Joost Willemse
Universitair docent
- Naam
- Dr. ir. J.J. Willemse
- Telefoon
- 071 5274986
- jwillemse@biology.leidenuniv.nl
- ORCID iD
- 0000-0001-5210-650X
Voor meer informatie, zie de Engelse versie.
Nieuws
Supervisor(s)
Universitair docent
- Faculteit der Wiskunde en Natuurwetenschappen
- IBL
- Animal Sciences
- Willemse J.J. & Wezel G.P. van (2009), Imaging of Streptomyces coelicolor A3 (2) with reduced autofluorescence reveals a novel stage of FtsZ localization, PLoS ONE 4(1): e242.
- Noens E.E., Mersinias V., Willemse J.J., Traag B.A., Laing E., Chater K.F., Smith C.P., Koerten H.K. & Wezel G.P. van (2007), Loss of the controlled localization of growth stage‐specific cell‐wall synthesis pleiotropically affects developmental gene expression in an ssgA mutant of Streptomyces coelicolor, Molecular Microbiology 64(5): 1244-1259.
- Bakker M.A.G. de, Nurhidayat L., Dijkerman A.K., Chung W.Y., Oudesluys E.C., Jager K. de, Willemse J.J. & Richardson M.K. (2025), Changes in evolutionary developmental control points in the amniote limb may explain hyperphalangy, Molecular Biology and Evolution 42(6): msaf113.
- Luten T., Lieshout J. van, Mehrem S.L., Snoek B.L., Willemse J.J. & Offringa R. (2025), GreenLeafVI: a FIJI plugin for high‐throughput analysis of leaf chlorophyll content, Physiologia Plantarum 177(5): e70588.
- Charitou V., Izquierdo Lafuente B., Habjan E., Kuijl C., Willemse J.J., Bitter W. & Speer A. (2025), PPE51 modulates membrane integrity in Mycobacterium marinum, mBio 16(11): e01044-25.
- Lubbers M., Bajramovic B., Ongenae V., Willemse J.J., Bruin D. de, Mulder N., Zhang L., Vriesendorp B., Barona-Gomez F., Briegel A., Wezel G.P. van, Flärdh K. & Claessen D. (2025), Essential and dispensable domains of DivIVA for walled growth in filamentous Actinomycetota, Open Biology 15(11): 250213.
- Cleenewerk L., Otto A., Wouters W., Willemse J.J., Gao M., Lysenko V., Punt J.M., Stelt M. van der, Martin N.I., Ulsen P. van & Luirink J. (2025), An Rcs stress-based high-throughput screen reveals novel gyrase inhibitors as indirect inducers of cell envelope stress in gram-negative bacteria, ACS infectious diseases 11(9): 2577-2592.
- Wang M., Chen S., Cheng S., Nederstigt T.A.P., Poelmann R.E., DeRuiter M.C., Lamers G.E.M., Willemse J.J., Mascitelli C., Vijver M.G. & Richardson M.K. (2024), The biodistribution of polystyrene nanoparticles administered intravenously in the chicken embryo, Environment International 188: 108723.
- Verschoor J., Croese M.R.J., Lakemeier S.E., Mugge A., Burgers C.M.C., Innocenti P., Willemse J.J., Crooijmans M.E., Wezel G.P. van, Ram A.F.J. & Winde J.H. de (2024), Polyester degradation by soil bacteria: identification of conserved BHETase enzymes in Streptomyces, Communications Biology 7: 725.
- Machushynets V., Al Ayed K., Terlouw R., Du C., Buijs P., Willemse J., Elsayed S., Schill J., Trebosc V.: Pieren M., Alexander F.M., Cochrane S.A., Liles M.R., Medema M.H., Martin N.I. & Wezel G.P. van (2024), Discovery and derivatization of tridecaptin antibiotics with altered host specificity and enhanced bioactivity, ACS Chemical Biology 19(5): 1106-1115.
