Research project
Predictive pharmacology
The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.
- Contact
- Elizabeth (Liesbeth) de Lange
We mostly focus on the central nervous system (CNS), and through the use of state-of-the-art quantitative animal models we are able to obtain dynamical multiple level systems information from plasma and CNS compartments, under different conditions.
Connection with other research
- Predictive pharmacology
- Spatial (3-D) CNS drug distribution in vivo
- Pharmacometabolomics; prediction of system-wide multi-biomarker drug response
- Prediction of human (CNS) target site concentrations in health and disease
- Drug-target binding kinetics in vivo
- Predicting early Alzheimer's disease stage in human
- Prediction of human gut (colon cancer) target site concentrations and PKPD relationships