From Descriptive to Predictive Pharmacology in Children using Semi-Physiological population modelling
An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.
As 40-80% of medicines in children is still used unlicensed or off-label, children are at risk of receiving inappropriate doses leading to toxicity or lack of efficacy. For ethical and practical reasons paediatric clinical studies are difficult to perform, therefore, we propose to develop semi-physiological computer models that can be used to predict drug doses for each individual child. For these systems models, we integrate physiological concepts, advanced data analysis approaches, and large datasets from routine clinical practice.
The following projects are related to this research: