Jaco van Veldhoven
Arbo- en milieudeskundige
- Naam
- Ing. J.P.D. van Veldhoven
- Telefoon
- 071 5274333
- j.van.veldhoven@science.leidenuniv.nl
Arbo- en milieudeskundige
- Faculteit der Wiskunde en Natuurwetenschappen
- FWN Faculteitsbureau
- FWN Arbo & Milieu
- Dilweg M.A., Gorostiola González M., Ruiter M.D. de, Meijboom N.J., Veldhoven J.P.D. van, Liu R., Jespers W., Westen G.J.P. van, Heitman L.H., IJzerman A.P. & Es D. van der (2025), Exploring novel dilazep derivatives as hENT1 inhibitors and potentially covalent molecular tools, Purinergic Signalling 21: 289-316.
- Hollander L.S. den, Beerkens B.L.H., Dekkers S., Veldhoven J.P.D. van, Ortiz Zacarías N.V., Horst C. van der, Sieders E.G., Valk B. de, Wang J., IJzerman A.P., Es D. van der & Heitman L.H. (2024), Labeling of CC chemokine receptor 2 with a versatile intracellular allosteric probe, ACS Chemical Biology 19(9): 2070-2080.
- Mocking T.A.M., Oostveen W.M. van, Veldhoven J.P.D. van, Minnee H., Fehres C.M., Whitehurst C.E., IJzerman A.P. & Heitman L.H. (2024), Label-free detection of prostaglandin transporter (SLCO2A1) function and inhibition: insights by wound healing and TRACT assays, Frontiers in Pharmacology 15: 1372109.
- Beerkens B.L.H., Wang X., Avgeropoulou M., Adistia L.N., Veldhoven J.P.D. van, Jespers W., Liu R., Heitman L.H., IJzerman A.P. & Es D. van der (2022), Development of subtype-selective covalent ligands for the adenosine A2B receptor by tuning the reactive group, RSC Medicinal Chemistry 13(7): 850-856.
- Amelia T., Veldhoven J.P.D. van, Falsini M., Liu R., Heitman L.H., Westen G.J.P. van, Segala E., Verdon G., Cheng R.K.Y., Cooke R.M., Es D. van der & IJzerman A.P. (2021), Crystal structure and subsequent ligand design of a nonriboside partial agonist bound to the adenosine A2A receptor, Journal of Medicinal Chemistry 64(7): 3827-3842.
- Veldhoven J.P.D. van, Campostrini G., Gessel C.J.E. van, Ward-van Oostwaard D., Liu R., Mummery C.L., Bellin M. & IJzerman A.P. (2021), Targeting the Kv11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives, European Journal of Medicinal Chemistry 212: 113033.
- Mever M. van, Willacey C.C.W., Zhang W., Drouin N.F.P., Christina A.E., Lindenburg P.W., Veldhoven J.P. D. van, Es D. van der, Harms A.C., Hankemeier T. & Ramautar R. (2021), Profiling acidic metabolites by capillary electrophoresis‐mass spectrometry in low numbers of mammalian cells using a novel chemical derivatization approach, Analytical Science Advances 3(1-2): 3-13.
- Yang X., Veldhoven J.P.D. van, Offringa J., Kuiper B.J., Lenselink E.B., Heitman L.H., Es D. van der & IJzerman A.P. (2019), Development of Covalent Ligands for G Protein-Coupled Receptors: A Case for the Human Adenosine A3 Receptor, Journal of Medicinal Chemistry 62(7): 3539-3552.
- Ortiz Zacarías N.V., Veldhoven J.P.D. van, Hollander L.S. den, Dogan B., Openy J., Hsiao Y.Y., Lenselink E.B., Heitman L.H. & IJzerman A.P. (2019), Synthesis and Pharmacological Evaluation of Triazolopyrimidinone Derivatives as Noncompetitive, Intracellular Antagonists for CC Chemokine Receptors 2 and 5, Journal of Medicinal Chemistry 62(24): 11035-11053.
- Du L., Gao Z.G., Paoletta S., Wan T.C., Gizewski E.T., Barbour S., Veldhoven J.P.D. van, IJzerman A.P., Jacobson K.A. & Auchampach J.A. (2018), Species differences and mechanism of action of A(3) adenosine receptor allosteric modulators, Purinergic Signalling 14(1): 59-71.