- Bakker A.T., Kotsogianni I., Avalos Garcia M., Punt J.M., Liu B., Piermarini D., Gagestein B., Slingerland C.J., Zhang L., Willemse J.J., Ghimire L.B., Berg Richard J.H.B.N. van den, Janssen A.P.A., Ottenhoff T.H.M., Boeckel C.A.A. van, Wezel G.P. van, Ghilarov D., Martin N.I. & Stelt M. van der (2024), Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria, Nature Chemistry 16: 1462-1472.
- Bergeijk D.A. van, Augustijn H.E., Elsayed S.S.M.A., Willemse J.J., Carrion Bavo V.J., Du C., Urem M., Grigoreva L.V., Cheprasov M.Y., Grigoriev S., Jansen H., Wintermans B., Budding A.E., Spaink H.P., Medema M.H. & Wezel G.P. van (2024), Taxonomic and metabolic diversity of Actinomycetota isolated from faeces of a 28,000‐year‐old mammoth, Environmental Microbiology 26(2): e16589.
- Groesen E. van, Mons E., Kotsogianni A.I., Arts M., Tehrani K.H.M.E., Wade N., Lysenko V., Stel F.M., Zwerus J.T., De Benedetti S., Bakker A.T., Chakraborty P., Stelt M. van der, Scheffers D.-J., Gooskens J., Smits W.K., Holden K., Gilmour P., Willemse J.J., Hitchcock C.A., Hasselt J.G.C. van, Schneider T. & Martin N.I. (2024), Semisynthetic guanidino lipoglycopeptides with potent in vitro and in vivo antibacterial activity, Science Translational Medicine 16(759): eabo4736.
- Buijs N.P., Vlaming H.C., Kotsogianni A.I, Willemse J.J., Duan Y., Alexander F.M., Cochrane S.A., Schneider T. & Martin N.I. (2024), A classic antibiotic reimagined: rationally designed bacitracin variants exhibit potent activity against vancomycin-resistant pathogens, Proceedings of the National Academy of Sciences 121(29): e2315310121.
- Hosseini R., Vlasveld M.P., Willemse J.J., Water B. van de, Le Dévédec S.E. & Wolstencroft K.J. (2023), FAIR high content screening in bioimaging, Scientific Data 10(1): 462.
- Zhang L., Willemse J.J., Yagüe Menéndez P., Waal E.C. de, Claessen D. & Wezel G.P. van (2023), The SepF-like proteins SflA and SflB prevent ectopic localization of FtsZ and DivIVA during sporulation of Streptomyces coelicolor, Biochemical and Biophysical Research Communications 645: 79-87.
- Meij A. van der, Elsayed S.S.M.A., Willemse J.J., Du C., Wood T.M., Martin N.I., Raaijmakers J.M. & Wezel G.P. van (2023), The plant stress hormone jasmonic acid evokes defensive responses in streptomycetes, 89(11): e01239-23.
- Yague P., Willemse J., Xiao X.S., Zhang L., Manteca A. & Wezel G.P. van (2023), FtsZ phosphorylation pleiotropically affects Z-ladder formation, antibiotic production, and morphogenesis in Streptomyces coelicolor, Antonie van Leeuwenhoek 116(1): 1-19.
- Du C., Willemse J.J., Erkelens A.M., Carrion Bravo V.J., Dame R.T. & Wezel G.P. van (2022), System-wide analysis of the GATC-binding nucleoid-associated protein Gbn and its impact on Streptomyces development, mSystems 7(3): e00061-22.
- Berckx F., Bandong C.M., Wibberg D., Kalinowski J., Willemse J.J., Brachmann A., Simbahan J. & Pawlowski K. (2022), Streptomyces coriariae sp. nov., a novel streptomycete isolated from actinorhizal nodules of Coriaria intermedia, International Journal of Systematic and Evolutionary Microbiology 72(12): 005603.
- Zhang L., Ramijan K., Carrion Bravo V.J., Aart L.T. van der, Willemse J.J., Wezel G.P. van & Claessen D. (2021), An alternative and conserved cell wall enzyme that can substitute for the lipid II synthase MurG, mBio 12(2): e03381.
- Xiao X., Willemse J.J., Voskamp P., Li X., Prota A.E., Lamers M., Pannu N.S., Abrahams J.P. & Wezel G.P. van (2021), Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB in Streptomyces, Open Biology 11(2): 200409.
