Universiteit Leiden

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Research project

Predictive value of semi-physiological models for clearance of renally excreted drugs across the paediatric age range

The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.

Catherijne Knibbe

Project in collaboration with Prof. dr. Karel Allegaert (Erasmus MC/KU Leuven).

This project is part of the PKPD platform 2.0

To provide safe and effective drug therapy to children, a framework is needed that quantifies the influences of these changes on drug pharmacokinetics and identifies descriptors of variability in drug elimination. This framework can subsequently be used to accurately predict drug exposure and associated risks of over and under dosing and form the basis of personalize drug therapy in children.

The primary goal of this project is to guide dosing in the paediatric population by taking into account developmental changes in drug exposure of renally excreted drugs. A thorough investigation of maturation of glomerular filtration, tubular processes and kidney metabolism will be performed. For this, both physiologically based approaches and population analysis techniques are combined.

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