Research project
Predictive pharmacology
The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.
- Contact
- Elizabeth (Liesbeth) de Lange
We mostly focus on the central nervous system (CNS), and through the use of state-of-the-art quantitative animal models we are able to obtain dynamical multiple level systems information from plasma and CNS compartments, under different conditions.
Connection with other research
- Predictive pharmacology
- Towards a 3D brain drug distribution model
- Assessment of the impact of in vivo drug-target binding kinetics on local drug concentrations
- Integration of PKPD modelling and metabolomics of the dopaminergic system
- Prediction of CNS target site pharmacokinetics in humans
- The impact of drug-target binding kinetics on in vivo drug effects
- Development of a QSP model for the prediction of intestinal/colonic drug distribution and efficacy of COX inhibitors targeting colorectal cancer
- Fingerprint biomarker analysis and modeling for disease progression stage diagnostics in Alzheimer's Disease