Universiteit Leiden

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Proefschrift

Synthetic Study on ADP-ribosylation

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Auteur
Liu, Q.
Datum
27 november 2019
Links
Thesis in Leiden Repositroy

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.The limitations of the contemporary methods of chemical ADP-ribosylation and a relative scarcity of the well-defined synthetic ADP-ribosylated derivative was an incentive to undertake synthetic studies to further advance the methodologies in the bioorganic chemistry of ADP-ribosylated molecules. This Thesis aims specifically at the developing of new and improved synthetic methodologies and to synthesize advanced mono- or oligo-ADP-ribosylated biomolecules. The target compounds that are described in this Thesis are not only represent a synthetic challenge but also have great value in biology for a better understanding of ADP-ribosylation.

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