Research project
Predictive pharmacology
The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.
- Contact
- Elizabeth (Liesbeth) de Lange
We mostly focus on the central nervous system (CNS), and through the use of state-of-the-art quantitative animal experimentation and mathematical models we are able to obtain insights on rate and extent of CNS processes that govern drug behavior in multiple CNS compartments, in a condition dependent manner.
Connection with other research
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Predictive pharmacology
- Prediction of human (CNS) target site concentrations in health and disease
- Predicting early Alzheimer's disease stage in human
- Drug-target binding kinetics in vivo
- Spatial (3-D) CNS drug distribution in vivo
- Prediction of human gut (colon cancer) target site concentrations and PKPD relationships
- Pharmacometabolomics; prediction of system-wide multi-biomarker drug response