- Zacarias N.V.O., Veldhoven J.P.D. van, Portner L., Spronsen E. van, Ullo S, Veenhuizen M., Velden W.J.C. van der, Zweemer A.J.M., Kreekel R.M., Oenema K., Lenselink E.B., Heitman L.H.I & IJzerman A.P. (2018), Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2, Journal of Medicinal Chemistry 61(20): 9146-9161.
- Xia L., Burger W.A.C., Veldhoven J.P.D. van, Kuiper B.J., Duijl T.T. van, Lenselink E.B., Paasman E., Heitman L.H. & IJzerman A.P. (2017), Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A(3) Receptor Antagonists, Journal of Medicinal Chemistry 60(17): 7555-7568.
- Liu R., Veldhoven J.P.D. van & IJzerman A.P. (2016), The role of the C-terminus of the human hydroxycarboxylic acid receptors 2 and 3 in G protein activation using Gα-engineered yeast cells, European Journal of Pharmacology 2016(770): 70-77.
- Lenselink E.B., Louvel J.A., Forti A.F., Veldhoven J.P.D. van, Vries H. de, Mulder-Krieger T., McRobb F.M., Negri A., Goose J., Abel R., Vlijmen H.W.T. van, Wang L., Harder E., Sherman W., IJzerman A.P. & Beuming T. (2016), Predicting binding affinities for GPCR ligands using free-energy perturbation, ACS Omega 1(2): 293-304.
- Sala L., Yu Z., Ward-van Oostwaard D., Veldhoven J.P.D. van, Moretti A., Laugwitz K.L., Mummery C.L., IJzerman A.P. & Bellin M. (2016), A new hERG allosteric modulator rescues genetic and drug‐induced long‐QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells, EMBO Molecular Medicine 8(9): 1065-1081.
- Yu Z., Liu J., Veldhoven J.P.D. van, IJzerman A.P., Schalij M.J., Pijnappels D.A., Heitman L.H. & Vries A.A.F. de (2016), Allosteric modulation of K(v)11.1 (hERG) channels protects against drug-induced ventricular arrhythmias, Circulation: Arrhythmia and Electrophysiology 9(4): e003439.
- Veldhoven J.P.D. van, Liu R., Thee S.A., Wouters Y., Verhoork S.J.M., Mooiman C., Louvel J. & IJzerman A.P. (2015), Affinity and kinetics study of anthranilic acids as HCA(2) receptor agonists, Bioorganic & Medicinal Chemistry 23(14): 4013-4025.
- Vilums M., Zweemer A.J.M., Dilanchian A., Veldhoven J.P.D., Vries H. de, Brussee J., Saunders J., Stamos D., Heitman L.H. & IJzerman A.P. (2015), Evaluation of (4-Arylpiperidin-1-yl)cyclopentanecarboxamides As High-Affinity and Long-Residence-Time Antagonists for the CCR2 Receptor, ChemMedChem 10(7): 1249-1258.
- Zhiyi Y., Veldhoven J.P.D. van, Louvel J.A., Hart I.M.E. 't, Rook M.B., Heyden M.A.G. van der, Heitman L.H. & IJzerman A.P. (2015), Structure-affinity relationships (SARs) and structure-kinetics relationships (SKRs) of Kv11.1 blockers, Journal of Medicinal Chemistry 58(15): 5916-5929.
- Yu Z., Veldhoven J.P.D. van, Hart I.M. 't, Kopf A.H., Heitman L.H. & IJzerman A.P. (2015), Synthesis and biological evaluation of negative allosteric modulators of the Kv11.1(hERG) channel, European Journal of Medicinal Chemistry 106: 50-9.
- Du L., Gao Z.-G., Paoletta S., Wan T., Veldhoven J.P.D. van, IJzerman A.P., Jacobson K. & Auchampach J. (2014), Species differences and molecular mechanism of action of A(3) adenosine receptor allosteric modulators, 10(4): 755-755.
- Guo D., Xia L., Veldhoven J.P.D. van, Hazeu M.D., Mocking T., Brussee J.M., IJzerman A.P. & Heitman L.H. (2014), Binding kinetics of ZM241385 derivatives at the human adenosine A(2A) receptor, ChemMedChem 9(4): 752-761.