- Polling M., Li C., Cao L., Verbeek F.J., Weger L.A. de, Belmonte J., De Linares C., Willemse J.J., Boer H. de & Gravendeel B. (2021), Neural networks for increased accuracy of allergenic pollen monitoring, Scientific Reports 11: 11357.
- Sommer F., Torraca V., Xie Y., Veld A.E. in 't, Willemse J.J. & Meijer A.H. (2021), Disruption of Cxcr3 chemotactic signaling alters lysosomal function and renders macrophages more microbicidal, Cell Reports 35(2): 10900.
- Wenzel M., Gulsoy I.N.C., Gao Y.Q., Teng Z.H., Willemse J.J., Middelkamp M., Rosmalen M.G.M. van, Larsen P.W.B., Wel N.N. van der, Wuite G.J.L., Roos W.H. & Hamoen L.W. (2021), Control of septum thickness by the curvature of SepF polymers, Proceedings of the National Academy of Sciences 118(2): e2002635118.
- Willemse J.J., Vaart M. van der, Yang W. & Briegel A. (2020), Mathematical mirroring for identification of local symmetry centers in microscopic images local symmetry detection in FIJI, Microscopy and Microanalysis 26(5): 978-988.
- Aart L.T. van der, Nouioui I., Kloosterman A., Mariano Igual J., Willemse J., Goodfellow M. & Wezel G.P. van (2019), Polyphasic classification of the gifted natural product producer Streptomyces roseifaciens sp. nov, International Journal of Systematic and Evolutionary Microbiology 69(4): 899-908.
- Willemse J.J., Büke F., Dissel M.D. van, Grevink S., Claessen D. & Wezel G.P. van (2018), SParticle, an algorithm for the analysis of filamentous microorganisms in submerged cultures, Antonie van Leeuwenhoek 111: 171-182.
- Ramijan Carmiol A.K., Ultee E., Willemse J.J., Zhang Z., Wondergem A.J., Meij A. van der, Heinrich D.M., Briegel A., Wezel G.P. van & Claessen D. (2018), Stress-induced formation of cell wall-deficient cells in filamentous actinomysetes, Nature Communications 9: 5164.
- Meij A. van der, Willemse J.J., Schneijderberg M.A., Geurts R., Raaijmakers J.M. & Wezel G.P. van (2018), Inter- and intracellular colonization of Arabidopsis roots by endophytic actinobacteria and the impact of plant hormones on their antimicrobial activity, Antonie van Leeuwenhoek 111(5): 679-690.
- Zhang L., Willemse J.J., Hoskisson P.A. & Wezel G.P. van (2018), Sporulation-specific cell division defects in ylmE mutants of Streptomyces coelicolor are rescued by additional deletion of ylmD, Scientific Reports 8(1): 7328.
- Dissel M.D. van, Willemse J.J., Zacchetti B., Claessen D., Pier G.B. & Wezel G.P. van (2018), Production of poly-β-1, 6-N-acetylglucosamine by MatAB is required for hyphal aggregation and hydrophilic surface adhesion by Streptomyces, Microbial Cell 5(6): 269-279.
- Yang W., Willemse J., Sawyer E.B., Lou F., Gong W., Zhang H., Gras S.L., Claessen D. & Perrett S. (2017), The propensity of the bacterial rodlin protein RdlB to form amyloid fibrils determines its function in Streptomyces coelicolor, Scientific Reports 7: 42867.
- Salamaga B., Prajsnar T.K., Jareno-Martinez A., Willemse J.J., Bewley M.A., Chau F., Ben Belkacem T., Meijer A.H., Dockrell D.H., Renshaw S.A. & Mesnage S. (2017), Bacterial size matters: Multiple mechanisms controlling septum cleavage and diplococcus formation are critical for the virulence of the opportunistic pathogen Enterococcus faecalis, PLoS Pathogens 13(7): e1006526.
