Universiteit Leiden

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Research project

Cell adhesion signaling: dynamics, migration, and metastasis

Cell adhesion signaling

Contact
Erik Danen

Cell adhesion signaling: dynamics, migration, and metastasis. We have a long standing interest in understanding how interactions of cells with their natural environment – the extracellular matrix – control cell behavior. We study the receptors involved in this interaction and the associated signaling machinery that controls in a very dynamic fashion cytoskeletal organization and cell shape. We also study bidirectional force-transmission between cells and the extracellular matrix, which occurs at cell adhesions and which regulates various processes implicated in tumor progression such as differentiation, growth, invasion, and angiogenesis.

Connection with other research

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