Proefschrift
Release and transport of endocannabinoids
Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport remain largely unknown.
- Auteur
- V.M. Straub
- Datum
- 04 februari 2025
- Links
- Thesis in Leiden Repository
This is in part due to the lack of methods available to interrogate the spatial aspects of endogenous endocannabinoid signaling. The aim of this thesis was to develop novel techniques for the study of endocannabinoid release and apply them to investigate the mechanisms regulating that process, with a focus on extracellular vesicles. The findings described in this thesis led to the proposal of a new ‘on-demand release’ model for the endocannabinoid 2-arachidonoylglycerol.