Manfred Wuhrer
Hoogleraar Proteomics and Glycomics
- Naam
- Prof.dr. M. Wuhrer
- Telefoon
- +31 71 526 9111
- m.wuhrer@lumc.nl
Manfred Wuhrer is hoogleraar proteomics en glycomics en hoofd van het Center for Proteomics and Metabolomics van het Leids Universitair Medisch Centrum (LUMC). Daarnaast is hij voorzitter van de Nederlandse Vereniging voor Massa Spectrometrie (NVMS).
Meer informatie over Manfred Wuhrer
Manfred Wuhrer is hoogleraar proteomics en glycomics en hoofd van het Center for Proteomics and Metabolomics van het Leids Universitair Medisch Centrum (LUMC). Daarnaast is hij voorzitter van de Nederlandse Vereniging voor Massa Spectrometrie (NVMS).
Wetenschappelijke carrière
Manfred Wuhrer heeft biochemie gestudeerd aan de Universiteit van Regensburg, Duitsland. Hij promoveerde aan de Universiteit van Giessen in 1999 over de characterisatie van stadium-specifiek geexprimeerde glycolipiden van de humane parasiet Schistosoma mansoni. In 2003 kwam hij naar het LUMC en begon met het opzetten van een onderzoekslijn over de massa spectrometrische analyse van glycosylering.
Hij werd in 2013 benoemd als hoogleraar Analytics of Biomolecular Interactions aan de Vrije Universiteit Amsterdam. Sinds 2015 is hij hoogleraar Proteomics and Glycomics en hoofd van het Center for Proteomics en Metabolomics van het LUMC. De titel van zijn oratie is 'Ziekten op de weegschaal'.
Hoogleraar Proteomics and Glycomics
- Faculteit Geneeskunde
- Divisie 4
- Klinische Farmacie en Toxicologie
- Wang, D.; Kuzyk, V.; Madunic, K.; Zhang, T.; Mayboroda, O.A.; Wuhrer, M. & Lageveen-Kammeijer, G.S.M. (2023), In-depth analysis of the N-glycome of colorectal cancer cell lines, International Journal of Molecular Sciences 24(5).
- Guo, R.R.; Lageveen-Kammeijer, G.S.M.; Wang, W.J.; Dalebout, H.; Zhang, W.A.; Wuhrer, M.; Liu, L.; Heijs, B. & Voglmeir, J. (2023), Analysis of Immunogenic Galactose-alpha-1,3-galactose-Containing N-Glycans in beef, mutton, and pork tenderloin by Combining Matrix-Assisted Laser Desorption/Ionization-mass spectroscopy and capillary electrophoresis hyphenated with mass spectrometry via electrospray ionization, Journal of Agricultural and Food Chemistry 71(9).
- Schaick, G. van; Dominguez-Vega, E.; Castel, J.; Wuhrer, M.; Hernandez-Alba, O. & Cianferani, S. (2023), Online collision-induced unfolding of therapeutic monoclonal antibody glyco-variants through direct hyphenation of cation exchange chromatography with native ion mobility-mass spectrometry, Analytical Chemistry 95(8).
- Blochl, C.; Wang, D.; Mayboroda, O.A.; Lageveen-Kammeijer, G.S.M. & Wuhrer, M. (2023), Transcriptionally imprinted glycomic signatures of acute myeloid leukemia, Cell & Bioscience 13(1).
- Oskam, N.; Damelang, T.; Streutker, M.; Heer, P.; Nouta, J.; Koeleman, C.; Coillie, J. van; Wuhrer, M.; Vidarsson, G. & Rispens, T. (2023), Factors affecting IgG4-mediated complement activation, Frontiers in Immunology 14.
- Spanov, B.; Baartmans, B.; Olaleye, O.; Nicolardi, S.; Govorukhina, N.; Wuhrer, M.; Merbel, N.C. van de & Bischoff, R. (2023), Revealing charge heterogeneity of stressed trastuzumab at the subunit level, Analytical and Bioanalytical Chemistry 415(8): 1505-1513.
- Volkov, M.; Brinkhaus, M.; Schie, K.A. van; Bondt, A.; Kissel, T.; Kooi, E.J. van der; Bentlage, A.E.H.; Koeleman, C.A.M.; Taeye, S.W. de; Derksen, N.I.; Dolhain, R.J.E.M.; Braig-Scherer, U.; Huizinga, T.W.J.; Wuhrer, M.; Toes, R.E.M.; Vidarsson, G. & Woude, D. van der (2023), IgG Fab glycans hinder FcRn-mediated placental transport, The Journal of Immunology 210(2): 158-167.
- Buhre, J.S.; Pongracz, T.; Kunsting, I.; Lixenfeld, A.S.; Wang, W.J.; Nouta, J.; Lehrian, S.; Schmelter, F.; Lunding, H.B.; Duhring, L.; Kern, C.; Petry, J.; Martin, E.L.; Foh, B.; Steinhaus, M.; Kopylow, V. von; Sina, C.; Graf, T.; Rahmoller, J.; Wuhrer, M. & Ehlers, M. (2023), mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses compared to an adenovirus-based vaccine, Frontiers in Immunology 13.
- Falck, D.; Lechmann, M.; Momcilovic, A.; Thomann, M.; Koeleman, C.A.M.; Jany, C.; Malik, S.; Wuhrer, M. & Reusch, D. (2022), Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model, mAbs 14(1).
- Coillie, J. van; Pongracz, T.; Rahmoller, J.; Chen, H.J.; Geyer, C.E.; Vught, L.A. van; Buhre, J.S.; Sustic, T.; Osch, T.L. van; Steenhuis, M.; Hoepel, W.; Wang, W.J.; Lixenfeld, A.S.; Nouta, J.; Keijzer, S.; Linty, F.; Visser, R.; Larsen, M.D.; Martin, E.L.; Kunsting, I.; Lehrian, S.; Kopylow, V. von; Kern, C.; Lunding, H.B.; Winther, M. de; Mourik, N. van; Rispens, T.; Graf, T.; Slim, M.A.; Minnaar, R.P.; Bomers, M.K.; Sikkens, J.J.; Vlaar, A.P.J.; Schoot, C.E. van der; Dunnen, J. den; Wuhrer, M.; Ehlers, M.; Vidarsson, G.; Fatebenefratelli-Sacco Infect Dis & UMC COVID-19 S HCW Study Grp (2023), The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees, EBioMedicine 87.
- Zhang, J.; Zon, G. van der; Ma, J.; Mei, H.L.; Cabukusta, B.; Agaser, C.C.; Madunic, K.; Wuhrer, M.; Zhang, T. & Dijke, P. ten (2022), ST3GAL5-catalyzed gangliosides inhibit TGF-beta-induced epithelial-mesenchymal transition via T beta RI degradation, The EMBO Journal.
- Grunert, I.; Heinrich, K.; Hingar, M.; Ernst, J.; Winter, M.; Bomans, K.; Wagner, K.; Fevre, A.; Reusch, D.; Wuhrer, M. & Bulau, P. (2022), Comprehensive multidimensional liquid chromatography-mass spectrometry for the characterization of charge variants of a bispecific antibody, Journal of The American Society for Mass Spectrometry 33(12): 2319-2327.
- Kissel, T.; Toes, R.E.M.; Huizinga, T.W.J. & Wuhrer, M. (2022), Glycobiology of rheumatic diseases, Nature Reviews Rheumatology 19.
- Bharadwaj, P.; Shrestha, S.; Pongracz, T.; Concetta, C.; Sharma, S.; Moine, A. le; Haan, N. de; Murakami, N.; Riella, L.V.; Holovska, V.; Wuhrer, M.; Marchant, A. & Ackerman, M.E. (2022), Afucosylation of HLA-specific IgG1 as a potential predictor of antibody pathogenicity in kidney transplantation, Cell Reports Medicine 3(11).
- Siekman, S.L.; Pongracz, T.; Wang, W.J.; Nouta, J.; Kremsner, P.G.; Silva-Neto, P.V. da; Esen, M.; Kreidenweiss, A.; Held, J.; Trape, A.A.; Fendel, R.; Santos, I.K.F.D. & Wuhrer, M. (2022), The IgG glycome of SARS-CoV-2 infected individuals reflects disease course and severity, Frontiers in Immunology 13.
- Osch, T.L.J. van; Pongracz, T.; Geerdes, D.M.; Mok, J.Y.; Esch, W.J.E. van; Voorberg, J.; Kapur, R.; Porcelijn, L.; Kerkhoffs, J.L.H.; Meer, P.F. van der; Schoot, C.E. van der; Haas, M. de; Wuhrer, M. & Vidarsson, G. (2022), Altered Fc glycosylation of anti-HLA alloantibodies in hemato-oncological patients receiving platelet transfusions, Journal of Thrombosis and Haemostasis 20(12).
- Lageveen-Kammeijer, G.S.M.; Wagt, S.; Haan, N. de; Wang, W.J.; Zhang, T. & Wuhrer, M. (2022), N-glycan isomer differentiation by zero flow capillary electrophoresis coupled to mass spectrometry, Analytical Chemistry 94(38).
- Gstottner, C.; Knaupp, A.; Vidarsson, G.; Reusch, D.; Schlothauer, T.; Wuhrer, M. & Dominguez-Vega, E. (2022), Affinity capillary electrophoresis , Frontiers in Immunology 13.
