Universiteit Leiden

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Research project

Prediction of human gut (colon cancer) target site concentrations and PKPD relationships

The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

Elizabeth (Liesbeth) de Lange

This research is part of the IWT TRAIN project and is a collaboration with Janssen Pharmaceutica (coordinator Dr Jan Snoeys), KU Leuven, University of and the Hubrecht Organoid Technology (HUB).

Current PhD student:

  • Anthony Gebhart (Development of a Gut PBPKPD model)
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