Universiteit Leiden

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Research project

Predicting early Alzheimer's disease stage in human

A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).

Elizabeth (Liesbeth) de Lange


A literature search on current state-of-the-art-knowledge on fluid-based biomarkers of AD, especially at the earlier stages, indicated gaps in useful (longitudinal and multilevel) data. Currently, such smart data are being obtained from animal experimentation and from humans. The final goal is to develop a systems model on Alzheimer’s disease progression, based on multiple body fluid biomarker fingerprints, which would allow assessment of AD stage, and effects of drugs.

  • Qin T, Prins S, Groeneveld GJ, Van Westen G, de Vries HE, Wong YC, Bischoff LJM, de Lange ECM*. Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals. Int J Mol Sci. 2020 Apr 30;21(9). pii: E3158. doi: 10.3390/ijms21093158.
  • Hurtado MO, Kohler I, de Lange EC. Next-generation biomarker discovery in Alzheimer's disease using metabolomics - from animal to human studies. Bioanalysis. 2018 Sep 1;10(18):1525-1546. doi: 10.4155/bio-2018-0135. Epub 2018 Sep 10.


Current Postdoc:

  • Frédérique Kok (Cytokines in Alzheimer’s disease)

Current PhD student:

  • Tian Qin (extracellular vesicles in Alzheimer’s didease)

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