- Trbojevic-Akmaciic, I.; Lageveen-Kammeijer, G.S.M.; Heijs, B.; Petrovic, T.; Deris, H.; Wuhrer, M. & Lauc, G. (2022), High-throughput glycomic methods, Chemical Reviews 122(20).
- Sustic, T.; Coillie, J. van; Larsen, M.D.; Derksen, N.I.L.; Szittner, Z.; Nouta, J.; Wang, W.J.; Damelang, T.; Rebergen, I.; Linty, F.; Visser, R.; Mok, J.Y.; Geerdes, D.M.; Esch, W.J.E. van; Taeye, S.W. de; Gils, M.J. van; Watering, L. van de; Schoot, C.E. van der; Wuhrer, M.; Rispens, T. & Vidarsson, G. (2022), Immunoassay for quantification of antigen-specific IgG fucosylation, EBioMedicine 81.
- Wang, D.; Maduni, K.; Zhang, T.; Mayboroda, O.A.; Lageveen-Kammeijer, G.S.M. & Wuhrer, M. (2022), High diversity of glycosphingolipid glycans of colorectal cancer cell lines reflects the cellular differentiation phenotype, Molecular & Cellular Proteomics 21(6).
- Kissel, T.; Hafkenscheid, L.; Wesemael, T.J.; Tamai, M.; Kawashiri, S.Y.; Kawakami, A.; El-Gabalawy, H.S.; Schaardenburg, D.; Rantapaa-Dahlqvist, S.; Wuhrer, M.; Mil, A.H.M.V.V.; Allaart, C.F.; Woude, D.; Scherer, H.U.; Toes, R.E.M. & Huizinga, T.W.J. (2022), IgG anti-citrullinated protein antibody variable domain glycosylation increases before the onset of rheumatoid arthritis and stabilizes thereafter, Arthritis & Rheumatology 74(7).
- Rossi, M.; Altea-Manzano, P.; Demicco, M.; Doglioni, G.; Bornes, L.; Fukano, M.; Vandekeere, A.; Cuadros, A.M.; Fernandez-Garcia, J.; Riera-Domingo, C.; Jauset, C.; Planque, M.; Alkan, H.F.; Nittner, D.; Zuo, D.M.; Broadfield, L.A.; Parik, S.; Pane, A.A.; Rizzollo, F.; Rinaldi, G.; Zhang, T.; Teoh, S.T.; Aurora, A.B.; Karras, P.; Vermeire, I.; Broekaert, D.; Elsen, J. van; Knott, M.M.L.; Orth, M.F.; Demeyer, S.; Eelen, G.; Dobrolecki, L.E.; Bassez, A.; Brussel, T. van; Sotlar, K.; Lewis, M.T.; Bartsch, H.; Wuhrer, M.; Veelen, P. van; Carmeliet, P.; Cools, J.; Morrison, S.J.; Marine, J.C.; Lambrechts, D.; Mazzone, M.; Hannon, G.J.; Lunt, S.Y.; Grunewald, T.G.P.; Park, M.; Rheenen, J. van & Fendt, S.M. (2022), PHGDH heterogeneity potentiates cancer cell dissemination and metastasis, Nature 605(7911): 747-+.
- Moran, A.B.; Gardner, R.A.; Wuhrer, M.; Lageveen-Kammeijer, G.S.M. & Spencer, D.I.R. (2022), Sialic Acid Derivatization of Fluorescently Labeled N-Glycans Allows Linkage Differentiation by Reversed-Phase Liquid Chromatography-Fluorescence Detection-Mass Spectrometry, Analytical Chemistry 94(18): 6639-6648.
- Pongracz, T.; Vidarsson, G. & Wuhrer, M. (2022), Antibody glycosylation in COVID-19, Glycoconjugate Journal 39.
- Chinello, C.; Haan, N. de; Capitoli, G.; Trezzi, B.; Radice, A.; Pagani, L.; Criscuolo, L.; Signorini, S.; Galimberti, S.; Sinico, R.A.; Wuhrer, M. & Magni, F. (2022), Definition of IgG subclass-specific glycopatterns in idiopathic membranous nephropathy: , International Journal of Molecular Sciences 23(9).
- Levink, I.J.M.; Klatte, D.C.F.; Hanna-Sawires, R.G.; Vreeker, G.C.M.; Ibrahim, I.S.; Burgt, Y.E.M. van der; Overbeek, K.A.; Koopmann, B.D.M.; Cahen, D.L.; Fuhler, G.M.; Wuhrer, M.; Bonsing, B.A.; Tollenaar, R.A.E.M.; Vleggaar, F.P.; Vasen, H.F.A.; Leerdam, M.E. van; Bruno, M.J. & Mesker, W.E. (2022), Longitudinal changes of serum protein N-Glycan levels for earlier detection of pancreatic cancer in high-risk individuals, Pancreatology 22(4): 497-506.
- Haan, N. de; Pucic-Bakovic, M.; Novokmet, M.; Falck, D.; Lageveen-Kammeijer, G.; Razdorov, G.; Vuckovic, F.; Trbojevic-Akmacic, I.; Gornik, O.; Hanic, M.; Wuhrer, M.; Lauc, G. & Human Glycome Project (2022), Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples, Glycobiology 32(8): 651-663.
- Wang, D.; Zhang, T.; Madunic, K.; Waard, A.A. de; Blochl, C.; Mayboroda, O.A.; Griffioen, M.; Spaapen, R.M.; Huber, C.G.; Lageveen-Kammeijer, G.S.M. & Wuhrer, M. (2022), Glycosphingolipid-glycan signatures of acute myeloid leukemia cell lines reflect hematopoietic differentiation, Journal of Proteome Research 21(4): 1029-1040.
- Pongracz, T.; Nouta, J.; Wang, W.J.; Meijgaarden, K.E. van; Linty, F.; Vidarsson, G.; Joosten, S.A.; Ottenhoff, T.H.M.; Hokke, C.H.; Vries, J.J.C. de; Arbous, S.M.; Roukens, A.H.E.; Wuhrer, M.; BEAT-COVID Grp & COVID-19 Grp (2022), Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19, EBioMedicine 78.
- Nicolardi, S.; Danuser, R.; Dotz, V.; Dominguez-Vega, E.; Kaabi, A. al; Beurret, M.; Anish, C. & Wuhrer, M. (2022), Glycan and protein analysis of glycoengineered bacterial E. coli vaccines by MALDI-in-source decay FT-ICR mass spectrometry, Analytical Chemistry 94(12): 4979-4987.
- Osch, T.L.J. van; Steuten, J.; Nouta, J.; Koeleman, C.A.M.; Bentlage, A.E.H.; Heidt, S.; Mulder, A.; Voorberg, J.; Ham, S.M. van; Wuhrer, M.; Brinke, A. ten & Vidarsson, G. (2022), Phagocytosis of platelets opsonized with differently glycosylated anti-HLA hIgG1 by monocyte-derived macrophages, Platelets 34(1).
- Boyaval, F.; Dalebout, H.; Zeijl, R. van; Wang, W.J.; Farina-Sarasqueta, A.; Lageveen-Kammeijer, G.S.M.; Boonstra, J.J.; McDonnell, L.A.; Wuhrer, M.; Morreau, H. & Heijs, B. (2022), High-Mannose N-glycans as malignant progression markers in early-stage colorectal cancer, Cancers 14(6).
- Zhang, J.; Zhang, Z.J.; Holst, S.; Bloechl, C.; Madunic, K.; Wuhrer, M.; Dijke, P. ten & Zhang, T. (2022), Transforming growth factor-beta challenge alters the N-, O-, and glycosphingolipid glycomes in PaTu-S pancreatic adenocarcinoma cells, Journal of Biological Chemistry 298(3).
- Lavado-Garcia, J.; Zhang, T.; Cervera, L.; Godia, F. & Wuhrer, M. (2022), Differential N- and O-glycosylation signatures of HIV-1 Gag virus-like particles and coproduced extracellular vesicles, Biotechnology and Bioengineering 119(5): 1207-1221.
- Vanacore, A.; Vitiello, G.; Wanke, A.; Cavasso, D.; Clifton, L.A.; Mahdi, L.; Campanero-Rhodes, M.A.; Solis, D.; Wuhrer, M.; Nicolardi, S.; Molinaro, A.; Marchetti, R.; Zuccaro, A.; Paduano, L. & Silipo, A. (2022), Lipopolysaccharide O-antigen molecular and supramolecular modifications of plant root microbiota are pivotal for host recognition, Carbohydrate Polymers 277.
- Schaick, G. van; Hajjouti, N. el; Nicolardi, S.; Hartog, J. den; Jansen, R.; Hoeven, R. van der; Bijleveld, W.; Abello, N.; Wuhrer, M.; Olsthoorn, M.M.A. & Dominguez-Vega, E. (2022), Native liquid chromatography and mass spectrometry to structurally and functionally characterize endo-xylanase proteoforms, International Journal of Molecular Sciences 23(3).
