Drug discovery and development
Our contribution to society:
Accelerating the development of safe, accessible therapies to improve health and healthcare.
News
Our research and teaching
New medicines emerge when expertise from different fields comes together. Fundamental research can uncover new targets and mechanisms, but developing a successful therapy requires much more: technology development, preclinical and clinical studies, manufacturing, regulation, behavioural science, ethics, patient involvement, and use in healthcare all play key roles.
Our research focuses on the full drug discovery and development process. We study the mechanisms underlying disease, identify potential treatment targets and develop new molecules, biologics and advanced therapies such as cell and gene therapies. We also investigate how to develop and evaluate these interventions to ensure they are safe, effective and of consistent quality.
This involves looking beyond the drug itself. How do we design research that generates relevant and reliable answers? How do we take account of differences between patients? What are the requirements for quality, safety and efficacy? And how do we ensure that new treatments can be implemented safely and responsibly for patients? By combining these perspectives, we help turn discoveries into practical applications.
Leiden University offers an excellent ecosystem for this multidisciplinary approach. We bring together expertise in medicine and the natural, life, and social and behavioural sciences. Across the university, the LUMC and the Leiden Bio Science Park, researchers work with healthcare professionals, industry, public organisations, policymakers and civil society partners. This environment enables us to explore therapeutic innovation from multiple perspectives.
Our teaching also reflects the full drug development process. Students, PhD candidates, postdocs and professionals learn not only about individual academic disciplines but also about the links among discovery, development, clinical application and societal impact. We bring together existing programmes and training, and encourage teaching that helps students and researchers collaborate across disciplinary boundaries.
Through our research, we contribute to the development of new therapies. Through our teaching, we prepare the next generation of researchers and professionals to develop and bring new medicines to patients responsibly, across disciplines and with patients’ needs at the centre.
Experts
-
Mario van der Stelt Topics: artificial intelligence, drug discovery, endocannabinoid, kinase, medicinal chemistry -
Judy Veldhuijzen Topics: drug discovery -
Annemieke Aartsma-Rus -
Joost Batenburg Topics: algebra, artificial intelligence, computational drug design, computational imaging, drug discovery, geometry, number theory, tomography -
Ilze Bot Topics: drug discovery -
Jeroen Codee Topics: adjuvants, artificial intelligence, carbohydrates, drug discovery, inhibitors, stereoselective synthesis, synthetic methodology, vaccines -
Eline Dekeyster Topics: clinical trials, drug development, healthy aging, metabolic psychiatry, neurobiology -
Michiel van Elk Topics: altered states of consciousness, open science, open science community leiden, placebo effects, psychedelics, religion, spirituality -
Teun van Gelder -
Hans Gelderblom -
Arko Ghosh Topics: brain plasticity, codelab, digital medicine, sensory motor systems, smartphone behavior -
Stephan Hacker Topics: drug discovery -
Thomas Hankemeier Topics: analytical chemistry, biomedical applications, drug discovery, drug research, electrophoresis-mass spectrometry, high resolution mass spectrometry, metabolomics, organ-on-a-chip, pathway analysis -
Laura Heitman Topics: allosteric modulation, drug discovery, drug-target binding kinetics, g protein-coupled receptors, novel drug discovery concepts, small molecules -
Sandra Irmisch Topics: biochemistry, biosynthesis, drug discovery, metabolic engineering, natural products, pathway analysis, plant metabolomics, synthetic biology -
Henriët van Middendorp Topics: chronic pain, e-health, placebo, psychoneurobiology, stress -
Sjaak Neefjes -
Hermen Overkleeft Topics: activity-based protein profiling, artificial intelligence, chemical biology, chemical proteomics, drug discovery, glycosidases, inhibitors, proteases -
Paul Parren -
Meta Roestenberg -
Judith Schomaker Topics: attention, learning, memory, motivation, novelty, open science community leiden -
Aleksandrina Skvortsova Topics: communication, metabolism, nocebo, open science community leiden, placebo effects, psychoendocrinology -
Martine de Vries Topics: artificial intelligence -
Anne Wentink Topics: drug discovery -
Rob van Wijk Topics: drug development, drug discovery, high-throughput experimentation, immuno-pharmacology, infectious diseases, modelling and simulation, pharmacokinetics-pharmacodynamics, preclinical to clinical scaling, rodents, translational pharmacology, tuberculosis, zebrafish