A., Moerland M., Bois F.Y., Quignot N., Water B. van de & Bennekou S.H. (2025), Identifying human toxicodynamic variability: a systematic evidence map of the current knowledge, Regulatory Toxicology and Pharmacology 161: 105842.
- Bahtiri S., Hagens T.M.S., Water B. van de & Niemeijer M.C. (2025), Mechanism-based drug safety testing using innovative in vitro liver models: from DILI prediction to idiosyncratic DILI liability assessment, Expert Opinion on Drug Metabolism & Toxicology 21(7): 769-787.
- Bahtiri S., Hagens T.M.S., Water B. van de & Niemeijer M.C. (2025), Mechanism-based drug safety testing using innovative in vitro liver models: from DILI prediction to idiosyncratic DILI liability assessment, Expert Opinion on Drug Metabolism & Toxicology 21(7): 769-787.
- Sharma R.P., Loonstra-Wolters L., Braak S.J. ter, Niemeijer M.C., White A., Water B. van de, Middleton A.M. & Beltman J.B. (2025), Deciphering the quantitative relationship between NRF2 and SRXN1 through semi-mechanistic computational modeling, Toxicology 519: 154284.
- Niemeijer M.C., Danilyuk T.Y., Hagens T.M.S. Bahtiri S., Wijaya L.S., Davidse S.C., Kunnen S.J., Sinke L.J., Hochane M., Berk L. van den, Snijders K.E., Braak S.J. ter, Callegaro G., Le Dévédec S.E., Bouwman R.J.P. & Water B. van de (2025), Human hiPSC-derived hepatocyte-like cell stress response fluorescent protein reporter imaging platform for chemical screening, Toxicology Letters 411: 39.
- Niemeijer M.C., Więcek W., Fu S., Huppelschoten S., Bouwman R.J.P., Baze A., Parmentier C., Richert L., Paules R.S., Bois F.Y. & Water B. van de (2024), Mapping interindividual variability of toxicodynamics using high-throughput transcriptomics and primary human hepatocytes from fifty donors, Environmental Health Perspectives 132(3): 37005.
- Danilyuk T.Y., Niemeijer M.C., Wijaya L.S., Snijders K., Berk L. van der, Braak S.J. ter, Callegaro G., Bouwman R.J.P., Le Dévédec S.E. & Water B. van de (2023), Human-induced pluripotent stem cell reporters for high-content screening of stress response activation identifying target organ-specific toxicities, Toxicology Letters 384: S192.
- Niemeijer M.C. (7 februari 2023), Unfolding the regulation of stress response pathways upon liver injury (Dissertatie. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University). Promotor(en): Water B. van de.
- Braak S.J. ter, Niemeijer M.C., Wolters L., Le Dévédec S.E., Bouwman R.J.P. & Water B. van de (2022), Towards an advanced testing strategy for genotoxicity using image-based 2D and 3D HepG2 DNA damage response fluorescent protein reporters, Mutagenesis 37(2): 130-142.
- Heldring M.M., Wijaya L.S., Niemeijer M.C., Yang H., Lakhal T., Le Dévédec S.E., Water B. van de & Beltman J.B. (2022), Model-based translation of DNA damage signaling dynamics across cell types, PLoS Computational Biology 18(7): e1010264.
- Llewellyn S.V., Kermanizadeh A., Ude V., Jacobsen N.R., Conway G.E., Shah U.K., Niemeijer M.C., Moné M.J., Water B. van de, Roy S., Moritz W., Stone V., Jenkins G.J.S. & Doak S.H. (2022), Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids, Toxicology In Vitro 85: 105473.
- Sharma R.P., Wolters L., Braak B.T., Niemeijer M., Sparham C., Nicol B., White A., Water B. van de, Middleton A.M. & Beltman J.B. (2022), Deciphering the quantitative relationship between chemical kinetics and Nrf2 pathway dynamics, Toxicology Letters 368(Supplement 1): S288.
- Wijaya L.S., Trairatphisan P., Gabor A., Niemeijer M.C., Keet J., Alcalà Morera A., Snijders K.E., Wink S., Yang H., Schildknecht S., Stevens J.L., Bouwman R.J.P., Kamp H., Hengstler J., Beltman J.B., Leist M., Le Dévédec S.E., Saez-Rodriguez J. & Water B. van de (2021), Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury, Biochemical Pharmacology 190: 114591.
- Llewellyn S.V., Niemeijer M., Nymark P., Moné M.J., Water B.van de, Conway G.E., Jenkins G.J.S. & Doak S.H. (2021), In vitro three-dimensional liver models for nanomaterial DNA damage assessment, Small 17(15): e2006055.
- Braak B. ter, Niemeijer M., Boon R., Parmentier C., Baze A., Richert. L., Huppelschoten S., Wink S., Verfaillie C. & Water B. van de (2021), Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes, Toxicology In Vitro 73: 105107.
- Snijders K.E., Fehér A., Táncos Z., Bock I., Téglási A., Berk L. van den, Niemeijer M., Bouwman P., Le Dévédec S.E., Moné M.J., Rossom R. van, Kumar M., Wilmes A., Jennings P., Verfaillie C.M., Kobolák J., Braak B. ter, Dinnyés A. & Water B. van de (2021), Fluorescent tagging of endogenous heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages, Archives of Toxicology 95(10): 3285-3302.
- Callegaro G., Kunnen S.J., Trairatphisan P., Grosdidier S., Niemeijer M., Hollander W. den, Guney E., Piñero Gonzalez J., Furlong L., Webster Y.W., Saez-Rodriguez J., Sutherland J.J., Mollon J., Stevens J.L. & Water B. van de (2021), The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment, Archives of Toxicology 95(12): 3745-3775.
- Yang H., Niemeijer M.C., Water B. van de & Beltman J.B. (2020), ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response, iScience 23(2): 100860.
- Mav. D., Phadke D.P., Balik-Meisner M.R., Merrick B.A., Auerbach S., Niemeijer M.C., Huppelschoten S., Baze A., Parmentier C., Richert L., Water B. van de, Shah R.R. & Paules R.S. (2020), Utility of extrapolating human S1500+ genes to the whole transcriptome: tunicamycin case study, Bioinformatics and Biology Insights 14: 1-14.
- Schimming J.P., Braak B. ter, Niemeijer M., Wink S. & Water B. van de (2019), System Microscopy of Stress Response Pathways in Cholestasis Research. In: Vinken M. (red.), Experimental Cholestasis Research. Methods in Molecular Biology nr. 1981. New York, NY, U.S.A.: Humana Press. 187-202.
- Niemeijer M.C., Hiemstra S.W., Wink S., Hollander W. den, Braak S.J. ter & Water B. van de (2018), Systems microscopy approaches in unraveling and predicting Drug-Induced Liver Injury (DILI). In: Chen M. & Will Y. (red.), Drug-Induced Liver Toxicity. Methods in Pharmacology and Toxicology. New York: Humana Press. 611-625.
- Hiemstra S., Niemeijer M., Koedoot E., Wink S., Pip J.E., Vlasveld M., Zeeuw E. de , Os B. van, White A. & Water B. van de (2017), Comprehensive Landscape of Nrf2 and p53 Pathway Activation Dynamics by Oxidative Stress and DNA Damage, Chemical Research in Toxicology 30(4): 923-933.
- Wink S., Hiemstra S., Huppelschoten S., Danen E.H.J., Niemeijer M., Hendriks G., Vrieling H., Herpers B. & Water B. van de (2014), Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment, Chemical Research in Toxicology 27(3): 338-355.