- Kissel, T.; Ge, C.R.; Hafkenscheid, L.; Kwekkeboom, J.C.; Slot, L.M.; Cavallari, M.; He, Y.B.; Schie, K.A. van; Vergroesen, R.D.; Kampstra, A.S.B.; Reijm, S.; Stoeken-Rijsbergen, G.; Koeleman, C.; Voortman, L.M.; Heitman, L.H.; Xu, B.Z.; Pruijn, G.J.M.; Wuhrer, M.; Rispens, T.; Huizinga, T.W.J.; Scherer, H.U.; Reth, M.; Holmdahl, R. & Toes, R.E.M. (2022), Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation, Science Advances 8(6).
- Schaick, G. van; Haselberg, R.; Somsen, G.W.; Wuhrer, M. & Dominguez-Vega, E. (2022), Studying protein structure and function by native separation-mass spectrometry, Nature Reviews Chemistry 6(3): 215-231.
- Grunert, I.; Heinrich, K.; Ernst, J.; Hingar, M.; Briguet, A.; Leiss, M.; Wuhrer, M.; Reusch, D. & Bulau, P. (2022), Detailed analytical characterization of a bispecific IgG1 CrossMab antibody of the knob-into-hole format applying various stress conditions revealed pronounced stability, ACS Omega 7(4): 3671-3679.
- Rodriguez, E.; Boelaars, K.; Brown, K.; Madunic, K.; Ee, T. van; Dijk, F.; Verheij, J.; Li, R.J.E.; Schetters, S.T.T.; Meijer, L.L.; Large, T.Y.S. le; Driehuis, E.; Clevers, H.; Bruijns, S.C.M.; O'Toole, T.; Vliet, S.J. van; Bijlsma, M.F.; Wuhrer, M.; Kazemier, G.; Giovannetti, E.; Garcia-Vallejo, J.J. & Kooyk, Y. van (2022), Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits, Communications Biology 5(1).
- Schaick, G. van; Dominguez-Vega, E.; Gstottner, C.; Berg-Verleg, J.H. van den; Schouten, O.; Akeroyd, M.; Olsthoorn, M.M.A.; Wuhrer, M.; Heck, A.J.R.; Abello, N. & Franc, V. (2021), Native structural and functional proteoform characterization of the prolyl-alanyl-specific endoprotease EndoPro from Aspergillus niger, Journal of Proteome Research 20(10).
- Madunic, K.; Mayboroda, O.A.; Zhang, T.; Weber, J.; Boons, G.J.; Morreau, H.; Vlierberghe, R. van; Wezel, T. van; Lageveen-Kammeijer, G.S.M. & Wuhrer, M. (2022), Specific (sialyl-)Lewis core 2 O-glycans differentiate colorectal cancer from healthy colon epithelium, Theranostics 12(10): 4498-4512.
- Wojcik, I.; Schmidt, D.E.; Neef, L.A. de; Rab, M.A.E.; Meek, B.; Weerdt, O. de; Wuhrer, M.; Schoot, C.E. van der; Zwaginga, J.J.; Haas, M. de; Falck, D. & Vidarsson, G. (2021), A functional spleen contributes to afucosylated IgG in humans, Scientific Reports 11(1).
- Selke, P.; Bork, K.; Zhang, T.; Wuhrer, M.; Strauss, C.; Horstkorte, R. & Scheer, M. (2021), Glycation Interferes with the expression of sialyltransferases in meningiomas, Cells 10(12).
- Gstottner, C.; Hook, M.; Christopeit, T.; Knaupp, A.; Schlothauer, T.; Reusch, D.; Haberger, M.; Wuhrer, M. & Dominguez-Vega, E. (2021), Affinity capillary electrophoresis-mass spectrometry as a tool to unravel proteoform-specific antibody-receptor interactions, Analytical Chemistry 93(45): 15133-15141.
- Lippold, S.; Lippold, S.; Thavarajah, R.; Thavarajah, R.; Reusch, D.; Reusch, D.; Wuhrer, M.; Wuhrer, M.; Nicolardi, S. & Nicolardi, S. (2021), Glycoform analysis of intact erythropoietin by MALDI FT-ICR mass spectrometry, Analytica Chimica Acta 1185.
- Blochl, C.; Wang, D.; Madunic, K.; Lageveen-Kammeijer, G.S.M.; Huber, C.G.; Wuhrer, M. & Zhang, T. (2021), Integrated N- and O-glycomics of acute myeloid leukemia (AML) cell lines, Cells 10(11).
- Bye, A.P.; Hoepel, W.; Mitchell, J.L.; Jegouic, S.; Loureiro, S.; Sage, T.; Vidarsson, G.; Nouta, J.; Wuhrer, M.; Taeye, S. de; Gils, M. van; Kriek, N.; Cooper, N.; Jones, I.; Dunnen, J. den & Gibbins, J.M. (2021), Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic stimulus for platelets, Blood 138(16): 1481-1489.
- Crowley, A.R.; Osei-Owusu, N.Y.; Dekkers, G.; Gao, W.D.; Wuhrer, M.; Magnani, D.M.; Reimann, K.A.; Pincus, S.H.; Vidarsson, G. & Ackerman, M.E. (2021), Biophysical evaluation of rhesus macaque Fc gamma receptors reveals similar IgG Fc glycoform preferences to human receptors, Frontiers in Immunology 12.
- Larsen, M.D.; Lopez-Perez, M.; Dickson, E.K.; Ampomah, P.; Ndam, N.T.; Nouta, J.; Koeleman, C.A.M.; Ederveen, A.L.H.; Mordmuller, B.; Salanti, A.; Nielsen, M.A.; Massougbodji, A.; Schoot, C.E. van der; Ofori, M.F.; Wuhrer, M.; Hviid, L. & Vidarsson, G. (2021), Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination, Nature Communications 12(1).
- Dotz, V.; Visconti, A.; Lomax-Browne, H.J.; Clerc, F.; Ederveen, A.L.H.; Medjeral-Thomas, N.R.; Cook, H.T.; Pickering, M.C.; Wuhrer, M. & Falchi, M. (2021), O- and N-glycosylation of serum immunoglobulin A is associated with IgA nephropathy and glomerular function, Journal of the American Society of Nephrology 32(10): 2455-2465.
- Memarian, E.; Hart, L.M. 't; Slieker, R.C.; Lemmers, R.F.L.; Heijden, A.A. van der; Rutters, F.; Nijpels, G.; Schoep, E.; Lieverse, A.G.; Sijbrands, E.J.G.; Wuhrer, M.; Hoek, M. van & Dotz, V. (2021), Plasma protein N-glycosylation is associated with cardiovascular disease, nephropathy, and retinopathy in type 2 diabetes, BMJ Open Diabetes Research and Care 9(1).
- Alves, I.; Santos-Pereira, B.; Dalebout, H.; Santos, S.; Vicente, M.M.; Campar, A.; Thepaut, M.; Fieschi, F.; Strahl, S.; Boyaval, F.; Vizcaino, R.; Silva, R.; Holst-Bernal, S.; Vasconcelos, C.; Santos, L.; Wuhrer, M.; Marinho, A.; Heijs, B. & Pinho, S.S. (2021), Protein Mannosylation as a Diagnostic and Prognostic Biomarker of Lupus Nephritis: An Unusual Glycan Neoepitope in Systemic Lupus Erythematosus, Arthritis and Rheumatology.
- Osch, T.L.J. van; Nouta, J.; Derksen, N.I.L.; Mierlo, G. van; Schoot, C.E. van der; Wuhrer, M.; Rispens, T. & Vidarsson, G. (2021), Fc galactosylation promotes hexamerization of human IgG1, leading to enhanced classical complement activation, Journal of Immunology 207(6): 1545-+.
- Lageveen-Kammeijer, G.S.M.; Kuster, B.; Reusch, D. & Wuhrer, M. (2021), High sensitivity glycomics in biomedicine, Mass Spectrometry Reviews.
- Kissel, T.; Wesemael, T.J. van; Lundquist, A.; Kokkonen, H.; Kawakami, A.; Tamai, M.; Schaardenburg, D. van; Wuhrer, M.; Huizinga, T.W.J.; Scherer, H.U.; Woude, D. van der; Rantapaa-Dahlqvist, S. & Toes, R.E.M. (2021), Genetic predisposition (HLA-SE) is associated with ACPA-IgG variable domain glycosylation in the predisease phase of RA, Annals of the Rheumatic Diseases.
- Kotsias, M.; Madunic, K.; Nicolardi, S.; Kozak, R.P.; Gardner, R.A.; Jansen, B.C.; Spencer, D.I.R. & Wuhrer, M. (2021), A semi-automated, high throughput approach for O-glycosylation profiling of in vitro established cancer cell lines by MALDI-FT-ICR MS, Glycoconjugate Journal.
- Hoepel, W.; Chen, H.J.; Geyer, C.E.; Allahverdiyeva, S.; Manz, X.D.; Taeye, S.W. de; Aman, J.; Mes, L.; Steenhuis, M.; Griffith, G.R.; Bonta, P.I.; Brouwer, P.J.M.; Caniels, T.G.; Straten, K. van der; Golebski, K.; Jonkers, R.E.; Larsen, M.D.; Linty, F.; Nouta, J.; Roomen, C.P.A.A. van; Baarle, F.E.H.P. van; Drunen, C.M. van; Wolbink, G.; Vlaar, A.P.J.; Bree, G.J. de; Sanders, R.W.; Willemsen, L.; Neele, A.E.; Beek, D. van de; Rispens, T.; Wuhrer, M.; Bogaard, H.J.; Gils, M.J. van; Vidarsson, G.; Winther, M. de & Dunnen, J. den (2021), High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages, Science Translational Medicine 13(596).
