Laura Bosmans
Universitair docent
- Naam
- Dr. L.A. Bosmans
- Telefoon
- 071 5274378
- l.a.bosmans@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-1984-9691
Universitair docent
- LACDR
- Divisie Biotherapeutics
- Strijdhorst A., Vos W.G., Bosmans L.A., Dzobo K.E., Kusters P.J H., Hanssen N.M.J., Kroon J., Lutgens E., Laarhoven H.W.M. van, Seijkens T.T.P. & Es N. (2025), Accelerated atherosclerosis associated with immune checkpoint inhibitors: a systematic review and meta-analysis of pre-clinical studies, European Heart Journal Supplements 27(6): suaf083.005.
- Mak A.L. Augustijn, QuintenJ.J., Heymann C.J. F., Havik S., Verdoes X., Rios-Morales M., Bosmans L.A., Verheij J., Meijnikman A.S., Jonge P.A. de, Herrema H, Vos W.M. de, Nieuwdorp M., Grefhorst A. & Holleboom A.G. (2024), Anaerobutyricum soehngenii reduces hepatic lipogenic pathways and increases intestinal gluconeogenic gene Expression in metabolic-dysfunction-associated steatotic liver disease (MASLD) mice, International Journal of Molecular Sciences 25(6): 3481.
- Porteiro B., Roscam Abbing R.L.P., Panhuis W. In het, Waart D.R. de, Duijst S., Bolt I., Vogels E.W., Levels J.H.M., Bosmans L.A., Vos W.G., Oude Elfrink R.P.J., Lutgens E. & Graaf S.F.J. van de (2024), Inhibition of hepatic bile salt uptake by Bulevirtide reduces atherosclerosis in Oatp1a1-Ldlr-/ mice, Journal of Lipid Research 65(8): 100594.
- Kane J., Vos W.G., Bosmans L.A., Os B.W. van, Toom M. den, Hoeksema-Hackmann S., Moen-de Wit D., Gijbels M.J., Beckers L., Grefhorst A., Levels J.H. M., Jakulj L., Vervloet M.G., Lutgens E. & Eringa E.C. (2024), Peritoneal dialysis aggravates and accelerates atherosclerosis in uremic ApoE-/- Mice, Journal of the American Heart Association 13(14): e034066.
- Vos W.G., Os B.W. van, Toom M. den, Beckers L., Roomen C.P.A.A. van, Tiel C.M. van, Mohapatra B.C., Band H., Nitz K., Weber C., Atzler D., Winther M.P.J. de, Bosmans L.A., Lutgens E. & Seijkens T.T.P. (2024), T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation, Frontiers in Immunology 15: 1297893.
- Panhuis W. in het, Schönke M., Modder M., Tom H.E., Lalai R.A., Pronk A.C.M., Streefland T.C.M., Kerkhof L.W.M. van, Dollé M.E.T., Depuydt M.A.C., Bot I., Vos W.G., Bosmans L.A., Os B.W. van, Lutgens E., Rensen P.C.N. & Kooijman S. (2023), Time-restricted feeding attenuates hypercholesterolaemia and atherosclerosis development during circadian disturbance in APOE∗3-Leiden.CETP mice, EBioMedicine 93: 104680.
- Reiche M.E., Poels K., Bosmans L.A., Vos W.G., Tiel C.M. van, Gijbels M.J.J., Aarts S.A.B.M., Toom M. den, Beckers L., Weber C., Atzler D., Rensen P.C.N., Kooijman S. & Lutgens E. (2023), Adipocytes control hematopoiesis and inflammation through CD40 signaling, Haematologica 108(7): 1873-1885.
- Os B.W. van, Kuster P.J.H., Toom M. den, Beckers L., Tiel C.M. van, Vos W.G., Jong E. de, Kieser A., Roomen C. van, Binder C.J., Reiche M.E., Winther M.P. de, Bosmans L.A. & Lutgens E. (2023), Deficiency of germinal center kinase TRAF2 and NCK-interacting kinase (TNIK) in B cells does not affect atherosclerosis, Frontiers in Cardiovascular Medicine 10: 1171764.
- Os B.W. van, Vos W.G., Bosmans L.A., Tiel C.M. van, Lith S.C., Toom M.S. den, Beckers L., Levels J. H.M., Wouw S.A.E. van, Zelcer N., Zaal E.A., Berkers C.R., Lest C.H.A. van der, Bernd Helms J., Weber C., Atzler D., Winther M.P.J. de, Baardman J. & Lutgens E. (2023), Hyperlipidaemia elicits an atypical, T helper 1-like CD4+ T-cell response: a key role for very low-density lipoprotein, European Heart Journal Open 3(2): oead013.
- Bosmans L.A., Tiel C.M. van, Aarts S.A.B.M., Willemsen L., Baardman J., Os B.W. van, Toom M. den, Beckers L., Ahern D.J., Levels J.H.M., Jongejan A., Moerland P.D., Verberk S.G.S., Bossche J. van den, Winther M.M.P.J. de, Weber C., Atzler D., Monaco C., Gerdes N., Shami A. & Lutgens E. (2023), Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state, Cardiovascular Research 119(5): 1146-1160.
- Os B.W. van, Vos W.G., Bosmans L.A., Tiel C.M. van, Toom M. den, Becker L., Admiraal M., Hoeksema M.A., Winther M.P. de & Lutgens E. (2023), CD40L modulates CD4+ T-cell activation through receptor for activated C kinase 1, European Journal of Immunology 53(12): 2350520.
- Kane J., Jansen M., Hendrix S., Bosmans L.A., Beckers L., Tiel C. van, Gijbels M., Zelcer N., Vries C.J. de, Hundelshausen P. von, Vervloet M., Eringa E., Horrevoets A.J, Royen N. van & Lutgens E. (2022), Anti-Galectin-2 antibody treatment reduces atherosclerotic plaque size and alters macrophage polarity, Thrombosis and Haemostasis 122(06): 1047-1057.
- Bosmans L.A., Shami A., Atzler D., Weber C., Goncalves I. & Lutgens E. (2021), Glucocorticoid induced TNF receptor family-related protein (GITR)-A novel driver of atherosclerosis, Vascular Pharmacology 139: 106884.
- Bosmans L.A., Bosch L., Kusters P.J.H, Lutgens E. & Seijkens T.T.P. (2021), The CD40-CD40L dyad as immunotherapeutic target in cardiovascular disease, Journal of Cardiovascular Translational Research 14(1): 13-22.
- Schilperoort M., Berg R. van den, Bosmans L.A., Os B.W. van, Dolle M.E.T., Smits N.A.M., Guichelaar T., Baarle D. van, Koemans L., Berbee J.F.P., Deboer T., Meijer J.H., Vries M.R. de, Vreeken D., Gils J.M. van, Willems van Dijk K., Kerkhof L.W.M. van, Lutgens E., Biermasz N.R., Rensen P.C.N. & Kooijman S. (2020), Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice, Journal of Pineal Research 68(1): e12614.
- Shami A., Atzler D., Bosmans L.A., Winkels H., Meiler S., Lacy M., Tiel C. van, Ta Megens R., Nitz K., Baardman J., Kusters P., Seijkens T., Buerger C., Janjic A., Riccardi C., Edsfeldt A, Monaco C., Daemen M., Winther M P.J. de, Nilsson J., Weber C., Gerdes N., Goncalves I. & Lutgens E. (2020), Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans, European Heart Journal 41: 2938-2948.