Universiteit Leiden

nl en

Proefschrift

Two-photon luminescence of gold nanorods: applications to single-particle tracking and spectroscopy

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

Auteur
S. Carozza
Datum
04 juli 2017
Links
Thesis in Leiden Repository

We explored the use of gold nanorods as labels for single-particle tracking in live cells, both not functionalized and functionalized with nuclear localization signal for nuclear targeting. For single-particle tracking we used mean square displacement analysis, after characterizing the limitations of this analysis with simulations. We also tested the acquisition of excitation spectra of single gold nanorods for sensing applications.