- Madunic, K.; Wagt, S.; Zhang, T.; Wuhrer, M. & Lageveen-Kammeijer, G.S.M. (2021), Dopant-enriched nitrogen gas for enhanced electrospray ionization of released glycans in negative ion mode, Analytical Chemistry 93(18): 6919-6923.
- Demus, D.; Naber, A.; Dotz, V.; Jansen, B.C.; Bladergroen, M.R.; Nouta, J.; Sijbrands, E.J.G.; Hoek, M. van; Nicolardi, S. & Wuhrer, M. (2021), Large-scale analysis of apolipoprotein CIII glycosylation by ultrahigh resolution mass spectrometry, Frontiers in Chemistry 9.
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- Smit, C.H.; Diepen, A. van; Nguyen, D.L.; Wuhrer, M.; Hoffmann, K.F.; Deelder, A.M. & Hokke, C.H. (2015), Glycomic Analysis of Life Stages of the Human Parasite Schistosoma mansoni Reveals Developmental Expression Profiles of Functional and Antigenic Glycan Motifs, Molecular and Cellular Proteomics 14(7): 1750-1769.
- Reusch, D.; Haberger, M.; Falck, D.; Peter, B.; Maier, B.; Gassner, J.; Hook, M.; Wagner, K.; Bonnington, L.; Bulau, P. & Wuhrer, M. (2015), Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles-Part 2: Mass spectrometric methods, mAbs 7(4): 732-742.
- Plomp, R.; Dekkers, G.; Rombouts, Y.; Visser, R.; Koeleman, C.A.M.; Kammeijer, G.S.M.; Jansen, B.C.; Rispens, T.; Hensbergen, P.J.; Vidarsson, G. & Wuhrer, M. (2015), Hinge-Region O-Glycosylation of Human Immunoglobulin G3 (IgG3), Molecular and Cellular Proteomics 14(5): 1373-1384.
- Wuhrer, M.; Stavenhagen, K.; Koeleman, C.A.M.; Selman, M.H.J.; Harper, L.; Jacobs, B.C.; Savage, C.O.S.; Jefferis, R.; Deelder, A.M. & Morgan, M. (2015), Skewed Fc Glycosylation Profiles of Anti-proteinase 3 Immunoglobulin G1 Autoantibodies from Granulomatosis with Polyangiitis Patients Show Low Levels of Bisection, Galactosylation, and Sialylation, Journal of Proteome Research 14(4): 1657-1665.
- Stavenhagen, K.; Kolarich, D. & Wuhrer, M. (2015), Clinical Glycomics Employing Graphitized Carbon Liquid Chromatography-Mass Spectrometry, Chromatographia 78(5-6): 307-320.
- Shubhakar, A.; Reiding, K.R.; Gardner, R.A.; Spencer, D.I.R.; Fernandes, D.L. & Wuhrer, M. (2015), High-Throughput Analysis and Automation for Glycomics Studies, Chromatographia 78(5-6): 321-333.
- Kapur, R.; Valle, L. della; Verhagen, O.J.H.M.; Ederveen, A.H.; Ligthart, P.; Haas, M. de; Kumpel, B.; Wuhrer, M.; Schoot, C.E. van der & Vidarsson, G. (2015), Prophylactic anti-D preparations display variable decreases in Fc-fucosylation of anti-D, Transfusion 55(3): 553-562.
- Giera, M. & Wuhrer, M. (2015), Recent Developments in Clinical Omics, Chromatographia 78(5-6): 305-306.
- Reusch, D.; Haberger, M.; Maier, B.; Maier, M.; Kloseck, R.; Zimmermann, B.; Hook, M.; Szabo, Z.; Tep, S.; Wegstein, J.; Alt, N.; Bulau, P. & Wuhrer, M. (2015), Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles-Part 1: Separation-based methods, mAbs 7(1): 167-179.
- Rombouts, Y.; Ewing, E.; Stadt, L.A. van de; Selman, M.H.J.; Trouw, L.A.; Deelder, A.M.; Huizinga, T.W.J.; Wuhrer, M.; Schaardenburg, D. van; Toes, R.E.M. & Scherer, H.U. (2015), Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis, Annals of the Rheumatic Diseases 74(1): 234-241.
- Gardinassi, L.G.; Dotz, V.; Ederveen, A.H.; Almeida, R.P. de; Costa, C.H.N.; Costa, D.L.; Jesus, A.R. de; Mayboroda, O.A.; Garcia, G.R.; Wuhrer, M. & Santosa, I.K.F.D. (2014), Clinical Severity of Visceral Leishmaniasis Is Associated with Changes in Immunoglobulin G Fc N-Glycosylation, mBio 5(6).
- Fokkink, W.J.R.; Selman, M.H.C.; Wuhrer, M. & Jacobs, B.C. (2014), Immunoglobulin G Fc N-glycosylation in Guillain-Barre syndrome treated with intravenous immunoglobulin, Clinical and Experimental Immunology 178: 105-107.
- Nagelkerke, S.Q.; Dekkers, G.; Kustiawan, I.; Bovenkamp, F.S. van de; Geissler, J.; Plomp, R.; Wuhrer, M.; Vidarsson, G.; Rispens, T.; Berg, T.K. van den & Kuijpers, T.W. (2014), Inhibition of Fc gamma R-mediated phagocytosis by IVIg is independent of IgG-Fc sialylation and Fc gamma RIIb in human macrophages, Blood 124(25): 3709-3718.
- Bondt, A.; Rombouts, Y.; Selman, M.H.J.; Hensbergen, P.J.; Reiding, K.R.; Hazes, J.M.W.; Dolhain, R.J.E.M. & Wuhrer, M. (2014), Immunoglobulin G (IgG) Fab Glycosylation Analysis Using a New Mass Spectrometric High-throughput Profiling Method Reveals Pregnancy-associated Changes, Molecular and Cellular Proteomics 13(11): 3029-3039.
- Theodoratou, E.; Campbell, H.; Ventham, N.T.; Kolarich, D.; Pucic-Bakovic, M.; Zoldos, V.; Fernandes, D.; Pemberton, I.K.; Rudan, I.; Kennedy, N.A.; Wuhrer, M.; Nimmo, E.; Annese, V.; McGovern, D.P.B.; Satsangi, J. & Lauc, G. (2014), The role of glycosylation in IBD, Nature Reviews Gastroenterology and Hepatology 11(10): 588-600.
- Kapur, R.; Valle, L. della; Sonneveld, M.; Ederveen, A.H.; Visser, R.; Ligthart, P.; Haas, M. de; Wuhrer, M.; Schoot, C.E. van der & Vidarsson, G. (2014), Low anti-RhD IgG-Fc-fucosylation in pregnancy: a new variable predicting severity in haemolytic disease of the fetus and newborn, British Journal of Haematology 166(6): 936-945.
- Scherer, H.U.; Rombouts, Y.; Willemze, A.; Beers, J. van; Shi, J.; Kerkman, P.; Janssen, G.; Veelen, P. van; Zaldumbide, A.; Hoeben, R.; Pruijn, G.; Deelder, A.; Wolbink, G.J.; Rispens, T.; Huizinga, T.W.; Wuhrer, M.; Trouw, L. & Toes, R. (2014), A HIGH FREQUENCY OF N-GLYCANS IN THE ACPA-IGG VARIABLE DOMAIN MODULATES REACTIVITY TO CITRULLINATED ANTIGENS, Annals of the Rheumatic Diseases 73: 129-129.
- Huffman, J.E.; Pucic-Bakovic, M.; Klaric, L.; Hennig, R.; Selman, M.H.J.; Vuckovic, F.; Novokmet, M.; Kristic, J.; Borowiak, M.; Muth, T.; Polasek, O.; Razdorov, G.; Gornik, O.; Plomp, R.; Theodoratou, E.; Wright, A.F.; Rudan, I.; Hayward, C.; Campbell, H.; Deelder, A.M.; Reichl, U.; Aulchenko, Y.S.; Rapp, E.; Wuhrer, M. & Lauc, G. (2014), Comparative Performance of Four Methods for High-throughput Glycosylation Analysis of Immunoglobulin G in Genetic and Epidemiological Research, Molecular and Cellular Proteomics 13(6): 1598-1610.
- Reiding, K.R.; Blank, D.; Kuijper, D.M.; Deelder, A.M. & Wuhrer, M. (2014), High-Throughput Profiling of Protein N-Glycosylation by MALDI-TOF-MS Employing Linkage-Specific Sialic Acid Esterification, Analytical Chemistry 86(12): 5784-5793.
- Kozak, R.P.; Royle, L.; Gardner, R.A.; Bondt, A.; Fernandes, D.L. & Wuhrer, M. (2014), Improved nonreductive O-glycan release by hydrazinolysis with ethylenediaminetetraacetic acid addition, Analytical Biochemistry 453: 29-37.
