Anne Wentink
Universitair docent
- Naam
- Dr. A.S. Wentink
- Telefoon
- 071 5274534
- a.s.wentink@lic.leidenuniv.nl
Meer informatie is beschikbaar op de Engelse profielpagina.
Promovendi
Nieuws
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Hoe bepalen cellen het lot van eiwitten (en kunnen wij dat ook)? -
Zwaartekracht-subsidies voor vijf projecten met Leidse onderzoekers -
Is Parkinson te stoppen door eiwitvezels te ontrafelen? Anne Wentink zoekt het uit met een Vidi-subsidie van NWO -
Vidi-financiering voor acht wetenschappers Universiteit Leiden
Universitair docent
- Faculteit der Wiskunde en Natuurwetenschappen
- LIC
- Chemistry for Human Health
- Macromolecular Biochemistry
- Jager S., Tittelmeier J., Dang T.L., Bellande T., Redeker V., Buell A.K., Hennig J., Melki R., Nussbaum-Krammer C., Bukau B. & Wentink A.S. (2025), Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation, The EMBO Journal 44(22): 6499-6526.
- Herling T.W., Cassaignau A.M.E., Wentink A.S., Peter Q.A.E., Kumar P.C., Kartanas T., Schneider M.M., Cabrita L. D., Christodoulou J. & Knowles T.P.J. (2024), Thermodynamic profiles for cotranslational trigger factor substrate recognition, Science Advances 10(28): eadn4824.
- Zoltsman G., Dang T.L., Kuchersky M., Faust O., Silva M.S., Ilani T., Wentink A.S., Bukau B. & Rosenzweig R. (2024), A unique chaperoning mechanism in class A JDPs recognizes and stabilizes mutant p53, Molecular Cell 84(8): 1512-1526.
- Wentink A.S. & Rosenzweig R. (2023), Protein disaggregation machineries in the human cytosol, Current Opinion in Structural Biology 83: 102735.
- Beton J.G., Monistrol J., Wentink A.S., Johnston E.C., Roberts A.J., Bukau B.G., Hoogenboom B.W. & Saibil H.R. (2022), Cooperative amyloid fibre binding and disassembly by the Hsp70 disaggregase, The EMBO Journal 41(16): e110410.
- Nachman E., Wentink A.S., Madiona K., Bousset L., Katsinelos T., Allinson K., Kampinga H., McEwan W.A., Jahn T.R., Melki R., Mogk A., Bukau B. & Nussbaum-Krammer C. (2020), Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species, Journal of Biological Chemistry 295(28): 9676-9690.
- Serlidaki D., Waarde M.A.W.H. van, Rohland L., Wentink A.S., Dekker S.L., Kamphuis M.J., Boertien J.M., Brunsting J.F., Nillegoda N.B., Bukau B., Mayer M.P., Kampinga H.H. & Bergink S. (2020), Functional diversity between HSP70 paralogs caused by variable interactions with specific co-chaperones, Journal of Biological Chemistry 295(21): 7301-7316.
- Faust O., Abayev-Avraham M., Wentink A.S., Maurer M., Nillegoda N.B., London N., Bukau B. & Rosenzweig R. (2020), HSP40 proteins use class-specific regulation to drive HSP70 functional diversity, Nature 587(7834): 489-+.
- Wentink A.S., Nillegoda N.B., Feufel J., Ubartaite G., Schneider C.P., De Los Rios P., Hennig J., Barducci A. & Bukau B. (2020), Molecular dissection of amyloid disaggregation by human HSP70, Nature 587(7834): 483-+.
- Mattos E.P. de, Wentink A., Nussbaum-Krammer C., Hansen C., Bergink S., Melki R. & Kampinga H.H. (2020), Protein Quality Control Pathways at the Crossroad of Synucleinopathies, Journal of Parkinson's Disease 10(2): 369-382.
- Wentink A., Nussbaum-Krammer C. & Bukau B. (2019), Modulation of Amyloid States by Molecular Chaperones, Cold Spring Harbor Perspectives in Biology 11(7): a033969.
- Nillegoda N.B., Wentink A.S. & Bukau B. (2018), Protein Disaggregation in Multicellular Organisms, Trends in Biochemical Sciences 43(4): 285-300.
- Waudby C.A., Wlodarski T., Karyadi M.E., Cassaignau A.M.E., Chan S.H.S., Wentink A.S., Schmidt-Engler J.M., Camilloni C., Vendruscolo M., Cabrita L.D. & Christodoulou J. (2018), Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis, Proceedings of the National Academy of Sciences 115(39): 9744-9749.
- Mashaghi A., Bezrukavnikov S., Minde D.P., Wentink A.S., Kityk R., Zachmann-Brand B., Mayer M.P., Kramer G., Bukau B. & Tans S.J. (2016), Alternative modes of client binding enable functional plasticity of Hsp70, Nature 539(7629): 448-451.
- Cabrita L.D., Cassaignau A.M.E., Launay H.M.M., Waudby C.A., Wlodarski T., Camilloni C., Karyadi M.E., Robertson A.L., Wang X.L., Wentink A.S., Goodsell L.S., Woolhead C.A., Vendruscolo M., Dobson C.M. & Christodoulou J. (2016), A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding, Nature Structural and Molecular Biology 23(4): 278-285.
- Deckert A., Waudby C.A., Wlodarski T., Wentink A.S., Wang X.L., Kirkpatrick J.P., Paton J.F.S., Camilloni C., Kukic P., Dobson C.M., Vendruscolo M., Cabrita L.D. & Christodoulou J. (2016), Structural characterization of the interaction of alpha-synuclein nascent chains with the ribosomal surface and trigger factor, Proceedings of the National Academy of Sciences 113(18): 5012-5017.