- Guo Dong, Van Dorp Erika J.H., Mulder-Krieger Thea, Van Veldhoven Jacobus P.D., Brussee Johannes, IJzerman Adriaan P. & Heitman Laura H. (2013), Dual-Point Competition Association Assay: A Fast and High-Throughput Kinetic Screening Method for Assessing Ligand-Receptor Binding Kinetics, Journal of Biomolecular Screening 18(3): 309-320.
- Du Lili, Gao Zhan-Guo, Nithipatikom Kasem, IJzerman Adriaan P., Van Veldhoven Jacobus P.D., Jacobson Kenneth A., Gross Garrett J. & Auchampach John A. (2012), Protection from Myocardial Ischemia/Reperfusion Injury by a Positive Allosteric Modulator of the A(3) Adenosine Receptor, Journal of Pharmacology and Experimental Therapeutics 340(1): 210-217.
- Blad Clara C., Van Veldhoven Jacobus P.D., Klopman Corne, Wolfram Dieter R., Brussee Johannes, Lane J. Robert & IJzerman Adriaan P. (2012), Novel 3,6,7-Substituted Pyrazolopyrimidines as Positive Allosteric Modulators for the Hydroxycarboxylic Acid Receptor 2 (GPR109A), Journal of Medicinal Chemistry 55(7): 3563-3567.
- Horst Eelke van der, Marques-Gallego P., Mulder-Krieger Thea, Veldhoven J.P.D. van, Kruisselbrink J.W., Aleman A., Emmerich Michael T.M., Brussee J., Bender Andreas & IJzerman A.P. (2012), Multi-Objective Evolutionary Design of Adenosine Receptor Ligands, Journal of Chemical Information and Modeling 52(7): 1713-1721.
- Bot I., Vries H. de, Korporaal S.J.A., Foks A.C., Bot M., Veldhoven J.P.D., Borg M.N.D. ter, Santbrink P.J. van, Berkel T.J. van.C., Kuiper J. & Ijzerman A.P. (2012), Adenosine A(2B) Receptor Agonism Inhibits Neointimal Lesion Development After Arterial Injury in Apolipoprotein E-Deficient Mice, Arteriosclerosis, Thrombosis, and Vascular Biology 32(9): 2197-2205.
- Du L.L., Gao Z.G., Veldhoven J.P.D. van, IJzerman A.P., Jacobson K.A. & Auchampach J.A. (2012), Activity of LUF6000 and LUF6096 as positive allosteric modulators (PAMs) for the A3 adenosine receptor (AR) is species-dependent, 340(1): 210-217.
- Veldhoven J.P.D. van, Blad C.C., Artsen C.M., Klopman C., Wolfram D.R., Abdelkadir M.J., Lane J.R., Brussee J. & IJzerman A.P. (2011), Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A), Bioorganic and Medicinal Chemistry Letters 21(9): 2736-2739.
- Heitman L.H., Göblyös A., Zweemer A.M., Bakker R., Mulder-Krieger T., Veldhoven J.P.D. van, Vries H. de, Brussee J. & IJzerman A.P. (2009), A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A(3) receptor, Journal of Medicinal Chemistry 52(4): 926-931.
- Heitman L.H., Veldhoven J.P.D. van, Zweemer A.M., Ye K., Brussee J. & IJzerman A.P. (2008), False Positives in a Reporter Gene Assay: Identification and Synthesis of Substituted N-Pyridin-2-yl-benzamides as Competitive Inhibitors of Firefly Luciferase, Journal of Medicinal Chemistry 51(15): 4724-4729.
- Mantri M., Graaf O. de, Veldhoven J.P.D. van, Göblyös A., Frijtag Drabbe Künzel J.K. von, Mulder-Krieger T., Link R., Vries H. de, Beukers M.W., Brussee J. & IJzerman A.P. (2008), 2-Amino-6-furan-2-yl-4-substituted-nicotinonitriles as A2A adenosine receptor antagonists, Journal of Medicinal Chemistry 51(15): 4449-4455.
- Veldhoven J.P.D. van, Chang L.C.W., Frijtag Drabbe Kűnzel J.K. von, Mulder-Krieger T., Struensee-Link R., Beukers M.W., Brussee J. & IJzerman A.P. (2008), A new generation of adenosine receptor antagonists: From di- to trisubstituted aminopyrimidines, Bioorganic & Medicinal Chemistry 16(6): 2741-2752.
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