- Scherpenzeel, M. van; Timal, S.; Rymen, D.; Hoischen, A.; Wuhrer, M.; Hipgrave-Ederveen, A.; Grunewald, S.; Peanne, R.; Saada, A.; Edvardson, S.; Gronborg, S.; Ruijter, G.; Kattentidt-Mouravieva, A.; Brum, J.M.; Freckmann, M.L.; Tomkins, S.; Jalan, A.; Prochazkova, D.; Ondruskova, N.; Hansikova, H.; Willemsen, M.A.; Hensbergen, P.J.; Matthijs, G.; Wevers, R.A.; Veltman, J.A.; Morava, E. & Lefeber, D.J. (2014), Diagnostic serum glycosylation profile in patients with intellectual disability as a result of MAN1B1 deficiency, Brain 137: 1030-1038.
- Fokkink, W.J.R.; Selman, M.H.J.; Dortland, J.R.; Durmus, B.; Kuitwaard, K.; Huizinga, R.; Rijs, W. van; Tio-Gillen, A.P.; Doorn, P.A. van; Deelder, A.M.; Wuhrer, M. & Jacobs, B.C. (2014), IgG Fc N-Glycosylation in Guillain-Barre Syndrome Treated with Immunoglobulins, Journal of Proteome Research 13(3): 1722-1730.
- Ruhaak, L.R.; Uh, H.W.; Deelder, A.M.; Dolhain, R.E.J.M. & Wuhrer, M. (2014), Total Plasma N-Glycome Changes during Pregnancy, Journal of Proteome Research 13(3): 1657-1668.
- Reusch, D.; Haberger, M.; Kailich, T.; Heidenreich, A.K.; Kampe, M.; Bulau, P. & Wuhrer, M. (2014), High-throughput glycosylation analysis of therapeutic immunoglobulin G by capillary gel electrophoresis using a DNA analyzer, mAbs 6(1): 185-196.
- Plomp, R.; Hensbergen, P.J.; Rombouts, Y.; Zauner, G.; Dragan, I.; Koeleman, C.A.M.; Deelder, A.M. & Wuhrer, M. (2014), Site-Specific N-Glycosylation Analysis of Human Immunoglobulin E, Journal of Proteome Research 13(2): 536-546.
- Kapur, R.; Kustiawan, I.; Vestrheim, A.; Koeleman, C.A.M.; Visser, R.; Einarsdottir, H.K.; Porcelijn, L.; Jackson, D.; Kumpel, B.; Deelder, A.M.; Blank, D.; Skogen, B.; Killie, M.K.; Michaelsen, T.E.; Haas, M. de; Rispens, T.; Schoot, C.E. van der; Wuhrer, M. & Vidarsson, G. (2014), A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy, Blood 123(4): 471-480.
- Holst, S.; Stavenhagen, K.; Balog, C.I.A.; Koeleman, C.A.M.; McDonnell, L.M.; Mayboroda, O.A.; Verhoeven, A.; Mesker, W.E.; Tollenaar, R.A.E.M.; Deelder, A.M. & Wuhrer, M. (2013), Investigations on Aberrant Glycosylation of Glycosphingolipids in Colorectal Cancer Tissues Using Liquid Chromatography and Matrix-Assisted Laser Desorption Time-of-Flight Mass Spectrometry (MALDI-TOF-MS), Molecular and Cellular Proteomics 12(11): 3081-3093.
- Bondt, A.; Selman, M.H.J.; Deelder, A.M.; Hazes, J.M.W.; Willemsen, S.P.; Wuhrer, M. & Dolhain, R.J.E.M. (2013), Association between Galactosylation of Immunoglobulin G and Improvement of Rheumatoid Arthritis during Pregnancy Is Independent of Sialylation, Journal of Proteome Research 12(10): 4522-4531.
- Leymarie, N.; Griffin, P.J.; Jonscher, K.; Kolarich, D.; Orlando, R.; McComb, M.; Zaia, J.; Aguilan, J.; Alley, W.R.; Altmann, F.; Ball, L.E.; Basumallick, L.; Bazemore-Walker, C.R.; Behnken, H.; Blank, M.A.; Brown, K.J.; Bunz, S.C.; Cairo, C.W.; Cipollo, J.F.; Daneshfar, R.; Desaire, H.; Drake, R.R.; Go, E.P.; Goldman, R.; Gruber, C.; Halim, A.; Hathout, Y.; Hensbergen, P.J.; Horn, D.M.; Hurum, D.; Jabs, W.; Larson, G.; Ly, M.; Mann, B.F.; Marx, K.; Mechref, Y.; Meyer, B.; Moginger, U.; Neususs, C.; Nilsson, J.; Novotny, M.V.; Nyalwidhe, J.O.; Packer, N.H.; Pompach, P.; Reiz, B.; Resemann, A.; Rohrer, J.S.; Ruthenbeck, A.; Sanda, M.; Schulz, J.M.; Schweiger-Hufnagel, U.; Sihlbom, C.; Song, E.; Staples, G.O.; Suckau, D.; Tang, H.X.; Thaysen-Andersen, M.; Viner, R.I.; An, Y.M.; Valmuv, L.; Wada, Y.; Watson, M.; Windwarder, M.; Whittal, R.; Wuhrer, M.; Zhu, Y.Y. & Zou, C.X. (2013), Interlaboratory Study on Differential Analysis of Protein Glycosylation by Mass Spectrometry: The ABRF Glycoprotein Research Multi-Institutional Study 2012, Molecular and Cellular Proteomics 12(10): 2935-2951.
- Ruhaak, L.R.; Koeleman, C.A.M.; Uh, H.W.; Stam, J.C.; Heemst, D. van; Maier, A.B.; Houwing-Duistermaat, J.J.; Hensbergen, P.J.; Slagboom, P.E.; Deelder, A.M. & Wuhrer, M. (2013), Targeted Biomarker Discovery by High Throughput Glycosylation Profiling of Human Plasma Alpha1-Antitrypsin and Immunoglobulin A, PLoS ONE 8(9).
- Zauner, G.; Selman, M.H.J.; Bondt, A.; Rombouts, Y.; Blank, D.; Deelder, A.M. & Wuhrer, M. (2013), Glycoproteomic Analysis of Antibodies, Molecular and Cellular Proteomics 12(4): 856-865.
- Nicolardi, S.; Burgt, Y.E.M. van der; Wuhrer, M. & Deelder, A.M. (2013), Mapping O-glycosylation of apolipoprotein C-III in MALDI-FT-ICR protein profiles, Proteomics 13(6): 992-1001.
- Dall'Olio, F.; Vanhooren, V.; Chen, C.C.; Slagboom, P.E.; Wuhrer, M. & Franceschi, C. (2013), N-glycomic biomarkers of biological aging and longevity: A link with inflammaging, Ageing Research Reviews 12(2): 685-698.
- Einarsdottir, H.K.; Selman, M.H.J.; Kapur, R.; Scherjon, S.; Koeleman, C.A.M.; Deelder, A.M.; Schoot, C.E. van der; Vidarsson, G. & Wuhrer, M. (2013), Comparison of the Fc glycosylation of fetal and maternal immunoglobulin G, Glycoconjugate Journal 30(2): 147-157.
- Heemskerk, A.A.M.; Wuhrer, M.; Busnel, J.M.; Koeleman, C.A.M.; Selman, M.H.J.; Vidarsson, G.; Kapur, R.; Schoenmaker, B.; Derks, R.J.E.; Deelder, A.M. & Mayboroda, O.A. (2013), Coupling porous sheathless interface MS with transient-ITP in neutral capillaries for improved sensitivity in glycopeptide analysis, ELECTROPHORESIS 34(3): 383-387.
- Bakovic, M.P.; Selman, M.H.J.; Hoffmann, M.; Rudan, I.; Campbell, H.; Deelder, A.M.; Lauc, G. & Wuhrer, M. (2013), High-Throughput IgG Fc N-Glycosylation Profiling by Mass Spectrometry of Glycopeptides, Journal of Proteome Research 12(2): 821-831.
- Wuhrer, M. (2013), Glycomics using mass spectrometry, Glycoconjugate Journal 30(1): 11-22.
- Lauc, G.; Huffman, J.E.; Pucic, M.; Zgaga, L.; Adamczyk, B.; Muzinic, A.; Novokmet, M.; Polasek, O.; Gornik, O.; Kristic, J.; Keser, T.; Vitart, V.; Scheijen, B.; Uh, H.W.; Molokhia, M.; Patrick, A.L.; McKeigue, P.; Kolcic, I.; Lukic, I.K.; Swann, O.; Leeuwen, F.N. van; Ruhaak, L.R.; Houwing-Duistermaat, J.J.; Slagboom, P.E.; Beekman, M.; Craen, A.J.M. de; Deelder, A.M.; Zeng, Q.; Wang, W.; Hastie, N.D.; Gyllensten, U.; Wilson, J.F.; Wuhrer, M.; Wright, A.F.; Rudd, P.M.; Hayward, C.; Aulchenko, Y.; Campbell, H. & Rudan, I. (2013), Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers, PLoS Genetics 9(1): -.
- Reusch, D.; Haberger, M.; Selman, M.H.J.; Bulau, P.; Deelder, A.M.; Wuhrer, M. & Engler, N. (2013), High-throughput work flow for IgG Fc-glycosylation analysis of biotechnological samples, Analytical Biochemistry 432(2): 82-89.