- Nouioui I., Rückert C., Willemse J., Wezel G.P. van, Klenk H.-P., Busche T., Kalinowski J., Bredhold H. & Zotchev S.B. (2017), Actinoalloteichus fjordicus sp. nov. isolated from marine sponges: phenotypic, chemotaxonomic and genomic characterisation, Antonie van Leeuwenhoek 110(12): 1705–1717.
- Reijer P.M. den, Haisma E.M., Lemmens-den Toon N.A., Willemse J.J., Koning R.A., Demmers J.A.A., Dekkers D.H.W., Rijkers E., Ghalbzouri A. El, Nibbering P.H. & Wamel W. van (2016), Detection of alpha-toxin and other virulence factors in biofilms of Staphylococcus aureus on polystyrene and a human epidermal model, PLoS ONE 11(1): e0145722.
- Zacchetti B., Willemse J.J., Recter B., Dissel M.D. van, Wezel G.P. van, Wösten H.A.B. & Claessen D. (2016), Aggregation of germlings is a major contributing factor towards mycelial heterogeneity of Streptomyces, Scientific Reports 6: 27045.
- Zhang L., Willemse J., Claessen D. & Wezel G.P. van (2016), SepG coordinates sporulation-specific cell division and nucleoid organization in Streptomyces coelicolor, Open Biology 6(4): 150164.
- Urem M., Rossum T. van, Bucca G., Moolenaar G.F., Laing E., Swiatek-Połatynska M.A., Willemse J., Tenconi E., Rigali S., Goosen N., Smith C.P. & Wezel G.P. van (2016), OsdR of Streptomyces coelicolor and the dormancy regulator DevR of Mycobacterium tuberculosis control overlapping regulons, mSphere 1(3): e00014.
- Celler K., Koning R.I., Willemse J., Koster A.J. & Wezel G.P. van (2016), Cross-membranes orchestrate compartmentalization and morphogenesis in Streptomyces, Nature Communications 7: 11836.
- Yagüe Menéndez P., Willemse J.J., Koning R.I., Rioseras B., López-García M.T., Gonzalez-Quinonez N., Lopez-Iglesias C., Shliaha P.V., Rogowska-Wrzesinska A., Koster A.J., Jensen O.N., Wezel G.P. van & Manteca A. (2016), Subcompartmentalization by cross-membranes during early growth of Streptomyces hyphae, Nature Communications 7: 12467.
- Girard G.A.O., Willemse J.J., Zhu H., Claessen D., Bukarasam K., Goodfellow M. & Wezel G.P. van (2014), Analysis of novel kitasatosporae reveals significant evolutionary changes in conserved developmental genes between Kitasatospora and Streptomyces, Antonie van Leeuwenhoek 106(2): 365-380.
- Koning R.I., Faas F.G., Boonekamp M., Visser B. de, Janse J., Wiegant J.C.A.G., Breij A. de, Willemse J., Nibbering P.H., Tanke H.J. & Koster A.J. (2014), MAVIS: An integrated system for live microscopy and vitrification, Ultramicroscopy 143: 67-76.
- Chenouard N., Smal I., De Chaumont F., Maska M., Sbalzarini I.F., Gong Y., Cardinale J., Carthel C., Coraluppi S., Winter M., Cohen A.R., Godinez W.J., Rohr K., Kalaidzidis Y., Liang L., Duncan J., Shen H., Xu Y., Magnusson K.E.G., Jaldén J., Blau H.M., Paul-Gilloteaux P., Roudot P., Kervrann C., Waharte F., Tinevez J.Y., Shorte S.L., Willemse J.J., Celler K.A., Wezel G.P. van, Dan H.W., Tsai Y.S., Ortiz de Solórzano C., Olivo-Marin J.C. & Meijering E. (2014), Objective comparison of particle tracking methods, Nature Methods 11(3): 281-289.
- Koning R.I., Celler K., Willemse J.J., Bos E., Wezel G.P. van & Koster A.J. (2014), Correlative cryo-fluorescence light microscopy and cryo-electron tomography of Streptomyces, Methods in Cell Biology 124: 217-239.
- Celler K.A., Wezel G.P. van & Willemse J.J/ (2013), Single particle tracking of dynamically localizing TatA complexes in Streptomyces coelicolor, Biochemical and Biophysical Research Communications 438(1): 38-42.
