Cell adhesion signaling: dynamics, migration, and metastasis. We have a long standing interest in understanding how interactions of cells with their natural environment – the extracellular matrix – control cell behavior. We study the receptors involved in this interaction and the associated signaling machinery that controls in a very dynamic fashion cytoskeletal organization and cell shape. We also study bidirectional force-transmission between cells and the extracellular matrix, which occurs at cell adhesions and which regulates various processes implicated in tumor progression such as differentiation, growth, invasion, and angiogenesis.