- Zauner, G.; Hoffmann, M.; Rapp, E.; Koeleman, C.A.M.; Dragan, I.; Deelder, A.M.; Wuhrer, M. & Hensbergen, P.J. (2012), Glycoproteomic Analysis of Human Fibrinogen Reveals Novel Regions of O-Glycosylation, Journal of Proteome Research 11(12): 5804-5814.
- Kapur, R.; Vestrheim, A.; Koeleman, C.A.M.; Porcelijn, L.; Jackson, D.; Kumpel, B.; Deelder, A.M.; Michaelsen, T.E.; Haas, M. de; Schoot, C.E. van der; Wuhrer, M. & Vidarsson, G. (2012), Skewing towards Decreased Fc-Fucosylation of Platelet-Alloantibodies in Pregnancy, Blood 120(21): -.
- Kapur, R.; Vestrheim, A.; Koeleman, C.A.M.; Porcelijn, L.; Jackson, D.; Kumpel, B.; Deelder, A.M.; Michaelsen, T.E.; Haas, M. de; Schoot, C.E. van der; Wuhrer, M. & Vidarsson, G. (2012), Skewing towards Decreased Fc-Fucosylation of Platelet-Alloantibodies in Pregnancy, Blood 120(21): -.
- Carlsson, M.C.; Balog, C.I.A.; Kilsgard, O.; Hellmark, T.; Bakoush, O.; Segelmark, M.; Ferno, M.; Olsson, H.; Malmstrom, J.; Wuhrer, M. & Leffler, H. (2012), Different fractions of human serum glycoproteins bind galectin-1 or galectin-8, and their ratio may provide a refined biomarker for pathophysiological conditions in cancer and inflammatory disease, BBA - General Subjects 1820(9): 1366-1372.
- Zauner, G.; Koeleman, C.A.M.; Deelder, A.M. & Wuhrer, M. (2012), Mass spectrometric O-glycan analysis after combined O-glycan release by beta-elimination and 1-phenyl-3-methyl-5-pyrazolone labeling, BBA - General Subjects 1820(9): 1420-1428.
- Balog, C.I.A.; Stavenhagen, K.; Fung, W.L.J.; Koeleman, C.A.; McDonnell, L.A.; Verhoeven, A.; Mesker, W.E.; Tollenaar, R.A.E.M.; Deelder, A.M. & Wuhrer, M. (2012), N-glycosylation of Colorectal Cancer Tissues.
- Balog, C.I.A.; Stavenhagen, K.; Fung, W.L.J.; Koeleman, C.A.; McDonnell, L.A.; Verhoeven, A.; Mesker, W.E.; Tollenaar, R.A.E.M.; Deelder, A.M. & Wuhrer, M. (2012), N-glycosylation of Colorectal Cancer Tissues, Molecular and Cellular Proteomics 11(9): 571-585.
- Wuhrer, M. & Horstkorte, R. (2012), Highlight: Dolce vita - a sample from European glycobiology, Biological Chemistry 393(8): 659-659.
- Zauner, G.; Kozak, R.P.; Gardner, R.A.; Fernandes, D.L.; Deelder, A.M. & Wuhrer, M. (2012), Protein O-glycosylation analysis, Biological Chemistry 393(8): 687-708.
- Bruggink, C.; Poorthuis, B.H.M.; Deelder, A.M. & Wuhrer, M. (2012), Analysis of urinary oligosaccharides in lysosomal storage disorders by capillary high-performance anion-exchange chromatography-mass spectrometry, Analytical and Bioanalytical Chemistry 403(6): 1671-1683.
- Selman, M.H.J.; Hoffmann, M.; Zauner, G.; McDonnell, L.A.; Balog, C.I.A.; Rapp, E.; Deelder, A.M. & Wuhrer, M. (2012), MALDI-TOF-MS analysis of sialylated glycans and glycopeptides using 4-chloro-alpha-cyanocinnamic acid matrix, Proteomics 12(9): 1337-1348.
- Selman, M.H.J.; Jong, S.E. de; Soonawala, D.; Kroon, F.P.; Adegnika, A.A.; Deelder, A.M.; Hokke, C.H.; Yazdanbakhsh, M. & Wuhrer, M. (2012), Changes in Antigen-specific IgG1 Fc N-glycosylation Upon Influenza and Tetanus Vaccination.
- Kozak, R.P.; Royle, L.; Gardner, R.A.; Fernandes, D.L. & Wuhrer, M. (2012), Suppression of peeling during the release of O-glycans by hydrazinolysis, Analytical Biochemistry 423(1): 119-128.
- Huhn, C.; Ruhaak, L.R.; Mannhardt, J.; Wuhrer, M.; Neususs, C.; Deelder, A.M. & Meyer, H. (2012), Alignment of laser-induced fluorescence and mass spectrometric detection traces using electrophoretic mobility scaling in CE-LIF-MS of labeled N-glycans, ELECTROPHORESIS 33(4): 563-566.
- Huhn, C.; Ruhaak, L.R.; Wuhrer, M. & Deelder, A.M. (2012), Hexapeptide library as a universal tool for sample preparation in protein glycosylation analysis, Journal of Proteomics 75(5): 1515-1528.
- Selman, M.H.J.; Derks, R.J.E.; Bondt, A.; Palmblad, M.; Schoenmaker, B.; Koeleman, C.A.M.; Geijn, F.E. van de; Dolhain, R.J.E.M.; Deelder, A.M. & Wuhrer, M. (2012), Fc specific IgG glycosylation profiling by robust nano-reverse phase HPLC-MS using a sheath-flow ESI sprayer interface, Journal of Proteomics 75(4): 1318-1329.
- Lebeer, S.; Claes, I.J.J.; Balog, C.I.A.; Schoofs, G.; Verhoeven, T.L.A.; Nys, K.; Ossowski, I. von; Vos, W.M. de; Tytgat, H.L.P.; Agostinis, P.; Palva, A.; Damme, E.J.M. van; Deelder, A.M.; Keersmaecker, S.C.J. de; Wuhrer, M. & Vanderleyden, J. (2012), The major secreted protein Msp1/p75 is O-glycosylated in Lactobacillus rhamnosus GG, Microbial Cell Factories 11: -.
- Pacchiarotta, T.; Hensbergen, P.J.; Wuhrer, M.; Nieuwkoop, C. van; Nevedomskaya, E.; Derks, R.J.E.; Schoenmaker, B.; Koeleman, C.A.M.; Dissel, J. van; Deelder, A.M. & Mayboroda, O.A. (2012), Fibrinogen alpha chain O-glycopeptides as possible markers of urinary tract infection, Journal of Proteomics 75(3): 1067-1073.
- Kozak, R.P.; Royle, L.; Gardner, R.A.; Fernandes, D.L. & Wuhrer, M. (2012), Suppression of peeling during the release of O-glycans by hydrazinolysis., Analytical Biochemistry 423(1).
- Geijn, F.E. van de; Man, Y.A. de; Wuhrer, M.; Willemsen, S.P.; Deelder, A.M.; Hazes, J.M.W. & Dolhain, R.J.E.M. (2011), Mannose-binding lectin does not explain the course and outcome of pregnancy in rheumatoid arthritis, Arthritis Research and Therapy 13(1).
- Zauner, G.; Deelder, A.M. & Wuhrer, M. (2011), Recent advances in hydrophilic interaction liquid chromatography (HILIC) for structural glycomics, ELECTROPHORESIS 32(24): 3456-3466.
- Selman, M.H.J.; Jong, S.E. de; Soonawala, D.; Kroon, F.P.; Adegnika, A.A.; Deelder, A.M.; Hokke, C.H.; Yazdanbakhsh, M. & Wuhrer, M. (2011), Changes in antigen-specific IgG1 Fc N-glycosylation upon influenza and tetanus vaccination., Molecular and Cellular Proteomics.
- Huffman, J.E.; Knezevic, A.; Vitart, V.; Kattla, J.; Adamczyk, B.; Novokmet, M.; Igl, W.; Pucic, M.; Zgaga, L.; Johannson, A.; Redzic, I.; Gornik, O.; Zemunik, T.; Polasek, O.; Kolcic, I.; Pehlic, M.; Koeleman, C.A.M.; Campbell, S.; Wild, S.H.; Hastie, N.D.; Campbell, H.; Gyllensten, U.; Wuhrer, M.; Wilson, J.F.; Hayward, C.; Rudan, I.; Rudd, P.M.; Wright, A.F. & Lauc, G. (2011), Polymorphisms in B3GAT1, SLC9A9 and MGAT5 are associated with variation within the human plasma N-glycome of 3533 European adults, Human Molecular Genetics 20(24): 5000-5011.
- Pucic, M.; Knezevic, A.; Vidic, J.; Adamczyk, B.; Novokmet, M.; Polasek, O.; Gornik, O.; Supraha-Goreta, S.; Wormald, M.R.; Redzic, I.; Campbell, H.; Wright, A.; Hastie, N.D.; Wilson, J.F.; Rudan, I.; Wuhrer, M.; Rudd, P.M.; Josic, D. & Lauc, G. (2011), High Throughput Isolation and Glycosylation Analysis of IgG-Variability and Heritability of the IgG Glycome in Three Isolated Human Populations.