- Clark L.C., Seipke R.F., Prieto P., Willemse J.J., Wezel G.P. van, Hutchings M.I. & Hoskisson P.A. (2013), Mammalian cell entry genes in Streptomyces may provide clues to the evolution of bacterial virulence, Scientific Reports 3: 1109.
- Willemse J., Ruban-Osmialowska B., Widdick D., Celler K., Hutchings M.I., Wezel G.P. van & Palmer T. (2012), Dynamic Localization of Tat Protein Transport Machinery Components in Streptomyces coelicolor, Journal of Bacteriology 194(22): 6272-6281.
- Yang Y.H., Song E., Willemse J., Park S.H., Kim W.S., Kim E.J., Lee B.R., Kim J.N., Wezel G.P. van & Kim B.G. (2012), A novel function of Streptomyces integration host factor (sIHF) in the control of antibiotic production and sporulation in Streptomyces coelicolor, Antonie van Leeuwenhoek 101(3): 479-492.
- Willemse J.J., Mommaas A.M. & Wezel G.P. van (2012), Constitutive expression of ftsZ overrides the whi developmental genes to initiate sporulation of Streptomyces coelicolor, Antonie van Leeuwenhoek 101(3): 619-632.
- Willemse J.J., Borst J.W., Waal E.C. de, Bisseling T. & Wezel G.P. van (2011), Positive control of cell division: FtsZ is recruited by SsgB during sporulation of Streptomyces, Genes & Development 25(1): 89-99.
- Barends S., Zehl M., Bialek S., Waal E. de, Traag B.A., Willemse J., Nørregaard Jensen O., Vijgenboom E. & Wezel G.P. van (2010), Transfer–messenger RNA controls the translation of cell-cycle and stress proteins in Streptomyces, EMBO Reports 11(2): 119-125.
- Xu Q., Traag B.A., Willemse J.J., McMullan D., Miller M.D., Elslier M.-A., Abdubek P., Astakhova T., Axelrod H.L., Bakolitsa C., Carlton D., Chen C., Chiu H.-J., Chruszcz M., Clayton T., Das D., Deller M.C., Duan L., Ellrott K., Ernst D., Farr C.L., Feuerhelm J., Grant J.C., Grzechnik A., Grzechnik S.K., Won Han G., Jaroszewski L., Jin K.K., Klock H.E., Knuth M.W., Kozbial P., Sri Krishna S., Kumar A., Marciano D., Minor W., Mommaas A.M., Morse A.T., Nigoghossian E., Nopakun A., Okach L., Oommachen S., Paulsen J., Puckett C., Reyes R., Rife C.L., Sefcovic N., Tien H.J., Trame C.B., Bedeam H. van den, Wang S., Weekes D., Hodgson K.O., Wooley J., Deacon A.M., Godzik A., Lesley S.A., Wilson I.A. & Wezel G.P. van (2009), Structural and Functional Characterizations of SsgB, a Conserved Activator of Developmental Cell Division in Morphologically Complex Actinomycetes, Journal of Biological Chemistry 284: 25268-25279.
- Willemse J., Kulikova O., De Jong H. & Bisseling T. (2008), A new whole‐mount DNA quantification method and the analysis of nuclear DNA content in the stem‐cell niche of Arabidopsis roots, The Plant Journal 55(5): 886-894.
- Pouwels J., Van der Velden T., Willemse J., Borst J.W., Van Lent J., Bisseling T. & Wellink J. (2004), Studies on the origin and structure of tubules made by the movement protein of Cowpea mosaic virus, Journal of General Virology 85(12): 3787-3796.
- Limpens E., Franken C., Smit P., Willemse J., Bisseling T. & Geurts R. (2003), LysM domain receptor kinases regulating rhizobial Nod factor-induced infection, Science 302(5645): 630-633.
- Shah K., Russinova E., Gadella T.W.J., Willemse J. & De Vries S.C. (2002), The Arabidopsis kinase-associated protein phosphatase controls internalization of the somatic embryogenesis receptor kinase 1, Genes & Development 16(13): 1707-1720.
- Penningmeester