- Carlsson, M.C.; Cederfur, C.; Schaar, V.; Balog, C.I.A.; Lepur, A.; Touret, F.; Salomonsson, E.; Deelder, A.M.; Ferno, M.; Olsson, H.; Wuhrer, M. & Leffler, H. (2011), Galectin-1-Binding Glycoforms of Haptoglobin with Altered Intracellular Trafficking, and Increase in Metastatic Breast Cancer Patients, PLoS ONE 6(10): -.
- Wuhrer, M.; Deelder, A.M. & Burgt, Y.E.M. van der (2011), MASS SPECTROMETRIC GLYCAN REARRANGEMENTS.
- Guhr, T.; Bloem, J.; Derksen, N.I.L.; Wuhrer, M.; Koenderman, A.H.L.; Aalberse, R.C. & Rispens, T. (2011), Enrichment of Sialylated IgG by Lectin Fractionation Does Not Enhance the Efficacy of Immunoglobulin G in a Murine Model of Immune Thrombocytopenia, PLoS ONE 6(6): -.
- Wang, J.; Balog, C.I.A.; Stavenhagen, K.; Koeleman, C.A.M.; Scherer, H.U.; Selman, M.H.J.; Deelder, A.M.; Huizinga, T.W.J.; Toes, R.E.M. & Wuhrer, M. (2011), Fc-Glycosylation of IgG1 is Modulated by B-cell Stimuli, Molecular and Cellular Proteomics 10(5).
- Meevissen, M.H.J.; Balog, C.I.A.; Koeleman, C.A.M.; Doenhoff, M.J.; Schramm, G.; Haas, H.; Deelder, A.M.; Wuhrer, M. & Hokke, C.H. (2011), Targeted Glycoproteomic Analysis Reveals That Kappa-5 is a Major, Uniquely Glycosylated Component of Schistosoma mansoni Egg Antigens, Molecular and Cellular Proteomics 10(5).
- Selman, M.H.J.; Hemayatkar, M.; Deelder, A.M. & Wuhrer, M. (2011), Cotton HILIC SPE Microtips for Microscale Purification and Enrichment of Glycans and Glycopeptides, Analytical Chemistry 83(7): 2492-2499.
- Taganna, J.; Boer, A.R. de; Wuhrer, M. & Bouckaert, J. (2011), Glycosylation changes as important factors for the susceptibility to urinary tract infection, Biochemical Society Transactions 39: 349-354.
- Selman, M.H.J.; Niks, E.H.; Titulaer, M.J.; Verschuuren, J.J.G.M.; Wuhrer, M. & Deelder, A.M. (2011), IgG Fc N-Glycosylation Changes in Lambed-Eaton Myasthenic Syndrome and Myasthenia Gravis, Journal of Proteome Research 10(1): 143-152.
- Ruhaak, L.R.; Hennig, R.; Huhn, C.; Borowiak, M.; Dolhain, R.J.E.M.; Deelder, A.M.; Rapp, E. & Wuhrer, M. (2010), Optimized Workflow for Preparation of APTS-Labeled N-Glycans Allowing High-Throughput Analysis of Human Plasma Glycomes using 48-Channel Multiplexed CGE-LIF, Journal of Proteome Research 9(12): 6655-6664.
- Ruhaak, L.R.; Uh, H.W.; Beekman, M.; Hokke, C.H.; Westendorp, R.G.J.; Houwing-Duistermaat, J.; Wuhrer, M.; Deelder, A.M. & Sagboom, P.E. (2010), Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health., Journal of Proteome Research.
- Wuhrer, M.; Remoortere, A. van; Balog, C.I.A.; Deelder, A.M. & Hokke, C.H. (2010), Ligand identification of carbohydrate-binding proteins employing a biotinylated glycan binding assay and tandem mass spectrometry, Analytical Biochemistry 406(2): 132-140.
- Lonardi, E.; Balog, C.I.A.; Deelder, A.M. & Wuhrer, M. (2010), Natural glycan microarrays., Expert Review of Proteomics 7(5): 761-74.
- Ruhaak, L.R.; Uh, H.W.; Beekman, M.; Koeleman, C.A.M.; Hokke, C.H.; Westendorp, R.G.J.; Wuhrer, M.; Houwing-Duistermaat, J.J.; Slagboom, P.E. & Deelder, A.M. (2010), Decreased Levels of Bisecting GlcNAc Glycoforms of IgG Are Associated with Human Longevity, PLoS ONE 5(9).
- Ruhaak, L.R.; Zauner, G.; Huhn, C.; Bruggink, C.; Deelder, A.M. & Wuhrer, M. (2010), Glycan labeling strategies and their use in identification and quantification, Analytical and Bioanalytical Chemistry 397(8): 3457-3481.
- Bruggink, C.; Poorthuis, B.J.H.M.; Piraud, M.; Froissart, R.; Deelder, A.M. & Wuhrer, M. (2010), Glycan profiling of urine, amniotic fluid and ascitic fluid from galactosialidosis patients reveals novel oligosaccharides with reducing end hexose and aldohexonic acid residues, FEBS Journal 277(14): 2970-2986.
- Ruhaak, L.R.; Steenvoorden, E.; Koeleman, C.A.M.; Deelder, A.M. & Wuhrer, M. (2010), 2-Picoline-borane: A non-toxic reducing agent for oligosaccharide labeling by reductive amination, Proteomics 10(12): 2330-2336.
- Scherer, H.U.; Woude, D. van der; Ioan-Facsinay, A.; Bannoudi, H. el; Trouw, L.A.; Wang, J.; Haupl, T.; Burmester, G.R.; Deelder, A.M.; Huizinga, T.W.J.; Wuhrer, M. & Toes, R.E.M. (2010), Glycan Profiling of Anti-Citrullinated Protein Antibodies Isolated From Human Serum and Synovial Fluid, Arthritis and Rheumatism 62(6): 1620-1629.
- Eggink, D.; Melchers, M.; Wuhrer, M.; Montfort, T. van; Dey, A.K.; Naaijkens, B.A.; David, K.B.; Douce, V. le; Deelder, A.M.; Kang, K.; Olson, W.C.; Berkhout, B.; Hokke, C.H.; Moore, J.P. & Sanders, R.W. (2010), Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function, Virology 401(2): 236-247.
- Meevissen, M.H.J.; Wuhrer, M.; Doenhoff, M.J.; Schramm, G.; Haas, H.; Deelder, A.M. & Hokke, C.H. (2010), Structural Characterization of Glycans on Omega-1, a Major Schistosoma mansoni Egg Glycoprotein That Drives Th2 Responses, Journal of Proteome Research 9(5): 2630-2642.
- Zauner, G.; Koeleman, C.A.M.; Deelder, A.M. & Wuhrer, M. (2010), Protein glycosylation analysis by HILIC-LC-MS of Proteinase K-generated N- and O-glycopeptides, Journal of Separation Science 33(6-7): 903-910.
- Selman, M.H.J.; McDonnell, L.A.; Palmblad, M.; Ruhaak, L.R.; Deelder, A.M. & Wuhrer, M. (2010), Immunoglobulin G Glycopeptide Profiling by Matrix-Assisted Laser Desorption Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Analytical Chemistry 82(3): 1073-1081.
- Huhn, C.; Ramautar, R.; Wuhrer, M. & Somsen, G.W. (2010), Relevance and use of capillary coatings in capillary electrophoresis-mass spectrometry, Analytical and Bioanalytical Chemistry 396(1): 297-314.
- van de Geijn FE, Wuhrer M, Selman MHJ, Willemsen SP, de Man YA, Deelder AM, Hazes JMW & Dolhain RJEM (2009), Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study.
- Wuhrer M, Koeleman CA & Deelder AM (2009), Two-dimensional HPLC separation with reverse-phase-nano-LC-MS/MS for the characterization of glycan pools after labeling with 2-aminobenzamide., Methods in Molecular Biology 534: 79-91.
- Schramm G, Hamilton JV, Balog CIA, Wuhrer M, Gronow A, Beckmann S, Wippersteg V, Grevelding CG, Goldmann T & Weber E (2009), Molecular characterisation of kappa-5, a major antigenic glycoprotein from Schistosoma mansoni eggs, Molecular and Biochemical Parasitology 166(1): 4-14.
- Wuhrer M, Koeleman CAM & Deelder AM (2009), Hexose Rearrangements upon Fragmentation of N-Glycopeptides and Reductively Aminated N-Glycans, Analytical Chemistry 81(11): 4422-4432.
- Ruhaak LR, Deelder AM & Wuhrer M (2009), Oligosaccharide analysis by graphitized carbon liquid chromatography-mass spectrometry, Analytical and Bioanalytical Chemistry 394(1): 163-174.
- Heiskanen A, Hirvonen T, Salo H, Impola U, Olonen A, Laitinen A, Tiitinen S, Natunen S, Aitio O, Miller-Podraza H, Wuhrer M, Deelder AM, Natunen J, Laine J, Lehenkari P, Saarinen J, Satomaa T & Valmu L (2009), Glycomics of bone marrow-derived mesenchymal stem cells can be used to evaluate their cellular differentiation stage, Glycoconjugate Journal 26(3): 367-384.
- Wuhrer M, de Boer AR & Deelder AM (2009), STRUCTURAL GLYCOMICS USING HYDROPHILIC INTERACTION CHROMATOGRAPHY (HILIC) WITH MASS SPECTROMETRY, Mass Spectrometry Reviews 28(2): 192-206.
- Huhn C, Selman MHJ, Ruhaak LR, Deelder AM & Wuhrer M (2009), IgG glycosylation analysis, Proteomics 9(4): 882-913.
- Wuhrer M, Porcelijn L, Kapur R, Koeleman CAM, Deelder AM, de Haas M & Vidarsson G (2009), Regulated Glycosylation Patterns of IgG during Alloimmune Responses against Human Platelet Antigens, Journal of Proteome Research 8(2): 450-456.
- Scherer HU, Wang J, Toes REM, van der Woude D, Koeleman CAM, de Boer AR, Huizinga TWJ, Deelder AM & Wuhrer M (2009), Immunoglobulin 1 (IgG1) Fc-glycosylation profiling of anti-citrullinated peptide antibodies from human serum, PROTEOMICS - Clinical Applications 3(1): 106-115.
- Johswich A, Kraft B, Wuhrer M, Berger M, Deelder AM, Hokke CH, Gerardy-Schahn R & Bakker H (2009), Golgi targeting of Drosophila melanogaster beta 4GalNAcTB requires a DHHC protein family-related protein as a pilot, Journal of Cell Biology 184(1): 173-183.
- van Alphen LB, Wuhrer M, Bleumink-Pluym NMC, Hensbergen PJ, Deelder AM & van Putten JPM (2008), A functional Campylobacter jejuni maf4 gene results in novel glycoforms on flagellin and altered autoagglutination behaviour, Microbiology 154.
- Ruhaak LR, Huhn C, Waterreus WJ, de Boer AR, Neususs C, Hokke CH, Deelder AM & Wuhrer M (2008), Hydrophilic interaction chromatography-based high-throughput sample preparation method for N-glycan analysis from total human plasma glycoproteins, Analytical Chemistry 80(15).
- Stolz A, Haines N, Pich A, Irvine KD, Hokke CH, Deelder AM, Gerardy-Schahn R, Wuhrer M & Bakker H (2008), Distinct contributions of beta 4GalNAcTA and beta 4GalNAcTB to Drosophila glycosphingolipid biosynthesis, Glycoconjugate Journal 25(2).
- de Boer AR, Hokke CH, Deelder AM & Wuhrer M (2008), Serum antibody screening by surface plasmon resonance using a natural glycan microarray, Glycoconjugate Journal 25(1).
- Hokke CH, Deelder AM, Hoffmann KF & Wuhrer M (2007), Glycomics-driven discoveries in schistosome research, Experimental Parasitology 117(3).
- Wuhrer M, Stam JC, van de Geijn FE, Koeleman CAM, Verrips CT, Dolhain RJEM, Hokke CH & Deelder AM (2007), Glycosylation profiling of immunoglobulin G (IgG) subclasses from human serum, Proteomics 7(22).
- de Boer AR, Hokke CH, Deelder AM & Wuhrer M (2007), General microarray technique for immobilization and screening of natural glycans, Analytical Chemistry 79(21).
- Wuhrer M, Catalina MI, Deelder AM & Hokke CH (2007), Glycoproteomics based on tandem mass spectrometry of glycopeptides, Journal of Chromatography B 849(1-2).
- Rouwendal GJA, Wuhrer M, Florack DEA, Koeleman CAM, Deelder AM, Bakker H, Stoopen GM, van Die I, Helsper JPFG, Hokke CH & Bosch D (2007), Efficient introduction of a bisecting GlcNAc residue in tobacco N-glycans by expression of the gene encoding human N-acetylglucosaminyltransferase III, Glycobiology 17(3).
- Robijn MLM, Koeleman CAM, Wuhrer M, Royle L, Geyer R, Dwek RA, Rudd PM, Deelder AM & Hokke CH (2007), Targeted identification of a unique glycan epitope of Schistosoma mansoni egg antigens using a diagnostic antibody, Molecular and Biochemical Parasitology 151(2).
- Catalina MI, Koeleman CAM, Deelder AM & Wuhrer M (2007), Electron transfer dissociation of N-glycopeptides: loss of the entire N-glycosylated asparagine side chain, Rapid Communications in Mass Spectrometry 21(6).
- Wuhrer M, Koeleman CAM, Fitzpatrick JM, Hoffmann KF, Deelder AM & Hokke CH (2006), Gender-specific expression of complex-type N-glycans in schistosomes, Glycobiology 16(10).
- Van Riet E, Wuhrer M, Wahyuni S, Retra K, Deelder AM, Tielens AGM, Van der Kleij D & Yazdanbakhsh M (2006), Antibody responses to Ascaris-derived proteins and glycolipids: the role of phosphorylcholine, Parasite Immunology 28(8).
- Wuhrer M, Balog CIA, Catalina MI, Jones FM, Schramm G, Haas H, Doenhoff MJ, Dunne DW, Deelder AM & Hokke CH (2006), IPSE/alpha-1, a major secretory glycoprotein antigen from schistosome eggs, expresses the Lewis X motif on core-difucosylated N-glycans, FEBS Journal 273(10).
- Wuhrer M, Koeleman CAM, Deelder AM & Hokke CH (2006), Repeats of LacdiNAc and fucosylated LacdiNAc on N-glycans of the human parasite Schistosoma mansoni, FEBS Journal 273(2).
- Wuhrer M, Koeleman CAM, Hokke CH & Deelder AM (2006), Mass spectrometry of proton adducts of fucosylated N-glycans: fucose transfer between antennae gives rise to misleading fragments, Rapid Communications in Mass Spectrometry 20(11).
- Wuhrer M & Deelder AM (2006), Matrix-assisted laser desorption/ionization in-source decay combined with tandem time-of-flight mass spectrometry of permethylated oligosaccharides: targeted characterization of specific parts of the glycan structure, Rapid Communications in Mass Spectrometry 20(6).
- Bruggink C, Wuhrer M, Koeleman CAM, Barreto V, Liu Y, Pohl C, Ingendoh A, Hokke CH & Deelder AM (2005), Oligosaccharide analysis by capillary-scale high-pH anion-exchange chromatography with on-line ion-trap mass spectrometry, Journal of Chromatography B 829(1-2).
- Geyer H, Wuhrer M, Resemann A & Geyer R (2005), Identification and characterization of keyhole limpet hemocyanin N-glycans mediating cross-reactivity with Schistosoma mansoni, Journal of Biological Chemistry 280(49).
- Fitzsimmons CM, Schramm G, Jones FM, Chalmers IW, Hoffmann KE, Grevelding CG, Wuhrer M, Hokke CH, Haas H, Doenhoff MJ & Dunne DW (2005), Molecular characterization of omega-1: A hepatotoxic ribonuclease from Schistosoma mansoni eggs, Molecular and Biochemical Parasitology 144(1).
- Wuhrer M & Deelder AM (2005), Negative-mode MALDI-TOF/TOF-MS of oligosaccharides labeled with 2-aminobenzamide, Analytical Chemistry 77(21).
- Wuhrer M, Deelder AM & Hokke CH (2005), Protein glycosylation analysis by liquid chromatography-mass spectrometry, Journal of Chromatography B 825(2).
- Wuhrer M, Balog CIA, Koeleman CAM, Deelder AM & Hokke CH (2005), New features of site-specific horseradish peroxidase (HRP) glycosylation uncovered by nano-LC-MS with repeated ion-isolation/fragmentation cycles, BBA - General Subjects 1723(1-3).
- Wuhrer M, Koeleman CAM, Hokke CH & Deelder AM (2005), Protein glycosylation analyzed by normal-phase nano-liquid chromatography-mass spectrometry of glycopeptides, Analytical Chemistry 77(3).
- Robijn MLM, Wuhrer M, Kornelis D, Deelder AM, Geyer R & Hokke CH (2005), Mapping fucosylated epitopes on glycoproteins and glycolipids of Schistosoma mansoni cercariae, adult worms and eggs, Parasitology 130.
- Wuhrer M, Koeleman CAM, Hokke CH & Deelder AM (2004), Nano-scale liquid chromatography-mass spectrometry of 2-aminobenzamide-labeled oligosaccharides at low femtomole sensitivity, International Journal of Mass Spectrometry 232(1).
- Wuhrer M, Robijn MLM, Koeleman CAM, Balog CIA, Geyer R, Deelder AM & Hokke CH (2004), A novel Gal(beta 1-4)Gal(beta 1-4)Fuc(alpha 1-6)-core modification attached to the proximal N-acetylglucosamine of keyhole limpet haemocyanin (KLH) N-glycans, Biochemical Journal 378.
- Wuhrer M, Koeleman CAM, Deelder AM & Hokke CN (2004), Normal-phase nanoscale liquid chromatography - Mass spectrometry of underivatized oligosaccharides at low-femtomole sensitivity, Analytical Chemistry 76(3).
- Wuhrer M, Hokke CH & Deelder AM (2004), Glycopeptide analysis by matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry reveals novel features of horseradish peroxidase glycosylation, Rapid Communications in Mass Spectrometry 18(15).
- Member of ExCom European Journal of Immunology